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Why do we get side effects from vaccines? Experts say that means it’s working

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The cooling sensation of an alcohol swab in your higher bicep is a cue for what’s about to come back subsequent: the injection of a needle that delivers a dose of vaccine.

Greater than 69% of Individuals have acquired at the very least one dose of a COVID-19 vaccine, and as a bandage is utilized to your arm, you’re a part of the membership.

Whether or not you’re getting your first shot, a second dose or a booster, you’re more likely to expertise some uncomfortable side effects.

They might be inconvenient, and so they definitely might be uncomfortable. However immunologists and virologists say they’re to be anticipated. And also you may even welcome them.

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Right here’s why, and what it is best to count on if in case you have a date with a needle.

Why do vaccines trigger uncomfortable side effects?

To place it merely, the uncomfortable side effects are a organic signal that the vaccine is working.

All three of the COVID-19 vaccines out there within the U.S. successfully work in the identical manner, mentioned Dr. David Pleasure, an infectious illness specialist at UC San Diego.

The vaccines include genetic directions for making copies of the coronavirus’ spike protein. The Pfizer-BioNTech and Moderna vaccines use mRNA to hold the directions, and the Johnson & Johnson shot employs a disabled adenovirus, which is innocent.

As soon as the directions are delivered, it’s as much as your cells to do the work. The pretend spike proteins can’t do any injury since they’re not linked to precise coronaviruses. However your physique will detect them and suppose an an infection is underway, prompting the immune system to swing into motion, Pleasure mentioned. You’ll be able to consider it as a coaching run.

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The immune response is available in two elements. First, the innate immune system is alerted to the arrival of attainable viruses or different pathogens in your physique, mentioned Dr. Peter Hotez, co-director of the Texas Kids’s Hospital Middle for Vaccine Growth. Then the adaptive immune system produces antibodies that may reply appropriately to the intruder — and, if needed sooner or later, to an precise encounter with the virus.

The uncomfortable side effects you’re feeling are a pure a part of your immune system’s response to the vaccine’s viral payload.

What’s regular and what’s not?

Negative effects to a COVID-19 vaccine are generally delicate and generally extra intense, like a foul chilly or a case of the flu. Both manner, they shouldn’t final greater than 72 hours.

The commonest uncomfortable side effects are low-grade fever, fatigue, muscle ache, headache, chills and nausea, based on the Facilities for Illness Management and Prevention. Short-term soreness on the injection website can be frequent. As Dr. George Rutherford, professor of epidemiology and biostatistics at UC San Francisco, places it: You simply acquired caught with a needle; vaccine or not, that’s going to harm.

The clinic or pharmacy the place you get your shot will ask you to hold round for 15 or half-hour after after your injection, to allow them to monitor you for uncommon however critical reactions, resembling an acute allergic response that requires epinephrine.

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When you get residence, you’ll be able to take over-the-counter ache relievers resembling Tylenol or Advil. (Don’t take them earlier than your shot as a result of that may dampen the vaccine’s effectiveness.) Past permitting your physique to relaxation, there’s not a lot else you are able to do whereas using out regular uncomfortable side effects.

In uncommon circumstances, folks — largely teenage boys and younger males — expertise myocarditis (irritation of the center muscle) or pericarditis (irritation of the tissue that surrounds the center) within the week after getting a shot. Signs embrace chest ache, shortness of breath and emotions of getting a fast-beating or pounding coronary heart. If this occurs to you, search medical consideration instantly. Most often, the situations are simply handled with medication and relaxation.

A really small variety of folks — largely girls beneath age 50 — who get the Johnson & Johnson vaccine might expertise a critical facet impact known as thrombosis with thrombocytopenia syndrome, or TTS. Signs embrace chest ache, leg swelling, shortness of breath, complications and stomach ache. In case you develop these signs after getting a J&J shot, see a health care provider instantly.

Some other signs that usually aren’t related to vaccines ought to be monitored. In the event that they don’t enhance, name your physician or go to the emergency room.

Does a scarcity of uncomfortable side effects imply the vaccine isn’t working?

No. Some “fortunate folks” expertise few or no uncomfortable side effects. However that doesn’t imply their immune system isn’t correctly responding.

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Hotez mentioned there isn’t a correlation between the severity of uncomfortable side effects and the energy of the immune response. In different phrases, having no uncomfortable side effects doesn’t imply the vaccine is just not working, and having extra uncomfortable side effects doesn’t imply it’s working higher.

Antibody assessments can present how nicely your immune system has responded to a vaccine, however Pleasure mentioned people who find themselves immunocompromised are the one ones who want to fret about that. For most individuals, there’s little likelihood the vaccine will fail to stimulate an immune response. Speak to your physician for those who’re not sure.

Different issues to learn about vaccines

  • It’s unimaginable so that you can get coronavirus from the vaccines.
  • Likewise, for those who’re feeling sick after getting a vaccine, you don’t want to fret about being contagious and spreading COVID-19 to anybody else.
  • Booster photographs are needed, Hotez mentioned. Vaccinations are virtually at all times given in a collection, and the COVID-19 vaccine is popping out to be no completely different. For the very best immune response, it’s important to proceed coaching your system, he mentioned.
  • You may have the choice of getting a distinct sort of vaccine on your booster shot than you probably did on your preliminary immunization. Whether or not you stick to the identical model or go together with a mix-and-match method gained’t make a lot distinction by way of uncomfortable side effects, Pleasure mentioned.
  • Breakthrough infections in absolutely vaccinated folks can happen, nevertheless it’s uncommon for them to lead to extreme sickness, hospitalization or demise. You’ll be able to verify if in case you have an lively an infection through the use of an over-the-counter fast check.

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Opinion: Fentanyl could fuel another cycle of loss in L.A.'s Black communities. It doesn't have to

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Opinion: Fentanyl could fuel another cycle of loss in L.A.'s Black communities. It doesn't have to

The death of a parent is typically a gutting and disorienting experience for adults. For a child, it’s even worse, stoking feelings of frustration and abandonment and sometimes self-destructive behaviors such as drug use that can continue well into adulthood. This has particularly serious implications when the child is Black and therefore more likely to end up in the child welfare system.

A recent report by federal researchers provides the fullest picture yet of the sprawling impact of overdose deaths on Black children in Los Angeles and other cities — and what we can do about it.

From 2011 to 2021, the report found, more than 321,000 American children lost a parent to a drug overdose. Black children experienced the highest increases in the rate of such losses during those years, compounding a long-standing public health crisis across Black America. Like much of the United States, Los Angeles has seen drug overdoses soar in recent years, with disproportionate losses among the city’s Black adults.

Black people are significantly more likely to experience drug-related deaths due to limited access to treatment and resources such as naloxone, which can reverse overdoses. When they’re parents, the toll on their children is both rapid and deep. Parental drug use is highly associated with use among children.

Although Black children make up just 7.4% of the Los Angeles County population, they represented 24% of those who entered the child welfare system in one recent year. One study found that about 47% of Black children in California were the subject of a maltreatment investigation before the age of 18, with substance use accounting for 41% of the state’s child maltreatment cases.

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The disproportionate number of Black children in Los Angeles’ child welfare system has been scrutinized since the late 1980s, the height of Los Angeles’ heroin and crack epidemics. The drugs, then largely addressed as a criminal issue through heavy-handed policing and prosecution, consigned a generation of young and middle-aged Black Angelenos, both users and dealers, to premature death and incarceration. Many of their children wound up in the city’s fragmented child welfare system and, all too often, on a similar path toward addiction and entanglement with the legal system.

When a child’s parent dies, other family members — the child’s other parent, grandparents, aunts or uncles — are the first resort to assume responsibility for their care. But Black children, especially those from low-income communities, often end up in the child welfare system instead.

Why? The child’s surviving family members may lack the resources to fill the breach. But racial biases also predispose child welfare workers to remove Black children from their families and impede reunification efforts.

Research has consistently shown that child welfare workers more readily define Black parents’ behavior as abusive or neglectful even when it’s comparable to the conduct of parents of other races. Child welfare workers are also more likely to regard Black families as less loving of their children and less redeemable.

Children who enter the child welfare system due to parental death already spend twice as much time in the system. Black children tend to remain in the system even longer because of bias.

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The twin depredations of Los Angeles’ opioid epidemic and its child welfare system are daunting but not beyond repair. The first necessity is to revamp the city’s racially biased child removal process. Los Angeles officials have been piloting a “blind removal” approach in which investigations are followed by a decision-making process that excludes demographic details such as the child’s race. This is a step in the right direction.

However, a UCLA study of the pilot program revealed that racial disproportionality persists, demonstrating how deep-seated child welfare biases are. For blind removal to be effective in eliminating racial disparities, it must be supplemented by greater transparency, expanded civilian review boards and training in implicit bias.

Second, we need a better understanding of the consequences of placing Black children in the child welfare system. In general, Black children in the system are highly stigmatized, especially when they come from families with histories of drug abuse. That contributes to making them less likely to be adopted. The trauma of losing a parent also means they’re more likely to experience depression and anxiety.

These experiences frequently devolve into social isolation, poor academic outcomes, limited employment prospects and incarceration. Officials must work to identify these patterns early and provide resources such as mental health care to disrupt this harmful cascade.

Lastly, policymakers must continue to explore the benefits of guaranteed basic income to provide a cushion for personal and professional growth. Another California pilot program would provide guaranteed basic income to those who age out of foster care at 21 or older. The state should lower the eligibility age to 18 to account for the steep challenges in housing and employment Black youths face as soon as they become adults. Researchers at Stanford and other institutions have found that such policies support better health, housing security and employment prospects.

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Addressing the deepening overdose epidemic in Los Angeles’ Black communities requires attention not just to the immediate risks to drug users but also to the childhood experiences that often drive them to use. One of our most powerful tools for preventing future overdoses is to take better care of the children most directly affected by today’s losses.

Jerel Ezell is an assistant professor of community health sciences at UC Berkeley who studies the racial politics of substance use.

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NASA JPL team hopes to give greenhouse gas-monitoring satellite 'unprecedented' vision

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NASA JPL team hopes to give greenhouse gas-monitoring satellite 'unprecedented' vision

It was almost 10 years ago when Andrew Thorpe received a text from the crew flying overhead in a small aircraft: They had spotted a new methane hot spot.

Thorpe drove along winding dirt and mountain roads in an unwieldy rental SUV near the Four Corners region of the southwestern U.S. When he arrived at the spot relayed from the plane, he pulled out a thermal camera to scan for the plume. Sure enough, methane was seeping out of the ground, likely from a pipeline leak.

He found a marker sticking out of the desert with the phone number for a gas company, so he gave them a call. “I had the most confused individual on the other side of the phone,” Thorpe said. “I was trying to explain to them why I was calling, but this was back many years ago when there really weren’t any technologies that could do this.”

Over the years, the work has gotten Thorpe some unwanted attention. “I did some driving surveys in California .… A rent-a-cop was very suspicious of me and tried to scare me off,” said Thorpe. “If you set up a thermal camera on a public road and you’re pointing it at a tank beyond the fence, people are going to get nervous. I’ve been heckled by some oil and gas workers, but that’s par for the course.”

Today, Thorpe is part of a group that is at the forefront of greenhouse gas monitoring at NASA’s Jet Propulsion Laboratory in La Cañada Flintridge. For over 40 years, the Microdevices Laboratory at JPL has developed specialized instruments to measure methane and carbon dioxide with extreme precision.

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The instruments, called spectrometers, detect gases based on which colors of sunlight they absorb. Earlier this year, a team of researchers from JPL, Caltech and research nonprofit Carnegie Science was selected as a finalist for a NASA award to put the technology into orbit.

JPL technicians work on an Airborne Visible/Infrared Imaging Spectrometer, or AVIRIS, that will be installed in an airplane to search for methane and other greenhouse gases.

(Myung J. Chun/Los Angeles Times)

If chosen for the satellite mission, the team’s carbon investigation, called Carbon-I, would launch in the early 2030s. Over the course of three years, Carbon-I would continuously map greenhouse gas emissions around the globe and take daily snapshots of areas of interest, allowing scientists to identify sources of climate pollution, such as power plants, pipeline leaks, farms and landfills.

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While there are already multiple satellites monitoring these gases, Carbon-I’s resolution is unprecedented and would eliminate any guesswork in determining where the gas was emitted. “There’s no denying it anymore — once we see a plume, there’s no other potential source,” said Christian Frankenberg, co-principal investigator for Carbon-I and a professor of environmental science and engineering at Caltech.

Caltech professor Christian Frankenberg peers into the AVIRIS-5.

Caltech professor Christian Frankenberg, co-principal investigator for the proposed space-based Carbon-I emission-monitoring system, peers into an AVIRIS monitor under construction in a JPL lab.

(Myung J. Chun/Los Angeles Times)

Carbon-I’s finest, 100-foot resolution “is a very high resolution from space. That’s an incredible resolution to be able to get,” said Debra Wunch, a professor at the University of Toronto who studies Earth’s carbon cycle and is not involved in the Carbon-I proposal. “It would be able to give us much more insight into exactly the source of emissions .… This would be groundbreaking. You would be able to see individual stacks, individual parts of landfills, even.”

Historically, monitoring the release of greenhouse gases from individual emitters has been challenging — both carbon dioxide and methane are colorless and odorless. So scientists have often had to rely on adding up self-reported values from companies and estimates from research. For example, to estimate the amount of methane cows produce, scientists would have to determine how much methane one cow releases and multiply it by the total number of cows on Earth.

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“If you look at international policies … currently they’re all based on these bottom-up inventories,” said Anna Michalak, co-principal investigator for Carbon-I and the founding director of the Carnegie Climate and Resilience Hub at Carnegie Science. “We need to get to a point where … we actually have an independent way of tracking what the emissions are.”

Carbon-I’s resolution will also give scientists new access to the atmosphere of the tropics, where clouds currently obscure most forms of satellite surveillance. “It’s their Achilles’ heel,” said Frankenberg.

Since tropical and subtropical forests absorb roughly a quarter of the CO2 humanity produces by burning fossil fuels, accurate data from this region of the globe is badly needed.

Satellites currently orbiting Earth with lower resolution can’t see through small gaps in the cloud coverage. They only see a blurred average of the cloudy and clear spots in the sky for each pixel. Carbon-I, with each pixel’s area almost 50 times smaller than that of most other satellites, can see the clearings and take measurements through them. In an April 2024 paper, Frankenberg, Michalak and their collaborators estimated that Carbon-I would be able to see past the clouds in the tropics anywhere from 10 to 100 times more frequently than its predecessors.

Carbon-I “is going to see things where people don’t know what’s going on,” said Thorpe, who has moved on from his graduate school days pointing thermal cameras at gas leaks and now works as a research technologist with the Microdevices Laboratory. “It’s going to open a whole new realm of science.”

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JPL’s airborne greenhouse gas-monitoring program goes back decades, but the field of space monitoring is still fairly new. Near the start of 2016, NASA headquarters contacted the JPL team. There was an ongoing massive blowout at the Aliso Canyon gas storage facility near Porter Ranch, and NASA wanted the team to check it out.

The team flew over the site in a variant of a 1960s-era spy plane on three days over the course of a month while the Southern California Gas Co. fought to contain the blowout. At the same time, NASA’s Goddard Flight Center in Maryland pointed the NASA Earth Observing spacecraft’s Hyperion spectrometer at the leak.

Hyperion was designed to make observations of the Earth’s surface and filter out noise from the atmosphere. Now, they were trying to observe the atmosphere and filter out the surface, and for the first time, scientists observed a human-made point source of methane from orbit.

“The Hyperion result was pretty noisy, but you could still see the plume,” said Thorpe. “This was really a proof of concept that we could do it from space.”

Even if Carbon-I launches, it doesn’t mean the team will stop putting instruments on planes. From aircraft, the team is able to monitor areas of interest in even sharper resolution and for consecutive days at a time. Right now, a leaner, meaner version of the spectrometers that observed the Four Corners leak and Aliso Canyon blowout is flying a series of missions to monitor the emissions of offshore oil rigs in the Gulf of Mexico.

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A twin-propeller King Air airplane in a hangar.

The twin-engine King Air plane used by JPL to conduct greenhouse gas-monitoring flights in its hangar at Hollywood Burbank Airport.

(Noah Haggerty/Los Angeles Times)

Plane missions also give the team an opportunity to try out new and improve spectrometers. “You can fix them, and you can upgrade them,” said JPL engineer Michael Eastwood, who’s worked with the spectrometers for over three decades and regularly flies with them. “You can take more risks, as opposed to spacecraft that need really mature, really well-known, high reliability — we’re not constrained like that.”

The air team is nimble, too. Typically, two crew members sit in the second row of a King Air twin-propeller aircraft looking at a stack of laptops and instruments with enough buttons to rival the plane’s cockpit. On the screens, they can look at real-time GPS data and spectrometer results and coordinate a flight plan with the pilots. The spectrometer — called AVIRIS, short for Airborne Visible/Infrared Imaging Spectrometer — sits in the third row, looking down through a window cut out in the floor.

The NASA program for which Carbon-I was selected as a finalist aims to fund space-based Earth science that will benefit society. The team was awarded $5 million to sharpen its project proposal before a final NASA review in 2025. There are three other finalists, and two will be selected for the launch.

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This two-step process for selecting missions is new for NASA’s Earth science programs and requires JPL to compete with the rest of the scientific community, independent of their association with the space agency.

“If we’re talking about grocery money, [$5 million] seems like a lot of money, but it’s really a bargain,” said Michalak. “If you think about the fact that you’re committing $300 million toward a mission, spending 1.5% of that to really make sure it’s going to be fabulous and successful is extremely smart.”

In the meantime, the Carbon-I team is focused on showing NASA that it has the technical know-how to execute the project on time and under budget.

“I think all four of the missions in the current phase are absolutely worthwhile scientific missions,” said Michalak, “and 50% odds are not bad odds for a satellite mission.”

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Signs of avian flu found in San Francisco wastewater

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Signs of avian flu found in San Francisco wastewater

Signs of H5N1 bird flu virus have been detected at three wastewater sites in California’s Bay Area, according to sampling data.

While positive wastewater samples have been found in seven other states, California is the only one that has yet to report a bird flu outbreak in a herd of dairy cows.

Genetic evidence of bird flu was detected in San Francisco wastewater on June 18 and June 26. Additional H5 “hits” were seen at a site in Palo Alto on June 19, and another on June 10 from the West County Wastewater facility in Richmond.

According to the San Francisco Department of Public Health, officials have been closely monitoring H5N1 along with federal, state and local partners, and are “aware of the recent detections of fragments of H5N1 in San Francisco’s wastewater.”

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“As with the previous detections reported from before mid-May 2024, it is unclear what the source of H5N1 is, and an investigation is ongoing,” wrote department officials in a statement. “It is possible that it originated from bird waste or waste from other animals due to San Francisco’s sewer system that collects and treats both wastewater and stormwater in the same network of pipes.”

Health officials said the risk remains low for the general public.

The virus has not been identified in California cows, but it has been found in wild birds and domestic poultry in the state.

The finding “is concerning” because of their urban origin, said Devabhaktuni Srikrishna, an entrepreneur who is developing techniques for disease detection, and the chief executive and founder of PatientKnowHow.com. “There are not many dairy or animal farms in San Francisco.”

There are also no dairy farms in Palo Alto or Richmond.

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The plant manager from Palo Alto was out of the office Friday, so could not comment. A spokesperson for the Richmond site directed questions to the state.

A request for comment from the state’s Wastewater Surveillance Program had not yet been returned.

Although the samples from the Bay Area wastewater sites tested positive for H5, the testing was not specific to H5N1.

However, researchers say a positive genetic identification for H5 is suggestive of bird flu — whether H5N1, the virus that has been found in U.S. dairy cattle (and which has infected three dairy workers ) or H5N2, the subtype implicated in the death of a man from Mexico City this month.

Most human influenza A viruses are of the H1 and H3 variety.

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The virus has been detected in 133 dairy herds across 12 states. It has also been found in wild birds and domestic poultry flocks throughout the United States.

In recent weeks, H5 was also detected in wastewater samples in Idaho. among other states.

While there is “no threat to the general public from the H5 detection in wastewater” at this time, said Christine Hahn, Idaho state epidemiologist, “we have determined that it is important that we work to understand these recent findings as much as possible.”

The state is working in conjunction with the Centers for Disease Control and Prevention to investigate the issue.

WastewaterSCAN, the research organization that detected the virus, is an infectious disease monitoring network run by researchers at Stanford, Emory University and Verily, Alphabet Inc.’s life sciences organization.

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A review of their data — which samples from 194 locations across the country — suggests H5 has also been detected at sites in Michigan, Texas, Minnesota, South Dakota and Iowa.

California is the only one of these states that has not reported H5N1-infected cattle.

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