Health
Ovarian cancer treatment on fast track for FDA approval as chemo alternatives emerge: 'We're making progress'
A new wave of cancer treatments is looking promising for the future of oncologic care.
The ovarian cancer drug RC88, which is made by the Chinese biopharmaceutical company RemeGen, received FDA approval for Phase 2 clinical trials earlier this month.
The drug received fast-track designation (FTD) for the treatment of “platinum-resistant recurrent epithelial ovarian, fallopian tube and primary peritoneal cancers,” the company confirmed to Fox News Digital.
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RC88 is an anti-drug conjugate (ADC) designed to treat aggressive ovarian cancers in patients with “poor prognosis,” according to the company.
An ADC is “a class of drugs designed as a targeted therapy for treating disease,” per the National Institutes of Health.
RC88 aims to treat aggressive ovarian cancers in patients with a poor prognosis, according to RemeGen, the China-based company that makes the drug. (iStock)
The drug targets mesothelin, a protein found in tumors.
“This development is not just a scientific advancement, but a beacon of hope for countless women battling this formidable disease,” a RemeGen spokesperson said in an email to Fox News Digital.
RemeGen intends to launch international and multicenter clinical studies in the U.S., China, the European Union and other regions, according to a press release.
The new drug received fast-track designation (FTD) for the treatment of “platinum-resistant recurrent epithelial ovarian, fallopian tube and primary peritoneal cancers,” RemeGen confirmed to Fox News Digital. (iStock)
The clinical trials will study participants in multiple countries to determine optimal dosage, effectiveness and safety of the treatment.
RC88’s clinical data findings are slated to be released at the Annual Meeting of the American Society of Clinical Oncology (ASCO) in May 2024 in Chicago.
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Dr. Brian Slomovitz, director of gynecologic oncology and co-chair of the Cancer Research Committee at Mount Sinai Medical Center in Miami Beach, Florida, is familiar with RemeGen’s treatment, noting that anti-drug conjugates have surfaced as a “relatively new class of drug.”
He told Fox News Digital in an interview, “[It] definitely has a lot of promise,” noting also that there have been many more failures than successes.
Brian Slomovitz, M.D., is director of Gynecologic Oncology and co-chair of the Cancer Research Committee at Mount Sinai Medical Center in Miami Beach, Florida. He noted the “promise” of the ovarian cancer drug RC88. (Mount Sinai Medical Center)
Among those successes is an ADC drug called Elahere (mirvetuximab soravtansine-gynx), which is indicated for FRa positive, platinum-resistant epithelial ovarian, fallopian tube, or peritoneal cancer.
The FDA granted accelerated approval for Elahere in Nov. 2022, according to an agency press release.
Other ADCs in development include a drug called TIVDAK for cervical cancer as well as anti-HER2 treatments for breast cancer, according to Slomovitz.
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“It’s going to be much more effective than [chemo drug] Herceptin,” he predicted. “So, it’s really a novel class [of drugs] that go into the cells in a unique way.”
Phase 3 clinical trials of TIVDAK (tisotumab vedotin) were linked to a 30% overall reduction in the risk of death compared to chemotherapy.
A cancer doctor described ADC approaches to treating cancer as a “novel class [of drugs] that go into the cells in a unique way.” (iStock)
In a previous interview with Fox News Digital, Dr. Kathleen Moore, associate director of clinical research at Stephenson Cancer Center in Oklahoma City, shared that the TIVDAK therapy has been effective in shrinking her own patients’ tumors.
“In the past, we just did not have active medications and our patients really were left with ineffective therapies, and they just died,” she said. “They’re feeling better because their disease is shrinking.”
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During the 2023 European Society of Medical Oncology Congress in Madrid, Spain, Moore presented another ADC treatment called raludotatug deruxtecan (R-DXd), which was confirmed as “efficacious” by the National Library of Medicine in treating ovarian and kidney cancers.
As ovarian cancer develops, the level of mesothelia increases — which gives RC88 its “unique” target.
“R-DXd is the first ADC targeting CDH6, [which has been] tested in ovarian cancer and demonstrates very strong signals of efficacy,” Moore said in her data presentation, according to OncLive, the Oncology Specialty Group’s website.
Seventy percent of women who were diagnosed with epithelial ovarian cancer (EOC) have already reached an advanced stage, according to RemeGen.
Phase 3 clinical trials of TIVDAK (tisotumab vedotin) were linked to a 30% overall reduction in the risk of death compared to chemotherapy. (iStock)
EOC remains a “significant cause of cancer deaths among women,” as there are “no effective screening methods” and most patients experience a relapse within two years, the company added.
As ovarian cancer develops, the level of mesothelia increases — which gives RC88 its “unique” target, the RemeGen press release stated.
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The FDA’s approval of RC88 as an investigational new drug “marks a pivotal moment in our commitment to address the challenges of platinum-resistant recurrent ovarian cancer,” RemeGen CEO Dr. Jianmin Fang wrote in a statement to Fox News Digital.
RemeGen calls RC88 — given its “unique targeting mechanism” — a “beacon of hope for countless women battling this formidable disease.” (iStock)
“Our focus remains on developing innovative treatments that can significantly improve patient outcomes in areas with critical unmet needs,” he said.
“RC88, with its unique targeting mechanism, exemplifies our dedication to pioneering advancements in cancer therapy.”
It’s important that ADCs are continuously studied, Slomovitz noted, as the bar for approval is “getting higher and higher.”
He added, “The good news is, we’re making progress.”
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Health
Loneliness may be silently eroding your memory, new research reveals
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Feeling lonely may take a toll on older adults’ memory — but it may not speed up cognitive decline, according to a new study.
Researchers from Colombia, Spain and Sweden analyzed data from more than 10,000 adults ages 65 to 94 across 12 European countries and found those who reported higher levels of loneliness did worse on memory tests at the start of the study, according to research published this month in the journal Aging & Mental Health.
Over a seven-year period, however, memory decline occurred at a similar rate regardless of how lonely participants felt.
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“The finding that loneliness significantly impacted memory, but not the speed of decline in memory over time was a surprising outcome,” lead author Dr. Luis Carlos Venegas-Sanabria of the School of Medicine and Health Sciences at the Universidad del Rosario said in a statement.
Loneliness may be linked to memory performance in older adults, a new study suggests. (iStock)
“It suggests that loneliness may play a more prominent role in the initial state of memory than in its progressive decline,” Venegas-Sanabria said, adding that the findings highlight the importance of addressing loneliness as a factor in cognitive performance.
The findings add to debate about whether loneliness contributes to dementia risk. While loneliness and social isolation are often considered risk factors for cognitive decline, research results have been mixed.
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The study looked at data from the long-running Survey of Health, Ageing and Retirement in Europe (SHARE), which tracked 10,217 older adults between 2012 and 2019. Participants were asked to recall words immediately and after a delay to measure memory performance.
Social isolation and loneliness could play a surprising role in cognitive health among seniors. (iStock)
Loneliness was assessed using three questions about how often participants felt isolated, left out or lacking companionship.
About 8% of participants reported high levels of loneliness at the outset. That group tended to be older, more likely to be female and more likely to have conditions such as depression.
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Researchers found that those with higher loneliness had lower scores on both immediate and delayed memory tests at baseline. Still, all groups — regardless of loneliness level — experienced similar declines in memory over time.
The results suggest loneliness may not directly accelerate the progression of memory loss, though it remains linked to poorer cognitive performance overall.
Researchers look at a brain scan at the National Institutes of Health in Bethesda, Maryland. (Saul Loeb/AFP/Getty Images)
Experts warn, however, that the findings should not be interpreted to mean loneliness is harmless.
“The finding that lonely older adults start with worse memory but don’t decline faster is actually the most interesting part of the paper, and I think it’s easy to misread,” said Jordan Weiss, Ph.D., a scientific advisor and aging expert at Assisted Living Magazine and a professor at NYU Grossman School of Medicine.
“It likely means loneliness does its damage earlier in life, well before people show up in a study like this at 65-plus,” Weiss told Fox News Digital.
By older age, long-term social patterns may already be established, making it harder to detect when the effects of loneliness first took hold, an aging expert says. (iStock)
He suggested that by older age, long-term social patterns may already be established, making it harder to detect when the effects of loneliness first took hold.
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“By the time you’re measuring someone in their late 60s, decades of social connection patterns are already baked in,” he said.
Weiss, who was not involved in the research, added that loneliness may coincide with other health conditions, and noted that participants who felt more isolated also had higher rates of depression, high-blood pressure and diabetes. The link, he said, may reflect a cluster of health risks rather than a direct cause.
“While they can go hand-in-hand, it’s not clear that loneliness contributes to dementia,” a psychotherapist says. (iStock)
Amy Morin, a Florida-based psychotherapist and author, said the findings reflect a broader pattern in research on loneliness and brain health, and that the relationship may be more complex than it appears.
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“The evidence shows there’s a link between loneliness and cognitive decline but there’s no direct evidence of a cause and effect relationship,” she said. “So while they can go hand-in-hand, it’s not clear that loneliness contributes to dementia.”
Morin added that loneliness, which can fluctuate, may not be the root of the problem, but rather a symptom of other underlying mental or physical health issues.
Researchers suggested screening for loneliness be incorporated into routine cognitive assessments as one way to support healthy aging. (iStock)
She said staying socially and mentally engaged is crucial for overall brain health.
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“It’s important to be proactive about social activities,” Morin said. “Joining a book club, having coffee with a friend, or attending faith-based services can be a powerful way to maintain connections in older age.”
The researchers also suggested screening for loneliness be incorporated into routine cognitive assessments as one way to support healthy aging.
Fox News Digital reached out to the researchers for comment.
Health
Eat More To Lose Weight? She Dropped 55 Pounds by Having 5 Meals a Day
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Health
Intermittent fasting’s real benefit may come after you start eating again
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Research continues to uncover new details on how fasting may help extend life.
A new study published in the journal Nature Communications investigated how intermittent fasting can boost longevity in small worms often used in aging research.
Researchers from the University of Texas Southwestern Medical Center in Dallas compared worms that were fed normally to those that underwent a 24-hour fast in early adulthood and were then fed again, according to a press release.
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The scientists measured a variety of factors, including stored fat, gene activity related to fat metabolism and lifespan.
The results showed that the life-boosting benefit did not depend on the fasting itself but on the body’s behavior after eating again.
Experts say sustainability is key when choosing a long-term weight-loss strategy. (iStock)
Study lead Peter Douglas, associate professor of molecular biology and a member of the Hamon Center for Regenerative Science and Medicine at UT Southwestern, suggested that these discoveries “shift the focus toward a neglected side of the metabolic coin – the re-feeding phase.”
“Our data suggest that the health-promoting effects of intermittent fasting are not merely a product of the fast itself, but are dependent on how the metabolic machinery recalibrates during the subsequent transition back to a fed state,” he said.
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“Our findings bridge a gap between lipid metabolism and aging research,” he added. “By targeting aging, the single greatest risk factor for human disease, we move beyond treating isolated conditions toward a preventive model of medicine that enhances quality of life for all individuals.”
Lauri Wright, director of nutrition programs at the University of South Florida’s College of Public Health, called this a “high-quality” study that adds an “important nuance to how we think about fasting and longevity.”
Intermittent fasting typically involves limiting meals to an eight-hour daily window or fasting every other day. (iStock)
The benefits of the refeeding phase after fasting were “especially interesting,” Wright, who was not involved in the study, told Fox News Digital.
“The researchers showed that longevity was linked to the body’s ability to turn off fat breakdown after fasting, allowing cells to restore energy balance,” she reiterated.
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“From a scientific standpoint, that’s a meaningful shift because it suggests fasting is not just about burning fat, but about metabolic flexibility.”
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Fasting may support longevity through triggering metabolic switching, enhancing cellular repair and stress resistance and improving markers like insulin sensitivity, research shows.
Limitations and cautions
Although this study provides “important insight” on the power of refeeding, Wright noted that the findings should be approached with caution, as the study was done on worms and cannot always be translated to humans.
“Additionally, it explains how a process might work in a controlled lab condition rather than real-world eating behaviors,” she added as a limitation. “Finally, the study is short-term and doesn’t give us the long-term translation on lifespan outcomes.”
The review found intermittent fasting was barely more effective than doing nothing, according to the study authors. (iStock)
Wright cautioned that fasting is “not a magic solution for longevity, and how you eat overall matters more than when you eat.”
“I advise, first and foremost, to focus on diet quality, including a variety of fruits and vegetables, healthy fats and minimally processed foods,” she said.
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For those who are considering fasting, it’s better to stick with a moderate plan — like a 12- to 14-hour overnight fast — rather than going to extremes, Wright said. After fasting, she recommends focusing on well-balanced meals.
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Several groups of people should be cautioned against fasting, according to Wright, including those with diabetes who are on insulin or hypoglycemic medications, those who are pregnant or breastfeeding, anyone with a history of eating disorders and older adults at risk of malnutrition.
Anyone considering intermittent fasting should consult with a doctor before starting.
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