Science
Should the definition of ‘fully vaccinated’ be changed to include a booster shot?
For a lot of People who scrambled to get vaccinated towards COVID-19 as quickly as their flip got here up, the reduction of gaining immunity was only one reward. Reaching “totally vaccinated” standing conferred a faint halo of advantage as nicely.
Now, each the pictures’ organic safety and the satisfaction of contributing to the herd’s immunity are proving short-lived. And with a worrisome new coronavirus variant threatening to erode vaccine-induced immunity additional, well being officers are debating whether or not the definition of “totally vaccinated” needs to be amended to incorporate a booster shot.
Scientists are leaning closely in favor, and public well being leaders are usually not far behind.
Thus far, the Facilities for Illness Management and Prevention hasn’t formally shifted the goalposts. People topic to job-related vaccine mandates or required to point out proof of “full vaccination” to enter gyms, eating places or public occasions can fulfill the requirement with no booster.
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However the CDC has tiptoed as much as these goalposts, telling all however the youngest vaccinated People that sturdy immunity would require an additional dose, and urging everybody 16 and older to get one as quickly as they’re eligible.
Dr. Anthony Fauci, President Biden’s senior advisor on the pandemic, additionally walked proper as much as the road — however didn’t cross it.
“Optimum safety goes to be with a 3rd shot,” Fauci informed CNN this week. He added that whereas he didn’t see the official definition of “totally vaccinated” altering this week or subsequent, it was sure to occur in some unspecified time in the future: “It’s going to be a matter of when, not if.”
The variety of totally vaccinated People, underneath the present definition, handed the 200 million mark this week, and 1 / 4 of them have gotten a booster. That leaves tens of millions of People with one other to-do merchandise on their checklist, asking whether or not they’ll be higher off in the event that they get one, and questioning whether or not will probably be the final.
Their confusion is comprehensible. The vaccines’ early promise of spectacular effectiveness has given strategy to some gloomy headlines about waning immunity. However the CDC has continued to claim that for many wholesome People, “full vaccination” — two jabs of the Pfizer-BioNTech or Moderna vaccine or a single Johnson & Johnson shot — supplies highly effective safety towards hospitalization or demise in these with “breakthrough” infections.
Till not too long ago, impartial vaccine specialists appeared ambivalent too. In September and October, advisors to the CDC and the Meals and Drug Administration who reviewed the most recent proof had been distinctly underwhelmed by the case made for recommending boosters for wholesome adults underneath 65.
They endorsed the additional pictures wholeheartedly for older People and folks with compromised immune programs. However many had been unwilling to conclude that youthful adults would profit from a booster, particularly contemplating the danger of heart-related unwanted effects that principally have an effect on youthful males and blood clotting dangers for girls underneath 50.
Their vote to restrict entry was promptly overruled by the CDC, which beneficial boosters for nearly all adults as soon as six months had handed since their second dose of one of many two mRNA vaccines or two months had handed since their J&J shot.
Now, mentioned Dr. William Schaffner, an infectious illness specialist at Vanderbilt College Medical College, specialists who had doubts are abandoning their qualms.
For starters, he mentioned, sending totally different messages to totally different age and occupation teams had proved too complicated. Plus, new analysis has made it more and more clear that the primary two doses of an mRNA vaccine and the only shot of the J&J vaccine, behave like a single “prime” dose that requires a follow-up “increase” to succeed in its full impact.
As with most vaccines, a COVID-19 booster shall be required to shore up immunity and make it final. And there’s precedent for a three-dose sequence, he famous. Broadly administered vaccines for hepatitis B, polio and different illnesses require three or extra pictures.
Dr. Peter Hotez, dean of Baylor School of Medication’s Nationwide College of Tropical Medication, agreed: “From the start, I’ve mentioned it is a three-dose vaccine.”
Given the sense of urgency that prevailed when vaccines first grew to become accessible, it made sense to area the primary and second doses of mRNA vaccine shut collectively, Hotez mentioned. “However primarily based on earlier expertise with vaccines, we all know that’s going to end in waning immunity. And also you’ll want a 3rd dose a while later.”
By summer season, the rising incidence of breakthrough infections supplied rising assist for that surmise. Many of the preliminary circumstances had been in older and immunocompromised individuals, who regularly don’t mount a powerful immune response to vaccines. Many specialists hoped the necessity for boosters would finish there.
However proof of waning immunity from all vaccines, and throughout the age spectrum, is rising. Even totally vaccinated youthful adults with breakthrough infections can turn out to be severely sick and die.
This week introduced the primary real-world proof of boosters’ advantages in younger, wholesome individuals. Israeli researchers discovered {that a} third dose of the Pfizer vaccine prevented infections extra dramatically in 16- to 29-year-olds than in every other age group measured. Given the important thing function of younger adults in sustaining pandemic unfold, some scientists recommended a coverage of common boosters may do greater than scale back hospitalizations and deaths. It may additionally suppress new waves of infections.
That and one other new research from Israel additionally shored up proof of boosters’ highly effective profit for middle-age adults. Israelis 50 and over who acquired a 3rd shot had been 10 instances much less prone to die of COVID-19 than their vaccinated-but-unboosted friends. Israelis 60 and over decreased their threat of extreme sickness by an element of greater than 12 in contrast with their counterparts who didn’t get a 3rd shot, they usually had been nearly 15 instances much less prone to die of COVID-19.
Los Angeles County has supplied additional proof of boosters’ affect. For the seven-day interval that ended Nov. 29, there have been 43 new infections for each 100,000 residents who had been totally vaccinated however not boosted. However amongst those that did get a booster, the speed of recent infections was simply 7 per 100,000.
For now, Hotez mentioned, speaking clearly to these 16 and up that they need to get booster pictures for their very own safety is extra essential than altering the definition of “totally vaccinated” — one thing that will have an effect on on a regular basis life in cities like Los Angeles and San Francisco that require proof of vaccination to enter indoor companies like eating places and gymnasiums.
As well being officers grapple with the pandemic’s subsequent transfer, he mentioned, they could resolve that lowering COVID-19 deaths and protecting individuals out of the hospital are essentially the most pressing priorities. That will dictate a better deal with rising charges of preliminary vaccinations over boosters.
But when case charges start to recede, emphasizing boosters may be a strategy to gradual transmission and finish the pandemic sooner — and altering the definition of totally vaccinated might nicely assist such a purpose, Hotez mentioned.
Some specialists stay skeptical that taking that step would make sense. They ask whether or not it’s moral and productive to supply further doses to these least prone to turn out to be very sick when most of the world’s poorest nations have barely begun vaccinating their populations.
The brand new findings from Israel clearly present that booster pictures are invaluable to individuals 50 and older, mentioned Dr. Emily P. Hyle, an infectious illness specialist at Massachusetts Common Hospital. However “it will get a bit of trickier” to conclude that they’re helpful for youthful individuals, she added.
“I’m in search of extra granular knowledge on what sort of signs they’re stopping. Is it a day of sniffles or per week or two of serious sickness?” Hyle mentioned. “That’ll be actually useful to know.”
The reply may inform a fuller debate on whether or not getting extra People — or the remainder of the world — their preliminary doses of vaccine is a more practical use of scarce sources, she mentioned. That, in flip, must also spark “some robust conversations” concerning the objectives U.S. well being officers ought to shoot for: to stamp out transmissions altogether, decrease extreme sickness and deaths, or return to pre-pandemic life with out public well being strictures.
Hotez mentioned it’s potential a fourth shot — or extra — shall be wanted. That may depend upon a bunch of unknowns past the human immune system’s response to boosters, together with the emergence of variants that erode vaccine safety, and the priorities of well being leaders.
“We don’t know until we all know,” he mentioned.
Science
FDA sets limits for lead in many baby foods as California disclosure law takes effect
The U.S. Food and Drug Administration this week set maximum levels for lead in baby foods such as jarred fruits and vegetables, yogurts and dry cereal, part of an effort to cut young kids’ exposure to the toxic metal that causes developmental and neurological problems.
The agency issued final guidance that it estimated could reduce lead exposure from processed baby foods by about 20% to 30%. The limits are voluntary, not mandatory, for food manufacturers, but they allow the FDA to take enforcement action if foods exceed the levels.
It’s part of the FDA’s ongoing effort to “reduce dietary exposure to contaminants, including lead, in foods to as low as possible over time, while maintaining access to nutritious foods,” the agency said in a statement.
Consumer advocates, who have long sought limits on lead in children’s foods, welcomed the guidance first proposed two years ago, but said it didn’t go far enough.
“FDA’s actions today are a step forward and will help protect children,” said Thomas Galligan, a scientist with the Center for Science in the Public Interest. “However, the agency took too long to act and ignored important public input that could have strengthened these standards.”
The new limits on lead for children younger than 2 don’t cover grain-based snacks such as puffs and teething biscuits, which some research has shown contain higher levels of lead. And they don’t limit other metals such as cadmium that have been detected in baby foods.
The FDA’s announcement comes just one week after a new California law took effect that requires baby food makers selling products in California to provide a QR code on their packaging to take consumers to monthly test results for the presence in their product of four heavy metals: lead, mercury, arsenic and cadmium.
The change, required under a law passed by the California Legislature in 2023, will affect consumers nationwide. Because companies are unlikely to create separate packaging for the California market, QR codes are likely to appear on products sold across the country, and consumers everywhere will be able to view the heavy metal concentrations.
Although companies are required to start printing new packaging and publishing test results of products manufactured beginning in January, it may take time for the products to hit grocery shelves.
The law was inspired by a 2021 congressional investigation that found dangerously high levels of heavy metals in packaged foods marketed for babies and toddlers. Baby foods and their ingredients had up to 91 times the arsenic level, up to 177 times the lead level, up to 69 times the cadmium level, and up to five times the mercury level that the U.S. allows to be present in bottled or drinking water, the investigation found.
There’s no safe level of lead exposure for children, according to the U.S. Centers for Disease Control and Prevention. The metal causes “well-documented health effects,” including brain and nervous system damage and slowed growth and development. However, lead occurs naturally in some foods and comes from pollutants in air, water and soil, which can make it impossible to eliminate entirely.
The FDA guidance sets a lead limit of 10 parts per billion for fruits, most vegetables, grain and meat mixtures, yogurts, custards and puddings and single-ingredient meats. It sets a limit of 20 parts per billion for single-ingredient root vegetables and for dry infant cereals. The guidance covers packaged processed foods sold in jars, pouches, tubs or boxes.
Jaclyn Bowen, executive director of the Clean Label Project, an organization that certifies baby foods as having low levels of toxic substances, said consumers can use the new FDA guidance in tandem with the new California law: The FDA, she said, has provided parents a “hard and fast number” to consider a benchmark when looking at the new monthly test results.
But Brian Ronholm, director of food policy for Consumer Reports, called the FDA limits “virtually meaningless because they’re based more on industry feasibility and not on what would best protect public health.” A product with a lead level of 10 parts per billion is “still too high for baby food. What we’ve heard from a lot of these manufacturers is they are testing well below that number.”
The new FDA guidance comes more than a year after lead-tainted pouches of apple cinnamon puree sickened more than 560 children in the U.S. between October 2023 and April 2024, according to the CDC.
The levels of lead detected in those products were more than 2,000 times higher than the FDA’s maximum. Officials stressed that the agency doesn’t need guidance to take action on foods that violate the law.
Aleccia writes for the Associated Press. Gold reports for The Times’ early childhood education initiative, focusing on the learning and development of California children from birth to age 5. For more information about the initiative and its philanthropic funders, go to latimes.com/earlyed.
Science
NASA punts Mars Sample Return decision to the next administration
Anyone hoping for a clear path forward this year for NASA’s imperiled Mars Sample Return mission will have to wait a little longer.
The agency has settled on two potential strategies for the first effort to bring rock and soil from another planet back to Earth for study, NASA Administrator Bill Nelson said Tuesday: It can either leverage existing technology into a simpler, cheaper craft or turn to a commercial partner for a new design.
But the final decision on the mission’s structure — or whether it should proceed at all — “is going to be a function of the new administration,” Nelson said. President-elect Donald Trump will take office Jan. 20.
“I don’t think we want the only [Mars] sample return coming back on a Chinese spacecraft,” Nelson said, referencing a rival mission that Beijing has in the works. “I think that the [Trump] administration will certainly conclude that they want to proceed. So what we wanted to do was to give them the best possible options so that they can go from there.”
The call also contained words of encouragement for NASA’s Jet Propulsion Laboratory in La Cañada Flintridge, which leads the embattled mission’s engineering efforts.
“To put it really bluntly, JPL is our Mars center in NASA science,” said Nicky Fox, associate administrator of the Science Mission Directorate. “They are the people who landed us on Mars, together with our industry partners. So they will be moving forward, regardless of which path, with a key role in the Mars Sample Return.”
In April, after an independent review found “near zero probability” of Mars Sample Return making its proposed 2028 launch date, NASA put out a request for alternative proposals to all of its centers and the private sector. JPL was forced to compete for what had been its own project.
The independent review board determined that the original design would probably cost up to $11 billion and not return samples to Earth until at least 2040.
“That was just simply unacceptable,” said Nelson, who paused the mission in late 2023 to review its chances of success.
Ensuing cuts to the mission’s budget forced a series of layoffs at JPL, which let go of 855 employees and 100 on-site contractors in 2024.
The NASA-led option that Nelson suggested Tuesday includes several elements from the JPL proposal, according to a person who reviewed the documents. This leaner, simpler alternative will cost between $6.6 billion and $7.7 billion, and will return the samples by 2039, he said. A commercial alternative would probably cost $5.8 billion to $7.1 billion.
Nelson, a former Democratic U.S. senator from Florida, will step down as head of the space agency when Trump takes office. Trump has nominated as his successor Jared Isaacman, a tech billionaire who performed the first private space walk, who must be confirmed by the Senate.
NASA has not had any conversations with Trump’s transition team about Mars Sample Return, Nelson said. How the new administration will prioritize the project is not yet clear.
“It’s very uncertain how the new administration will go forward,” said Casey Dreier, chief of space policy for the Planetary Society, a Pasadena nonprofit that promotes space research. “Cancellation is obviously still on the table. … It’s hard to game this out.”
Planetary scientists have identified Mars Sample Return as their field’s highest priority in the last three decadal surveys, reports that the National Academies of Sciences, Engineering, and Medicine prepare every 10 years in order to advise NASA.
Successfully completing the mission is “key for the nation’s leadership in space science,” said Bethany L. Ehlmann, a planetary scientist at Caltech in Pasadena. “I hope the incoming administrator moves forward decisively to select a plan and execute. There are extraordinary engineers at JPL and NASA industry partners eager and able to get to work to make it happen.”
Science
Panama Canal’s Expansion Opened Routes for Fish to Relocate
Night fell as the two scientists got to work, unfurling long nets off the end of their boat. The jungle struck up its evening symphony: the sweet chittering of insects, the distant bellowing of monkeys, the occasional screech of a kite. Crocodiles lounged in the shallows, their eyes glinting when headlamps were shined their way.
Across the water, cargo ships made dark shapes as they slid between the seas.
The Panama Canal has for more than a century connected far-flung peoples and economies, making it an essential artery for global trade — and, in recent weeks, a target of President-elect Donald J. Trump’s expansionist designs.
But of late the canal has been linking something else, too: the immense ecosystems of the Atlantic and the Pacific.
The two oceans have been separated for some three million years, ever since the isthmus of Panama rose out of the water and split them. The canal cut a path through the continent, yet for decades only a handful of marine fish species managed to migrate through the waterway and the freshwater reservoir, Lake Gatún, that feeds its locks.
Then, in 2016, Panama expanded the canal to allow supersize ships, and all that started to change.
In less than a decade, fish from both oceans — snooks, jacks, snappers and more — have almost entirely displaced the freshwater species that were in the canal system before, scientists with the Smithsonian Tropical Research Institute in Panama have found. Fishermen around Lake Gatún who rely on those species, chiefly peacock bass and tilapia, say their catches are growing scarce.
Researchers now worry that more fish could start making their way through from one ocean to the other. And no potential invader causes more concern than the venomous, candy-striped lionfish. They are known to inhabit Panama’s Caribbean coast, but not the eastern Pacific. If they made it there through the canal, they could ravage the defenseless local fish, just as they’ve done in the Gulf of Mexico and the Caribbean.
Already, marine species are more than occasional visitors in Lake Gatún, said Phillip Sanchez, a fisheries ecologist with the Smithsonian. They’re “becoming the dominant community,” he said. They’re “pushing everything else out.”
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