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San Francisco 49ers at Green Bay Packers: Predictions, picks and odds for NFL Week 12 game

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San Francisco 49ers at Green Bay Packers: Predictions, picks and odds for NFL Week 12 game


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The Green Bay Packers nearly lost to the Chicago Bears last week, in what would’ve been a massive upset, snapping a 10-game win streak for the cheese heads against their rivals. Now, the San Francisco 49ers are headed to Lambeau, fresh off a last-second defeat at the hands of the Seattle Seahawks.

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Neither team played their best in Week 11, but only one of them walked away with a win. That speaks to Green Bay’s persistence. Unlike the 49ers, Green Bay has been able to squeak out close games, where San Francisco crumbles to bits under any sort of pressure. All that is to say that it is a wonder how some people still believe in the 49ers. Perhaps a win over a tough Green Bay squad would restore some faith.

Here are our experts’ predictions for this Week 12 matchup.

PROP TALK: These are the best prop bets for NFL games this week 

Packers vs. 49ers odds, moneyline, over/under

The Packers are favorites to defeat the 49ers, according to the BetMGM NFL odds. Looking to wager? Check out the best mobile sports betting apps offering NFL betting promos in 2024 including the ESPN BET app and Fanatics Sportsbook promo code.

  • Spread: Packers (-2.5)
  • Moneyline: Packers (-140); Ravens (+115)
  • Over/under: 47.5

Not interested in this game? Our guide to NFL betting odds, picks and spreads has you covered with Thursday Night Football odds and Monday Night Football odds.

New to sports betting? USA TODAY readers can claim exclusive promos and bonus codes with the best online sportsbooks and sports betting sites.

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FEELING LUCKY? Here are the best parlay bets and odds for NFL games this week 

NFL Week 12 odds, predictions and picks

Browns vs. Steelers | Panthers vs. Chiefs | Bears vs. Vikings | Texans vs. Titans | Colts vs. Lions | Dolphins vs. Patriots | Giants vs. Buccaneers | Commanders vs. Cowboys | Raiders vs. Broncos | Packers vs. 49ers | Seahawks vs. Cardinals | Rams vs. Eagles | Chargers vs. Ravens

Lorenzo Reyes: 49ers 24, Packers 21

The Packers, frankly, should’ve lost last week against the Bears. The 49ers are wildly inconsistent, and the defense has had significant struggles this season. Time is running out for San Francisco, however, and the Niners must keep pace in the NFC West.

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Tyler Dragon: 49ers 23, Packers 22

The 49ers let one slip away against Seattle last week. At some point, the 49ers have to flip the switch if they want to make another Super Bowl run. A win in Green Bay can catapult the 49ers in what’s been a sluggish 11 weeks.

Richard Morin: Packers 30, 49ers 27

The 49ers have burned me (and a lot of other prognosticators) all season, so I just can’t side with them to win at Lambeau. San Francisco will still be alive in the division race even after a loss.

Jordan Mendoza: 49ers 26, Packers 24

This matchup is tough because of how inconsistent both sides have been this season. Look for Christian McCaffrey to finally break free and come out with a much-needed road victory.

MOST VALUABLE BET: Who is the favorite to win NFL MVP in 2024? 



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San Francisco, CA

Body cam footage released in South San Francisco police shooting

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Body cam footage released in South San Francisco police shooting


(KRON) — The South San Francisco Police Department released video Thursday showing what led up to two officers shooting a man who authorities said was armed with a knife.

On December 8 at around 5:10 a.m., police arrived at the 900 block of Sandra Court on the report of a man under the influence of drugs and making threats to kill himself. When officers made contact with the man, identified as 28-year-old Luis Francisco-Manzo, he initially complied with orders, authorities said.

Officer-worn body camera video shows Francisco-Manzo walking toward officers in the entrance hallway of an apartment complex with his arms raised. A small dog barks as officers give repeated commands. Suddenly, Francisco-Manzo appears in the entranceway next to officers as one calls out, “He’s got a knife.”

South San Francisco Police Department officers shot Luis Francisco-Manzo on December 8, 2025. Authorities said Francisco-Manzo charged at officers while armed with a knife. (Photo: South San Francisco Police Department)

Officer Brendan Hart, who has been with SSFPD for eight years, fired a Taser at Francisco-Manzo, but it did not have the intended effect, police said.

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Four gunshots are heard in the body camera video. Police said Officer Hart and Officer Martin Corona were the officers who discharged their weapons. Officer Corona has seven years of law enforcement experience with over four years at SSFPD.

(Photo: South San Francisco Police Department)

Francisco-Manzo was transported to the hospital in critical condition. On Thursday, authorities said he continues to recover in the hospital. No officers were injured in the incident.

The police shooting remains under investigation by the San Mateo County District Attorney’s Office.



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Pedestrian killed in San Francisco hit-and-run crash

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Pedestrian killed in San Francisco hit-and-run crash


A hit-and-run crash in San Francisco on Wednesday evening left a pedestrian dead.

Driver fled scene

What we know:

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According to the San Francisco Police Department, the crash happened around 6:05 p.m. in the 5500 block of Mission Street. The driver fled the scene after striking the pedestrian.

The victim died at the scene.

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Officers have not yet provided a description of the suspect vehicle involved in the incident.

No further details were immediately released. 

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San Francisco: Anti-ICE protester gets probation for ‘depredation’ of ICE van’s tire

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San Francisco: Anti-ICE protester gets probation for ‘depredation’ of ICE van’s tire


SAN FRANCISCO — A protester who was initially charged with misdemeanor assault has been sentenced to probation for a less serious offense, ending a federal prosecution that only started four months ago, court records show.

On Dec. 8, Angelica Guerrero, 35, pleaded guilty to misdemeanor “depredation” of an ICE van’s tire — a fancy legal term for slashing it with a knife. The same day, a federal judge sentenced Guerrero to probation, according to a minute order of the hearing.

The charge stemmed from an Aug. 20 protest, when Guerrero slashed the tire of an unmarked Chevrolet van being used in an ongoing “enforcement and removal” operation by the Department of Homeland Security on the 100 block of Montgomery Street, according to prosecutors. The complaint alleges that Guerrero “made repeated threats” against one of the officers, including stating, “I’m going to (expletive) you up” and “I’m going after your family,” as well as threatening to stab the officer.

Guerrero was released within 48 hours but complained of “barbaric” conditions inside Santa Rita Jail, during an interview with ABC7.

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