Science
Microplastics may be new risk factor for cardiovascular disease, researchers say
Add one more likely culprit to the long list of known cardiovascular risk factors including red meat, butter, smoking and stress: microplastics.
In a study released Wednesday in the New England Journal of Medicine, an international team of physicians and researchers showed that surgical patients who had a build-up of micro and nanoplastics in their arterial plaque had a 2.1 times greater risk of nonfatal heart attack, nonfatal stroke or death from any cause in the three years post surgery than those who did not.
It’s the first study to show these ubiquitous and pernicious fossil fuel-based particles are having a direct effect on human health, said study co-author, Antonio Ceriello, head of the diabetes department at IRCCS MultiMedica, a research hospital in Milan.
And it should serve as a caution to all people, governments and corporations that plastic is not just a nuisance and blight in the environment, but is also harming human health, he said.
As government officials, negotiators, environmental activists and corporate representatives get ready to gather next month in Ottawa to discuss a global ban on plastic pollution, many are hoping this study will help tip the scales to establish real and tangible regulations.
“This is a beginning … whereby people are going to see plastic is not just harmful to whales or sea turtles. It’s not just litter on a beach in some faraway country. It’s in them and it has the potential to cause harm. I think it’s going to change the narrative,” said Dr. Philip Landrigan, director of the Program for Global Public Health and the Common Good at Boston College.
He compared the awareness of the plastic crisis to climate change — in which people understood it in an abstract, theoretical way until wildfires burned their homes, sustained heatwaves killed their crops and flooding destroyed their communities.
“To my knowledge, this is the first report to link microplastics with human disease,” said Landrigan, who was not involved in the study but wrote an accompanying essay urging the global community to deliver on a “mandatory global cap on plastic production.”
Matt Seaholm, president and chief executive of the Plastics Industry Assn., suggested more research needs to be done.
“We encourage lawmakers to evaluate where those particles come from before using any type of microplastics or nanoplastics arguments for the justification or passage of any laws, because every study has shown that they are not coming from packaging or single-use items,” he said.
Studies have shown that the two biggest contributors of microplastics in the environment are car tires and synthetic clothing. However, as the plastic industry expands and the number of single-use plastic items grow, so, too does their contribution to environmental contamination and pollution. Around 151 million tons of single-use plastics were produced
from fossil fuels in 2021. That number is expected to rise another 19 million tons by 2027.
The research on arterial plaque was conducted by a team of 40 scientists — including surgeons, engineers, statisticians and pathologists — from more than a dozen institutions, including Harvard Medical School, Brigham and Women’s Hospital in Boston and Case Western Reserve School of Medicine in Cleveland.
The 257 patients who completed the study all had asymptomatic extracranial high-grade internal carotid artery stenosis — in other words, their carotid arteries were blocked with plaque. The patients underwent carotid endarterectomies, a procedure in which the artery is opened and the plaque is cleaned out. Patients who’d had previous heart failure, valvular defects, cancer or other causes of hypertension were disqualified.
The researchers then examined the plaque and found polyethylene micro- and nano- particles in 150 of the patients. Thirty patients had polyvinyl chloride particles in their plaque. Images from electron microscopy showed visible, jagged-edged “foreign bodies” along with the biological plaque in these patients.
Polythylene, or PET, is the plastic used to make soda and water bottles. Polyvinyl chloride, or PVC, is the plastic used in water pipes, packaging, medical devices, toothbrushes, children’s toys and window frames, to name a few.
The two patient populations were roughly the same in terms of age, sex, weight, smoking status, geographical location, blood pressure and heart rate.
The one glaring difference, the authors noted, was the two groups’ susceptibility to heart disease in the months following the surgery — an indication that the presence of microplastics may have played a role. Indeed, indicators of inflammation were higher in the plastic-exposed group. Nonfatal heart attack, nonfatal stroke, or death from any cause occurred in eight of the 107 patients who did not have microplastics in their plaque and 30 of the 150 patients with microplastics.
The authors stressed they could only show correlation, not causality. Additional research would be necessary to establish a clear connection.
Study co-author Leonardo Trasande, a pediatrician and public policy expert at New York University’s Grossman School of Medicine and Wagner School of Public Service, said it was equally possible that chemicals piggy-backing on the particles — such as bisphenol A, phthalates and/or other plasticizers and additives — could be the culprits. The paper also notes that lab contamination and patient behaviors that are unknown to the researchers could also influence their results.
“I can’t tell you it’s the microplastics and I can’t tell you it’s the chemicals. I couldn’t tell you because no study has measured both and they both coexist,” he said. “The fact is that plastics are horrible for human health and costly.”
He noted a recent study he authored that showed the disease burden of these chemicals costs the U.S. healthcare system roughly $250 billion a year.
Ceriello and his co-authors noted scores of animal studies that showed harmful effects of microplastics. He also said the authors were still unclear as to how patients were being exposed, whether through inhalation or ingestion.
Recent studies have found micro- and nanoplastics in water bottled in plastic, as well as in dust.
“This is very solid and should be taken very seriously at the highest level of government,” said Judith Enck, the director of Beyond Plastics and a former regional director at the U.S. Environmental Protection Agency. “This tracks with other studies that have found microplastics in various organs, human blood, placenta and breast milk so this is not all that surprising, but still stunning.”
Plastic has been found everywhere scientists have looked: From the deepest ocean trenches to the highest alpine peaks. Petroleum-based plastics do not biodegrade. Over time, they break down into smaller and smaller pieces — known as microplastics, microfibers and nanoplastics — and have been found in household dust, drinking water and human tissue and blood.
“Cardiologists need to inform their patients to avoid plastic packaging — which is very hard to do,” Enck said.
Tracey Woodruff, director of UC San Francisco’s Program on Reproductive Health and the Environment in the Department of Obstetrics, Gynecology and Reproductive Sciences, said physicians and clinicians need to begin talking to their patients about the harms of plastic. She authored an essay that looked at the harmful effects of endocrine disruptors in the same edition as the heart study.
She said advice from doctors to eat organic, unprocessed foods already reduces exposures to plastics. But more is needed, especially in the medical fields of reproduction, obstetrics and pediatrics, she said, where the evidence of harm from plastic chemicals and endocrine disruptors has been well established.
The mounting evidence, she said, is getting “hard to ignore.”
Science
What’s in a Name? For These Snails, Legal Protection
The sun had barely risen over the Pacific Ocean when a small motorboat carrying a team of Indigenous artisans and Mexican biologists dropped anchor in a rocky cove near Bahías de Huatulco.
Mauro Habacuc Avendaño Luis, one of the craftsmen, was the first to wade to shore. With an agility belying his age, he struck out over the boulders exposed by low tide. Crouching on a slippery ledge pounded by surf, he reached inside a crevice between two rocks. There, lodged among the urchins, was a snail with a knobby gray shell the size of a walnut. The sight might not dazzle tourists who travel here to see humpback whales, but for Mr. Avendaño, 85, these drab little mollusks represent a way of life.
Marine snails in the genus Plicopurpura are sacred to the Mixtec people of Pinotepa de Don Luis, a small town in southwestern Oaxaca. Men like Mr. Avendaño have been sustainably “milking” them for radiant purple dye for at least 1,500 years. The color suffuses Mixtec textiles and spiritual beliefs. Called tixinda, it symbolizes fertility and death, as well as mythic ties between lunar cycles, women and the sea.
The future of these traditions — and the fate of the snails — are uncertain. The mollusks are subject to intense poaching pressure despite federal protections intended to protect them. Fishermen break them (and the other mollusks they eat) open and sell the meat to local restaurants. Tourists who comb the beaches pluck snails off the rocks and toss them aside.
A severe earthquake in 2020 thrust formerly submerged parts of their habitat above sea level, fatally tossing other mollusks in the snail’s food web to the air, and making once inaccessible places more available to poachers.
Decades ago, dense clusters of snails the size of doorknobs were easy to find, according to Mr. Avendaño. “Full of snails,” he said, sweeping a calloused, violet-stained hand across the coves. Now, most of the snails he finds are small, just over an inch, and yield only a few milliliters of dye.
Science
Video: This Parrot Has No Beak, But Is at the Top of the Pecking Order
new video loaded: This Parrot Has No Beak, But Is at the Top of the Pecking Order
By Meg Felling and Carl Zimmer
April 20, 2026
Science
Contributor: Focus on the real causes of the shortage in hormone treatments
For months now, menopausal women across the U.S. have been unable to fill prescriptions for the estradiol patch, a long-established and safe hormone treatment. The news media has whipped up a frenzy over this scarcity, warning of a long-lasting nationwide shortage. The problem is real — but the explanations in the media coverage miss the mark. Real solutions depend on an accurate understanding of the causes.
Reporters, pharmaceutical companies and even some doctors have blamed women for causing the shortage, saying they were inspired by a “menopause moment” that has driven unprecedented demand. Such framing does a dangerous disservice to essential health advocacy.
In this narrative, there has been unprecedented demand, and it is explained in part by the Food and Drug Administration’s recent removal of the “black-box warning” from estradiol patches’ packaging. That inaccurate (and, quite frankly, terrifying) label had been required since a 2002 announcement overstated the link between certain menopause hormone treatments and breast cancer. Right-sizing and rewording the warning was long overdue. But the trouble with this narrative is that even after the black-box warning was removed, there has not been unprecedented demand.
Around 40% of menopausal women were prescribed hormone treatments in some form before the 2002 announcement. Use plummeted in its aftermath, dipping to less than 5% in 2020 and just 1.8% in 2024. According to the most recent data, the number has now settled back at the 5% mark. Unprecedented? Hardly. Modest at best.
Nor is estradiol a new or complex drug; the patch formulation has existed for decades, and generic versions are widely manufactured. There is no exotic ingredient, no rare supply chain dependency, no fluke that explains why women are suddenly being told their pharmacy is out of stock month after month.
The story is far more an indictment of the broken insurance industry: market concentration, perverse incentives and the consequences of allowing insurance companies to own the pharmacy benefit managers that effectively control drug access for the majority of users. Three companies — CVS Caremark, Express Scripts and OptumRx — manage 79% of all prescription drug claims in the United States. Those companies are wholly owned subsidiaries of three insurance behemoths: CVS Health, Cigna and UnitedHealth Group, respectively. This means that the same corporation that sells you your insurance plan also decides which drugs get covered, at what price, and whether your pharmacy can stock them. This is called vertical integration. In another era, we might have called it a cartel. The resulting problems are not unique to hormone treatments; they have affected widely used medications including blood thinners, inhalers and antibiotics. When a low-cost generic such as estradiol — a medication with no blockbuster profit margins and no patent protection — runs into friction in this system, the friction is not random. It is structural. Every decision in that chain is filtered through the same corporate profit motive. And when the drug in question is an off-patent estradiol patch that has negligible profit margins because of generic competition but requires logistical investment to keep consistently in stock? The math on “how much does this company care about ensuring access” is not complicated.
Unfortunately, there is little financial incentive to ensure smooth, consistent access. There is, however, significant financial incentive to steer patients toward branded alternatives, or simply to let supply tighten — because the companies aren’t losing much profit if sales of that product dwindle. This is not a conspiracy theory: The Federal Trade Commission noted this dynamic in a report that documented how pharmacy benefit managers’ practices inflate costs, reduce competition and harm patient access, particularly for independent pharmacies and for generic drugs.
Any claim that the estradiol patch shortage is meaningfully caused by more women now demanding hormone treatments is a distraction. It is also misogyny, pure and simple, to imply that the solution to the shortage is for women’s health advocates to dial it down and for women to temper their expectations. The scarcity of estradiol patches is the outcome of a broken system refusing to provide adequate supply.
Meanwhile, there are a few strategies to cope.
- Ask your prescriber about alternatives. Estradiol is available in multiple formulations, including gel, spray, cream, oral tablet, vaginal ring and weekly transdermal patch, which is a different product from the twice-weekly patch and may be more consistently available depending on manufacturer and region.
- Consider an online pharmacy. Many are doing a good job locating and filling these prescriptions from outside the pharmacy benefit manager system.
- Call ahead. Patch shortages are inconsistent across regions and distributors. A call to pharmacies in your area, or a broader geographic radius if you’re able, can locate stock that your regular pharmacy doesn’t have.
- Consider a compounding pharmacy. These sources can sometimes meet needs when commercially manufactured products are inaccessible. The hormones used are the same FDA-regulated bulk ingredients.
Beyond those Band-Aid solutions, more Americans need to fight for systemic change. The FTC report exists because Congress asked for it and committed to legislation that will address at least some of the problems. The FDA took action to change the labeling on estrogen in the face of citizen and medical experts’ pressure; it should do more now to demand transparency from patch manufacturers.
Most importantly, it is on all of us to call out the cracks in the current system. Instead of repeating “there’s a patch shortage” or a “surge in demand,” say that a shockingly small minority of menopausal women still even get hormonal treatments prescribed at all, and three drug companies control the vast majority of claims in this country. Those are the real problems that need real solutions.
Jennifer Weiss-Wolf, the executive director of the Birnbaum Women’s Leadership Center at New York University School of Law, is the author of the forthcoming book “When in Menopause: A User’s Manual & Citizen’s Guide.” Suzanne Gilberg, an obstetrician and gynecologist in Los Angeles, is the author of “Menopause Bootcamp.”
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