Health
COVID pandemic triggered spike in antidepressant use among young females, study finds
Young people turned to antidepressants in greater numbers during and after the COVID-19 pandemic, new research has shown.
Use of these medications was already on the rise prior to March 2020, but the pandemic accelerated that trend, according to a study published in the journal Pediatrics on Feb. 26.
“Using 2016-2022 data from a comprehensive national database, we found that the antidepressant dispensing rate to adolescents and young adults was increasing rapidly before March 2020 but increased nearly 64% faster afterward,” Kao Ping Chua, M.D., PhD, a pediatrician and researcher at University of Michigan Health C.S. Mott Children’s Hospital, told Fox News Digital in a statement.
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The data was pulled from the IQVIA Longitudinal Prescription Database, which compiles prescription information from most U.S. retail pharmacies.
Teen girls and young women were entirely responsible for the increase, the study found. “Among female adolescents aged 12 to 17 years, the antidepressant dispensing rate increased 130% faster after March 2020 than beforehand, compared with 57% faster among female young adults aged 18 to 25 years,” said Chua.
Teen girls and young women were entirely responsible for the increase in antidepressants, the study found. (iStock)
Among young males, however, antidepressant prescriptions decreased or changed very little, despite studies suggesting that the mental health of male adolescents worsened during the pandemic.
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“Given this, it is surprising that the rate of antidepressant dispensing to male adolescents declined,” Chua noted.
“I worry that this decline may reflect underdiagnosis and undertreatment of mental health concerns.”
Mental health experts share reactions
Marlene McDermott, LMFT, PhD, a Philadelphia-based licensed marriage and family therapist with Array Behavioral Care, said the increase is likely due to greater access to mental health care — which allows more teenagers to seek treatment that they may have always needed.
She was not involved in the study.
“I think it will be important to monitor these numbers over the next two years to determine if this is a new baseline, or if there is a significantly worsening mental health crisis for teens,” she told Fox News Digital.
Use of antidepressant medications was already on the rise before March 2020, but the pandemic accelerated that trend, according to the new study. (iStock)
“The destigmatization of mental health treatment is a good thing for the adolescent population,” McDermott added. “If the use of antidepressants lowers the death by suicide rates, we are on the right track.”
Marissa Stridiron, M.D., New Jersey-based medical director of acute care at Array Behavioral Care, who was also not involved in the study, pointed out that there was a large increase of children and adolescents in crisis coming into emergency rooms during the pandemic.
“The destigmatization of mental health treatment is a good thing for the adolescent population.”
“[This was] due to fewer earlier interventions from school-based therapeutic options, social isolation, a rise in social media use and resultant cyberbullying,” she told Fox News Digital.
Although crisis visits have decreased as the pandemic has ebbed, Stridiron noted that it still appears to be higher than pre-pandemic levels.
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“National media attention surrounding psychiatric crises in children and adults has led to increased access and earlier interventions in the outpatient realm, including from primary care physicians,” she said.
“This is great because it means we are capturing more patients in outpatient settings and initiating treatments earlier, thus reducing or preventing crises.”
Teens and young adults should seek medical attention if they are having depression symptoms, say mental health professionals. (iStock)
One limitation of the study, author Chua noted, is that it was not able to directly evaluate why antidepressant use by adolescents and young adults changed so much during the pandemic.
“In particular, it’s unclear why antidepressant dispensing to male adolescents declined,” he said.
Based on these findings, the researchers believe there may be an increased need for antidepressant medications as well as additional research into these trends.
“Adolescents and young adults with mental health symptoms should know that they are not alone,” said Chua.
“It is important for them to seek medical attention if they are having these symptoms and for their parents to encourage them to do so.”
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As colorectal cancer (CRC) is now the leading cause of cancer death in adults under 50, a new report reveals some surprising shifts in the incidence of the disease.
Although rates of CRC have been declining among seniors, those 65 and under are facing a rise in diagnoses, according to a report titled Colorectal Cancer Statistics, 2026, from the American Cancer Society.
Adults 65 and younger comprise nearly half (45%) of all new colorectal cancer cases — a significant increase from 27% in 1995, states the report, which was published in CA: A Cancer Journal for Clinicians.
The disease is rising fastest among adults 20 to 49 years old, at a rate of 3% per year.
Colorectal cancer is now the leading cause of cancer death in adults under 50. (iStock)
Among adults 50 and under, 75% of colorectal cancers are diagnosed at an advanced stage. Half of the diagnoses in that age range are made between the ages of 45 and 49. Although that age group is eligible to receive routine screenings, just 37% do so.
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The report also revealed that rectal cancer is on the rise, now accounting for about one-third (32%) of all CRC cases — an increase from 27% in the mid-2000s.
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“After decades of progress, the risk of dying from colorectal cancer is climbing in younger generations of men and women, confirming a real uptick in disease because of something we’re doing or some other exposure,” said Rebecca Siegel, senior scientific director, surveillance research at the American Cancer Society and lead author of the report, in a press release.
Among adults 50 and under, 75% of colorectal cancers are diagnosed at an advanced stage. Half of the diagnoses in that age range are made between the ages of 45 and 49. (iStock)
“We need to redouble research efforts to understand the cause, but also circumvent deaths through earlier detection by educating clinicians and the general public about symptoms and increasing screening in people 45-54 years.”
It is projected that 158,850 new cases of colorectal cancer will be diagnosed this year, and that the disease will cause 55,230 deaths, per the report.
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More than half of CRC cases can be linked to high-risk behaviors, the researchers said. Those include lack of nutrition, high alcohol consumption, smoking, lack of exercise and obesity.
“These findings further underscore that colorectal cancer is worsening among younger generations and highlight the immediate need for eligible adults to begin screening at the recommended age of 45,” said Dr. William Dahut, chief scientific officer at the American Cancer Society.
When the disease is caught at a local (early) stage, the five-year survival rate is 95%. (iStock)
“The report also shines a light on the crucial importance of continued funding for research to help discover new therapies to treat the disease and advance patient care.”
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When the disease is caught at a local (early) stage, the five-year survival rate is 95%, the report stated.
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A new study suggests that middle-aged men may be more vulnerable to faster biological aging, potentially linked to exposure to “forever chemicals.”
The research, published in the journal Frontiers in Aging, examined how perfluoroalkyl and polyfluoroalkyl substances, more commonly known as PFAS, could impact aging at the cellular level.
PFAS are synthetic chemicals commonly used in nonstick cookware, food packaging, water-resistant fabrics and other consumer products, the study noted.
Their chemical structure makes them highly resistant to breaking down, allowing them to accumulate in water, soil and the human body.
Chinese researchers analyzed blood samples from 326 adults enrolled in the U.S. National Health and Nutrition Examination Survey between 1999 and 2000.
A new study suggests that middle-aged men could face accelerated biological aging at the cellular level due to exposure to PFAS. (iStock)
The researchers measured levels of 11 PFAS compounds in participants’ blood and used DNA-based “epigenetic clocks” — tools that analyze chemical changes to DNA to estimate biological age — to determine how quickly their bodies were aging at the cellular level, the study stated.
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Two compounds, perfluorononanoic acid (PFNA) and perfluorooctanesulfonamide (PFOSA), were detected in 95% of participants.
Higher concentrations of those chemicals were associated with faster biological aging in men of certain age groups, but not in women.
“People should not panic.”
The compounds most strongly linked to accelerated aging were not the PFAS chemicals that typically receive the most public attention, the researchers noted.
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“The associations were strongest in adults aged 50 to 64, particularly in men,” Dr. Xiangwei Li, professor at Shanghai Jiao Tong University School of Medicine and the study’s corresponding author, told Fox News Digital.
“While this does not establish that PFAS cause aging, it suggests that these widely present ‘forever chemicals’ may be linked to molecular changes related to long-term health and aging.”
The study found that two of the compounds were detected in 95% of participants, and higher levels were linked to faster biological aging in men ages 50–64. (iStock)
Midlife may represent a more sensitive biological period, when the body becomes more vulnerable to age-related stressors, according to the researchers.
Lifestyle factors, such as smoking, may influence biological aging markers, potentially increasing vulnerability to environmental pollutants.
While Li said “people should not panic,” she does recommend looking for reasonable ways to reduce exposure.
That might mean checking local drinking water reports, using certified water filters designed to reduce PFAS, and limiting the use of stain- or grease-resistant products when alternatives are available.
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Meaningful reductions in PFAS exposure will likely depend on broader regulatory action and environmental cleanup efforts, Li added.
The researchers noted that midlife could be a particularly sensitive stage, when the body is more susceptible to stressors associated with aging. (iStock)
Study limitations
The researchers outlined several important limitations of the research, including that the findings show an association, but do not prove that PFAS directly causes accelerated aging.
“The study is cross-sectional, meaning exposure and aging markers were measured at the same time, so we cannot determine causality,” Li told Fox News Digital.
The study was also relatively small, limited to 326 adults age 50 or older, which means the findings may not apply to younger people or broader populations.
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Researchers measured PFAS levels using data collected between 1999 and 2000, and today’s exposure patterns may differ.
Li added that while PFAS is known to persist in the environment and the body, these results should be validated through larger, more recent studies that follow participants over time.
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