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New ‘Deltacron’ Variant Is Rare and Similar to Omicron, Experts Say

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New ‘Deltacron’ Variant Is Rare and Similar to Omicron, Experts Say

In latest days, scientists have reported {that a} hybrid of the Omicron and Delta coronavirus variants has been popping up in a number of international locations in Europe. Right here’s what is thought up to now concerning the hybrid, which has picked up the Frankensteinian nicknames of Deltamicron or Deltacron.

In February, Scott Nguyen, a scientist with the Washington, D.C., Public Well being Laboratory, was inspecting GISAID, a global database of coronavirus genomes, when he observed one thing odd.

He discovered samples collected in France in January that researchers had recognized as a mixture of Delta and Omicron variants. In uncommon instances, folks will be contaminated by two coronavirus variants directly. However when Dr. Nguyen appeared carefully on the information, he discovered hints that this conclusion was mistaken.

As a substitute, it appeared to Dr. Nguyen as if every virus within the pattern truly carried a mixture of genes from the 2 variants. Scientists name such viruses recombinants. When Dr. Nguyen appeared for a similar sample of mutations, he discovered extra doable recombinants within the Netherlands and Denmark. “That led me to suspect that these may be actual,” he stated in an interview.

Dr. Nguyen shared his findings in an internet discussion board known as cov-lineages, the place scientists assist each other monitor new variants. These collaborations are important to double-check doable new variants: A supposed Delta-Omicron recombinant present in January in Cyprus turned out to be a mirage ensuing from defective laboratory work.

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“There’s numerous proof that’s wanted to indicate that it’s actual,” Dr. Nguyen stated.

It turned out that Dr. Nguyen had been proper.

“That day, we rushed to double-check what he suspected,” Etienne Simon-Loriere, a virologist on the Institut Pasteur in Paris, stated in an interview. “And, yeah, we shortly confirmed that it was the case.”

Since then, Dr. Simon-Loriere and his colleagues have discovered extra samples of the recombinant virus. They ultimately obtained a frozen pattern from which they efficiently grew new recombinants within the laboratory, which they’re now learning. On March 8, the researchers posted the primary genome of the recombinant on GISAID.

In a March 10 replace, a global database of viral sequences reported 33 samples of the brand new variant in France, eight in Denmark, one in Germany and one within the Netherlands.

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As first reported by Reuters, the genetic sequencing firm Helix discovered two instances in the US. Dr. Nguyen stated he and his colleagues have been taking a contemporary have a look at some database sequences from the US in an effort to seek out extra instances.

The considered a hybrid between Delta and Omicron would possibly sound worrisome. However there are a variety of causes to not panic.

“This isn’t a novel concern,” Dr. Simon-Loriere stated.

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For one factor, the recombinant is extraordinarily uncommon. Though it has existed since not less than January, it has not but proven the flexibility to develop exponentially.

Dr. Simon-Loriere stated that the genome of the recombinant variant additionally instructed that it wouldn’t signify a brand new part of the pandemic. The gene that encodes the virus’s floor protein — often known as spike — comes virtually solely from Omicron. The remainder of the genome is Delta.

The spike protein is an important a part of the virus with regards to invading cells. It is usually the primary goal of antibodies produced by way of infections and vaccines. So the defenses that individuals have acquired towards Omicron — by way of infections, vaccines or each — ought to work simply as properly towards the brand new recombinant.

“The floor of the viruses is super-similar to Omicron, so the physique will acknowledge it in addition to it acknowledges Omicron,” Dr. Simon-Loriere stated.

Scientists suspect that Omicron’s distinctive spike can also be partly answerable for its decrease odds of inflicting extreme illness. The variant makes use of it to efficiently invade cells within the nostril and the higher airway, however it doesn’t accomplish that properly deep within the lungs. The brand new recombinant might show the identical penchant.

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Dr. Simon-Loriere and different researchers are conducting experiments to see how the brand new recombinant performs in dishes of cells. Experiments on hamsters and mice will present extra clues. However these experiments received’t yield insights for a number of weeks.

“It’s so contemporary that we don’t have any outcomes,” Dr. Simon-Loriere stated.

Individuals are generally contaminated with two variations of the coronavirus directly. For instance, for those who go to a crowded bar the place a number of persons are contaminated, you would possibly breathe in viruses from a couple of of them.

It’s doable for 2 viruses to invade the identical cell on the similar time. When that cell begins producing new viruses, the brand new genetic materials could also be combined up, probably producing a brand new, hybrid virus.

It’s most likely not unusual for coronaviruses to recombine. However most of those genetic shuffles might be evolutionary useless ends. Viruses with mixtures of genes might not fare in addition to their ancestors did.

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For now, some scientists are referring to the brand new hybrid because the AY.4/BA.1 recombinant. That may most likely change within the weeks to return.

A coalition of scientists has give you a system for formally naming new lineages of coronaviruses. They offer recombinant viruses a two-letter abbreviation beginning with X. XA, for instance, is a hybrid that arose in December 2020 from a mix of the Alpha variant and one other lineage of coronaviruses known as B.1.177.

It’s probably that Dr. Nguyen’s new recombinant might be designated XD.

However on March 8, this course of turned muddled when a second staff of French researchers posted a examine on-line with their very own evaluation of the identical recombinant. Like Dr. Simon-Loriere and his colleagues, they remoted the virus. However within the title of their examine, which has not been printed but in a scientific journal, they known as it Deltamicron.

Dr. Nguyen criticized the staff for not crediting Dr. Simon-Loriere’s staff for initially sharing the primary recombinant virus genomes. He additionally criticized the scientists for unleashing lurid nicknames for the recombinant that have been instantly picked up in information articles and social media posts claiming that it was a hoax or had been produced in a lab.

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“These unconventional names are stirring a hornet’s nest of conspiracy theories,” Dr. Nguyen stated.

It stays to be seen how properly the title XD sticks.

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FDA sets limits for lead in many baby foods as California disclosure law takes effect

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FDA sets limits for lead in many baby foods as California disclosure law takes effect

The U.S. Food and Drug Administration this week set maximum levels for lead in baby foods such as jarred fruits and vegetables, yogurts and dry cereal, part of an effort to cut young kids’ exposure to the toxic metal that causes developmental and neurological problems.

The agency issued final guidance that it estimated could reduce lead exposure from processed baby foods by about 20% to 30%. The limits are voluntary, not mandatory, for food manufacturers, but they allow the FDA to take enforcement action if foods exceed the levels.

It’s part of the FDA’s ongoing effort to “reduce dietary exposure to contaminants, including lead, in foods to as low as possible over time, while maintaining access to nutritious foods,” the agency said in a statement.

Consumer advocates, who have long sought limits on lead in children’s foods, welcomed the guidance first proposed two years ago, but said it didn’t go far enough.

“FDA’s actions today are a step forward and will help protect children,” said Thomas Galligan, a scientist with the Center for Science in the Public Interest. “However, the agency took too long to act and ignored important public input that could have strengthened these standards.”

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The new limits on lead for children younger than 2 don’t cover grain-based snacks such as puffs and teething biscuits, which some research has shown contain higher levels of lead. And they don’t limit other metals such as cadmium that have been detected in baby foods.

The FDA’s announcement comes just one week after a new California law took effect that requires baby food makers selling products in California to provide a QR code on their packaging to take consumers to monthly test results for the presence in their product of four heavy metals: lead, mercury, arsenic and cadmium.

The change, required under a law passed by the California Legislature in 2023, will affect consumers nationwide. Because companies are unlikely to create separate packaging for the California market, QR codes are likely to appear on products sold across the country, and consumers everywhere will be able to view the heavy metal concentrations.

Although companies are required to start printing new packaging and publishing test results of products manufactured beginning in January, it may take time for the products to hit grocery shelves.

The law was inspired by a 2021 congressional investigation that found dangerously high levels of heavy metals in packaged foods marketed for babies and toddlers. Baby foods and their ingredients had up to 91 times the arsenic level, up to 177 times the lead level, up to 69 times the cadmium level, and up to five times the mercury level that the U.S. allows to be present in bottled or drinking water, the investigation found.

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There’s no safe level of lead exposure for children, according to the U.S. Centers for Disease Control and Prevention. The metal causes “well-documented health effects,” including brain and nervous system damage and slowed growth and development. However, lead occurs naturally in some foods and comes from pollutants in air, water and soil, which can make it impossible to eliminate entirely.

The FDA guidance sets a lead limit of 10 parts per billion for fruits, most vegetables, grain and meat mixtures, yogurts, custards and puddings and single-ingredient meats. It sets a limit of 20 parts per billion for single-ingredient root vegetables and for dry infant cereals. The guidance covers packaged processed foods sold in jars, pouches, tubs or boxes.

Jaclyn Bowen, executive director of the Clean Label Project, an organization that certifies baby foods as having low levels of toxic substances, said consumers can use the new FDA guidance in tandem with the new California law: The FDA, she said, has provided parents a “hard and fast number” to consider a benchmark when looking at the new monthly test results.

But Brian Ronholm, director of food policy for Consumer Reports, called the FDA limits “virtually meaningless because they’re based more on industry feasibility and not on what would best protect public health.” A product with a lead level of 10 parts per billion is “still too high for baby food. What we’ve heard from a lot of these manufacturers is they are testing well below that number.”

The new FDA guidance comes more than a year after lead-tainted pouches of apple cinnamon puree sickened more than 560 children in the U.S. between October 2023 and April 2024, according to the CDC.

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The levels of lead detected in those products were more than 2,000 times higher than the FDA’s maximum. Officials stressed that the agency doesn’t need guidance to take action on foods that violate the law.

Aleccia writes for the Associated Press. Gold reports for The Times’ early childhood education initiative, focusing on the learning and development of California children from birth to age 5. For more information about the initiative and its philanthropic funders, go to latimes.com/earlyed.

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NASA punts Mars Sample Return decision to the next administration

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NASA punts Mars Sample Return decision to the next administration

Anyone hoping for a clear path forward this year for NASA’s imperiled Mars Sample Return mission will have to wait a little longer.

The agency has settled on two potential strategies for the first effort to bring rock and soil from another planet back to Earth for study, NASA Administrator Bill Nelson said Tuesday: It can either leverage existing technology into a simpler, cheaper craft or turn to a commercial partner for a new design.

But the final decision on the mission’s structure — or whether it should proceed at all — “is going to be a function of the new administration,” Nelson said. President-elect Donald Trump will take office Jan. 20.

“I don’t think we want the only [Mars] sample return coming back on a Chinese spacecraft,” Nelson said, referencing a rival mission that Beijing has in the works. “I think that the [Trump] administration will certainly conclude that they want to proceed. So what we wanted to do was to give them the best possible options so that they can go from there.”

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The call also contained words of encouragement for NASA’s Jet Propulsion Laboratory in La Cañada Flintridge, which leads the embattled mission’s engineering efforts.

“To put it really bluntly, JPL is our Mars center in NASA science,” said Nicky Fox, associate administrator of the Science Mission Directorate. “They are the people who landed us on Mars, together with our industry partners. So they will be moving forward, regardless of which path, with a key role in the Mars Sample Return.”

In April, after an independent review found “near zero probability” of Mars Sample Return making its proposed 2028 launch date, NASA put out a request for alternative proposals to all of its centers and the private sector. JPL was forced to compete for what had been its own project.

The independent review board determined that the original design would probably cost up to $11 billion and not return samples to Earth until at least 2040.

“That was just simply unacceptable,” said Nelson, who paused the mission in late 2023 to review its chances of success.

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Ensuing cuts to the mission’s budget forced a series of layoffs at JPL, which let go of 855 employees and 100 on-site contractors in 2024.

The NASA-led option that Nelson suggested Tuesday includes several elements from the JPL proposal, according to a person who reviewed the documents. This leaner, simpler alternative will cost between $6.6 billion and $7.7 billion, and will return the samples by 2039, he said. A commercial alternative would probably cost $5.8 billion to $7.1 billion.

Nelson, a former Democratic U.S. senator from Florida, will step down as head of the space agency when Trump takes office. Trump has nominated as his successor Jared Isaacman, a tech billionaire who performed the first private space walk, who must be confirmed by the Senate.

NASA has not had any conversations with Trump’s transition team about Mars Sample Return, Nelson said. How the new administration will prioritize the project is not yet clear.

“It’s very uncertain how the new administration will go forward,” said Casey Dreier, chief of space policy for the Planetary Society, a Pasadena nonprofit that promotes space research. “Cancellation is obviously still on the table. … It’s hard to game this out.”

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Planetary scientists have identified Mars Sample Return as their field’s highest priority in the last three decadal surveys, reports that the National Academies of Sciences, Engineering, and Medicine prepare every 10 years in order to advise NASA.

Successfully completing the mission is “key for the nation’s leadership in space science,” said Bethany L. Ehlmann, a planetary scientist at Caltech in Pasadena. “I hope the incoming administrator moves forward decisively to select a plan and execute. There are extraordinary engineers at JPL and NASA industry partners eager and able to get to work to make it happen.”

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Panama Canal’s Expansion Opened Routes for Fish to Relocate

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Panama Canal’s Expansion Opened Routes for Fish to Relocate

Night fell as the two scientists got to work, unfurling long nets off the end of their boat. The jungle struck up its evening symphony: the sweet chittering of insects, the distant bellowing of monkeys, the occasional screech of a kite. Crocodiles lounged in the shallows, their eyes glinting when headlamps were shined their way.

Across the water, cargo ships made dark shapes as they slid between the seas.

The Panama Canal has for more than a century connected far-flung peoples and economies, making it an essential artery for global trade — and, in recent weeks, a target of President-elect Donald J. Trump’s expansionist designs.

But of late the canal has been linking something else, too: the immense ecosystems of the Atlantic and the Pacific.

The two oceans have been separated for some three million years, ever since the isthmus of Panama rose out of the water and split them. The canal cut a path through the continent, yet for decades only a handful of marine fish species managed to migrate through the waterway and the freshwater reservoir, Lake Gatún, that feeds its locks.

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Then, in 2016, Panama expanded the canal to allow supersize ships, and all that started to change.

In less than a decade, fish from both oceans — snooks, jacks, snappers and more — have almost entirely displaced the freshwater species that were in the canal system before, scientists with the Smithsonian Tropical Research Institute in Panama have found. Fishermen around Lake Gatún who rely on those species, chiefly peacock bass and tilapia, say their catches are growing scarce.

Researchers now worry that more fish could start making their way through from one ocean to the other. And no potential invader causes more concern than the venomous, candy-striped lionfish. They are known to inhabit Panama’s Caribbean coast, but not the eastern Pacific. If they made it there through the canal, they could ravage the defenseless local fish, just as they’ve done in the Gulf of Mexico and the Caribbean.

Already, marine species are more than occasional visitors in Lake Gatún, said Phillip Sanchez, a fisheries ecologist with the Smithsonian. They’re “becoming the dominant community,” he said. They’re “pushing everything else out.”

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