Science
Omicron coronavirus variant seen as a clarion call to vaccinate the globe
For nearly a yr since COVID-19 vaccines first turned out there, many main well being authorities have urged rich nations and vaccine manufacturing corporations to prioritize inoculating folks in poorer Southern Hemisphere nations to assist forestall troublesome new variants from rising.
Since then, vaccines have change into available in america, Western Europe and different developed areas of the world. However in Africa, the place the brand new Omicron coronavirus variant was first detected in latest days, vaccines stay extraordinarily tough to come back by and simply 7% of the inhabitants is absolutely inoculated, in contrast with 42% of the worldwide inhabitants and 58% of america.
“With this degree of vaccine inequality, variants like Omicron are fully predictable,” mentioned Matthew Kavanagh, director of the International Well being Coverage and Politics Initiative at Georgetown’s O’Neill Institute on Friday. “Boosters and journey bans won’t defend People. We are going to proceed to dwell in concern till we repair the vaccine inequalities.”
On Friday, specialists on the World Well being Group categorized Omicron as a “variant of concern,” the group’s most critical class.
Scientists warning towards drawing conclusions in regards to the variant’s capabilities too shortly: It’ll take days and even weeks for researchers to run checks and pore over knowledge, based on Tim Schacker, the vice dean of analysis on the College of Minnesota’s medical faculty.
Nonetheless, the WHO’s announcement is critical: The “variant of concern” label is often reserved for these with mutations that might doubtlessly make the virus extra contagious or virulent, or might render defenses resembling vaccinations much less efficient.
Some earlier variants haven’t lived as much as the preliminary alarm. However the Omicron variant has greater than 50 mutations, greater than half of them on the virus’ spike protein, the important thing goal of vaccines and subsequent antibodies. Michael Osterholm, an epidemiologist on the College of Minnesota who served on President Biden’s COVID-19 advisory board throughout his transition into workplace, referred to as it “certainly a lot, rather more regarding than [the] Delta” variant, which now accounts for nearly all COVID-19 instances in america.
“Of all of the variants we have now seen to this point, that is most likely the best public well being concern we’ve had,” he mentioned. “It might evade some or all the immunity we have now from earlier infections and vaccines. We simply don’t know.”
Whereas a number of jabs and even boosters have considerably lowered the possibilities of critical sickness or loss of life to those that have taken benefit throughout america and far of Europe, massive unvaccinated populations within the growing world present way more alternatives for the coronavirus to evolve into new varieties that might threaten the effectiveness of vaccines.
Africa’s two most populous international locations, Nigeria and Ethiopia, each have vaccination charges beneath 2%. Until the speed rises dramatically, international variants will probably be thought-about inevitable.
COVAX, the WHO initiative to ship vaccines to low-income international locations, has struggled with setbacks, together with underwhelming investments by rich international locations and a surge in Delta instances that saved photographs from leaving India, the place lots of them are manufactured and have been distributed. The marketing campaign is anticipating to produce virtually half a billion new doses by the top of the yr, however has to this point delivered solely a few third of what it had anticipated.
Some public well being specialists fear a few discouraging cycle wherein new variants immediate rich international locations to order extra boosters, depleting the manufacturing capability for first and second doses wanted in largely unvaccinated areas.
Greater than 60 growing international locations, led by India and South Africa, have proposed briefly suspending vaccine patents and different mental property to allow nations to supply their very own vaccines, driving up stock. Biden, underneath strain to assist vaccinate folks in poorer nations, many within the Southern Hemisphere, has mentioned he helps such a waiver. He repeated his stance Friday, saying that Omicron “reiterates the significance of transferring on this shortly.”
However drug corporations and the European Union oppose such a transfer as a result of they are saying it might discourage pharmaceutical funding, and america has completed little to push negotiations ahead.
“For the final yr, wealthy international locations have hoarded doses and paid excessive costs for boosters in hopes that may hold them protected” as an alternative of specializing in international vaccination, Kavanagh mentioned. He identified that a lot of the cutting-edge vaccine improvement credited to non-public corporations in 2020 was funded by U.S. taxpayers and used copious quantities of presidency analysis.
“It’s lengthy overdue to share this publicly funded know-how with the world so Africa, Asia and Latin America could make vaccines,” he mentioned.
Osterholm counters that though vaccine manufacturing capability is finite, it’s “not useful or correct” to recommend that america booster rollout had nice bearing on the emergence of Omicron. There are different extraordinary challenges to vaccination campaigns in distant areas, together with the necessity for refrigerated transport, coordinated groups of well being employees, and — as evidenced in rich and poor nations alike — public confidence within the effort. Widespread vaccination relies upon upon each provide and demand.
“It’s not simply a difficulty of handing folks vaccines,” mentioned Anne Rimoin, an epidemiologist at UCLA.
The USA, Britain, Australia and different rich nations had been swift late this week to limit journey from southern Africa, triggering backlash from critics who say their vaccine hoarding contributed to the emergence within the first place.
And whereas journey bans in some instances purchase officers time to coordinate a public well being response, they usually come too late. Omicron has already been detected in locales together with Hong Kong, Belgium, Israel and Britain. “The cat’s out of the bag,” Rimoin mentioned.
She and different scientists credit score South Africa for a powerful surveillance system that detected, analyzed and reported the brand new variant to the WHO shortly.
The USA “wouldn’t have caught it at almost this velocity,” Osterholm mentioned. “Those that consider South Africa as contributing to an issue: You should be grateful to them.”
As soon as researchers know the way present vaccine formulation stack up towards Omicron, subsequent steps will change into clearer. Producers may have to change the components, and officers would wish to organize a plan to ship new ones.
Within the meantime, public well being specialists urge international leaders to behave upon what’s already clear: With out extra vaccines in southern Africa, the virus will retain thousands and thousands of alternatives to duplicate and adapt.
“I’ve been saying for months and months that the way forward for this pandemic will come down to 2 points: waning immunity and new variants,” Osterholm mentioned. “What you see right here is that, whereas so many individuals around the globe are completed with this pandemic, the virus isn’t completed with us.”
Science
FDA sets limits for lead in many baby foods as California disclosure law takes effect
The U.S. Food and Drug Administration this week set maximum levels for lead in baby foods such as jarred fruits and vegetables, yogurts and dry cereal, part of an effort to cut young kids’ exposure to the toxic metal that causes developmental and neurological problems.
The agency issued final guidance that it estimated could reduce lead exposure from processed baby foods by about 20% to 30%. The limits are voluntary, not mandatory, for food manufacturers, but they allow the FDA to take enforcement action if foods exceed the levels.
It’s part of the FDA’s ongoing effort to “reduce dietary exposure to contaminants, including lead, in foods to as low as possible over time, while maintaining access to nutritious foods,” the agency said in a statement.
Consumer advocates, who have long sought limits on lead in children’s foods, welcomed the guidance first proposed two years ago, but said it didn’t go far enough.
“FDA’s actions today are a step forward and will help protect children,” said Thomas Galligan, a scientist with the Center for Science in the Public Interest. “However, the agency took too long to act and ignored important public input that could have strengthened these standards.”
The new limits on lead for children younger than 2 don’t cover grain-based snacks such as puffs and teething biscuits, which some research has shown contain higher levels of lead. And they don’t limit other metals such as cadmium that have been detected in baby foods.
The FDA’s announcement comes just one week after a new California law took effect that requires baby food makers selling products in California to provide a QR code on their packaging to take consumers to monthly test results for the presence in their product of four heavy metals: lead, mercury, arsenic and cadmium.
The change, required under a law passed by the California Legislature in 2023, will affect consumers nationwide. Because companies are unlikely to create separate packaging for the California market, QR codes are likely to appear on products sold across the country, and consumers everywhere will be able to view the heavy metal concentrations.
Although companies are required to start printing new packaging and publishing test results of products manufactured beginning in January, it may take time for the products to hit grocery shelves.
The law was inspired by a 2021 congressional investigation that found dangerously high levels of heavy metals in packaged foods marketed for babies and toddlers. Baby foods and their ingredients had up to 91 times the arsenic level, up to 177 times the lead level, up to 69 times the cadmium level, and up to five times the mercury level that the U.S. allows to be present in bottled or drinking water, the investigation found.
There’s no safe level of lead exposure for children, according to the U.S. Centers for Disease Control and Prevention. The metal causes “well-documented health effects,” including brain and nervous system damage and slowed growth and development. However, lead occurs naturally in some foods and comes from pollutants in air, water and soil, which can make it impossible to eliminate entirely.
The FDA guidance sets a lead limit of 10 parts per billion for fruits, most vegetables, grain and meat mixtures, yogurts, custards and puddings and single-ingredient meats. It sets a limit of 20 parts per billion for single-ingredient root vegetables and for dry infant cereals. The guidance covers packaged processed foods sold in jars, pouches, tubs or boxes.
Jaclyn Bowen, executive director of the Clean Label Project, an organization that certifies baby foods as having low levels of toxic substances, said consumers can use the new FDA guidance in tandem with the new California law: The FDA, she said, has provided parents a “hard and fast number” to consider a benchmark when looking at the new monthly test results.
But Brian Ronholm, director of food policy for Consumer Reports, called the FDA limits “virtually meaningless because they’re based more on industry feasibility and not on what would best protect public health.” A product with a lead level of 10 parts per billion is “still too high for baby food. What we’ve heard from a lot of these manufacturers is they are testing well below that number.”
The new FDA guidance comes more than a year after lead-tainted pouches of apple cinnamon puree sickened more than 560 children in the U.S. between October 2023 and April 2024, according to the CDC.
The levels of lead detected in those products were more than 2,000 times higher than the FDA’s maximum. Officials stressed that the agency doesn’t need guidance to take action on foods that violate the law.
Aleccia writes for the Associated Press. Gold reports for The Times’ early childhood education initiative, focusing on the learning and development of California children from birth to age 5. For more information about the initiative and its philanthropic funders, go to latimes.com/earlyed.
Science
NASA punts Mars Sample Return decision to the next administration
Anyone hoping for a clear path forward this year for NASA’s imperiled Mars Sample Return mission will have to wait a little longer.
The agency has settled on two potential strategies for the first effort to bring rock and soil from another planet back to Earth for study, NASA Administrator Bill Nelson said Tuesday: It can either leverage existing technology into a simpler, cheaper craft or turn to a commercial partner for a new design.
But the final decision on the mission’s structure — or whether it should proceed at all — “is going to be a function of the new administration,” Nelson said. President-elect Donald Trump will take office Jan. 20.
“I don’t think we want the only [Mars] sample return coming back on a Chinese spacecraft,” Nelson said, referencing a rival mission that Beijing has in the works. “I think that the [Trump] administration will certainly conclude that they want to proceed. So what we wanted to do was to give them the best possible options so that they can go from there.”
The call also contained words of encouragement for NASA’s Jet Propulsion Laboratory in La Cañada Flintridge, which leads the embattled mission’s engineering efforts.
“To put it really bluntly, JPL is our Mars center in NASA science,” said Nicky Fox, associate administrator of the Science Mission Directorate. “They are the people who landed us on Mars, together with our industry partners. So they will be moving forward, regardless of which path, with a key role in the Mars Sample Return.”
In April, after an independent review found “near zero probability” of Mars Sample Return making its proposed 2028 launch date, NASA put out a request for alternative proposals to all of its centers and the private sector. JPL was forced to compete for what had been its own project.
The independent review board determined that the original design would probably cost up to $11 billion and not return samples to Earth until at least 2040.
“That was just simply unacceptable,” said Nelson, who paused the mission in late 2023 to review its chances of success.
Ensuing cuts to the mission’s budget forced a series of layoffs at JPL, which let go of 855 employees and 100 on-site contractors in 2024.
The NASA-led option that Nelson suggested Tuesday includes several elements from the JPL proposal, according to a person who reviewed the documents. This leaner, simpler alternative will cost between $6.6 billion and $7.7 billion, and will return the samples by 2039, he said. A commercial alternative would probably cost $5.8 billion to $7.1 billion.
Nelson, a former Democratic U.S. senator from Florida, will step down as head of the space agency when Trump takes office. Trump has nominated as his successor Jared Isaacman, a tech billionaire who performed the first private space walk, who must be confirmed by the Senate.
NASA has not had any conversations with Trump’s transition team about Mars Sample Return, Nelson said. How the new administration will prioritize the project is not yet clear.
“It’s very uncertain how the new administration will go forward,” said Casey Dreier, chief of space policy for the Planetary Society, a Pasadena nonprofit that promotes space research. “Cancellation is obviously still on the table. … It’s hard to game this out.”
Planetary scientists have identified Mars Sample Return as their field’s highest priority in the last three decadal surveys, reports that the National Academies of Sciences, Engineering, and Medicine prepare every 10 years in order to advise NASA.
Successfully completing the mission is “key for the nation’s leadership in space science,” said Bethany L. Ehlmann, a planetary scientist at Caltech in Pasadena. “I hope the incoming administrator moves forward decisively to select a plan and execute. There are extraordinary engineers at JPL and NASA industry partners eager and able to get to work to make it happen.”
Science
Panama Canal’s Expansion Opened Routes for Fish to Relocate
Night fell as the two scientists got to work, unfurling long nets off the end of their boat. The jungle struck up its evening symphony: the sweet chittering of insects, the distant bellowing of monkeys, the occasional screech of a kite. Crocodiles lounged in the shallows, their eyes glinting when headlamps were shined their way.
Across the water, cargo ships made dark shapes as they slid between the seas.
The Panama Canal has for more than a century connected far-flung peoples and economies, making it an essential artery for global trade — and, in recent weeks, a target of President-elect Donald J. Trump’s expansionist designs.
But of late the canal has been linking something else, too: the immense ecosystems of the Atlantic and the Pacific.
The two oceans have been separated for some three million years, ever since the isthmus of Panama rose out of the water and split them. The canal cut a path through the continent, yet for decades only a handful of marine fish species managed to migrate through the waterway and the freshwater reservoir, Lake Gatún, that feeds its locks.
Then, in 2016, Panama expanded the canal to allow supersize ships, and all that started to change.
In less than a decade, fish from both oceans — snooks, jacks, snappers and more — have almost entirely displaced the freshwater species that were in the canal system before, scientists with the Smithsonian Tropical Research Institute in Panama have found. Fishermen around Lake Gatún who rely on those species, chiefly peacock bass and tilapia, say their catches are growing scarce.
Researchers now worry that more fish could start making their way through from one ocean to the other. And no potential invader causes more concern than the venomous, candy-striped lionfish. They are known to inhabit Panama’s Caribbean coast, but not the eastern Pacific. If they made it there through the canal, they could ravage the defenseless local fish, just as they’ve done in the Gulf of Mexico and the Caribbean.
Already, marine species are more than occasional visitors in Lake Gatún, said Phillip Sanchez, a fisheries ecologist with the Smithsonian. They’re “becoming the dominant community,” he said. They’re “pushing everything else out.”
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