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Why do we get side effects from vaccines? Experts say that means it’s working

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Why do we get side effects from vaccines? Experts say that means it’s working

The cooling sensation of an alcohol swab in your higher bicep is a cue for what’s about to come back subsequent: the injection of a needle that delivers a dose of vaccine.

Greater than 69% of Individuals have acquired at the very least one dose of a COVID-19 vaccine, and as a bandage is utilized to your arm, you’re a part of the membership.

Whether or not you’re getting your first shot, a second dose or a booster, you’re more likely to expertise some uncomfortable side effects.

They might be inconvenient, and so they definitely might be uncomfortable. However immunologists and virologists say they’re to be anticipated. And also you may even welcome them.

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Right here’s why, and what it is best to count on if in case you have a date with a needle.

Why do vaccines trigger uncomfortable side effects?

To place it merely, the uncomfortable side effects are a organic signal that the vaccine is working.

All three of the COVID-19 vaccines out there within the U.S. successfully work in the identical manner, mentioned Dr. David Pleasure, an infectious illness specialist at UC San Diego.

The vaccines include genetic directions for making copies of the coronavirus’ spike protein. The Pfizer-BioNTech and Moderna vaccines use mRNA to hold the directions, and the Johnson & Johnson shot employs a disabled adenovirus, which is innocent.

As soon as the directions are delivered, it’s as much as your cells to do the work. The pretend spike proteins can’t do any injury since they’re not linked to precise coronaviruses. However your physique will detect them and suppose an an infection is underway, prompting the immune system to swing into motion, Pleasure mentioned. You’ll be able to consider it as a coaching run.

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The immune response is available in two elements. First, the innate immune system is alerted to the arrival of attainable viruses or different pathogens in your physique, mentioned Dr. Peter Hotez, co-director of the Texas Kids’s Hospital Middle for Vaccine Growth. Then the adaptive immune system produces antibodies that may reply appropriately to the intruder — and, if needed sooner or later, to an precise encounter with the virus.

The uncomfortable side effects you’re feeling are a pure a part of your immune system’s response to the vaccine’s viral payload.

What’s regular and what’s not?

Negative effects to a COVID-19 vaccine are generally delicate and generally extra intense, like a foul chilly or a case of the flu. Both manner, they shouldn’t final greater than 72 hours.

The commonest uncomfortable side effects are low-grade fever, fatigue, muscle ache, headache, chills and nausea, based on the Facilities for Illness Management and Prevention. Short-term soreness on the injection website can be frequent. As Dr. George Rutherford, professor of epidemiology and biostatistics at UC San Francisco, places it: You simply acquired caught with a needle; vaccine or not, that’s going to harm.

The clinic or pharmacy the place you get your shot will ask you to hold round for 15 or half-hour after after your injection, to allow them to monitor you for uncommon however critical reactions, resembling an acute allergic response that requires epinephrine.

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When you get residence, you’ll be able to take over-the-counter ache relievers resembling Tylenol or Advil. (Don’t take them earlier than your shot as a result of that may dampen the vaccine’s effectiveness.) Past permitting your physique to relaxation, there’s not a lot else you are able to do whereas using out regular uncomfortable side effects.

In uncommon circumstances, folks — largely teenage boys and younger males — expertise myocarditis (irritation of the center muscle) or pericarditis (irritation of the tissue that surrounds the center) within the week after getting a shot. Signs embrace chest ache, shortness of breath and emotions of getting a fast-beating or pounding coronary heart. If this occurs to you, search medical consideration instantly. Most often, the situations are simply handled with medication and relaxation.

A really small variety of folks — largely girls beneath age 50 — who get the Johnson & Johnson vaccine might expertise a critical facet impact known as thrombosis with thrombocytopenia syndrome, or TTS. Signs embrace chest ache, leg swelling, shortness of breath, complications and stomach ache. In case you develop these signs after getting a J&J shot, see a health care provider instantly.

Some other signs that usually aren’t related to vaccines ought to be monitored. In the event that they don’t enhance, name your physician or go to the emergency room.

Does a scarcity of uncomfortable side effects imply the vaccine isn’t working?

No. Some “fortunate folks” expertise few or no uncomfortable side effects. However that doesn’t imply their immune system isn’t correctly responding.

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Hotez mentioned there isn’t a correlation between the severity of uncomfortable side effects and the energy of the immune response. In different phrases, having no uncomfortable side effects doesn’t imply the vaccine is just not working, and having extra uncomfortable side effects doesn’t imply it’s working higher.

Antibody assessments can present how nicely your immune system has responded to a vaccine, however Pleasure mentioned people who find themselves immunocompromised are the one ones who want to fret about that. For most individuals, there’s little likelihood the vaccine will fail to stimulate an immune response. Speak to your physician for those who’re not sure.

Different issues to learn about vaccines

  • It’s unimaginable so that you can get coronavirus from the vaccines.
  • Likewise, for those who’re feeling sick after getting a vaccine, you don’t want to fret about being contagious and spreading COVID-19 to anybody else.
  • Booster photographs are needed, Hotez mentioned. Vaccinations are virtually at all times given in a collection, and the COVID-19 vaccine is popping out to be no completely different. For the very best immune response, it’s important to proceed coaching your system, he mentioned.
  • You may have the choice of getting a distinct sort of vaccine on your booster shot than you probably did on your preliminary immunization. Whether or not you stick to the identical model or go together with a mix-and-match method gained’t make a lot distinction by way of uncomfortable side effects, Pleasure mentioned.
  • Breakthrough infections in absolutely vaccinated folks can happen, nevertheless it’s uncommon for them to lead to extreme sickness, hospitalization or demise. You’ll be able to verify if in case you have an lively an infection through the use of an over-the-counter fast check.

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FDA sets limits for lead in many baby foods as California disclosure law takes effect

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FDA sets limits for lead in many baby foods as California disclosure law takes effect

The U.S. Food and Drug Administration this week set maximum levels for lead in baby foods such as jarred fruits and vegetables, yogurts and dry cereal, part of an effort to cut young kids’ exposure to the toxic metal that causes developmental and neurological problems.

The agency issued final guidance that it estimated could reduce lead exposure from processed baby foods by about 20% to 30%. The limits are voluntary, not mandatory, for food manufacturers, but they allow the FDA to take enforcement action if foods exceed the levels.

It’s part of the FDA’s ongoing effort to “reduce dietary exposure to contaminants, including lead, in foods to as low as possible over time, while maintaining access to nutritious foods,” the agency said in a statement.

Consumer advocates, who have long sought limits on lead in children’s foods, welcomed the guidance first proposed two years ago, but said it didn’t go far enough.

“FDA’s actions today are a step forward and will help protect children,” said Thomas Galligan, a scientist with the Center for Science in the Public Interest. “However, the agency took too long to act and ignored important public input that could have strengthened these standards.”

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The new limits on lead for children younger than 2 don’t cover grain-based snacks such as puffs and teething biscuits, which some research has shown contain higher levels of lead. And they don’t limit other metals such as cadmium that have been detected in baby foods.

The FDA’s announcement comes just one week after a new California law took effect that requires baby food makers selling products in California to provide a QR code on their packaging to take consumers to monthly test results for the presence in their product of four heavy metals: lead, mercury, arsenic and cadmium.

The change, required under a law passed by the California Legislature in 2023, will affect consumers nationwide. Because companies are unlikely to create separate packaging for the California market, QR codes are likely to appear on products sold across the country, and consumers everywhere will be able to view the heavy metal concentrations.

Although companies are required to start printing new packaging and publishing test results of products manufactured beginning in January, it may take time for the products to hit grocery shelves.

The law was inspired by a 2021 congressional investigation that found dangerously high levels of heavy metals in packaged foods marketed for babies and toddlers. Baby foods and their ingredients had up to 91 times the arsenic level, up to 177 times the lead level, up to 69 times the cadmium level, and up to five times the mercury level that the U.S. allows to be present in bottled or drinking water, the investigation found.

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There’s no safe level of lead exposure for children, according to the U.S. Centers for Disease Control and Prevention. The metal causes “well-documented health effects,” including brain and nervous system damage and slowed growth and development. However, lead occurs naturally in some foods and comes from pollutants in air, water and soil, which can make it impossible to eliminate entirely.

The FDA guidance sets a lead limit of 10 parts per billion for fruits, most vegetables, grain and meat mixtures, yogurts, custards and puddings and single-ingredient meats. It sets a limit of 20 parts per billion for single-ingredient root vegetables and for dry infant cereals. The guidance covers packaged processed foods sold in jars, pouches, tubs or boxes.

Jaclyn Bowen, executive director of the Clean Label Project, an organization that certifies baby foods as having low levels of toxic substances, said consumers can use the new FDA guidance in tandem with the new California law: The FDA, she said, has provided parents a “hard and fast number” to consider a benchmark when looking at the new monthly test results.

But Brian Ronholm, director of food policy for Consumer Reports, called the FDA limits “virtually meaningless because they’re based more on industry feasibility and not on what would best protect public health.” A product with a lead level of 10 parts per billion is “still too high for baby food. What we’ve heard from a lot of these manufacturers is they are testing well below that number.”

The new FDA guidance comes more than a year after lead-tainted pouches of apple cinnamon puree sickened more than 560 children in the U.S. between October 2023 and April 2024, according to the CDC.

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The levels of lead detected in those products were more than 2,000 times higher than the FDA’s maximum. Officials stressed that the agency doesn’t need guidance to take action on foods that violate the law.

Aleccia writes for the Associated Press. Gold reports for The Times’ early childhood education initiative, focusing on the learning and development of California children from birth to age 5. For more information about the initiative and its philanthropic funders, go to latimes.com/earlyed.

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NASA punts Mars Sample Return decision to the next administration

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NASA punts Mars Sample Return decision to the next administration

Anyone hoping for a clear path forward this year for NASA’s imperiled Mars Sample Return mission will have to wait a little longer.

The agency has settled on two potential strategies for the first effort to bring rock and soil from another planet back to Earth for study, NASA Administrator Bill Nelson said Tuesday: It can either leverage existing technology into a simpler, cheaper craft or turn to a commercial partner for a new design.

But the final decision on the mission’s structure — or whether it should proceed at all — “is going to be a function of the new administration,” Nelson said. President-elect Donald Trump will take office Jan. 20.

“I don’t think we want the only [Mars] sample return coming back on a Chinese spacecraft,” Nelson said, referencing a rival mission that Beijing has in the works. “I think that the [Trump] administration will certainly conclude that they want to proceed. So what we wanted to do was to give them the best possible options so that they can go from there.”

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The call also contained words of encouragement for NASA’s Jet Propulsion Laboratory in La Cañada Flintridge, which leads the embattled mission’s engineering efforts.

“To put it really bluntly, JPL is our Mars center in NASA science,” said Nicky Fox, associate administrator of the Science Mission Directorate. “They are the people who landed us on Mars, together with our industry partners. So they will be moving forward, regardless of which path, with a key role in the Mars Sample Return.”

In April, after an independent review found “near zero probability” of Mars Sample Return making its proposed 2028 launch date, NASA put out a request for alternative proposals to all of its centers and the private sector. JPL was forced to compete for what had been its own project.

The independent review board determined that the original design would probably cost up to $11 billion and not return samples to Earth until at least 2040.

“That was just simply unacceptable,” said Nelson, who paused the mission in late 2023 to review its chances of success.

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Ensuing cuts to the mission’s budget forced a series of layoffs at JPL, which let go of 855 employees and 100 on-site contractors in 2024.

The NASA-led option that Nelson suggested Tuesday includes several elements from the JPL proposal, according to a person who reviewed the documents. This leaner, simpler alternative will cost between $6.6 billion and $7.7 billion, and will return the samples by 2039, he said. A commercial alternative would probably cost $5.8 billion to $7.1 billion.

Nelson, a former Democratic U.S. senator from Florida, will step down as head of the space agency when Trump takes office. Trump has nominated as his successor Jared Isaacman, a tech billionaire who performed the first private space walk, who must be confirmed by the Senate.

NASA has not had any conversations with Trump’s transition team about Mars Sample Return, Nelson said. How the new administration will prioritize the project is not yet clear.

“It’s very uncertain how the new administration will go forward,” said Casey Dreier, chief of space policy for the Planetary Society, a Pasadena nonprofit that promotes space research. “Cancellation is obviously still on the table. … It’s hard to game this out.”

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Planetary scientists have identified Mars Sample Return as their field’s highest priority in the last three decadal surveys, reports that the National Academies of Sciences, Engineering, and Medicine prepare every 10 years in order to advise NASA.

Successfully completing the mission is “key for the nation’s leadership in space science,” said Bethany L. Ehlmann, a planetary scientist at Caltech in Pasadena. “I hope the incoming administrator moves forward decisively to select a plan and execute. There are extraordinary engineers at JPL and NASA industry partners eager and able to get to work to make it happen.”

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Panama Canal’s Expansion Opened Routes for Fish to Relocate

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Panama Canal’s Expansion Opened Routes for Fish to Relocate

Night fell as the two scientists got to work, unfurling long nets off the end of their boat. The jungle struck up its evening symphony: the sweet chittering of insects, the distant bellowing of monkeys, the occasional screech of a kite. Crocodiles lounged in the shallows, their eyes glinting when headlamps were shined their way.

Across the water, cargo ships made dark shapes as they slid between the seas.

The Panama Canal has for more than a century connected far-flung peoples and economies, making it an essential artery for global trade — and, in recent weeks, a target of President-elect Donald J. Trump’s expansionist designs.

But of late the canal has been linking something else, too: the immense ecosystems of the Atlantic and the Pacific.

The two oceans have been separated for some three million years, ever since the isthmus of Panama rose out of the water and split them. The canal cut a path through the continent, yet for decades only a handful of marine fish species managed to migrate through the waterway and the freshwater reservoir, Lake Gatún, that feeds its locks.

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Then, in 2016, Panama expanded the canal to allow supersize ships, and all that started to change.

In less than a decade, fish from both oceans — snooks, jacks, snappers and more — have almost entirely displaced the freshwater species that were in the canal system before, scientists with the Smithsonian Tropical Research Institute in Panama have found. Fishermen around Lake Gatún who rely on those species, chiefly peacock bass and tilapia, say their catches are growing scarce.

Researchers now worry that more fish could start making their way through from one ocean to the other. And no potential invader causes more concern than the venomous, candy-striped lionfish. They are known to inhabit Panama’s Caribbean coast, but not the eastern Pacific. If they made it there through the canal, they could ravage the defenseless local fish, just as they’ve done in the Gulf of Mexico and the Caribbean.

Already, marine species are more than occasional visitors in Lake Gatún, said Phillip Sanchez, a fisheries ecologist with the Smithsonian. They’re “becoming the dominant community,” he said. They’re “pushing everything else out.”

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