Science
Can probiotic supplements prevent hangovers?
The ads on podcasts and social media were tantalizing: over-the-counter probiotic supplements that could ward off the worst effects of a hangover if taken before drinking.
As a bourbon reviewer who enjoys the flavor of spirits but has always been easily prone to hangovers, Eric Burke was intrigued. He ordered a few bottles of Pre-Alcohol, a probiotic drink from the company ZBiotics, to test it out.
He downed the mixture of water, salt, flavoring and genetically modified bacteria. He followed it with a cocktail, a meal and two bourbons, and woke the next morning feeling considerably more chipper than he’d have expected.
The next night, emboldened by success, he drank another half-ounce bottle of Pre-Alcohol. He drank a bit more than the previous night — a beer with dinner and then four tumblers of bourbon.
That amount that typically would leave him feeling achy and sluggish the day after.
Which was exactly how he felt when he opened his eyes hours later.
“That one was unpleasant,” said Burke, 48. “I woke up that morning being just like, ‘Well, I’m not 21 anymore.’ ”
A hangover is a collection of physical and mental symptoms resulting from the inflammation and oxidative stress that alcohol wreaks in the human body.
One of many factors contributing to day-after misery is the accumulation of acetaldehyde, a chemical byproduct of the beverages’ ethanol breaking down in the body. Acetaldehyde is a carcinogen that features prominently in the nausea, stomach upset, sweats and other physical symptoms associated with over-consumption.
ZBiotic’s Pre-Alcohol and the Swedish biotech company De Faire Medical AB’s competitor supplement Myrkl both rely on live bacteria to process excess acetaldehyde. Other researchers and recreational drinkers have also experimented with probiotics for similar ends.
Reducing the amount of acetaldehyde, the hypothesis goes, should also reduce the physical symptoms caused by its buildup.
A bartender holds a martini with lemon.
(Myung J. Chun / Los Angeles Times)
“The more you drink, the more you’ll have to deal with the effects of other things besides acetaldehyde,” ZBiotics CEO Zack Abbott said via email when asked about Burke’s results. “That being said, for the vast majority of people, acetaldehyde is a major factor, and Pre-Alcohol therefore results in them feeling better (if not perfect) the next day.”
The U.S. Food and Drug Administration considers ZBiotics and Myrkl to be dietary supplements or functional foods, not drugs, and thus doesn’t evaluate their health claims. Microbiome experts caution that a probiotic supplement alone won’t spare you from the worst effects of overindulgence.
For starters, the bloodstream carries most of the ethanol in an alcoholic beverage straight to the liver, where an enzyme called alcohol dehydrogenase breaks it down into acetaldehyde. The brain, gastrointestinal tract and pancreas process some alcohol as well. Only a relatively small amount of ethanol is metabolized in the intestines, where probiotics do their work.
Adding probiotics to your pre-party regimen won’t cause you any harm, said Karsten Zengler, a microbiologist and professor of pediatrics and bioengineering at UC San Diego.
But it’s also unlikely to have a substantial effect on how you feel the next day, as your intestines come pre-equipped with an army of bacteria capable of breaking down alcohol’s byproducts, he said.
“There is not a lot of ethanol and acetaldehyde in your large intestine to start with,” Zengler said, and “the vast majority of the bacteria in your gut already metabolize acetaldehyde for you, so just adding something more might not do the trick.”
ZBiotics has funded studies demonstrating both the safety of their product and that their bacteria effectively broke down a significant amount of acetaldehyde in simulated gut conditions in a lab. As for the real-world effects of that breakdown, Abbott pointed to an outside 2006 paper that found that rats given ethanol had fewer hangover-like symptoms the next day when acetaldehyde was removed.
Myrkl funded a small study that showed its product lowered blood-alcohol levels in some participants. Subjects were instructed to take the supplement for a week prior to drinking, rather than the single pre-party dose instructed on the packet.
The hard truth, said Joris C. Verster, a pharmacology professor at Utrecht University in the Netherlands and founder of the Alcohol Hangover Research Group consortium, is that there is currently one scientifically validated way to prevent hangovers: drink less alcohol.
“Although there are many hangover products marketed, there is no convincing scientific evidence that these treatments are effective. Independent double-blind, placebo-controlled clinical trials in social drinkers are needed,” Verster said. “Currently, the only effective way to prevent a hangover is to consume alcohol in moderation.”
Unpleasant as they are, hangovers serve a valuable purpose, said Dr. Daryl Davies, a clinical pharmacy professor and director of the Alcohol and Brain Research Laboratory at USC Mann School of Pharmacy and Pharmaceutical Sciences.
“What I tend to tell people is if you are getting hangovers, you are drinking too much,” Davies said. “It is the body trying to tell you that something is wrong.”
Science
Video: NASA Announces Artemis III Crew
new video loaded: NASA Announces Artemis III Crew
transcript
transcript
NASA Announces Artemis III Crew
NASA announced the crew of Artemis III mission, which will fly to low-Earth orbit to test rendezvous and docking maneuvers with one or two lunar landers.
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“I am excited to welcome you as the next crew in the Artemis journey to successfully return to the moon — this time to stay.” “I’m honored by the role that I’ve been given. I’m also very humbled by the task in front of us. But first and foremost, I’m grateful.” “So with that, the Artemis II crew, comrade, hands you the baton. You got the controls.” “As you know, we had a significant anomaly at our Launch Complex 36A on May 28. We’ve redoubled our efforts and are moving forward.”
By Alisa Shodiyev Kaff
June 9, 2026
Science
Santa Monica Mountains’ last steelhead trout survived the Palisades fire — and even had babies
Scientists feared the Santa Monica Mountains’ last remaining steelhead trout were dead, smothered by debris flows unleashed by the Palisades fire.
But the endangered fish surprised them: A team of biologists recently spotted 30 of the rare trout — and 21 babies — in Topanga Creek.
“There was a lot of happy dancing in the creek,” said Rosi Dagit, principal conservation biologist for the Resource Conservation District of the Santa Monica Mountains, which works with public and private landowners to conserve natural resources.
That’s because the steelhead here are endangered, at both the state and federal levels. Once, they swam in most streams of the Santa Monicas, but their numbers plummeted amid overfishing and coastal development. Increasingly frequent wildfire has further stressed their habitat. Topanga Creek, a biodiversity hot spot, is home to their last known population in the mountains that stretch from the Hollywood Hills to Point Mugu in Ventura County.
The trout that were spotted, including this one, are part of a distinct Southern California population that’s listed as endangered at the state and federal levels.
(RCDSMM Stream Team)
The California Department of Fish and Wildlife spearheaded a complex mission to rescue trout threatened by the Palisades fire that sparked in January 2025.
Time was of the essence. The fire hadn’t yet been fully contained. But rain was on the way, which would sweep massive amounts of sediment from the denuded hillsides into the water. Fish are often killed this way.
Crews stunned the fish with electricity, scooped them up in buckets, trucked them to a hatchery and ultimately moved them to Arroyo Hondo Creek in Santa Barbara County.
Within days, Topanga Creek was choked with mud. Some assumed the fish left behind were goners.
But in March, the conservation district’s team found four. The following month, when water conditions were clearer, they saw more.
“These fish continue to amaze me,” said Kyle Evans, environmental program manager for the state Department of Fish and Wildlife, who had seen the damage to the creek. “I had seen populations get wiped out in similar situations. So when I heard, I was thrilled.”
Evans surmises the fish that survived were in an area of the creek where less charred material and sediment were swept in.
“These fish likely hunkered down, were hiding under some rocks or places to try to get away from the main concentration of flow,” he said. “And luckily they weren’t buried.”
The ones that were spotted were fairly small, around 6 to 14 inches. Rainbow trout and steelhead trout are the same species, but with different lifestyles. If the fish remain in freshwater, they’ll be considered rainbows. However, they can migrate to the ocean and become steelhead, where they typically grow larger before returning to their natal waters to spawn.
Topanga Creek hasn’t fully recovered from the damage it sustained, but scientists say it’s looking better. Surveys last year were “so depressing,” Dagit said, with very few animals, and stretches that were essentially transformed into flat roads from all the sediment buildup. Some of the riparian canopy burned right down to the creek.
Then came 32 inches of rain over the last nine months, scouring out and moving sediment, creating deeper pools. Dagit said they recently found newt egg masses for the first time in years, as well as a few adult newts and many frogs. Plants that provide cover are starting to recover.
She provided photos comparing certain pools last year and this year, some dramatically transformed. In September 2025, the Shrine Pool could have been an overgrown hiking trail. This April, it was filled with shallow water.
The Shrine Pool in September 2025, left, and the same location in April 2026, right, with RCDSMM’s Isaac Yelchin donning a wetsuit.
(RCDSMM Stream Team)
Topanga Creek is home to another endangered fish, the small but hardy northern tidewater goby, often described as cute. Not long before the trout operation, Dagit led a rescue of hundreds of these fish too. Many were repatriated to the lagoon at the mouth of the creek in a moving ceremony last June.
There’s still the matter of what to do with the trout that were moved to Santa Barbara County last year. Evans would like to bring them home to the Santa Monicas at some point, but isn’t sure if it will happen. On one hand, they could bolster the small, genetically isolated surviving population. On the other, they might inadvertently bring in a disease or bacteria. There is some time to decide. Evans estimates the creek still needs to recover for two to three more years.
For now, the fish are functioning fine in their adopted creek. Experts worried the trauma wrought by the move would disrupt their spawning process, but they had babies that spring. This year, they spawned again.
Science
Pacifica pier cracks, another coastal casualty as seas continue to rise
The Pacifica Municipal Pier was shut down and taped off Thursday after city workers noticed cracks running through the landmark structure and concrete chunks falling into the ocean.
It’s just one of many coastal California structures that have recently crumbled under pressure from a rising and relentless ocean.
Officials from the small, beach city south of San Francisco said the pier was closed due to “cracking, separation, and displacement of the concrete walkway and structural elements.”
It will stay closed while structural engineers asses its safety.
Photos taken by city employees show a wide crack that runs from top to bottom and across the structure as well. Other photos show a large horizontal crack under the foundation of a small restaurant on the pier, the Chit Chat Cafe.
The cafe was also shut down.
This is not the first time the 53-year-old pier has shown signs of stress. In 2021, part of it was shut down after handrails along the edge collapsed. And in 2023, after a series of storms pummeled the Central California coast, damaging parts of the pier, the structure was partially closed for more than year.
Those same storms caused extensive damage in Aptos and Capitola, 70 miles south, where piers and waterfront infrastructure were swept away or damaged.
In 2024, a 150- to 180- foot section of the Santa Cruz wharf was ripped off by powerful waves.
At least 10 of the state’s dozens of coastal public piers were closed for part or all of 2024 due to structural damage sustained in winter storms since 2022. At least five others have longer-term upgrades planned to address structural issues.
“These things are costly to maintain,” said Zach Plopper, senior environmental director at Surfrider. “They are a part of our California coastal culture in many ways, but we’re going to need to reckon with, one, the state that they’re in, and two, the continuous and worsening threats they’re going to experience,”
He said most of the piers were constructed in the early 1900s, and they weren’t built to withstand decades of rough seas, storms and rising sea level.
“With this incoming El Niño, which is forecasted to be significant, and this marine heat wave we’re in the midst of, we’re kind of in uncharted waters as far as what this winter could bring in terms of storms and swells to the California coast, and we’re likely going to see a lot more damage,” he said. “Not just piers, but roads and other coastal infrastructure up and down the state.”
There was no storm in Pacifica earlier this week, so no single event could be blamed for the destruction.
However, a 2025 report from an outside engineering firm, GHD, found that several sections of the pier were in “poor” or “serious” condition, and they recommended closure before anticipated storms or events that could “subject the piles to high winds, swells and large waves.”
The firm found several areas of the pier where concrete was missing and rebar was exposed and corroding.
“The pier has continued to experience high winds and large waves in a harsh marine environment,” the engineers wrote in the report, noting that continuous exposure to seawater or marine spray was “detrimental” to the structure.
A 2023 city report estimated it would cost $19 million to repair.
That same year, a state law was enacted to require local governments along the California coast to plan for sea level rise in the coming decades.
Sea level has risen some 8 inches, on average, along the coast in the past 150 years, Plopper said, and researchers anticipate another foot in the next 25 years.
“We’re going to see profound shifts on our coastline, none that we have ever experienced before, and building static structures on the coast just doesn’t work all that well,” he said. “We’re going to have to make some really hard decisions.”
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