Science
New Vaccine Findings Pose Tough Questions for Parents of Young Children
For American dad and mom, significantly these with younger youngsters, the final couple of months have been dizzying and past irritating.
In early February, federal regulators introduced that they’d consider Pfizer-BioNTech’s coronavirus vaccine for the youngest youngsters — solely to scrap that plan 10 days later, citing doubts concerning the vaccine’s effectiveness in that age group.
Quickly after, scientists reported that the vaccine was solely weakly protecting towards an infection with the Omicron variant amongst youngsters aged 5 to 11 and that it appeared to supply little protection towards average Covid sickness amongst adolescents aged 12 to 17.
On Monday, citing these information, Florida’s surgeon basic declared that wholesome youngsters needn’t be immunized, recommendation that Jen Psaki, the White Home press secretary, referred to as “deeply disturbing.”
By all of it, specialists have continued to endorse vaccines, noting that whereas the Omicron variant could possibly penetrate immune defenses and infect individuals, the vaccines nonetheless stop extreme sickness and dying — and will accomplish that for years.
The Facilities for Illness Management and Prevention discovered that file numbers of youngsters below 5 had been hospitalized throughout the Omicron surge, underscoring the necessity for vaccines for these youngsters. However the company has since stated that 90 % of People can safely cease carrying masks in public indoor areas, even in faculties with younger youngsters.
Who may blame dad and mom for feeling bewildered?
“The half that’s complicated is like there’s not any clear, proper reply,” stated Anne Gonzalez, a 41-year-old mom of two who manages volunteers for a big non secular nonprofit in St. Louis. “I’ve come to the purpose that each one I can do is what I believe is true for my household.”
Thankfully, the approaching weeks ought to carry some readability. Each Pfizer and Moderna plan to report outcomes from trials of their vaccines in younger youngsters. The outcomes, if optimistic, ought to result in a brand new spherical of regulatory overview, maybe as early as April, that will properly enable vaccinations for tens of hundreds of thousands of kids.
However these findings will arrive because the Omicron variant fades in the US, complicating parental selections about whether or not to vaccinate youngsters.
Fewer than one in 4 youngsters aged 5 to 11 at the moment are totally vaccinated. Greater than half of adolescents 12 to 17 are totally vaccinated, however solely about 12 % have obtained a booster dose. These percentages are even decrease in rural areas of the US.
Youngsters are much less prone to expertise sickness, so the stability of threat and profit was by no means the identical as for adults. And by now, as a lot as 95 % of the nation has a point of safety from the virus due to vaccines or prior an infection, in response to latest information from the C.D.C.
Consultants fear that the newest findings have made it much more difficult to influence some dad and mom to immunize their youngsters.
“We must be upset with the info — we want it may very well be higher,” stated Luciana Borio, a former appearing chief scientist on the Meals and Drug Administration. “However within the close to time period, it’s essential for fogeys to nonetheless vaccinate youngsters.”
The nation should see a surge within the fall or winter, and the perfect safety for kids might be to have had a minimum of two photographs earlier than then, she stated.
The vaccines are persevering with to stop extreme illness and dying, even with the Omicron variant. That pattern is especially clear at hospitals, stated Dr. James Campbell, a doctor on the College of Maryland Faculty of Drugs and a member of the American Academy of Pediatrics committee on infectious illnesses.
Amongst his pediatric sufferers who have been sick sufficient to wish a mechanical ventilator or die, “each single certainly one of them was unvaccinated,” Dr. Campbell stated.
A Dosing Conundrum
The latest research recommend that the issue shouldn’t be a lot the vaccine because the dose.
Within the trials in adults in 2020, vaccine producers made finest guesses on the proper dose and opted for brief intervals between the photographs to guard individuals as rapidly as doable throughout the preliminary surge.
The Pfizer-BioNTech and Moderna vaccines proved to be protected and powerfully protecting in scientific trials and have been speedily licensed to be used. However the trials in youngsters have been sophisticated by the arrival of the Delta and Omicron variants, and the vaccine seemed to be much less protecting in youngsters aged 2 to 4.
For the time being, the Pfizer-BioNTech vaccine is the one one licensed for kids. (The vaccines made by Moderna and Johnson & Johnson are licensed just for adults.)
Within the Pfizer trials, adolescents aged 12 to 17 got 30 micrograms, the identical dose given to adults. However youngsters aged 5 to 11 obtained 10 micrograms, and people 6 months to five years previous obtained simply three micrograms.
These doses might have been too low to evoke an enough and lasting response. However federal officers who’ve seen the info instructed The New York Occasions that increased doses produced too many fevers in youngsters.
What to do when you possibly can’t administer a dose excessive sufficient to defend youngsters towards the Omicron variant due to negative effects? That’s the issue that scientists and federal officers at the moment are wrestling with.
Pfizer and BioNTech at the moment are testing a 3rd dose in youngsters below 12 to find out whether or not it may ship the extent of safety that two doses couldn’t. The F.D.A. continues to be evaluating the Moderna vaccine to be used in youngsters 6 to 11. Final week, the company rejected an utility for authorization of the Indian-made vaccine Covaxin for kids.
There are different Covid vaccines, like these made by Novavax and Sanofi, that will end up to work properly in youngsters. Federal well being officers ought to think about all of those choices and take a look at whether or not a unique dose or an extended interval between doses would enhance the immune response, specialists stated.
“It appears to me that vaccines for kids are taking longer than they need to, given the significance of defending that inhabitants,” Dr. Borio stated. “The earlier we re-energize our seek for protected and efficient vaccines for kids, the higher off we’ll be.”
Masks in Faculties
The disappointing findings, together with the receding Omicron surge, have drastically sophisticated coverage selections for native well being officers.
Countering Florida’s suggestions, Louisiana and California would require schoolchildren to be immunized by fall 2022, and the District of Columbia set a deadline of March 1 for college students 12 and older to be totally vaccinated.
Different states might undertake comparable insurance policies however are probably to take action provided that the F.D.A. grants the vaccine full approval to be used in schoolchildren, stated Hemi Tewarson, govt director on the Nationwide Academy for State Well being Coverage, a nonpartisan group.
“For lots of them, that’s going to be key for requiring vaccines as a mandate,” she stated.
A faculty vaccine mandate would ease the fears of many households with youngsters who’ve medical vulnerabilities.
Practically each member of Heather Keever’s household, together with her son, Wesley, 14, has coronary heart illness, hypertension and kidney illness. However as a result of they aren’t technically immunocompromised, they haven’t certified for lodging at work or in school, stated Ms. Keever, 42, a marketing consultant in suburban Chicago.
“They neglect that there’s a few of us who simply actually can’t take the masks off,” a minimum of till the charges fall a lot additional, she stated. “I felt like I didn’t matter and I wasn’t essential and I used to be arguably disposable. And I nonetheless do.”
Some scientists, too, have stated they’d proceed to put on masks till the numbers dip due to the chance of an infection.
As a result of the youngest youngsters haven’t but been vaccinated, “I’d be very hesitant to ask a toddler under 5 to take away masks indoors,” stated Akiko Iwasaki, an immunologist at Yale College who research lengthy Covid, the cluster of signs that may persist lengthy after the acute an infection is resolved.
Given the muddled outcomes on the effectiveness of vaccines and the blended messages on the advantages of masks, households are weighing dangers on their very own — and coming to very totally different conclusions.
Jennifer Steinberg, a administration marketing consultant in Wilmington, Del., has two daughters who break up their time together with her and their immunocompromised father.
“Sure, nice, it protects towards extreme sickness,” Ms. Steinberg stated of the vaccine. “But when your youngsters are nonetheless going to get contaminated, this can be a enormous disruption to household lives. I’m in all probability going to remain masked for the foreseeable future.”
Katie Sunderland of Arlington, Va., has lengthy been prepared to surrender masks. If her youngsters, 7 and 5, do grow to be contaminated, “that’s a trade-off I’m OK with if they’re able to unmask and see faces,” she stated.
“I’m not satisfied that carrying a masks would considerably scale back the chance of getting Covid anyway — particularly not the kind of masks I see most youngsters carrying,” Ms. Sunderland, 37, stated. “It doesn’t make sense to me to impede my youngsters’ growth for that very, very, very low threat.”
However many different dad and mom are nonetheless not sure of what to do. Ms. Gonzalez has a niece and nephew who’ve congenital coronary heart defects and issues with lung capability, and she’s going to proceed to put on masks to guard them, she stated.
But when her son’s college drops the masks requirement, “we don’t know what we’re going do but.”
Science
FDA sets limits for lead in many baby foods as California disclosure law takes effect
The U.S. Food and Drug Administration this week set maximum levels for lead in baby foods such as jarred fruits and vegetables, yogurts and dry cereal, part of an effort to cut young kids’ exposure to the toxic metal that causes developmental and neurological problems.
The agency issued final guidance that it estimated could reduce lead exposure from processed baby foods by about 20% to 30%. The limits are voluntary, not mandatory, for food manufacturers, but they allow the FDA to take enforcement action if foods exceed the levels.
It’s part of the FDA’s ongoing effort to “reduce dietary exposure to contaminants, including lead, in foods to as low as possible over time, while maintaining access to nutritious foods,” the agency said in a statement.
Consumer advocates, who have long sought limits on lead in children’s foods, welcomed the guidance first proposed two years ago, but said it didn’t go far enough.
“FDA’s actions today are a step forward and will help protect children,” said Thomas Galligan, a scientist with the Center for Science in the Public Interest. “However, the agency took too long to act and ignored important public input that could have strengthened these standards.”
The new limits on lead for children younger than 2 don’t cover grain-based snacks such as puffs and teething biscuits, which some research has shown contain higher levels of lead. And they don’t limit other metals such as cadmium that have been detected in baby foods.
The FDA’s announcement comes just one week after a new California law took effect that requires baby food makers selling products in California to provide a QR code on their packaging to take consumers to monthly test results for the presence in their product of four heavy metals: lead, mercury, arsenic and cadmium.
The change, required under a law passed by the California Legislature in 2023, will affect consumers nationwide. Because companies are unlikely to create separate packaging for the California market, QR codes are likely to appear on products sold across the country, and consumers everywhere will be able to view the heavy metal concentrations.
Although companies are required to start printing new packaging and publishing test results of products manufactured beginning in January, it may take time for the products to hit grocery shelves.
The law was inspired by a 2021 congressional investigation that found dangerously high levels of heavy metals in packaged foods marketed for babies and toddlers. Baby foods and their ingredients had up to 91 times the arsenic level, up to 177 times the lead level, up to 69 times the cadmium level, and up to five times the mercury level that the U.S. allows to be present in bottled or drinking water, the investigation found.
There’s no safe level of lead exposure for children, according to the U.S. Centers for Disease Control and Prevention. The metal causes “well-documented health effects,” including brain and nervous system damage and slowed growth and development. However, lead occurs naturally in some foods and comes from pollutants in air, water and soil, which can make it impossible to eliminate entirely.
The FDA guidance sets a lead limit of 10 parts per billion for fruits, most vegetables, grain and meat mixtures, yogurts, custards and puddings and single-ingredient meats. It sets a limit of 20 parts per billion for single-ingredient root vegetables and for dry infant cereals. The guidance covers packaged processed foods sold in jars, pouches, tubs or boxes.
Jaclyn Bowen, executive director of the Clean Label Project, an organization that certifies baby foods as having low levels of toxic substances, said consumers can use the new FDA guidance in tandem with the new California law: The FDA, she said, has provided parents a “hard and fast number” to consider a benchmark when looking at the new monthly test results.
But Brian Ronholm, director of food policy for Consumer Reports, called the FDA limits “virtually meaningless because they’re based more on industry feasibility and not on what would best protect public health.” A product with a lead level of 10 parts per billion is “still too high for baby food. What we’ve heard from a lot of these manufacturers is they are testing well below that number.”
The new FDA guidance comes more than a year after lead-tainted pouches of apple cinnamon puree sickened more than 560 children in the U.S. between October 2023 and April 2024, according to the CDC.
The levels of lead detected in those products were more than 2,000 times higher than the FDA’s maximum. Officials stressed that the agency doesn’t need guidance to take action on foods that violate the law.
Aleccia writes for the Associated Press. Gold reports for The Times’ early childhood education initiative, focusing on the learning and development of California children from birth to age 5. For more information about the initiative and its philanthropic funders, go to latimes.com/earlyed.
Science
NASA punts Mars Sample Return decision to the next administration
Anyone hoping for a clear path forward this year for NASA’s imperiled Mars Sample Return mission will have to wait a little longer.
The agency has settled on two potential strategies for the first effort to bring rock and soil from another planet back to Earth for study, NASA Administrator Bill Nelson said Tuesday: It can either leverage existing technology into a simpler, cheaper craft or turn to a commercial partner for a new design.
But the final decision on the mission’s structure — or whether it should proceed at all — “is going to be a function of the new administration,” Nelson said. President-elect Donald Trump will take office Jan. 20.
“I don’t think we want the only [Mars] sample return coming back on a Chinese spacecraft,” Nelson said, referencing a rival mission that Beijing has in the works. “I think that the [Trump] administration will certainly conclude that they want to proceed. So what we wanted to do was to give them the best possible options so that they can go from there.”
The call also contained words of encouragement for NASA’s Jet Propulsion Laboratory in La Cañada Flintridge, which leads the embattled mission’s engineering efforts.
“To put it really bluntly, JPL is our Mars center in NASA science,” said Nicky Fox, associate administrator of the Science Mission Directorate. “They are the people who landed us on Mars, together with our industry partners. So they will be moving forward, regardless of which path, with a key role in the Mars Sample Return.”
In April, after an independent review found “near zero probability” of Mars Sample Return making its proposed 2028 launch date, NASA put out a request for alternative proposals to all of its centers and the private sector. JPL was forced to compete for what had been its own project.
The independent review board determined that the original design would probably cost up to $11 billion and not return samples to Earth until at least 2040.
“That was just simply unacceptable,” said Nelson, who paused the mission in late 2023 to review its chances of success.
Ensuing cuts to the mission’s budget forced a series of layoffs at JPL, which let go of 855 employees and 100 on-site contractors in 2024.
The NASA-led option that Nelson suggested Tuesday includes several elements from the JPL proposal, according to a person who reviewed the documents. This leaner, simpler alternative will cost between $6.6 billion and $7.7 billion, and will return the samples by 2039, he said. A commercial alternative would probably cost $5.8 billion to $7.1 billion.
Nelson, a former Democratic U.S. senator from Florida, will step down as head of the space agency when Trump takes office. Trump has nominated as his successor Jared Isaacman, a tech billionaire who performed the first private space walk, who must be confirmed by the Senate.
NASA has not had any conversations with Trump’s transition team about Mars Sample Return, Nelson said. How the new administration will prioritize the project is not yet clear.
“It’s very uncertain how the new administration will go forward,” said Casey Dreier, chief of space policy for the Planetary Society, a Pasadena nonprofit that promotes space research. “Cancellation is obviously still on the table. … It’s hard to game this out.”
Planetary scientists have identified Mars Sample Return as their field’s highest priority in the last three decadal surveys, reports that the National Academies of Sciences, Engineering, and Medicine prepare every 10 years in order to advise NASA.
Successfully completing the mission is “key for the nation’s leadership in space science,” said Bethany L. Ehlmann, a planetary scientist at Caltech in Pasadena. “I hope the incoming administrator moves forward decisively to select a plan and execute. There are extraordinary engineers at JPL and NASA industry partners eager and able to get to work to make it happen.”
Science
Panama Canal’s Expansion Opened Routes for Fish to Relocate
Night fell as the two scientists got to work, unfurling long nets off the end of their boat. The jungle struck up its evening symphony: the sweet chittering of insects, the distant bellowing of monkeys, the occasional screech of a kite. Crocodiles lounged in the shallows, their eyes glinting when headlamps were shined their way.
Across the water, cargo ships made dark shapes as they slid between the seas.
The Panama Canal has for more than a century connected far-flung peoples and economies, making it an essential artery for global trade — and, in recent weeks, a target of President-elect Donald J. Trump’s expansionist designs.
But of late the canal has been linking something else, too: the immense ecosystems of the Atlantic and the Pacific.
The two oceans have been separated for some three million years, ever since the isthmus of Panama rose out of the water and split them. The canal cut a path through the continent, yet for decades only a handful of marine fish species managed to migrate through the waterway and the freshwater reservoir, Lake Gatún, that feeds its locks.
Then, in 2016, Panama expanded the canal to allow supersize ships, and all that started to change.
In less than a decade, fish from both oceans — snooks, jacks, snappers and more — have almost entirely displaced the freshwater species that were in the canal system before, scientists with the Smithsonian Tropical Research Institute in Panama have found. Fishermen around Lake Gatún who rely on those species, chiefly peacock bass and tilapia, say their catches are growing scarce.
Researchers now worry that more fish could start making their way through from one ocean to the other. And no potential invader causes more concern than the venomous, candy-striped lionfish. They are known to inhabit Panama’s Caribbean coast, but not the eastern Pacific. If they made it there through the canal, they could ravage the defenseless local fish, just as they’ve done in the Gulf of Mexico and the Caribbean.
Already, marine species are more than occasional visitors in Lake Gatún, said Phillip Sanchez, a fisheries ecologist with the Smithsonian. They’re “becoming the dominant community,” he said. They’re “pushing everything else out.”
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