Science
NIH cuts put medical research at risk, scientists say, raising concerns at UC and elsewhere
Each year, the National Institutes of Health gives billions of dollars to the University of California to pay for research into cancer, Alzheimer’s, Parkinson’s, heart disease, diabetes and other diseases it has been at the forefront of studying for decades.
But a drastic cut to NIH funding under the Trump administration set to take place Monday has caused alarm among UC leaders and many medical researchers, who said the move would “jeopardize America’s research preeminence.”
Speaking to The Times since the cuts were announced Friday night, UC medical researchers expressed concerns about the future of their labs and lifesaving endeavors — as have others at universities and academic medical centers nationwide.
The NIH said late Friday that it would slash by more than half so-called “indirect funding” — overhead for research supplies, building maintenance, utilities, support staff and other costs — that institutions receive as part of medical research grants.
Beginning Monday, NIH-sponsored indirect funding will be capped at 15% of grants, down from 57% that many UCLA research projects receive and the 64% given at UC San Francisco, which has the highest rate in the UC system.
In its X post on the change Friday, the NIH shared a graphic that compared the indirect funding rates for Harvard, Yale and Johns Hopkins with their multibillion-dollar endowments. The highest among them, Harvard, was 69%.
The NIH’s move would save roughly $4 billion a year in tax dollars, the post stated. The agency said that more than a quarter of its $35 billion in research funding last year went to overhead. As a comparison, it cited private foundations, including the Chan Zuckerberg Initiative and the Gates Foundation, saying their overhead costs are 15% or lower.
“The United States should have the best medical research in the world,” the NIH said in guidance posted to its website. “It is accordingly vital to ensure that as many funds as possible go towards direct scientific research costs rather than administrative overhead.”
University researchers said the money, despite being labeled “indirect funding,” is essential to their work and pays to keep lifesaving science going — from ensuring the proper storage of biological samples to keeping alive animals for medical trials. They also contend that private foundations do not have to follow the same rules in how they categorize spending, saying it is unfair to compare overheads between the two.
Republicans argue that the costs are superfluous, part of bloated spending of taxpayer funds that President Trump has appointed Elon Musk to pare down.
Scientists point out that universities have already been paying a greater share for research costs. Data from the National Center for Science and Engineering Statistics show that, since 1980, the federal slice of research support at universities has gone down 12% while university payments have gone up 11%.
Cuts could ‘imperil’ UC medical research
The NIH is the largest funder of UC research, providing $2.6 billion in the last academic year — 62% of the university’s federal awards of more than $4.2 billion.
In a statement, UC said that the “new administration guidance would imperil this vital support and jeopardize America’s research preeminence.”
“These time-honored university partnerships have led to some of the most powerful and impactful research discoveries in human history,” the statement said. “Life-saving treatments for cancer, diabetes, heart attacks, and strokes, including in children, and new technologies and industries that translate into hundreds of thousands of well-paying jobs are all at risk. America is first in research, but its dominance is not assured.”
On Saturday, UC officials were still analyzing the effect of the NIH move, and were in contact with UC lawyers, researchers and administrators on how to respond.
In an email to his science faculty after the NIH announcement, a UCLA dean said: “As with many announcements over the last several weeks, this no doubt causes significant anxiety. Please know that the leadership at UCLA and across the UC is working to understand the implications.”
White House defends move
The White House defended its action, saying in an email blast to media outlets Saturday that “the NIH did not announce any cuts to actual research.” It cited Vinay Prasad, a professor of epidemiology and biostatistics and medicine at UC San Francisco, who praised the NIH move on his blog.
The cut “might even mean more science. Less money spent on the administration is more money to give out to actual scientists,” wrote Prasad. “I am shocked to see researchers crying about how much money the university gets — it means more grants can be given per cycle.”
Several other UC researchers, many who had just applied for grant renewals after a recent application pause or were in the midst of assembling grant proposals, said they were stunned.
“All my research will be shut down if this goes through. There is no other way to say it. It will be done,” said Beate Ritz, a professor and vice chair of the epidemiology department at UCLA who has received at least $1 million a year for more than a decade from the NIH to research environmental pollution, Parkinson’s and Alzheimer’s. “It’s not my salary. I get paid by the state to teach. But it is the cost of much of everything else.”
What is being cut
Indirect costs cover items outside of salaries, travel, supplies and other direct expenses. The indirect costs are negotiated between the university and the federal government — typically every three or four years for UC campuses — which is why the change surprised scientists.
Gina Poe, a neurobiology professor in UCLA’s David Geffen School of Medicine, said she feared that her decades of research into memory, sleep and post-traumatic stress syndrome were threatened.
Poe explained how her grant works. She receives $250,000 a year from the NIH to pay five undergraduate and graduate research assistants, among other expenditures, including rats and mice. This does not include her indirect funding.
With UCLA’s indirect cost rate of 57%, at first glance, it appears Poe would receive an additional $142,500 in such funding. But she said the math is more complicated and she gets much less.
The federal government, Poe said, deducts certain costs from the grant before it calculates indirect funding levels. Major equipment costs, tuition awards to students and more are not included. In the end, her NIH indirect funding totals an additional $114,000, which mostly goes to UCLA and to the university’s life sciences division to cover facilities costs and other expenditures.
Among the budget items indirect funding pays for: workers who care for rats and mice, feeding them and cleaning their cages. It also pays for medicine and veterinarian visits.
Under the new NIH formula, Poe’s indirect funding allowance would be minimal.
“The only way left for me to make up that money is to move my work to a private company, for UCLA to raise tuition to cover extra costs or to apply to private foundations where the competition is going to increase significantly for funding,” Poe said.
Vivek Shetty, a UCLA professor of oral and maxillofacial surgery and biomedical engineering and former Academic Senate chair, expressed concerns that U.S. research power could be diminished.
“America’s global leadership in science and technology wasn’t built on genius alone. It relied heavily on infrastructure and systems that allowed universities to transform ideas into innovations. Cripple that infrastructure, and the next medical or AI advancement will happen elsewhere — taking with it not just jobs and prestige, but also the economic vitality and societal progress that innovation brings,” Shetty said.
The funding change has hit a particular nerve at universities since Trump’s inauguration. Many administrators have felt under the microscope from a president who has spoken out against what he describes as “Marxist” universities overrun with leftists.
Last month, UC officials raised concerns after a temporary NIH pause on research grant reviews. Trump’s executive orders have also targeted diversity, equity and inclusion programs — including in federal grants and programming. On Wednesday he signed an executive order designed to ban transgender athletes from participating in women’s or girls’ sporting events.
Times Staff Writer Corinne Purtill contributed to this story.
Science
Why new dads shouldn’t panic about low testosterone
Three months after his son was born, Kevin Maguire felt alone.
It was 2019. He had recently moved to Barcelona with his wife and daughter and was working on marketing projects for Fortune 500 companies. The birth of his son, Bodhi, should have been a joyous event. But Maguire, now 43, became sad and irritable, and didn’t want to be around his newborn. He withdrew from family and friends, often playing video games late into the night or finding excuses to get out of the house.
“I would take the dog out for a walk,” Maguire said. “I wanted to get far away enough that I wouldn’t bump into anyone I knew and I would just sit and cry.”
Desperate for answers, he entered his symptoms online. Maguire, author of the recently published book “The New Fatherhood: Why Everything They Told You About Being a Dad Is Wrong, and How Embracing It Will Transform Your Life,” knew to look for signs of the “baby blues” in his wife. But he was surprised by articles that said men could experience postpartum depression too. The diagnosis resonated and he began writing about his condition and the trials of fatherhood on Substack.
New dads face psychological pressures, from sleepless nights to sky-high bills, which can contribute to postpartum depression. So can shifting hormone levels.
“One thing I found in my lab’s research is that when new dads have really low levels of testosterone, they might report more symptoms of postpartum depression,” said Darby Saxbe, a professor of psychology at USC and author of the recently published “Dad Brain: The New Science of Fatherhood and How It Shapes Men’s Lives.”
While hormonal shifts can create challenges, they also help men adapt to fatherhood, Saxbe explained. Several hormones can spike in men when they become dads, including oxytocin, linked to better relationship quality; vasopressin, associated with emotional bonding; and prolactin, which promotes lactation in women and caregiving behavior in guys.
New dads can also experience a decline in testosterone. According to a 2011 paper from University of Notre Dame professor Lee Gettler, part of the largest study on fatherhood and testosterone ever conducted, men averaged around a 25% drop in testosterone after becoming fathers.
While dads have reasons to be concerned by plummeting levels of testosterone, a modest dip isn’t necessarily a disaster — in fact, it can make men better parents and partners.
“We often get invested in the idea that men should always have the highest possible levels of testosterone,” Saxbe said. “What the research tells us is a little more nuanced. You really want flexibility. You want a hormonal system that can adapt to the different demands of your life.”
The prospect of a decline might scare soon-to-be fathers, especially those on TikTok and Instagram, where accounts push the idea that having “high T” is the key to being a “real man,” according to a recent study in the journal Social Science & Medicine.
Influencers stand to profit persuading men there’s a widespread “masculinity crisis,” the researchers found, noting that 72% of the accounts they analyzed had a stake in testosterone supplements and treatments.
But studies show more testosterone isn’t always better. “We found that when dads have higher testosterone, even before birth, they’re less invested [than men with lower testosterone] in co-parenting a few months after birth,” Saxbe said. High T fathers were more stressed from parenting than their lower T counterparts, and had partners who were less satisfied in their romantic relationships.
This jibes with the challenge hypothesis, which says, in multiple species, testosterone levels rise when males battle for attention from potential mates and go down when it’s time to take care of the young.
While a small decline can be adaptive, dads face mental health risks when their testosterone drops too low.
There is no “normal” level of testosterone, said Dr. Jesse Mills, director of the Men’s Clinic at UCLA Health. Experts recommend that men should consider treatment if their levels dip below 300 nanograms per deciliter (ng/dL). But men metabolize testosterone in different ways, meaning a healthy level for one might be low for another.
“If a new dad comes to me and his testosterone is 298 [ng/dL], he’s below the threshold,” Mills said. “But if he has zero symptoms and everything else is going great — he’s over the moon with his new child, he’s so happy — that’s not somebody I’m going to treat with testosterone.”
He notes that the drop in testosterone fathers experience can partly be attributed to the stresses that come with a new kid: less sleep, a poor diet and fewer trips to the gym. That means there are precautions that expectant fathers can take that don’t involve testosterone replacement therapy (TRT).
Still, while some guys with low testosterone levels might not need TRT, others in the “normal” range could benefit from treatment. (Dads who want another kid soon, beware. Mills notes that testosterone replacement therapy can take a man’s sperm count to zero.)
Both Mills and Saxbe stress that men should be paying attention to symptoms of low testosterone — such as depression and low libido — rather than trying to reach or maintain an ideal number. They also agree that tending to mental health concerns is hugely important for new fathers.
Eventually, after Maguire researched his condition, he recovered after time spent meditating, exercising and bonding with his son.
“A lot of new dads don’t realize how much they’re struggling because they feel ashamed or because they don’t realize it’s common shortly after the birth of a baby,” Saxbe said.
When they struggle, fathers can fixate on testosterone because that’s what modern culture tells them will make them feel better. And sometimes testosterone replacement therapy works. But Saxbe stresses a lot of men could use psychotherapy or support groups that bring dads together, as well as more time bonding with loved ones in general.
“The thing that predicts a man’s well-being and longevity is the quality of his relationships with other people,” said Saxbe. “You can be the world’s best weightlifter. You can have a low body-fat percentage. You can be killing it at work. Those things don’t predict how happy you’re going to be at 80.”
Science
Video: NASA Announces Artemis III Crew
new video loaded: NASA Announces Artemis III Crew
transcript
transcript
NASA Announces Artemis III Crew
NASA announced the crew of Artemis III mission, which will fly to low-Earth orbit to test rendezvous and docking maneuvers with one or two lunar landers.
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“I am excited to welcome you as the next crew in the Artemis journey to successfully return to the moon — this time to stay.” “I’m honored by the role that I’ve been given. I’m also very humbled by the task in front of us. But first and foremost, I’m grateful.” “So with that, the Artemis II crew, comrade, hands you the baton. You got the controls.” “As you know, we had a significant anomaly at our Launch Complex 36A on May 28. We’ve redoubled our efforts and are moving forward.”
By Alisa Shodiyev Kaff
June 9, 2026
Science
Santa Monica Mountains’ last steelhead trout survived the Palisades fire — and even had babies
Scientists feared the Santa Monica Mountains’ last remaining steelhead trout were dead, smothered by debris flows unleashed by the Palisades fire.
But the endangered fish surprised them: A team of biologists recently spotted 30 of the rare trout — and 21 babies — in Topanga Creek.
“There was a lot of happy dancing in the creek,” said Rosi Dagit, principal conservation biologist for the Resource Conservation District of the Santa Monica Mountains, which works with public and private landowners to conserve natural resources.
That’s because the steelhead here are endangered, at both the state and federal levels. Once, they swam in most streams of the Santa Monicas, but their numbers plummeted amid overfishing and coastal development. Increasingly frequent wildfire has further stressed their habitat. Topanga Creek, a biodiversity hot spot, is home to their last known population in the mountains that stretch from the Hollywood Hills to Point Mugu in Ventura County.
The trout that were spotted, including this one, are part of a distinct Southern California population that’s listed as endangered at the state and federal levels.
(RCDSMM Stream Team)
The California Department of Fish and Wildlife spearheaded a complex mission to rescue trout threatened by the Palisades fire that sparked in January 2025.
Time was of the essence. The fire hadn’t yet been fully contained. But rain was on the way, which would sweep massive amounts of sediment from the denuded hillsides into the water. Fish are often killed this way.
Crews stunned the fish with electricity, scooped them up in buckets, trucked them to a hatchery and ultimately moved them to Arroyo Hondo Creek in Santa Barbara County.
Within days, Topanga Creek was choked with mud. Some assumed the fish left behind were goners.
But in March, the conservation district’s team found four. The following month, when water conditions were clearer, they saw more.
“These fish continue to amaze me,” said Kyle Evans, environmental program manager for the state Department of Fish and Wildlife, who had seen the damage to the creek. “I had seen populations get wiped out in similar situations. So when I heard, I was thrilled.”
Evans surmises the fish that survived were in an area of the creek where less charred material and sediment were swept in.
“These fish likely hunkered down, were hiding under some rocks or places to try to get away from the main concentration of flow,” he said. “And luckily they weren’t buried.”
The ones that were spotted were fairly small, around 6 to 14 inches. Rainbow trout and steelhead trout are the same species, but with different lifestyles. If the fish remain in freshwater, they’ll be considered rainbows. However, they can migrate to the ocean and become steelhead, where they typically grow larger before returning to their natal waters to spawn.
Topanga Creek hasn’t fully recovered from the damage it sustained, but scientists say it’s looking better. Surveys last year were “so depressing,” Dagit said, with very few animals, and stretches that were essentially transformed into flat roads from all the sediment buildup. Some of the riparian canopy burned right down to the creek.
Then came 32 inches of rain over the last nine months, scouring out and moving sediment, creating deeper pools. Dagit said they recently found newt egg masses for the first time in years, as well as a few adult newts and many frogs. Plants that provide cover are starting to recover.
She provided photos comparing certain pools last year and this year, some dramatically transformed. In September 2025, the Shrine Pool could have been an overgrown hiking trail. This April, it was filled with shallow water.
The Shrine Pool in September 2025, left, and the same location in April 2026, right, with RCDSMM’s Isaac Yelchin donning a wetsuit.
(RCDSMM Stream Team)
Topanga Creek is home to another endangered fish, the small but hardy northern tidewater goby, often described as cute. Not long before the trout operation, Dagit led a rescue of hundreds of these fish too. Many were repatriated to the lagoon at the mouth of the creek in a moving ceremony last June.
There’s still the matter of what to do with the trout that were moved to Santa Barbara County last year. Evans would like to bring them home to the Santa Monicas at some point, but isn’t sure if it will happen. On one hand, they could bolster the small, genetically isolated surviving population. On the other, they might inadvertently bring in a disease or bacteria. There is some time to decide. Evans estimates the creek still needs to recover for two to three more years.
For now, the fish are functioning fine in their adopted creek. Experts worried the trauma wrought by the move would disrupt their spawning process, but they had babies that spring. This year, they spawned again.
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