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Texas attorney-general Ken Paxton said Donald Trump’s endorsement is “the most powerful force in politics” as he comfortably won the Republican nomination for the Senate last night.

Paxton defeated four-term senator John Cornyn in the latest contest where president Trump sought to oust an incumbent he saw as insufficiently loyal, AP reported.

Trump endorsed Paxton, calling him a “true MAGA warrior”, with Paxton’s victory in the runoff making Cornyn – who was first elected to the Senate in 2002 – the first Republican senator from Texas to lose the party’s nomination for reelection.

“When everyone in Washington told him to abandon me and abandon the people of Texas, he didn’t listen,” Paxton said. “President Trump is the leader of our party, and his endorsement is the most powerful force in politics.”

Cornyn’s loss followed primaries this month where Trump successfully backed challengers to Republican lawmakers who had displeased him in Louisiana, Kentucky and Indiana, a sign of his enduring influence among primary voters.

“After a public service career lasting more than four decades and 18 consecutive campaign wins, tonight we’ve come up short in this primary runoff,” Cornyn said shortly after the race was called. “I’ve always supported the GOP ticket. I intend to do so again this general election.”

The race had wide implications for Trump’s strength heading into November’s midterm elections, where Paxton will now face James Talarico, a Democratic pastor and state legislator whose message of peace and populism has attracted much attention. If he wins, Talarico would become the first Democrat in more than 30 years to win statewide office in Texas.

In other developments:

• Christian Menefee defeated Al Green to represent Texas’s newly redrawn 18th congressional district. Green, 78, had served 11 terms as a Democrat, earning a reputation as one of Donald Trump’s top critics, when he became the first member of Congress to call for his impeachment, as early as 2017. Menefee, 38, began serving in Congress earlier this year after he won a special election. The two Democrats faced off against each other in this year’s election after Republican redistricting saw their home districts near Houston redrawn.

• Two Republican-led efforts to redraw congressional maps in Alabama and South Carolina hit setbacks. In Alabama, a federal court said the proposed map could not be used because it was drawn to intentionally discriminate against Black voters. The South Carolina Senate voted against redrawing the state’s congressional map due to political and administrative reasons.

• Construction is under way on the White House lawn for a UFC arena that will host a cage-match next month to mark the United States’s 250th anniversary and Trump’s 80th birthday. The mixed martial arts fight is planned for 14 June.

• Trump completed his annual physical after year of public attention to health issues. Trump, the oldest inaugurated president in US history, completed a physical exam on Tuesday at Walter Reed national military medical center, amid questions around his health. “Everything checked out PERFECTLY,” the US president declared in a social media post.

• The Trump administration considered asking federal workers to sign NDAs. The goal of asking federal employees to sign nondisclosure agreements is to prevent them from sharing confidential information with journalists.