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Pakistan says at least one case of mpox virus detected

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Pakistan says at least one case of mpox virus detected

Sequencing of confirmed case under way to determine whether virus is same deadly Clade 1 variant discovered by Sweden.

Pakistan has confirmed at least one case of the mpox virus, a day after Sweden confirmed an infection with a more easily spread and deadlier variant linked to a recent outbreak in Africa.

Pakistan’s Ministry of Health said in a statement on Friday that the mpox strain that had caused the confirmed case was not immediately known.

Irshad Roghani, director of public health in the northwestern province of Khyber Pakhtunkhwa, where the 34-year-old patient is being treated, said samples had been sent to Islamabad for genetic sequencing to ascertain which variant of the virus the patient contracted.

On Thursday, Sweden announced it had discovered a more dangerous variant of the virus, named Clade 1, in an infected patient.

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Clade 1, which spreads more easily through close contact, is linked to a deadly surge of the virus in the Democratic Republic of the Congo (DRC) that began in September. The Swedish case marks the first such infection outside the African continent, according to Sweden’s Public Health Agency.

A statement from the agency quoted epidemiologist Magnus Gisslen as saying the patient had been infected during a visit to “the part of Africa where there is a major outbreak of mpox Clade 1”.

An earlier outbreak in 2022 was linked to a milder variant, known as Clade 2, endemic in West Africa. It caused about 140 deaths and 90,000 cases, mostly affecting gay and bisexual men.

Health emergency

The World Health Organization (WHO) declared a public health emergency of international concern on Wednesday over the spread of Clade 1 in Africa after a surge in the DRC spread to Burundi, Kenya, Rwanda and Uganda.

It said there have been more than 14,000 cases and 524 deaths in Africa caused by mpox this year, which already exceed last year’s figures. More than 96 percent of all cases and deaths have been in the DRC.

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After the discovery of the case in Sweden, the WHO said it reflected “the interconnectedness of our world” and further imported cases of the new strain in Europe were likely

The organisation has advised against any travel restrictions and border closures to stop the spread of mpox, saying they “don’t work and should be avoided”.

Reporting from London, Al Jazeera’s Jonah Hull said the WHO’s declaration was “specifically to encourage governments to release funding aimed at research, to release funding to boost health systems and to accelerate the rollout of those sorts of measures again”.

“Epidemiologists in Europe are saying there may only be one case detected in Sweden but that almost certainly means there are a number of cases that are unidentified out there and that of course points to the possibility of rapid international transmission.”

Pakistan’s Health Ministry has directed officials at border crossings and airports to ensure strict surveillance and collect samples for medical tests if they see symptoms of the disease in any passenger returning from abroad.

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The disease caused by the virus leads to flu-like symptoms, pus-filled lesions and muscular pain. It is usually mild but can kill with children, pregnant women and people with weakened immune systems, such as those with HIV, all at higher risk of complications.

China said on Friday that it will begin screening people and goods entering the country for mpox over the next six months.

Danish drugmaker Bavarian Nordic said it was ready to produce up to 10 million doses of its vaccine targeting mpox by 2025 and was seeking European approval to use its mpox vaccine in children aged 12 and above.

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Eugene and Dan Levy to Host 2024 Primetime Emmys

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Eugene and Dan Levy to Host 2024 Primetime Emmys


Emmys 2024: Eugene Levy & Dan Levy to Host Ceremony for ABC



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Underwater archaeologists discover ancient objects during dive in Bulgaria bay

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Underwater archaeologists discover ancient objects during dive in Bulgaria bay

Researchers made an exciting discovery during a dive in Bulgaria’s Chengene Skele Bay in the Black Sea when they found over 100 ancient glass objects.

The June 2024 discovery was made by a team from the National History Museum, led by professor Ivan Histrov, according to a translated Facebook post by the Burgas Regional History Museum. 

The 112 glass objects most recently found joined a larger collection of 310 glass vessels that have been uncovered in the same bay in 2020 and 2021. 

The glass objects were found in Bulgaria’s Chengene Skele Bay, located in the Black Sea.  (John Wreford/SOPA Images/LightRocket via Getty Images)

SKELETAL REMAINS OF MAN, WOMAN DISCOVERED IN POMPEII OFFER CHILLING DETAILS OF FINAL MOMENTS

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The glass objects were found at a depth of 2 to 2.5 meters, according to the statement. These ancient items are believed to be from the late 16th or early 17th century. 

The glass objects have been credited to the Venetian island of Murano, which is still known today for its production of high-quality glassware. 

“Until now, the hypothesis has been proposed that the vessels were most likely produced in a workshop on the island of Murano, Venice, in the second half of the 16th century or the beginning of the 17th century. Here the question of the exact dating of the glass objects and the possible shipwreck remains to be determined,” the statement said. 

Overview of Murano

Experts point to Murano as the place where the glass was originally produced.  (Massimo Insabato/Archivio Massimo Insabato/Mondadori Portfolio via Getty Images)

ART HISTORIAN SPOTS ANCIENT PORTRAIT THOUGHT TO BE LOST IN THE BACKGROUND OF PHOTO SHARED ON SOCIAL MEDIA

It has been theorized that the glass found could have been on a boat or ship that faced destruction by a storm, sending the ancient artifacts into the water. 

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It’s likely the ship wreckage will be discovered near the area where the glass fragments were found, according to the museum. 

While much of the glassware was found in fragments, there are pieces that are very much intact, displaying the intricate craftsmanship in their creation many years ago. 

Murano Glass Factory

Murano is still known for its glass production today. It is home to the Murano Glass Factory, a popular tourist attraction for visitors.  (Gisela Schober/Getty Images)

 

The discovery of these underwater artifacts is “an important source of information on the poorly researched topic of consumption, trade, and production of glass in the Balkans during the Late Ottoman Period,” the museum wrote in the Facebook post. 

The new underwater finds will be exhibited at the Burgas Regional Historical Museum.

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Matthew Perry's death leads to sweeping indictment of 5, including doctors and reputed dealers

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Matthew Perry's death leads to sweeping indictment of 5, including doctors and reputed dealers

LOS ANGELES (AP) — Nearly 10 months after the death of Matthew Perry, the long-simmering investigation into the ketamine that killed him came dramatically into public view with the announcement that five people had been charged with having roles in the overdose of the beloved “Friends” star.

Here are key things to know about the case, including the two key figures who could be headed for trial and the possibility of the steepest of prison sentences.

A sweeping set of indictments

One or more arrests had been expected since investigators from three different agencies revealed in May they had been conducting a joint probe into how the 54-year-old Perry got such large amounts of ketamine.

The actor had been among the growing number of patients using legal but off-label medical means to treat depression, or in other cases chronic pain, with the powerful surgical anesthetic.

Recent reports suggested indictments might be imminent, but few outside observers, if any, knew how wide-ranging the prosecution would be, reaching much further than previous cases stemming from celebrity overdoses.

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When Michael Jackson died in 2009 from a lethal dose of the anesthetic propofol, his doctor was charged with providing it. After rapper Mac Miller died in 2017, two men who prosecutors described as a dealer and a middleman were convicted of providing fentanyl-laced oxycodone that helped kill him.

But Perry’s case pulled in both, with indictments against doctors and illegal distributors who prosecutors say preyed on his long and public struggles with addiction. The investigation even went after the live-in personal assistant who prosecutors say helped him get ketamine and injected it directly into him before Perry was found dead in his hot tub on Oct. 28, 2023.

“They knew what they were doing was risking great danger to Mr. Perry. But they did it anyway,” U.S. Attorney Martin Estrada said in announcing the charges.

The prosecution was well under way even before the announcement. Two people including the assistant, Kenneth Iwamasa, and a Perry acquaintance, Eric Fleming, have pleaded guilty to conspiracy to distribute the drug. A San Diego physician, Dr. Mark Chavez, has agreed to enter a guilty plea.

That leaves prosecutors free to pursue their two biggest targets.

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The doctor and the ‘Ketamine Queen’

An indictment unsealed Thursday alleges Perry turned to Los Angeles doctor Salvador Plasencia when his regular doctors refused to give him more ketamine. Prosecutors allege Plasencia cashed in on Perry’s desperation and addiction, getting him to pay $55,000 in cash for large amounts of the drug in the two months before his death.

“I wonder how much this moron will pay,” Plasencia texted a co-defendant, according to his indictment.

He pleaded not guilty to seven counts of distribution of ketamine in an appearance in federal court on Thursday afternoon.

Plasencia’s attorney, Stefan Sacks, said outside court that he “was operating with what he what he thought were the best of medical intentions,” and his actions “certainly didn’t rise to the level of criminal misconduct.”

Prosecutors allege Jasveen Sangha, whom they describe as a drug dealer known to customers as the “Ketamine Queen,” provided the doses of the drug that actually killed Perry, injected into the actor by Iwamasa with syringes supplied by Plasencia.

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Sangha also pleaded not guilty. Her attorney Alexandra Kazarian derided the “queen” moniker as made-for-media consumption during the hearing. The lawyer declined comment on the case outside court.

Prosecutors say the other doctor in the case, Chavez, helped Plasencia obtain the ketamine he gave to Perry, while Perry’s acquaintance, Fleming, helped get ketamine from Sangha to Perry.

Chavez could get up to 10 years in prison, Iwamasa up to 15 years and Fleming up to 25 years.

Multiple messages seeking comment from attorneys for the three men were not returned.

Looking ahead to trial

Sangha could get life in prison if convicted as charged, while Plasencia could get up to 120 years. Each has a trial date in October, but it is highly unlikely any would be facing a jury by then, and the two may be tried together. They also could face testimony from the co-defendants who reached plea agreements.

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Magistrate Judge Alka Sagar ruled Sangha should be held without bond while awaiting trial, citing prosecutors’ contentions that she had destroyed evidence and funded a lavish lifestyle with drug sales even after Perry’s death.

The judge agreed to release Plasencia after he posted a $100,000 bond.

His attorney argued the Perry case was “isolated” and the doctor should be allowed to treat patients who depended on him at his one-man practice while awaiting trial.

“I’m not buying that argument,” Sagar said, but agreed Plasencia could see patients so long as they signed a document in which he acknowledged the charges.

“People have probably already heard about it from the amount of press,” Sacks told the judge, noting if they hadn’t, they would soon.

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Records show Plasencia’s medical license has been in good standing with no records of complaints, though it is set to expire in October and he could face action. He already has surrendered his federal license to prescribe more dangerous drugs.

Pushing back against ketamine

Prosecutors and police presented the Perry case as part of a major pushback against a rise in the illegal use of ketamine that has shadowed the broadening of its legal use.

Los Angeles police said in May they were working with the U.S. Drug Enforcment Administration and the U.S. Postal Inspection Service with a probe into how Perry got the drug. His autopsy, released in December, found the amount of ketamine in his blood was in the range used for general anesthesia during surgery.

“As Matthew Perry’s ketamine addiction grew, he wanted more and he wanted it faster and cheaper. That is how he ended up buying from street dealers and stole the ketamine that ultimately led to his death,” U.S. Drug Enforcement Administrator Anne Milgram said Thursday. “In doing so, he followed the arc that we have tragically seen with many others. The substance use disorder begins in a doctor’s office and ends in the street.”

Perry had years of struggles with addiction dating back to his time on NBC’s megahit sitcom, “Friends,” for 10 seasons from 1994 to 2004. Playing Chandler Bing, he became one of the biggest television stars of his generation alongside Jennifer Aniston, Courteney Cox, Lisa Kudrow, Matt LeBlanc and David Schwimmer.

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