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Experiencing low back pain? Clinical trial at Brown Health could help.

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Experiencing low back pain? Clinical trial at Brown Health could help.



The injection could be “revolutionary” for treating degenerative disc disease, said the trial’s principal investigator

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A clinical trial at Brown University Health to treat chronic low back pain with a one-time, non-surgical injection treatment is seeking to enroll patients in Rhode Island.

The trial is testing whether a single injection of rexlemestrocel-L, an experimental stem cell therapy derived from healthy adult donors, combined with hyaluronic acid, a gel-like substance found in the body’s joints, and delivered directly into the damaged disc, can provide prolonged relief for low back pain.

Low back pain, or degenerative disc disease, can affect quality of life, disrupt daily activities, commission people out of work and have an impact on a person’s mood, said Alexios Carayannopoulos, chief of physical medicine and rehabilitation at Rhode Island Hospital, Newport Hospital and Brown Health Medical Group and the principal investigator in the trial.

The treatment Carayannopoulos is investigating involves an injection without the need for an incision or hardware. While other treatments, such as anti-inflammatory pills, physical therapy or steroid injections, assuage the pain, they don’t treat the underlying issues with the damaged disc. The trial’s injection aims to do more than numb pain: it seeks to change the environment inside the disc, reducing inflammation and potentially slowing or stabilizing disc degeneration, according to Carayannopoulos.

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Earlier clinical trials of the injection with over 400 patients “found substantial pain improvements” lasting up to two to three years, according to Carayannopoulos. They also showed signs that the injection slowed disc height loss.

Carayannopoulos reckons the treatment could be “revolutionary” for managing chronic low back pain.

“We have struggled through many years trying to figure out the holy grail for treating back pain,” Carayannopoulos said.

There are surgical options and non-surgical options for treating low back pain. In most cases, the non-surgical options are sought first, but some patients still get unnecessary surgeries, according to Carayannopoulos.

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The new treatment could also cut back on the use of opioids, which for some patients can be addictive to the point of overdose. More than half of opioid prescriptions are for low back pain, according to Carayannopoulos.

“If we can identify a treatment that has long-term promise, then we can sort of have a paradigm shift in the way we organize and treat a cohort of patients with degenerative disc pain, which is one of the common contributors to low back pain,” Carayannopoulos said.

Carayannopoulos did not have data on how many people suffer from low back pain in Rhode Island, but based on the number of spine centers in the state and anecdotal evidence, he reckons there is a significant number of people with the condition.

“Part of that comes from some of the legacy of blue-collar work that’s being done, industry stuff, line work that’s still being done, some jewelry business. But the type of stuff that we see is often degenerate, meaning it’s happened over time,” he said.

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The trial is funded by Mesoblast, an Australia-based medicine company specializing in inflammatory diseases. It is designed for adults 18 years and older who have experienced chronic low back pain for at least six months, have been diagnosed with degenerative disc disease and have not found relief from other treatment options.

The trial is recruiting participants at Rhode Island Hospital and Newport Hospital. They will not be charged for participating and will be reimbursed for time and travel, according to Brown Health. To inquire about the trial, call 401-793-9177 or fill out a pre-screening information form online.

The trial is in its third phase, where researchers and clinicians are comparing results with a larger group of patients. It will be followed by a fourth phase, which will seek FDA approval to monitor long-term effectiveness and safety.



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Rhode Island

Frostbitten lizard found in Rhode Island is healing

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Frostbitten lizard found in Rhode Island is healing


While shoveling his driveway during yet another winter storm, a man in Providence, Rhode Island found something rather unexpected—a very cold giant lizard. Fortunately, the animal rehabilitation experts at the New England Wildlife Center found that besides being very dehydrated and having frostbite on its tongue and toes, the female tegu named Frankie was doing okay. 

Tegus are large South American reptiles, so how did Frankie end up in the middle of a snowstorm in New England? Tess Gannaway, a veterinarian at the wildlife center who treated Frankie, tells Popular Science that she was probably someone’s pet. 

“Given their size they often roam folk’s homes like dogs or cats and there is a chance that in warmer months Frankie escaped and was surviving on her own outside until the weather got too cold for her to manage,” Gannaway explains. There’s also the more unfortunate possibility that the lizard was recently abandoned.

The black on the tip of Frankie’s tongue are the dead tissue as a result of the frostbite. Image: New England Wildlife Center Staff.

Either way, Frankie was likely unable to pull her tongue back into her mouth at the start of the storm, which caused the frostbite on both her tongue and her toes. The tongue frostbite is particularly notable because known cases of animals with mucus membrane related frostbite are exceedingly unusual. Because of the frostbite, Frankie no longer has the iconic reptilian V-shape in her tongue. 

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In fact, veterinary medicine as a whole didn’t have any published accounts of such an affliction. As such, Gannaway and her veterinary student turned to human medical literature to decide on Frankie’s best treatment option, and ultimately identified what they were looking for. 

This “is really cool and an example of something in veterinary medicine and other fields we call one health, so the intersection between human and animal health,” Gannaway explained in a New England Wildlife Center video. 

In the human report, a portion of a patient’s tongue had unintentionally frozen because of a medical intervention in the mouth. Doctors then removed the dead external tissue a number of times, healing the injury within three weeks. 

Similarly, the team at the New England Wildlife Center aims to remove part of Frankie’s dead tongue tissue every two or three weeks. Hopefully, the tongue will heal on its own, but the good news is that tongues are rapid healers. 

Gannaway says that the team is “cautiously optimistic” about Frankie’s future. 

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“She did great during her first debridement [the tissue removal] and has moved on from liquid to solid food. New England Wildlife Centers’ Veterinarians will keep checking her tongue every 2 weeks to see if she needs further sedation to remove more superficial tissue,” she adds.“Until then she is on pain medications and an antibiotic. Tegus can live normal lives with only part of their tongue so as long as we can get her tongue to stabilize she should be ready to live a warmer although slightly less adventurous life.” 

 

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Margherita is a trilingual freelance science writer.




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Bodycam footage shows moments police respond to Pawtucket shooting

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Bodycam footage shows moments police respond to Pawtucket shooting


Police bodycam footage shows the moments officers arrived to the scene of a deadly mass shooting in Pawtucket, Rhode Island.

The shooting on Feb. 16 at the Dennis M. Lynch Arena killed Rhonda Dorgan and Aidan Dorgan, the ex-wife and son of the shooter, who died by suicide.

Gerald Dorgan, Rhonda’s father, died from his injuries this week. His wife, Linda Dorgan, and family friend Thomas Geruso remain hospitalized.

Around five minutes after the first officer arrives, he beings helping paramedics with a man who identifies himself as Aidan. Twelve minutes in, Aidan Dorgan is transported to the hospital, where he would later die from his injuries.

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For the last 10 minutes of the footage, the officer then begins helping paramedics transport the other three gunshot victims.

The video ends with police prepping witness interviews.

The shooting rocked the Pawtucket community. Chris Librizzi, head coach of the Blackstone Valley Schools hockey team impacted by the shooting, said the players and coaching staff “are devastated over the events that took place at Lynch Arena on Monday and intimately affected one of our teammates.”

As authorities continue investigating the shooting in Pawtucket, three patients remain in critical condition.

“We will lean on each other and support one another, as we have always done as a team,” he added.

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Pawtucket police said two handguns were found at the scene after the shooting, a Sig Sauer P226 and Glock. Other weapons have been seized at the suspect’s storage unit in Maine.

Investigators continue reviewing all video evidence from before, during and after the shooting, including surveillance footage from the Dennis M. Lynch Arena, police body-worn camera footage and other records — a high school sports livestream captured the shooting from a distance — police said.



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Man killed in RI shooting; suspect involved in Mass. car crash that killed 2 others

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Man killed in RI shooting; suspect involved in Mass. car crash that killed 2 others


A man has died after a shooting in Cranston, Rhode Island, and investigators say a suspect was later involved in a car crash in Swansea, Massachusetts, that killed two other people.

The shooting victim was found Thursday on Legion Way, shot multiple times in the chest, Cranston police told NBC affiliate WJAR-TV. He was taken to Rhode Island Hospital where he later died. His name has not been released.

The suspect initially fled on foot, setting off a shelter-in-place order while investigators searched the area.

Police said Friday that investigators identified a suspect vehicle, which was later spotted by Massachusetts State Police. A trooper followed the car down Route 6 and Interstate 195, but stopped when it crossed back into Rhode Island. The car was later involved in a crash on Route 136 in Swansea, Mass.

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Swansea police say that crash on Route 136 (James Reynolds Road) resulted in the deaths of two other people.

According to the Swansea Police Department, two officers saw a white Infinity G37 speed past them around 12:18 a.m. Friday on Route 6, otherwise known as Grand Army of the Republic Highway. Moments later, officers observed that the vehicle had crashed into the side of a blue Subaru Ascent that had been traveling southbound on Route 136.

Both vehicles sustained catastrophic damage, police said.

The vehicle that was struck was fully engulfed in flames. First responders and bystanders tried to extinguish the fire, but both occupants — a man and a woman — were pronounced dead at the scene, police said. Their names have not been released.

The 28-year-old Infinity driver, who struck the victims’ Subaru, was taken to Rhode Island Hospital with serious injuries and later into custody by Cranston Police. They have not been publicly identified at this time.

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Swansea police said they are aware that the Infinity was the subject of a police pursuit, and know the driver was wanted in connection to the Rhode Island homicide investigation. While Swansea police had been alerted to be on the lookout for the suspect’s vehicle, however, they say they were not involved in the pursuit and were not pursuing the vehicle at the time of the deadly crash.

The crash in Swansea is under investigation by Massachusetts authorities, including state police and the Bristol County District Attorney’s Office. Meanwhile, Cranston police said they would give an update on their investigation around 1 p.m.



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