Science
NIH budget cuts threaten the future of biomedical research — and the young scientists behind it
Over the last several months, a deep sense of unease has settled over laboratories across the United States. Researchers at every stage — from graduate students to senior faculty — have been forced to shelve experiments, rework career plans, and quietly warn each other not to count on long-term funding. Some are even considering leaving the country altogether.
This growing anxiety stems from an abrupt shift in how research is funded — and who, if anyone, will receive support moving forward. As grants are being frozen or rescinded with little warning and layoffs begin to ripple through institutions, scientists have been left to confront a troubling question: Is it still possible to build a future in U.S. science?
On May 2, the White House released its Fiscal Year 2026 Discretionary Budget Request, proposing a nearly $18-billion cut from the National Institutes of Health. This cut, which represents approximately 40% of the NIH’s 2025 budget, is set to take effect on Oct. 1 if adopted by Congress.
“This proposal will have long-term and short-term consequences,” said Stephen Jameson, president of the American Assn. of Immunologists. “Many ongoing research projects will have to stop, clinical trials will have to be halted, and there’ll be the knock-on effects on the trainees who are the next generation of leaders in biomedical research. So I think there’s going to be varied and potentially catastrophic effects, especially on the next generation of our researchers, which in turn will lead to a loss of the status of the U.S. as a leader in biomedical research.“
In the request, the administration justified the move as part of its broader commitment to “restoring accountability, public trust, and transparency at the NIH.” It accused the NIH of engaging in “wasteful spending” and “risky research,” releasing “misleading information,” and promoting “dangerous ideologies that undermine public health.”
National Institutes of Health.
(NIH.gov)
To track the scope of NIH funding cuts, a group of scientists and data analysts launched Grant Watch, an independent project that monitors grant cancellations at the NIH and the National Science Foundation. This database compiles information from public government records, official databases, and direct submissions from affected researchers, grant administrators, and program directors.
As of July 3, Grant Watch reports 4,473 affected NIH grants, totaling more than $10.1 billion in lost or at-risk funding. These include research and training grants, fellowships, infrastructure support, and career development awards — and affect large and small institutions across the country. Research grants were the most heavily affected, accounting for 2,834 of the listed grants, followed by fellowships (473), career development awards (374) and training grants (289).
The NIH plays a foundational role in U.S. research. Its grants support the work of more than 300,000 scientists, technicians and research personnel, across some 2,500 institutions and comprising the vast majority of the nation’s biomedical research workforce. As an example, one study, published in the Proceedings of the National Academy of Sciences, found that funding from the NIH contributed to research associated with every one of the 210 new drugs approved by the U.S. Food and Drug Administration between 2010 and 2016.
Jameson emphasized that these kinds of breakthroughs are made possible only by long-term federal investment in fundamental research. “It’s not just scientists sitting in ivory towers,” he said. “There are enough occasions where [basic research] produces something new and actionable — drugs that will save lives.”
That investment pays off in other ways too. In a 2025 analysis, United for Medical Research, a nonprofit coalition of academic research institutions, patient groups and members of the life sciences industry, found that every dollar the NIH spends generates $2.56 in economic activity.
A ‘brain drain’ on the horizon
Support from the NIH underpins not only research, but also the training pipeline for scientists, physicians and entrepreneurs — the workforce that fuels U.S. leadership in medicine, biotechnology and global health innovation. But continued American preeminence is not a given. Other countries are rapidly expanding their investments in science and research-intensive industries.
If current trends continue, the U.S. risks undergoing a severe “brain drain.” In a March survey conducted by Nature, 75% of U.S. scientists said they were considering looking for jobs abroad, most commonly in Europe and Canada.
This exodus would shrink domestic lab rosters, and could erode the collaborative power and downstream innovation that typically follows discovery. “It’s wonderful that scientists share everything as new discoveries come out,” Jameson said. “But, you tend to work with the people who are nearby. So if there’s a major discovery in another country, they will work with their pharmaceutical companies to develop it, not ours.”
At UCLA, Dr. Antoni Ribas has already started to see the ripple effects. “One of my senior scientists was on the job market,” Ribas said. “She had a couple of offers before the election, and those offers were higher than anything that she’s seen since. What’s being offered to people looking to start their own laboratories and independent research careers is going down — fast.”
In addition, Ribas, who directs the Tumor Immunology Program at the Jonsson Comprehensive Cancer Center, says that academia and industry are now closing their door to young talent. “The cuts in academia will lead to less positions being offered,” Ribas explained. “Institutions are becoming more reluctant to attract new faculty and provide startup packages.” At the same time, he said, the biotech industry is also struggling. “Even companies that were doing well are facing difficulties raising enough money to keep going, so we’re losing even more potential positions for researchers that are finishing their training.”
This comes at a particularly bitter moment. Scientific capabilities are soaring, with new tools allowing researchers to examine single cells in precise detail, probe every gene in the genome, and even trace diseases at the molecular level. “It’s a pity,” Ribas said, “Because we have made demonstrable progress in treating cancer and other diseases. But now we’re seeing this artificial attack being imposed on the whole enterprise.”
Without federal support, he warns, the system begins to collapse. “It’s as if you have a football team, but then you don’t have a football field. We have the people and the ideas, but without the infrastructure — the labs, the funding, the institutional support — we can’t do the research.”
For graduate students and postdoctoral fellows in particular, funding uncertainty has placed them in a precarious position.
“I think everyone is in this constant state of uncertainty,” said Julia Falo, a postdoctoral fellow at UC Berkeley and recording secretary of UAW 4811, the union for workers at the University of California. “We don’t know if our own grants are going to be funded, if our supervisor’s grants are going to be funded, or even if there will be faculty jobs in the next two years.”
She described colleagues who have had funding delayed or withdrawn without warning, sometimes for containing flagged words like “diverse” or “trans-” or even for having any international component.
The stakes are especially high for researchers on visas. As Falo points out for those researchers, “If the grant that is funding your work doesn’t exist anymore, you can be issued a layoff. Depending on your visa, you may have only a few months to find a new job — or leave the country.”
A graduate student at a California university, who requested anonymity due to the potential impact on their own position — which is funded by an NIH grant— echoed those concerns. “I think we’re all a little on edge. We’re all nervous,” they said. “We have to make sure that we’re planning only a year in advance, just so that we can be sure that we’re confident of where that funding is going to come from. In case it all of a sudden gets cut.”
The student said their decision to pursue research was rooted in a desire to study rare diseases often overlooked by industry. After transitioning from a more clinical setting, they were drawn to academia for its ability to fund smaller, higher-impact projects — the kind that might never turn a profit but could still change lives. They hope to one day become a principal investigator, or PI, and lead their own research lab.
Now, that path feels increasingly uncertain. “If things continue the way that they have been,” they said. “I’m concerned about getting or continuing to get NIH funding, especially as a new PI.”
Still, they are staying committed to academic research. “If we all shy off and back down, the people who want this defunded win.”
Rallying behind science
Already, researchers, universities and advocacy groups have been pushing back against the proposed budget cut.
On campuses across the country, students and researchers have organized rallies, marches and letter-writing campaigns to defend federal research funding. “Stand Up for Science” protests have occurred nationwide, and unions like UAW 4811 have mobilized across the UC system to pressure lawmakers and demand support for at-risk researchers. Their efforts have helped prevent additional state-level cuts in California: in June, the Legislature rejected Gov. Gavin Newsom’s proposed $129.7-million reduction to the UC budget.
Earlier this year, a coalition of public health groups, researchers and unions — led by the American Public Health Assn. — sued the NIH and Department of Health and Human Services over the termination of more than a thousand grants. On June 16, U.S. District Judge William Young ruled in their favor, ordering the NIH to reinstate over 900 canceled grants and calling the terminations unlawful and discriminatory. Although the ruling applies only to grants named in the lawsuit, it marks the first major legal setback to the administration’s research funding rollback.
Though much of the current spotlight (including that lawsuit) has focused on biomedical science, the proposed NIH cuts threaten research far beyond immunology or cancer. Fields ranging from mental health to environmental science stand to lose crucial support. And although some grants may be in the process of reinstatement, the damage already done — paused projects, lost jobs and upended career paths — can’t simply be undone with next year’s budget.
And yet, amid the fear and frustration, there’s still resolve. “I’m floored by the fact that the trainees are still devoted,” Jameson said. “They still come in and work hard. They’re still hopeful about the future.”
Science
Commentary: My toothache led to a painful discovery: The dental care system is full of cavities as you age
I had a nagging toothache recently, and it led to an even more painful revelation.
If you X-rayed the state of oral health care in the United States, particularly for people 65 and older, the picture would be full of cavities.
“It’s probably worse than you can even imagine,” said Elizabeth Mertz, a UC San Francisco professor and Healthforce Center researcher who studies barriers to dental care for seniors.
Mertz once referred to the snaggletoothed, gap-filled oral health care system — which isn’t really a system at all — as “a mess.”
But let me get back to my toothache, while I reach for some painkiller. It had been bothering me for a couple of weeks, so I went to see my dentist, hoping for the best and preparing for the worst, having had two extractions in less than two years.
Let’s make it a trifecta.
My dentist said a molar needed to be yanked because of a cellular breakdown called resorption, and a periodontist in his office recommended a bone graft and probably an implant. The whole process would take several months and cost roughly the price of a swell vacation.
I’m lucky to have a great dentist and dental coverage through my employer, but as anyone with a private plan knows, dental insurance can barely be called insurance. It’s fine for cleanings and basic preventive routines. But for more complicated and expensive procedures — which multiply as you age — you can be on the hook for half the cost, if you’re covered at all, with annual payout caps in the $1,500 range.
“The No. 1 reason for delayed dental care,” said Mertz, “is out-of-pocket costs.”
So I wondered if cost-wise, it would be better to dump my medical and dental coverage and switch to a Medicare plan that costs extra — Medicare Advantage — but includes dental care options. Almost in unison, my two dentists advised against that because Medicare supplemental plans can be so limited.
Sorting it all out can be confusing and time-consuming, and nobody warns you in advance that aging itself is a job, the benefits are lousy, and the specialty care you’ll need most — dental, vision, hearing and long-term care — are not covered in the basic package. It’s as if Medicare was designed by pranksters, and we’re paying the price now as the percentage of the 65-and-up population explodes.
So what are people supposed to do as they get older and their teeth get looser?
A retired friend told me that she and her husband don’t have dental insurance because it costs too much and covers too little, and it turns out they’re not alone. By some estimates, half of U.S. residents 65 and older have no dental insurance.
That’s actually not a bad option, said Mertz, given the cost of insurance premiums and co-pays, along with the caps. And even if you’ve got insurance, a lot of dentists don’t accept it because the reimbursements have stagnated as their costs have spiked.
But without insurance, a lot of people simply don’t go to the dentist until they have to, and that can be dangerous.
“Dental problems are very clearly associated with diabetes,” as well as heart problems and other health issues, said Paul Glassman, associate dean of the California Northstate University dentistry school.
There is one other option, and Mertz referred to it as dental tourism, saying that Mexico and Costa Rica are popular destinations for U.S. residents.
“You can get a week’s vacation and dental work and still come out ahead of what you’d be paying in the U.S.,” she said.
Tijuana dentist Dr. Oscar Ceballos told me that roughly 80% of his patients are from north of the border, and come from as far away as Florida, Wisconsin and Alaska. He has patients in their 80s and 90s who have been returning for years because in the U.S. their insurance was expensive, the coverage was limited and out-of-pocket expenses were unaffordable.
“For example, a dental implant in California is around $3,000-$5,000,” Ceballos said. At his office, depending on the specifics, the same service “is like $1,500 to $2,500.” The cost is lower because personnel, office rent and other overhead costs are cheaper than in the U.S., Ceballos said.
As we spoke by phone, Ceballos peeked into his waiting room and said three patients were from the U.S. He handed his cellphone to one of them, San Diegan John Lane, who said he’s been going south of the border for nine years.
“The primary reason is the quality of the care,” said Lane, who told me he refers to himself as 39, “with almost 40 years of additional” time on the clock.
Ceballos is “conscientious and he has facilities that are as clean and sterile and as medically up to date as anything you’d find in the U.S.,” said Lane, who had driven his wife down from San Diego for a new crown.
“The cost is 50% less than what it would be in the U.S.,” said Lane, and sometimes the savings is even greater than that.
Come this summer, Lane may be seeing even more Californians in Ceballos’ waiting room.
“Proposed funding cuts to the Medi-Cal Dental program would have devastating impacts on our state’s most vulnerable residents,” said dentist Robert Hanlon, president of the California Dental Assn.
Dental student Somkene Okwuego smiles after completing her work on patient Jimmy Stewart, 83, who receives affordable dental work at the Ostrow School of Dentistry of USC on the USC campus in Los Angeles on February 26, 2026.
(Genaro Molina / Los Angeles Times)
Under Proposition 56’s tobacco tax in 2016, supplemental reimbursements to dentists have been in place, but those increases could be wiped out under a budget-cutting proposal. Only about 40% of the state’s dentists accept Medi-Cal payments as it is, and Hanlon told me a CDA survey indicates that half would stop accepting Medi-Cal patients and many others will accept fewer patients.
“It’s appalling that when the cost of providing healthcare is at an all-time high, the state is considering cutting program funding back to 1990s levels,” Hanlon said. “These cuts … will force patients to forgo or delay basic dental care, driving completely preventable emergencies into already overcrowded emergency departments.”
Somkene Okwuego, who as a child in South L.A. was occasionally a patient at USC’s Herman Ostrow School of Dentistry clinic, will graduate from the school in just a few months.
I first wrote about Okwuego three years ago, after she got an undergrad degree in gerontology, and she told me a few days ago that many of her dental patients are elderly and have Medi-Cal or no insurance at all. She has also worked at a Skid Row dental clinic, and plans after graduation to work at a clinic where dental care is free or discounted.
Okwuego said “fixing the smiles” of her patients is a privilege and boosts their self-image, which can help “when they’re trying to get jobs.” When I dropped by to see her Thursday, she was with 83-year-old patient Jimmy Stewart.
Stewart, an Army veteran, told me he had trouble getting dental care at the VA and had gone years without seeing a dentist before a friend recommended the Ostrow clinic. He said he’s had extractions and top-quality restorative care at USC, with the work covered by his Medi-Cal insurance.
I told Stewart there could be some Medi-Cal cuts in the works this summer.
“I’d be screwed,” he said.
Him and a lot of other people.
steve.lopez@latimes.com
Science
Diablo Canyon clears last California permit hurdle to keep running
Central Coast Water authorities approved waste discharge permits for Diablo Canyon nuclear plant Thursday, making it nearly certain it will remain running through 2030, and potentially through 2045.
The Pacific Gas & Electric-owned plant was originally supposed to shut down in 2025, but lawmakers extended that deadline by five years in 2022, fearing power shortages if a plant that provides about 9 percent the state’s electricity were to shut off.
In December, Diablo Canyon received a key permit from the California Coastal Commission through an agreement that involved PG&E giving up about 12,000 acres of nearby land for conservation in exchange for the loss of marine life caused by the plant’s operations.
Today’s 6-0 vote by the Central Coast Regional Water Board approved PG&E’s plans to limit discharges of pollutants into the water and continue to run its “once-through cooling system.” The cooling technology flushes ocean water through the plant to absorb heat and discharges it, killing what the Coastal Commission estimated to be two billion fish each year.
The board also granted the plant a certification under the Clean Water Act, the last state regulatory hurdle the facility needed to clear before the federal Nuclear Regulatory Commission (NRC) is allowed to renew its permit through 2045.
The new regional water board permit made several changes since the last one was issued in 1990. One was a first-time limit on the chemical tributyltin-10, a toxic, internationally-banned compound added to paint to prevent organisms from growing on ship hulls.
Additional changes stemmed from a 2025 Supreme Court ruling that said if pollutant permits like this one impose specific water quality requirements, they must also specify how to meet them.
The plant’s biggest water quality impact is the heated water it discharges into the ocean, and that part of the permit remains unchanged. Radioactive waste from the plant is regulated not by the state but by the NRC.
California state law only allows the plant to remain open to 2030, but some lawmakers and regulators have already expressed interest in another extension given growing electricity demand and the plant’s role in providing carbon-free power to the grid.
Some board members raised concerns about granting a certification that would allow the NRC to reauthorize the plant’s permits through 2045.
“There’s every reason to think the California entities responsible for making the decision about continuing operation, namely the California [Independent System Operator] and the Energy Commission, all of them are sort of leaning toward continuing to operate this facility,” said boardmember Dominic Roques. “I’d like us to be consistent with state law at least, and imply that we are consistent with ending operation at five years.”
Other board members noted that regulators could revisit the permits in five years or sooner if state and federal laws changes, and the board ultimately approved the permit.
Science
Deadly bird flu found in California elephant seals for the first time
The H5N1 bird flu virus that devastated South American elephant seal populations has been confirmed in seals at California’s Año Nuevo State Park, researchers from UC Davis and UC Santa Cruz announced Wednesday.
The virus has ravaged wild, commercial and domestic animals across the globe and was found last week in seven weaned pups. The confirmation came from the U.S. Department of Agriculture’s National Veterinary Services Laboratory in Ames, Iowa.
“This is exceptionally rapid detection of an outbreak in free-ranging marine mammals,” said Professor Christine Johnson, director of the Institute for Pandemic Insights at UC Davis’ Weill School of Veterinary Medicine. “We have most likely identified the very first cases here because of coordinated teams that have been on high alert with active surveillance for this disease for some time.”
Since last week, when researchers began noticing neurological and respoiratory signs of the disease in some animals, 30 seals have died, said Roxanne Beltran, a professor of ecology and evolutionary biology at UC Santa Cruz. Twenty-nine were weaned pups and the other was an adult male. The team has so far confirmed the virus in only seven of the dead pups.
Infected animals often have tremors convulsions, seizures and muscle weakness, Johnson said.
Beltran said teams from UC Santa Cruz, UC Davis and California State Parks monitor the animals 260 days of the year, “including every day from December 15 to March 1” when the animals typically come ashore to breed, give birth and nurse.
The concerning behavior and deaths were first noticed Feb. 19.
“This is one of the most well-studied elephant seal colonies on the planet,” she said. “We know the seals so well that it’s very obvious to us when something is abnormal. And so my team was out that morning and we observed abnormal behaviors in seals and increased mortality that we had not seen the day before in those exact same locations. So we were very confident that we caught the beginning of this outbreak.”
In late 2022, the virus decimated southern elephant seal populations in South America and several sub-Antarctic Islands. At some colonies in Argentina, 97% of pups died, while on South Georgia Island, researchers reported a 47% decline in breeding females between 2022 and 2024. Researchers believe tens of thousands of animals died.
More than 30,000 sea lions in Peru and Chile died between 2022 and 2024. In Argentina, roughly 1,300 sea lions and fur seals perished.
At the time, researchers were not sure why northern Pacific populations were not infected, but suspected previous or milder strains of the virus conferred some immunity.
The virus is better known in the U.S. for sweeping through the nation’s dairy herds, where it infected dozens of dairy workers, millions of cows and thousands of wild, feral and domestic mammals. It’s also been found in wild birds and killed millions of commercial chickens, geese and ducks.
Two Americans have died from the virus since 2024, and 71 have been infected. The vast majority were dairy or commercial poultry workers. One death was that of a Louisiana man who had underlying conditions and was believed to have been exposed via backyard poultry or wild birds.
Scientists at UC Santa Cruz and UC Davis increased their surveillance of the elephant seals in Año Nuevo in recent years. The catastrophic effect of the disease prompted worry that it would spread to California elephant seals, said Beltran, whose lab leads UC Santa Cruz’s northern elephant seal research program at Año Nuevo.
Johnson, the UC Davis researcher, said the team has been working with stranding networks across the Pacific region for several years — sampling the tissue of birds, elephant seals and other marine mammals. They have not seen the virus in other California marine mammals. Two previous outbreaks of bird flu in U.S. marine mammals occurred in Maine in 2022 and Washington in 2023, affecting gray and harbor seals.
The virus in the animals has not yet been fully sequenced, so it’s unclear how the animals were exposed.
“We think the transmission is actually from dead and dying sea birds” living among the sea lions, Johnson said. “But we’ll certainly be investigating if there’s any mammal-to-mammal transmission.”
Genetic sequencing from southern elephant seal populations in Argentina suggested that version of the virus had acquired mutations that allowed it to pass between mammals.
The H5N1 virus was first detected in geese in China in 1996. Since then it has spread across the globe, reaching North America in 2021. The only continent where it has not been detected is Oceania.
Año Nuevo State Park, just north of Santa Cruz, is home to a colony of some 5,000 elephant seals during the winter breeding season. About 1,350 seals were on the beach when the outbreak began. Other large California colonies are located at Piedras Blancas and Point Reyes National Sea Shore. Most of those animals — roughly 900 — are weaned pups.
It’s “important to keep this in context. So far, avian influenza has affected only a small proportion of the weaned at this time, and there are still thousands of apparently healthy animals in the population,” Beltran said in a press conference.
Public access to the park has been closed and guided elephant seal tours canceled.
Health and wildlife officials urge beachgoers to keep a safe distance from wildlife and keep dogs leashed because the virus is contagious.
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