The United States launched military strikes and “major combat operations” against Iran on Feb. 28, President Donald Trump said, targeting the country’s missile capabilities.

“Our objective is to defend the American people by eliminating imminent threats from the Iranian regime, a vicious group of very hard, terrible people,” Trump said, calling the strikes “a massive and ongoing operation.”

The attack follows weeks of rising tensions as Trump repeatedly threatened to attack Iran if negotiations over its nuclear and missile development programs fail.

Live updates: Iran hit by ‘massive’ US attack; supreme leader targeted: Updates

Iran’s supreme leader, Ali Khamenei, was directly targeted, a Middle Eastern official familiar with the matter told USA TODAY. Khamenei’s fate was unknown.

Iran launched retaliatory drone and missile strikes against American and Israeli targets after the joint U.S.-Israeli attack, hitting a U.S. Navy base in Bahrain. Iran said its enemies would be “decisively defeated.”

Images from Tehran early Saturday showed smoke rising from the Iranian capital as residents ran for cover. Iran said 40 people were killed in a strike at a girl’s school in the south.

Officials from the Volunteer State reacted.

‘It’s time,’ says Sen. Marsha Blackburn

U.S. Sen. Marsha Blackburn, R-Tennessee, praised the operation on Saturday morning, Feb. 28.

“The Iranian regime has chanted ‘Death to America’ for decades,” she said, in a statement on X. “It’s time to end the reign of terror.”

Alongside her statement, she shared the announcement made by Trump early Saturday morning.

“A short time ago, the United States military began major combat operations in Iran. Our objective is to defend the American people by eliminating imminent threats from the Iranian regime, a vicious group of very hard terrible people,” Trump said in a video statement, which he delivered from his Mar-a-Lago resort in Florida.

The Trump administration has for weeks held negotiations with Iran over its nuclear program while also building up its military presence in the region. Tehran refused to abandon its nuclear ambitions, the U.S. president said, prompting the overnight airstrikes, which sent smoke plumes over Iran.

“They just wanted to practice evil,” Trump said in the video posted on social media. “And we can’t take it anymore.”

Sen. Bill Hagerty, Rep. Chuck Fleischmann support the operation in Iran

U.S. Senator Bill Hagerty stated his support for the operation.

“The world knows the death and destruction that Iran has perpetrated for decades,” he said, in a statement on social media. “The regime must be held accountable.

“(Trump) knows that strength—not weakness—brings peace. The president will not pass the buck to avoid necessary decisions to protect the American people. May God bless America, our Service Members, and our Allies.”

U.S. Rep. Chuck Fleischmann echoed Hagerty.

“For decades, Iran and its theocratic dictatorship have been the world’s largest state sponsor of terror, threatening the United States and the peace of the world,” he said on social media. “President Trump will always defend America’s national security and interests. May God bless the men and women of our armed forces and our coalition partners.”

Rep. Andy Ogles thanks Trump and Israeli Prime Minister

U.S. Rep Andy Ogles thanked Trump, alongside Israeli Prime Minister Benjamin Netanyahu, for the operation.

“I firmly stand with the people of Iran and support their right to take their country back from the mass murderer the Ayatollah. Thank you (Trump) and the White House for your leadership and (Netanyahu) for your partnership in securing freedom in the region.”

However, not everyone agreed with the strikes.

State legislator calls strikes ‘dangerous’

Rep. Justin Jones, D-Nashville, called the strikes “dangerous for us all.”

“The leader of his proclaimed ‘Board of Peace’ is dragging us into an illegal war to deflect from his failures and profit donors in the war industry,” he said. “We are being led by a madman with no check from Congress and no clear justification to the American people.”