A man is dead after a brutal stabbing inside a San Francisco hospital and now federal immigration officials are pointing squarely at California’s sanctuary policies and the Biden administration’s border decisions as contributing factors.

U.S. Immigration and Customs Enforcement (ICE) is urging Governor Gavin Newsom and state officials not to release the suspect, a Venezuelan national in the country illegally who had previously been encountered and released by Border Patrol.

Wilfredo Jose Tortolero-Arriechi is accused of fatally stabbing 51-year-old Alberto Rangel inside Zuckerberg San Francisco General Hospital on December 4. Rangel succumbed to his injuries two days later, on December 6.

According to the Department of Homeland Security, ICE has already lodged a detainer request to keep Tortolero-Arriechi in custody — a request that now hangs in the balance in a state that has repeatedly clashed with federal immigration enforcement.

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“If it weren’t for the Biden administration’s reckless open-border policies, Alberto Rangel would still be alive,” Acting Assistant Secretary Lauren Bis said in a statement, directly tying the killing to federal immigration policy. She also called on Newsom to ensure the suspect is not released, blasting sanctuary policies that she says “put American lives at risk.”

The suspect had reportedly displayed alarming behavior in the weeks leading up to the attack, allegedly threatening hospital staff and his own doctor before the deadly stabbing unfolded.

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Federal officials say Tortolero-Arriechi was first encountered by U.S. Border Patrol in 2023 and then released into the country. The case is adding new fuel to the fight over California’s sanctuary policies.

Earlier this year, ICE revealed that more than 33,000 criminal illegal immigrants are currently in custody across California with active detainers, including individuals accused or convicted of serious crimes such as homicide, sexual assault and drug trafficking.

Despite that, officials say thousands have been released.

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Since January 2026 alone, California jurisdictions have declined to honor ICE detainers in more than 4,500 cases, according to the agency. Those releases included individuals tied to dozens of homicides, hundreds of assaults and a wide range of other violent and drug-related offenses, ICE said.

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The latest push from federal officials builds on earlier warnings. In February, Acting ICE Director Todd Lyons sent a letter to California Attorney General Rob Bonta urging him to “put the safety of Americans first” by honoring detainers for more than 33,000 criminal illegal immigrants in state custody.

Lyons warned that “no community serious about keeping its residents safe will tolerate a clear aberration of the law,” pressing California officials to cooperate with ICE and take “the worst of the worst off the streets.”

Meanwhile, Alberto Rangel’s death is now being used by federal officials to underscore what they argue are the real-world consequences of those policies.

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Newsom’s office pushed back on that characterization, saying the state’s approach prioritizes accountability and public safety.

“If someone commits a serious crime, they should be held accountable in our justice system,” a spokesperson for Newsom’s office told Fox News Digital. “Allowing someone to evade responsibility simply by being deported undermines the rule of law and completely disrespects the victims harmed by that crime. Our focus must always be to ensure those who commit violent acts face their consequences here.”

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The governor’s office also pointed to California’s record of cooperating with federal immigration authorities in certain cases, noting that, since 2019, the state has coordinated the transfer of more than 12,000 individuals, including those convicted of serious and violent crimes, into ICE custody.

Officials added that state law allows coordination with ICE for individuals convicted of serious felonies or those facing credible charges, and said California does not interfere with federal immigration enforcement.

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They also argued that federal authorities do not always take custody of individuals when detainers are issued, claiming ICE fails to pick up roughly one in eight people released from state prisons who have immigration holds.

Tortolero-Arriechi remains in custody at the San Francisco County Jail, where he faces homicide and weapons charges, as pressure mounts on California leaders over whether they will comply with federal requests to keep him there.

In a statement issued after his death in December 2025, SEIU Local 521 Chief Elected Officer Riko Mendez said, “Our hearts are with the family, friends, and coworkers of Alberto Rangel,” remembering him as a dedicated social worker.