Montana
Path to a better TB vaccine runs through Montana
Jim Robbins
(KFF) A team of Montana researchers is playing a key role in the development of a more effective vaccine against tuberculosis, an infectious disease that has killed more people than any other.
The BCG (Bacille Calmette-Guérin) vaccine, created in 1921, remains the sole TB vaccine. While it is 40% to 80% effective in young children, its efficacy is very low in adolescents and adults, leading to a worldwide push to create a more powerful vaccine.
One effort is underway at the University of Montana Center for Translational Medicine. The center specializes in improving and creating vaccines by adding what are called novel adjuvants. An adjuvant is a substance included in the vaccine, such as fat molecules or aluminum salts, that enhances the immune response, and novel adjuvants are those that have not yet been used in humans. Scientists are finding that adjuvants make for stronger, more precise, and more durable immunity than antigens, which create antibodies, would alone.
Eliciting specific responses from the immune system and deepening and broadening the response with adjuvants is known as precision vaccination. “It’s not one-size-fits-all,” said Ofer Levy, a professor of pediatrics at Harvard University and the head of the Precision Vaccines Program at Boston Children’s Hospital. “A vaccine might work differently in a newborn versus an older adult and a middle-aged person.”
The ultimate precision vaccine, said Levy, would be lifelong protection from a disease with one jab. “A single-shot protection against influenza or a single-shot protection against covid, that would be the holy grail,” Levy said.
Jay Evans, the director of the University of Montana center and the chief scientific and strategy officer and a co-founder of Inimmune, a privately held biotechnology company in Missoula, said his team has been working on a TB vaccine for 15 years. The private-public partnership is developing vaccines and trying to improve existing vaccines, and he said it’s still five years off before the TB vaccine might be distributed widely.
It has not gone unnoticed at the center that this state-of-the-art vaccine research and production is located in a state that passed one of the nation’s most extreme anti-vaccination laws during the pandemic in 2021. The law prohibits businesses and governments from discriminating against people who aren’t vaccinated against covid-19 or other diseases, effectively banning both public and private employers from requiring workers to get vaccinated against covid or any other disease. A federal judge later ruled that the law cannot be enforced in health care settings, such as hospitals and doctors’ offices.
In mid-March, the Bill & Melinda Gates Medical Research Institute announced it had begun the third and final phase of clinical trials for the new vaccine in seven countries. The trials should take about five years to complete. Research and production are being done in several places, including at a manufacturing facility in Hamilton owned by GSK, a giant pharmaceutical company.
Known as the forgotten pandemic, TB kills up to 1.6 million people a year, mostly in impoverished areas in Asia and Africa, despite its being both preventable and treatable. The U.S. has seen an increase in tuberculosis over the past decade, especially with the influx of migrants, and the number of cases rose by 16% from 2022 to 2023. Tuberculosis is the leading cause of death among people living with HIV, whose risk of contracting a TB infection is 20 times as great as people without HIV.
“TB is a complex pathogen that has been with human beings for ages,” said Alemnew Dagnew, who heads the program for the new vaccine for the Gates Medical Research Institute. “Because it has been with human beings for many years, it has evolved and has a mechanism to escape the immune system. And the immunology of TB is not fully understood.”
The University of Montana Center for Translational Medicine and Inimmune together have 80 employees who specialize in researching a range of adjuvants to understand the specifics of immune responses to different substances. “You have to tailor it like tools in a toolbox towards the pathogen you are vaccinating against,” Evans said. “We have a whole library of adjuvant molecules and formulations.”
Vaccines are made more precise largely by using adjuvants. There are three basic types of natural adjuvants: aluminum salts; squalene, which is made from shark liver; and some kinds of saponins, which are fat molecules. It’s not fully understood how they stimulate the immune system. The center in Missoula has also created and patented a synthetic adjuvant, UM-1098, that drives a specific type of immune response and will be added to new vaccines.
One of the most promising molecules being used to juice up the immune system response to vaccines is a saponin molecule from the bark of the quillay tree, gathered in Chile from trees at least 10 years old. Such molecules were used by Novavax in its covid vaccine and by GSK in its widely used shingles vaccine, Shingrix. These molecules are also a key component in the new tuberculosis vaccine, known as the M72 vaccine.
But there is room for improvement.
“The vaccine shows 50% efficacy, which doesn’t sound like much, but basically there is no effective vaccine currently, so 50% is better than what’s out there,” Evans said. “We’re looking to take what we learned from that vaccine development with additional adjuvants to try and make it even better and move 50% to 80% or more.”
By contrast, measles vaccines are 95% effective.
According to Medscape, around 15 vaccine candidates are being developed to replace the BCG vaccine, and three of them are in phase 3 clinical trials.
One approach Evans’ center is researching to improve the new vaccine’s efficacy is taking a piece of the bacterium that causes TB, synthesizing it, and combining it with the adjuvant QS-21, made from the quillay tree. “It stimulates the immune system in a way that is specific to TB and it drives an immune response that is even closer to what we get from natural infections,” Evans said.
The University of Montana center is researching the treatment of several problems not commonly thought of as treatable with vaccines. They are entering the first phase of clinical trials for a vaccine for allergies, for instance, and first-phase trials for a cancer vaccine. And later this year, clinical trials will begin for vaccines to block the effects of opioids like heroin and fentanyl. The University of Montana received the largest grant in its history, $33 million, for anti-opioid vaccine research. It works by creating an antibody that binds with the drug in the bloodstream, which keeps it from entering the brain and creating the high.
For now, though, the eyes of health care experts around the world are on the trials for the new TB vaccines, which, if they are successful, could help save countless lives in the world’s poorest places.
Montana
Accident blocks Expressway in Missoula
MISSOULA, Mont. — UPDATE: Expressway lanes are back open after an accident.
The accident occurred around 6:45 p.m. today and obstructed traffic on Expressway from Majestic Drive to the Crestview Apartments Tuesday evening.
Missoula Police Department is asking the public to take an alternate route.
No additional information is available at this time.
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NBC Montana will keep you updated.
Montana
Montana Viewpoint: Money for nothing
Jim Elliott
Just before the official days of excessive purchasing named Black Friday, and Cyber Monday which follow immediately on the heels of the National Day of Gluttony, Turkey Thursday, I received a new credit card.
Just for giggles, I thought I’d read the fine print. The rate of interest would be 14.99 percent. “Didn’t Jesus throw the money lenders out of the Temple?” I thought. The late fee would be 29.99 percent and would apply to future purchasers at the discretion of the bank. I then thought of a friendly fellow I knew who was originally from Chicago. “What did you do there?” I asked him once. He smiled, and said, “I was in collections.” I wondered if he had worked for a bank or some other organization.
Where did these high credit card rates come from? Long ago there were state laws that prohibited usury, which is the charging of excessive interest on loans. When did that all change?
In the United State that date would be February 6, 1980, when a bill to abolish the South Dakota usury laws passed that state’s legislature. In the 1970s inflation was running at about 20 percent and to tame the trend, Paul Volker, the Chairman of the Federal Reserve Bank had allowed the rate at which the Fed loaned money to banks to rise to 20 percent. In South Dakota and elsewhere in the 1970s farmers were having a very hard time of it for many reasons and needed to borrow money from banks just to survive. But South Dakota banks were not about to lend out money at the legal maximum rate of 12 percent when they had to pay 20 percent interest just to borrow the money from the Federal Reserve.
In a related issue, in 1978 Marquette Bank of Minneapolis was having their credit card business undermined by First National Bank of Omaha, which was issuing credit cards to Minnesota residents at 18 percent interest which was the top usury rate in Nebraska but with no annual fee. Marquette was issuing credit cards at the 12 percent maximum interest rate imposed by Minnesota, but they did charge an annual fee. They were losing business to the Nebraska bank. Marquette went to court, arguing that Nebraska banks could not charge a rate of interest in Minnesota that was higher than Minnesota banks could charge in their own state. Marquette lost. In a unanimous opinion the Supreme Court ruled that the usury law of the issuing state held, no matter where the cardholder lived.
In a second related issue, Citibank of New York was bound to the New York usury law of 13 percent and was losing money. After the Marquette decision, Citibank began looking for a new state to do its credit card business in. Under federal banking law a bank could not move to a state without an invitation to relocate, which was conveniently provided by (usury free) South Dakota on the last day of its legislative session in 1980. Citibank relocated its credit card operations to Sioux Falls, S.D. as soon as it could, bringing with it 500 new jobs, a new building, and as a special gift to its cardholders, a higher interest rate.
That’s the history of the beginning of high rates. The morality of charging high rates on loans goes back at least—as I have said—to Jesus throwing the money lenders out of the Temple when he said, “It is written, My house shall be called the house of prayer; but ye have made it a den of thieves.” (Matthew 21:13 KJV).
People who loan money will tell you that the rate they charge reflects the risk they take that the loan won’t be repaid. The higher the risk, the higher the interest charged. It used to be that bankers didn’t like to take risks. They loaned money, sure. They made money on the interest charged, sure. But they also wanted the borrower to have a solid reason for borrowing money and to be successful in the business the customer was borrowing the money for. If it was a mortgage, they wanted you to be able to afford the loan. They did not loan money for toys or vacations. They looked out for themselves by looking out for their customers.
Now, it seems, all they want to do is make money off their customers, and the faster the better. Bankers used to educate their customers because success was a two-way street. Today, people are drowning in credit card debt, and nobody seems to care. Well, someone might, but it’s not the banks.
Have fun, but don’t go broke doing it.
Montana Viewpoint has appeared in weekly and online newspapers across Montana for over 30 years. Jim Elliott served sixteen years in the Montana Legislature as a state representative and state senator. He lives on his ranch in Trout Creek.
Montana
Helena names three finalists for city manager post
The Helena City Commission announced Monday the three finalists to fill its city manager position.
After nearly two months of a turbulent recruitment process that included an ongoing lawsuit, the commission selected Janet Hawkinson, the town manager from Palisade, Colorado; Douglas Schulze, most recently the city manager of Banning, California; and Helena’s Alana Lake, the current executive director of the Montana Public Service Commission.
The Helena City Commission will begin public interviews of the candidates on Monday, Dec. 8, at the City-County Building, 316 N. Park Ave. Schulze will be the first interview from 8:30 a.m. to 10:30 a.m., followed by Hawkinson’s interview from 10:30 a.m. to 12:30 p.m.
Later that day, the public will have the opportunity to ask questions of the two out-of-town finalists during town hall meetings on the second floor of the Montana Club, 24 W. Sixth Ave. Schulze’s town hall will be from 5 p.m. to 6 p.m., followed by Hawkinson from 6 p.m. to 7 p.m.
On Tuesday, Dec. 9, the commission will hold its public interview of Lake from 8:30 a.m. to 10:30 a.m. Her town hall will be in the City-County Building’s commission chambers from 5 p.m. to 6 p.m.
The city has provided online meeting links for each interview and town hall meeting, which can be accessed on the city commission’s Zoom hub.
The commission will hold its final deliberation on Wednesday, Dec. 10, at the commission chambers from 5:30 p.m. to 7 p.m.
Hawkinson has been the town manager of Palisade, a town with a population of 2,600 as of 2024, since 2018. According to the city press release, she previously served as the director of community development for Minturn, Colorado. She holds a master’s degree in landscape architecture and urban planning from the University of Colorado, Denver, and a bachelor’s degree in political science from Fort Lewis College.
Schulze has more than 36 years of experience in municipal leadership, according to the city release, and has led city governments in Sandstone, Minnesota, and the communities of Medina, Normandy Park and Bainbridge Island, all in Washington state. Most recently, he served as city manager of Banning, California, a city of approximately 32,000 people, although he was placed on indefinite paid leave from that position last February, according to the Riverside Record. It’s unclear if that paid leave is ongoing. The mayor of Banning told the local newspaper that Schulze was not under an investigation but that it was ” … a matter of looking at some concerns.”
Schulze holds a master’s degree in urban studies and a bachelor’s degree in public administration, although the city release doesn’t specify where he earned those degrees.
Lake joined the Montana Public Service Commission, the state board that regulates shareholder-owned utilities, as its executive director this past March. According to the city release, she has more than 10 years of experience in military and federal law enforcement, including work with the U.S. Air Force Office of Special Investigations. She has led teams across the globe that involved criminal investigation, security, and counterintelligence operations, gaining experience with interagency coordination and planning.
Lake previously served as a counterintelligence officer at the Idaho National Laboratory, advising senior officials on national security risks, guarding infrastructure and expanding intelligence programs, the release stated.
Lake graduated from Montana State University and earned her master’s degree in business administration from Boise State University. The release stated that she is currently attending the Command and Staff College through the Marine Corps University.
The release comes after current City Manager Tim Burton announced in September that he planned to retire at the end of this year, jumpstarting the commission’s process in finding his replacement.
That search sparked a lawsuit brought against the city by a former commissioner, who alleged that a commission subcommittee had violated Montana’s open meeting laws when initiating the recruitment process. The city responded to the lawsuit in November, claiming that the subcommittee, comprising City Mayor Wilmott Collins and Commissioner Sean Logan, had not violated any open meeting laws because the committee is not a “governmental body” or agency.
Additionally, the city also maintains that the lawsuit is void since the city revised its process to include all members of the commission in further meetings regarding the recruitment and hiring of the new city manager.
In a recent court filing, lawyers for the plaintiff have argued that the city’s change to involve all commission members does not resolve their original request for a preliminary injunction. They’ve also asked the court to disband the subcommittee.
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