Science
Outbreak of neurotoxin killing unprecedented number of sea lions along California coast
By the time the rescue squad got to her, a small crowd had formed around the agitated California sea lion. As the team crept toward her — carrying large wooden shields and a giant net — the animal’s head weaved, craned and rocked back and forth in frenzied rhythms.
Lucille — as she was later named by the Marine Mammal Center’s Morro Bay field office — had barely registered her captors’ approach as the team of five animal rescue volunteers pounced on her. A small struggle ensued as the creature’s body went rigid with seizures, but the team managed eventually to push her into an XXL portable dog crate.
“It’s really hard when they’re not acting like sea lions,” said Jake Roth, a 22-year-old volunteer who helped with the rescue.
It was the first of dozens of frantic rescue phone calls made by horrified beachgoers that day, as an acute domoic acid outbreak continued to wreak havoc along the San Luis Obispo and Santa Barbara coasts this summer.
“The levels we’re finding inside these animals is off the charts,” said Giancarlo Rulli, a spokesman for the Sausalito-based Marine Mammal Center. “It’s all hands on deck.”
Domoic acid is a neurotoxin released by Pseudo-nitzschia, a common phytoplankton species found in coastal waters. Sea lions — and other marine mammals — become poisoned when they eat large amounts of fish or invertebrates that have been chowing on the contaminated diatoms.
Symptoms include lethargy, vomiting, unusual behavior, seizures, loss of pregnancy and death.
Marine Mammal Center volunteer Cris Lewis guides a sick sea lion into a crate during a rescue at Cayucos State Beach.
(Justin Sullivan/Getty Images)
Domoic acid, which is an amino acid, is not always produced by the phytoplankton. It is only manufactured under certain conditions — ones which scientists are still trying to determine. But upwelling of seawater seems to be a common factor — and strong upwelling of cold, nutrient-rich water is currently hugging the Central California coastline.
The outbreak has been at crisis levels since late July.
“One of the things that has come out again and again in a lot of our studies… is that, yes, when you get upwelling — which is typified by colder water temperatures and lots of nutrients — you will stimulate a bloom of diatoms,” said Clarissa Anderson, director of Southern California Coastal Ocean Observing System and the Cooperative Institute for Marine, Earth, and Atmospheric Systems, which are operated out of UC San Diego’s Scripps Institution of Oceanography.
“But then the bigger question — the one we’ve not been able to totally wrap our heads around — is, when does it produce the toxin? What is the mixture of conditions that requires that? Because this organism is around all the time,” she said.
Domoic acid outbreaks are not new. They have been happening for decades, if not millennia. And although it wasn’t identified in California waters until 1991, it is believed to have been behind outbreaks before that — including the 1961 “invasion” of chaotic sea birds in Capitola that partly inspired Alfred Hitchcock’s 1963 film, “The Birds.”
What has changed, said Anderson, are the frequency, timing and location of the events.
“We know that upwelling season in California has always been a great time to expect a Pseudo-nitzschia bloom and potentially a domoic acid event, and that can start as early as March,” she said. As a result, scientists had associated springtime with domoic acid outbreaks.
“But now we’re starting to see something different: These past three summers there have been these intense, long, lasting blooms,” she said.
And while Monterey and Humboldt Bay had been considered the classical hot spots, it’s Southern California that has been clobbered since 2022.
She said climate change is likely playing a role in these changes — but not necessarily because of warm water temperatures.
Marine Mammal Center veterinarian Greg Frankfurter inspects a newly admitted California sea lion that was rescued from a beach showing signs of domoic acid poisoning in Sausalito.
(Justin Sullivan/Getty Images)
“One of the things we have seen in our years and years and years of data is that it’s the mixture of nutrients that come with upwelling that is potentially responsible for turning the toxin on or off,” she said. “And that mixture of nutrients may be impacted by global climate change, because climate change is changing ocean circulation physics at the basin scale — like the Pacific Ocean scale — and that can have ramification on what kinds of water — the flavor of water — that is upwelling onto the coast in California.”
Raphe Kudela, a professor of ocean science at UC Santa Cruz, said there might also be a connection to heat and runoff from inland rivers.
He said in the last few years, really wet winters have contributed to an increase in river runoff — and a resulting dump of nutrients into California’s coastal waters.
“So you get a pulse of upwelling, which brought some cool water with even more nutrients to the surface, and then everything warmed up. That’s just absolutely perfect conditions for a bloom like this,” he said.
It’s also a perfect recipe for creatures like sardines and anchovies, who feast on the diatoms, algae and phytoplankton in these cool, nutrient-rich waters. And those fish bring in predators, such as sea lions, dolphins, fur seals, birds and other fish that then proceed to feast on these “toxic bullets.”
Anderson said people will occasionally ask her if they, too, could get sick from eating anchovies.
“I’m like, are you planning on eating as many anchovy as a sea lion?” she said, noting that sea lions eat roughly 5% to 8% of their body weight per day. For a 150-pound person, that would be 7.5 to 12 pounds of anchovy.
And that’s part of the tragedy of this latest outbreak.
Barbie Halaska, a necropsy specialist with the Marine Mammal Center, showed visitors the milk-rich tissue enveloping the single six-inch incisions she had made in the chests of six of the dead sea lions that had died at the Morro Bay center.
All six were adult, lactating females, she said, with thick layers of fat.
“You can see how big she is. She’s gorgeous,” said Halaska, pointing at the dead but otherwise healthy-looking animal. “They’ve got a great food supply. It just happens to be tainted. When they’re lactating, and they find a good food stock, they just go and go and go. Unfortunately, that means the neurotoxin just bioaccumulates.”
She said female sea lions tend to give birth around June 15 — “we call it sea lion birthday” — which means these females most likely had a young, dependent pup with them before they were stranded. Sea lion pups are dependent on their mothers until they are about 9 months old.
Research shows that pups growing inside contaminated pregnant females suffer brain damage. Milk from contaminated females also carries the toxin, suggesting it could be transmitted to pups.
By early afternoon, Lucille and three other sea lions were being treated for domoic acid poisoning.
Lucille was passed out, snoring on the cement floor of the pen. Soon after she arrived, a center staff member had delivered a shot full of phenobarbital and midazolam into her back haunch, to control the seizures. Staff then hooked her up to an IV bag of fluid to help flush the toxin out of her body.
But one of the three newer arrivals, a large, adult female named Yippee, arrived with a broken and dislocated jaw. Staff concluded she’d die if she was returned to the wild. They made the hard decision to medically euthanize her.
She struggled to flee from the small team that came in to deliver the shot, but was finally backed into a corner and succumbed. Her breathing slowed and within a few minutes, she was still.
Rulli said such episodes are always painful, and the center works hard to support staff who respond to these events. Repeated encounters with suffering animals can take a toll.
Roughly 30% of the animals that have come to the center in this latest outbreak — which began at the end of July — have died, said Aliah Meza, operation manager of the Morro Bay field office.
Farther south, where staff from the Channel Islands Marine Wildlife Institute are responding to animals along the Santa Barbara and Ventura coasts, the number exceeds 50%, said Sam Dover, founder and chief veterinarian of Channel Islands Marine and Wildlife Institute.
To keep these facilities running and these teams operating, both institutions rely on donations and some level of state and federal funding.
State funding was nearly pulled last year when the governor’s office struck $2 million in funding from the state budget. For smaller operations, such as Dover’s, that would have been a 50% hit on its operating budget. The groups were able to convince lawmakers to replace the funding.
“I don’t envy the sharpened pencil and eraser work that they were doing,” said Jeffrey Boehm, the marine center’s chief external relations officer, who said he and others went to Sacramento to make the case that their work is in the public interest. “Having an entity that is prepared, skilled and professional to respond to wildlife that might be having a seizure on a public beach, that’s in the public interest. As is the science we advance through doing this work… Because at the end of the day, it’s all just one system.”
Lucille, who recovered from her seizures, was transported to the center’s Sausalito hospital via air-conditioned truck the following day. She died in transport.
Veggie, another sea lion who was rescued the same day, did make it to Sausalito however. She is now undergoing a seven-day protocol at the hospital, where roughly 50 other sea lions are being treated.
Rulli said that two sea lions were recently released back into the wild at Point Reyes National Seashore, where there is no sign of an outbreak and where humpback whales are currently feeding — an indication that there’s plenty of food available.
“Let’s just hope they stay up here,” he said.
Science
After rash of overdose deaths, L.A. banned sales of kratom. Some say they lost lifeline for pain and opioid withdrawal
Nearly four months ago, Los Angeles County banned the sale of kratom, as well as 7-OH, the synthetic version of the alkaloid that is its active ingredient. The idea was to put an end to what at the time seemed like a rash of overdose deaths related to the drug.
It’s too soon to tell whether kratom-related deaths have dissipated as a result — or, really, whether there was ever actually an epidemic to begin with. But many L.A. residents had become reliant on kratom as something of a panacea for debilitating pain and opioid withdrawal symptoms, and the new rules have made it harder for them to find what they say has been a lifesaving drug.
Robert Wallace started using kratom a few years ago for his knees. For decades he had been in pain, which he says stems from his days as a physical education teacher for the Glendale Unified School District between 1989 and 1998, when he and his students primarily exercised on asphalt.
In 2004, he had arthroscopic surgery on his right knee, followed by varicose vein surgery on both legs. Over the next couple of decades, he saw pain-management specialists regularly. But the primary outcome was a growing dependence on opioid-based painkillers. “I found myself seeking doctors who would prescribe it,” he said.
He leaned on opioids when he could get them and alcohol when he couldn’t, resulting in a strain on his marriage.
When Wallace was scheduled for his first knee replacement in 2021 (he had his other knee replaced a few years later), his brother recommended he take kratom for the post-surgery pain.
It seemed to work: Wallace said he takes a quarter of a teaspoon of powdered kratom twice a day, and it lets him take charge of managing his pain without prescription painkillers and eases harsh opiate-withdrawal symptoms.
He’s one of many Angelenos frustrated by recent efforts by the county health department to limit access to the drug. “Kratom has impacted my life in only positive ways,” Wallace told The Times.
For now, Wallace is still able to get his kratom powder, called Red Bali, by ordering from a company in Florida.
However, advocates say that the county crackdown on kratom could significantly affect the ability of many Angelenos to access what they say is an affordable, safer alternative to prescription painkillers.
Kratom comes from the leaves of a tree native to Southeast Asia called Mitragyna speciosa. It has been used for hundreds of years to treat chronic pain, coughing and diarrhea as well as to boost energy — in low doses, kratom appears to act as a stimulant, though in higher doses, it can have effects more like opioids.
Though advocates note that kratom has been used in the U.S. for more than 50 years for all sorts of health applications, there is limited research that suggests kratom could have therapeutic value, and there is no scientific consensus.
Then there’s 7-OH, or 7-Hydroxymitragynine, a synthetic alkaloid derived from kratom that has similar effects and has been on the U.S. market for only about three years. However, because of its ability to bind to opioid receptors in the body, it has a higher potential for abuse than kratom.
Public health officials and advocates are divided on kratom. Some say it should be heavily regulated — and 7-OH banned altogether — while others say both should be accessible, as long as there are age limitations and proper labeling, such as with alcohol or cannabis.
In the U.S., kratom and 7-OH can be found in all sorts of forms, including powder, capsules and liquids — though it depends on exactly where you are in the country. Though the Food and Drug Administration has recommended that 7-OH be included as a Schedule 1 controlled substance under the Controlled Substances Act, that hasn’t been made official. And the plant itself remains unscheduled on the federal level.
That has left states, counties and cities to decide how to regulate the substances.
California failed to approve an Assembly bill in 2024 that would have required kratom products to be registered with the state, have labeling and warnings, and be prohibited from being sold to anyone younger than 21.
It would also have banned products containing synthetic versions of kratom alkaloids. The state Legislature is now considering another bill that basically does the same without banning 7-OH — while also limiting the amount of synthetic alkaloids in kratom and 7-OH products sold in the state.
“Until kratom and its pharmacologically active key ingredients mitragynine and 7-OH are approved for use, they will remain classified as adulterants in drugs, dietary supplements and foods,” a California Department of Public Health spokesperson previously told The Times.
On Tuesday, California Gov. Gavin Newsom announced that the state’s efforts to crack down on kratom products has resulted in the removal of more than 3,300 kratom and 7-OH products from retail stores. According to a news release from the governor’s office, there has been a 95% compliance rate from businesses in removing the products.
(Los Angeles Times photo illustration; source photos by Getty Images)
Newsom has equated these actions to the state’s efforts in 2024 to quash the sale of hemp products containing cannabinoids such as THC. Under emergency state regulations two years ago, California banned these specific hemp products and agents with the state Department of Alcoholic Beverage Control seized thousands of products statewide.
Since the beginning of 2026, there have been no reported violations of the ban on sales of such products.
“We’ve shown with illegal hemp products that when the state sets clear expectations and partners with businesses, compliance follows,” Newsom said in a statement. “This effort builds on that model — education first, enforcement where necessary — to protect Californians.”
Despite the state’s actions, the Los Angeles County Board of Supervisors is still considering whether to regulate kratom, or ban it altogether.
The county Public Health Department’s decision to ban the sale of kratom didn’t come out of nowhere. As Maral Farsi, deputy director of the California Department of Public Health, noted during a Feb. 18 state Senate hearing, the agency “identified 362 kratom-related overdose deaths in California between 2019 and 2023, with a steady increase from 38 in 2019 up to 92 in 2023.”
However, some experts say those numbers aren’t as clear-cut as they seem.
For example, a Los Angeles Times investigation found that in a number of recent L.A. County deaths that were initially thought to be caused by kratom or 7-OH, there wasn’t enough evidence to say those drugs alone caused the deaths; it might be the case that the danger is in mixing them with other substances.
Meanwhile, the actual application of this new policy seems to be piecemeal at best.
The county Public Health Department told The Times it conducted 2,696 kratom-related inspections between Nov. 10 and Jan. 27, and found 352 locations selling kratom products. The health department said the majority stopped selling kratom after those inspections; there were nine locations that ignored the warnings, and in those cases, inspectors impounded their kratom products.
But the reality is that people who need kratom will buy it on the black market, drive far enough so they get to where it’s sold legally or, like Wallace, order it online from a different state.
For now, retailers who sell kratom products are simply carrying on until they’re investigated by county health inspectors.
Ari Agalopol, a decorated pianist and piano teacher, saw her performances and classes abruptly come to a halt in 2012 after a car accident resulted in severe spinal and knee injuries.
“I tried my best to do traditional acupuncture, physical therapy and hydrocortisone shots in my spine and everything,” she said. “Finally, after nothing was working, I relegated myself to being a pain-management patient.”
She was prescribed oxycodone, and while on the medication, battled depression, anhedonia and suicidal ideation. She felt as though she were in a fog when taking oxycodone, and when it ran out, ”the pain would rear its ugly head.” Agalopol struggled to get out of bed daily and could manage teaching only five students a week.
Then, looking for alternatives to opioids, she found a Reddit thread in which people were talking up the benefits of kratom.
“I was kind of hesitant at first because there’re so many horror stories about 7-OH, but then I researched and I realized that the natural plant is not the same as 7-OH,” she said.
She went to a local shop, Authentic Kratom in Woodland Hills, and spoke to a sales associate who helped her decide which of the 47 strains of kratom it sold would best suit her needs.
Agalopol currently takes a 75-milligram dose of mitragynine, the primary alkaloid in kratom, when necessary. It has enabled her to get back to where she was before her injury: teaching 40 students a week and performing every weekend.
Agalopol believes the county hasn’t done its homework on kratom. “They’re just taking these actions because of public pressure, and public pressure is happening because of ignorance,” she said.
During the course of reporting this story, Authentic Kratom has shut down its three locations; it’s unclear if the closures are temporary. The owner of the business declined to comment on the matter.
When she heard the news of the recent closures, Agalopol was seething. She told The Times she has enough capsules of kratom for now, but when she runs out, her option will have to be Tylenol and ibuprofen, “which will slowly kill my liver.”
“Prohibition is not a public health strategy,” said Jackie Subeck, executive director of 7-Hope Alliance, a nonprofit that promotes safe and responsible access to 7-OH for consumers, at the Feb. 18 Senate hearing. “[It’s] only going to make things worse, likely resulting in an entirely new health crisis for Californians.”
Science
There were 13 full-service public health clinics in L.A. County. Now there are 6
Because of budget cuts, the Los Angeles County Department of Public Health has ended clinical services at seven of its public health clinic sites.
As of Feb. 27, the county is no longer providing services such as vaccinations, sexually transmitted infection testing and treatment, or tuberculosis diagnosis and specialty TB care at the affected locations, according to county officials and a department fact sheet.
The sites losing clinical services are Antelope Valley in Lancaster; the Center for Community Health (Leavy) in San Pedro, Curtis R. Tucker in Inglewood, Hollywood-Wilshire, Pomona, Dr. Ruth Temple in South Los Angeles, and Torrance. Services will continue to be provided by the six remaining public health clinics, and through nearby community clinics.
The changes are the result of about $50 million in funding losses, according to official county statements.
“That pushed us to make the very difficult decision to end clinical services at seven of our sites,” said Dr. Anish Mahajan, chief deputy director of the L.A. County Department of Public Health.
Mahajan said the department selected clinics with relatively lower patient volumes. Over the last month, he said, the department has sent letters to patients about the changes, and referred them to unaffected county clinics, nearby federally qualified health centers or other community providers. According to Mahajan, for tuberculosis patients, particularly those requiring directly observed therapy, public health nurses will continue visiting patients.
Public health clinics form part of the county’s healthcare safety net, serving low-income residents and those with limited access to care. Officials said that about half of the patients the county currently sees across its clinics are uninsured.
Mahajan noted that the clinics were established decades ago, before the Affordable Care Act expanded Medi-Cal coverage and increased the number of federally qualified health centers. He said that as more residents gained access to primary care, utilization at some county-run clinics declined.
“Now that we have a more sophisticated safety net, people often have another place to go for their full range of care,” he said.
Still, the closures have unsettled providers who work closely with local vulnerable populations.
“I hate to see any services that serve our at-risk and homeless community shut down,” said Mark Hood, chief executive of Union Rescue Mission in downtown Los Angeles. “There’s so much need out there, so it always is going to create hardship for the people that actually need the help the most.”
Union Rescue Mission does not receive government funding for its healthcare services, Hood said. The mission’s clinics are open not only to shelter guests, up to 1,000 people nightly, but also to people living on the streets who walk in seeking care.
Its dental clinic alone sees nearly 9,000 patients a year, Hood said.
“We haven’t seen it yet, but I expect in the coming days and weeks we’ll see more people coming through our doors looking for help,” he said. “They’re going to have to find help somewhere.” Hood said women experiencing homelessness are especially vulnerable when preventive care, including sexual and reproductive health services, becomes harder to access.
County officials said staffing impacts so far have been managed through reassignment rather than layoffs. Roughly 200 to 300 positions across the department have been eliminated amid funding cuts, officials said, though many were vacant. About 120 employees whose positions were affected have been reassigned; according to Mahajan, no one has been laid off.
The clinic closures come amid broader fiscal uncertainty. Mahajan said that due to the Trump administration’s “Big Beautiful Bill,” Los Angeles County could lose $2.4 billion over the next several years. That funding, he said, supports clinics, hospitals and community clinic partners now absorbing patients who previously went to the clinics that closed on Feb. 27.
In response, the L.A. County Board of Supervisors has backed a proposed half-cent sales tax measure that would generate hundreds of millions of dollars annually for healthcare and public health services. Voters are expected to consider the measure in June.
Science
Mobile clinic brings mammograms to women on Skid Row
Sharon Horton stepped through the door of a sky-blue mobile clinic and onto a Skid Row sidewalk. She wore a yellow knit beanie, gold hoop earrings and the relieved grin of a woman who has finally checked a mammogram off her to-do list.
It had been years since her last breast cancer screening procedure. This one, which took place in City of Hope’s Cancer Prevention and Screening mobile clinic, was faster and easier. The staff was kind. The machine that X-rayed her breast was more comfortable than the cold hard contraption she remembered.
Relatively speaking, of course — it was still a mammogram.
“It’s like, OK, let me go already!” Horton, 68, said with a laugh.
The clinic was parked on South San Pedro Street in front of Union Rescue Mission, the nonprofit shelter where Horton resides. Within a week, City of Hope, a cancer research hospital, would share the results with Horton and Dr. Mary Marfisee, the mission’s family medical services director. If the mammogram detected anything of concern, they’d map out a treatment plan from there.
Naureen Sayani, 47, a resident of Union Rescue Mission, left, discusses her medical history with Adriana Galindo, a medical assistant, before getting a mammogram on last week.
(Kayla Bartkowski / Los Angeles Times)
“It’s very important to take care of your health, and you need to get involved in everything that you can to make your life a better life,” said Horton, who is looking forward to a forthcoming move into Section 8 housing.
Horton was one of the first patients of a new women’s health initiative from UCLA’s Homeless Healthcare Collaborative at Union Rescue Mission. Staffed by third-year UCLA Medical School students and led by Marfisee, a UCLA assistant clinical professor of family medicine, the clinic treats mission residents as well as unhoused people living in the surrounding neighborhood.
The new cancer screening project arrives at a time of dire financial pressures on county public health services.
Citing rising costs and a $50-million reduction in federal, state and local grant and contract income, the Los Angeles County Department of Public Health on Feb. 27 ended services at seven of 13 public clinics that provide vaccines, tests and treatment for sexually transmitted diseases and other services to housed and unhoused county residents.
Although Union Rescue Mission’s own funding comes mainly from private sources and is less imperiled by public cuts, the 135-year-old shelter expects the need for its services to rise, Chief Executive Mark Hood said.
Even as unsheltered homelessness declined for the last two years across Los Angeles County, the unsheltered population on Skid Row — long seen as the epicenter of the region’s homelessness crisis — grew 9% in 2024, the most recent year for which census data are available.
For many local women navigating daily concerns over housing, food and personal safety, “their own health is not a priority,” Marfisee said.
Those whose problems have become too serious to ignore face daunting obstacles to care. Marfisee recalled one patient who came to her with a lump in her breast and no identification.
In order to get a mammogram, Marfisee explained, the woman first needed to obtain a birth certificate, and then a state-issued identification card. Then she needed to enroll in Medi-Cal. After that, clinic staff helped her find a primary care physician who could order the imaging test.
Given the barriers to preventative care, homeless women die from breast cancer at nearly twice the rate of securely housed women, a 2019 study found. Marfisee’s own survey of the mission’s female residents found that nearly 90% were not up to date on recommended cancer screenings like mammograms and pap smears, which detect early cervical cancer.
To address this gap, Marfisee — a dogged patient advocate — reached out to City of Hope. The Duarte-based research and treatment center unveiled in March 2024 its first mobile cancer screening clinic, a moving van-sized clinic on wheels that it deploys to food banks and health centers, as well as to companies offering free mammograms as an employee benefit.
“In true Dr. Mary fashion, she saw the vision,” said Jessica Thies, the mobile screening program’s regional nursing director. After working through some logistical hurdles, the mission and City of Hope secured a date for the van’s first visit.
The next challenge was getting the word out to patients. Marfisee and her students walked through the surrounding neighborhood, went cot to cot in the women’s dorm and held two informational sessions in December and January to answer patients’ questions.
At the sessions, the team walked through the basics of who should get a mammogram (women age 40 or older, those with a family history of breast cancer) and the procedure itself. (“Like a tortilla maker?” one woman asked skeptically after hearing a description of the mammography unit.)
The medical students were able to dispel rumors some women had heard: The test doesn’t damage breast tissue, nor do the X-rays increase cancer risk. Others questioned a mammogram’s value: What good was it knowing they had cancer if they couldn’t get follow-up care?
On this latter point, Marfisee is determined not to let patients fall through the cracks.
Thirteen patients received mammograms at the van’s first visit on Wednesday. Within a week, City of Hope will contact patients with their results and send them to Marfisee and her team. She is already mentally mapping the next steps should any patient have a situation that requires a biopsy or further imaging: working with their case manager at the mission, calling in favors, wrangling with any insurance the patient might have.
“It’ll be a good fight,” Marfisee said, as residents in the adjacent cafeteria carried trays of sloppy joes and burgers to their lunch tables. “But we’ll just keep asking for help and get it done.”
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