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Higher dementia risk seen in women with common health issue

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Higher dementia risk seen in women with common health issue

An estimated 80% of women have some type of menopause symptoms — and the more symptoms they experience, the greater the chances of developing dementia later in life.

The findings were published in the journal PLOS One following a study by the University of Calgary.

The researchers analyzed the data of 896 postmenopausal women who participated in the Canadian Platform for Research Online to Investigate Health, Quality of Life, Cognition, Behaviour, Function, and Caregiving in Aging (CAN-PROTECT) study.

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The women reported their perimenopausal symptoms to researchers. Their cognitive function was measured using the Everyday Cognition (ECog-II) Scale and the Mild Behavioral Impairment Checklist (MBI-C), with higher scores indicating greater severity.

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Those with greater menopausal symptoms had higher scores for both cognitive tests, indicating more severe decline. 

An estimated 80% of women experience some type of menopause symptoms — and the worse they are, the greater the chances of developing dementia later in life, according to a new study. (iStock)

“One of the most interesting findings was the association between menopausal symptom burden and mild behavioral impairment (MBI) symptoms — a syndrome increasingly recognized as an early indicator of dementia risk,” lead study author Zahinoor Ismail, M.D., professor of psychiatry, neurology, epidemiology and pathology at the University of Calgary, told Fox News Digital.

“These novel findings highlight the need to consider not only cognitive changes, but also mood, social interaction and personality changes that emerge and persist in later life following menopause.”

“These novel findings highlight the need to consider not only cognitive changes, but also mood, social interaction and personality changes.”

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While hormone therapy was not significantly associated with cognitive function, it was shown to have a significant link to fewer MBI symptoms, according to the researchers, emphasizing the need for further research into the potential role of hormone therapy in long-term brain health.

“Interestingly, participants who reported using estrogen-based hormone therapy during perimenopause had significantly lower mild behavioral impairment symptom severity,” noted Ismail.

“One of the most interesting findings was the association between menopausal symptom burden and mild behavioral impairment symptoms — a syndrome increasingly recognized as an early indicator of dementia risk,” the lead study author noted. (iStock)

Alexa Fiffick, a board-certified family medicine physician specializing in menopause, stated that previous data has shown higher symptom burden is somehow related to decreased cognitive function and possibly dementia. 

Some studies have shown that even when hot flashes aren’t perceived by the woman, they are still associated with worsened cognitive function, according to the Ohio doctor. 

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“It is believed that the vasomotor symptoms are correlated with development of white matter hyperintensities in the brain, akin to what vascular dementia looks like on imaging,” Fiffick, who was not involved in the new study, told Fox News Digital. 

“We have yet to obtain the data that treating VMS will prevent cognitive decline, but are hopeful that with menopausal hormone therapy and other non-hormonal options, we may be able to obtain this data in the near future.”

Potential limitations

The researchers acknowledged several limitations of the study.

“This study is cross-sectional, meaning it captures a snapshot in time rather than tracking changes over the years,” Ismail told Fox News Digital.

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Some studies have shown that even when hot flashes aren’t perceived by the woman, they are still associated with worsened cognitive function. (iStock)

This means it can only identify associations between menopause symptoms and cognitive and behavioral health, but cannot determine whether the symptoms directly cause the changes in brain health. 

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“To better understand the long-term impact of menopause on dementia risk, future research should follow participants over time and incorporate biological data, such as hormone levels and brain-related biomarkers (we are, in fact, doing this now),” Ismail added.

The study also did not assess the severity of the symptoms, which could play a key role in understanding risk.

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“This research just reinforces that menopause is a neurological shift as much as it is a hormonal one.” (iStock)

Another limitation is that the study focused on the most commonly reported menopause symptoms, but it’s possible that some participants experienced additional symptoms. 

“In fact, it’s reported that there may be 30+ symptoms that females may experience when undergoing the menopause transition,” said Ismail. “While we included an ‘other symptoms’ category, it may not fully reflect the range of experiences.”

The study also did not distinguish between different types and formulations of hormone therapy. 

      

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“Future studies will be able to explore whether specific types of HT have different effects on brain health,” Ismail noted.

“Brain scans of women in menopause reveal real structural and metabolic changes, and this study reinforces that we can’t just brush these symptoms off as ‘normal aging.’”

Tamsen Fadal, a New York menopause expert and author of the upcoming book “How to Menopause: Take Charge of Your Health, Reclaim Your Life, and Feel Even Better than Before,” said she was not surprised by the results of the study.

“Research has been pointing to this connection for a while,” she told Fox News Digital. “Brain scans of women in menopause reveal real structural and metabolic changes, and this study reinforces that we can’t just brush these symptoms off as ‘normal aging.’”

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“For too long, women have been experiencing brain fog, memory lapses and mood changes, and many of us have been dismissed,” Fadal went on. 

“This research just reinforces that menopause is a neurological shift as much as it is a hormonal one.”

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How a Vegan Diet Can Help You Lose Weight 8X Faster

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How a Vegan Diet Can Help You Lose Weight 8X Faster


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Cancer-linked herbicide in the spotlight after controversial order: ‘Toxic by design’

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Cancer-linked herbicide in the spotlight after controversial order: ‘Toxic by design’

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There has been a shake-up in the Make America Healthy Again movement regarding glyphosate, a widely used herbicide that has been the subject of significant controversy.

The debate follows an executive order signed by President Donald Trump that ensures an adequate supply of elemental phosphorus and glyphosate-based herbicides related to national defense.

MAHA supporters have previously pushed a pesticide-free agenda, warning of potential health harms caused by glyphosate.

Dr. Marc Siegel, Fox News senior medical analyst, said he believes there is sufficient evidence linking glyphosate to neurodegenerative diseases, including ALS, Parkinson’s and multiple sclerosis, to warrant limiting exposure.

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President Donald Trump signed an executive order that ensures an adequate supply of elemental phosphorus and glyphosate-based herbicides related to national defense. (AP Photo/Charlie Neibergall)

“With Parkinson’s, this association appears to be due to the gut, vagus nerve and brain axis, where the exposure affects the microbiome in the gut, which then ascends slowly up to the brain, causing the neurodegenerative disease years later,” Siegel told Fox News Digital.

“There is also a growing association being found between high-dose glyphosate or occupational exposure and metabolic disorders, liver disease and some cancers, specifically lymphoma.”

He added, “Growing research backs this. I favor limiting it.”

“When we apply them across millions of acres and allow them into our food system, we put Americans at risk.”

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Studies have shown that glyphosate, which is used in products such as Roundup, owned by Monsanto, could raise cancer risk.

In one University of Washington study published in the journal Mutation Research, researchers found that exposure to it increased the risk of non-Hodgkin lymphoma by 41%.

The nonprofit Investigate Midwest, which analyzed data from both the U.S. Geological Survey and the National Cancer Institute, also recently found that pesticides may contribute to cancer rates.

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Among the top 500 counties for per-square-mile pesticide use, more than 60% had cancer rates above the national average of 460 cases per 100,000 people, according to the report.

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Investigate Midwest, which is based in Illinois, interviewed more than 100 farmers, environmentalists, lawmakers and scientists as part of a partnership with the Pulitzer Center’s StoryReach U.S. Fellowship.

Among the top 500 counties for per-square-mile pesticide use, more than 60% had cancer rates above the national average of 460 cases per 100,000 people, according to one study. (iStock)

Iowa, which used 53 million pounds of pesticides last year, holds the nation’s title for second-highest cancer rate.

Bill Billings, a resident of Red Oak, Iowa, was diagnosed with cancer in 2014. 

“The cancer specialist said, very directly, (my) cancer is a result of being exposed to chemicals,” Billings said in the report.

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Kelly Ryerson, founder of Glyphosate Facts and owner of the Instagram account @glyphosategirl, told Fox News Digital her journey researching the herbicide began with her own health struggles.

Ryerson, who is based in California, previously struggled with chronic illness and autoimmune issues, which she said improved when she stopped eating gluten. 

Iowa, which used 53 million pounds of pesticides last year, holds the nation’s title for second-highest cancer rate. (iStock)

After attending a medical conference at Columbia University’s Celiac Disease Center, Ryerson began to question modern farming practices rather than the gluten itself.

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“A lot of times, farmers are spraying Roundup on our grains right before harvest to facilitate an easier harvest,” she said. “After that easier harvest, because everything’s dry at the same time, those crops go directly to the mill and may end up in our food supply, at alarmingly high levels.”

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In 2015, the International Agency for Research on Cancer (IARC), part of the World Health Organization framework, classified glyphosate as “probably carcinogenic to humans.”

The classification was based on limited evidence of cancer in humans (notably non-Hodgkin lymphoma in some studies) and sufficient evidence in experimental animals.

“President Trump’s executive order reinforces the critical need for U.S. farmers to have access to essential, domestically produced crop protection tools, such as glyphosate,” a Monsanto spokesperson said. (Wolf von Dewitz/picture alliance via Getty Images)

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A spokesperson for Monsanto told Fox News Digital it will comply with Trump’s order to produce glyphosate and elemental phosphorus.

“President Trump’s executive order reinforces the critical need for U.S. farmers to have access to essential, domestically produced crop protection tools, such as glyphosate,” the spokesperson said.

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HHS Secretary Robert F. Kennedy Jr. has long been a vocal critic of Roundup, working with his legal team in 2018 to award $289 million to a man who alleged the weed killer caused his non-Hodgkin lymphoma, according to reports.

Following backlash to Trump’s executive order, Kennedy said he supports the order but acknowledged that “pesticides and herbicides are toxic by design, engineered to kill living organisms.”

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“When we apply them across millions of acres and allow them into our food system, we put Americans at risk,” he posted on X. “Chemical manufacturers have paid tens of billions of dollars to settle cancer claims linked to their products, and many agricultural communities report elevated cancer rates and chronic disease.”

Fox News Digital reached out to the White House for comment.

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Common nighttime noise exposure may trigger heart problems, study suggests

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Common nighttime noise exposure may trigger heart problems, study suggests

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Living near heavy traffic could negatively impact your heart health.

A European study, published in the journal Environmental Research, found that exposure to nighttime road traffic noise is linked to changes in the blood, leading to worsened cholesterol and cardiovascular risks.

The researchers considered data from the U.K. Biobank, Rotterdam Study, and Northern Finland Birth Cohort 1966, including more than 272,000 adults over the age of 30, according to a press release.

Nighttime road noise exposure was estimated at all participants’ homes based on national noise maps. Researchers also took blood samples to measure the participants’ metabolic biomarkers for disease, then mapped the link between nightly noise levels and existence of biomarkers.

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Exposure to loud noise was associated with increased concentrations of cholesterol-related biomarkers. (iStock)

The study found that people exposed to louder noise at night — especially sounds above 55 decibels — showed changes in 48 different substances in their blood. Twenty of these associations “remained robust” throughout all cohorts.

Exposure to loud noise was associated with increased concentrations of cholesterol-related biomarkers, especially LDL “bad” cholesterol, IDL (intermediate-density lipoprotein) and unsaturated fatty acids.

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As noise levels increased, starting at around 50 decibels, cholesterol markers rose steadily, the release stated.

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The authors concluded that this study “provides evidence that nighttime road traffic noise exposure from 50 dB upward is associated with alterations in blood cholesterol and lipid profiles in adults.”

Researchers noted a link between traffic noise and cardiometabolic disease. (iStock)

Study co-author Yiyan He, doctoral researcher at the University of Oulu in Finland, noted that in this type of research, small effect sizes are expected, and environmental exposures such as traffic noise are “typically modest.”

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“Despite this, we observed statistically robust and consistent associations across many biomarkers, especially those related to LDL and IDL lipoproteins,” she told Fox News Digital.

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“We also identified a clear exposure-response pattern starting at around 50 dB, suggesting that metabolic changes become more evident as noise levels increase.”

This aligns with public health guidance, as the World Health Organization recommends lower nighttime noise limits at around 40 to 45 dB, Yiyan He added.

“This finding may clarify the association between traffic noise and cardiometabolic diseases,” the researchers wrote. (iStock)

“The 55 dB level is often used as an interim benchmark associated with substantial noise annoyance and sleep disturbance,” she said. “In our study, we observed associations not only at 55 dB, but also indications of effects emerging at around 50 dB.”

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The strength and consistency of the cholesterol-related associations were surprising, as these changes are usually “subtle.”

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“Instead, we found consistent associations across multiple large European cohorts, which strengthens confidence that the findings may reflect real biological patterns,” Yiyan He went on. “We were also interested to see that effects were minimal below ~50 dB, suggesting a possible threshold-like pattern.”

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The researcher noted that these findings were consistent across genders, education levels and obesity status.

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The study was restricted to White Europeans, which posed a limitation. There was also a lack of information on the fasting status in the UK Biobank.

Changes in cholesterol levels were more severe than researchers expected. (iStock)

“Fasting can influence levels of certain metabolites, particularly fatty acids,” Yiyan He said. “However, based on UK Biobank documentation, fewer than 10% of participants were fasting for at least eight hours, and our main findings focused on cholesterol-related biomarkers, which are generally less sensitive to short-term fasting.”

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The researchers also lacked information on bedroom location, indoor noise exposure and time spent at home.

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“These factors may introduce non-differential exposure misclassification,” Yiyan He said. “Additionally, noise exposure estimates were based on participants’ temporary residential addresses at the time of blood sampling, without considering the duration of residence.”

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“Many of these limitations would tend to bias results toward the null, so the consistent associations we observed remain noteworthy.”

Experts recommend taking measures to limit traffic noise at night. (iStock)

Based on this latest research, Yiyan He noted that nighttime noise is a “health-relevant exposure,” not just “an annoyance.”

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“Our findings suggest that nighttime traffic noise may subtly but consistently affect metabolic health,” she said. “While the changes in cholesterol and lipid levels for any one individual are small, traffic noise affects a very large number of people, which means the potential public health impact could be substantial.”

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The researcher recommends taking measures like improving sound insulation, using noise-reducing strategies and placing bedrooms on the quieter side of the home when possible.

“Because sleep is a key pathway linking noise to health, protecting the nighttime sleep environment is especially important,” she added.

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