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Drug-resistant germs will kill millions more people in coming decades, researchers warn

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Drug-resistant germs will kill millions more people in coming decades, researchers warn

Since the dawn of the antibiotic age, opportunistic pathogens have evolved defenses faster than humans can develop drugs to combat them.

At the same time, humans have unwittingly given the bugs an advantage through the overuse of antibiotics, allowing pathogens that survive their exposure to pass on their resistant traits.

Now, a new report finds that unless officials take action to develop new medications, “superbug” infections could kill nearly 2 million people a year in 2050 — a 67.5% increase from the 1.14 million lives lost this way in 2021.

An additional 8.22 million will die of causes related to those infections in 2050, according to a study from the Global Research on Antimicrobial Resistance Project published this week in the Lancet, a medical journal.

GRAM is a joint project of the University of Oxford and the University of Washington School of Medicine’s Institute for Health Metrics and Evaluation. The report is the most comprehensive assessment yet of the risk of antimicrobial resistance, or AMR, which the World Health Organization has long identified as one of the top 10 threats to global public health.

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It was released in advance of a United Nations General Assembly meeting later this month on drug-resistant pathogens.

“The numbers in the Lancet paper represent a staggering and unacceptable level of human suffering,” said Henry Skinner, chief executive of the AMR Action Fund, a public-private partnership that invests in new antibiotic development, who was not involved in the study. “A continued failure of governments to meet their moral obligations to protect and care for their people, as this paper shows, will doom millions of people to needless deaths.”

Roughly two-thirds of AMR deaths in 2050 will be among people ages 70 years or older, the report estimated. Older people are already at greater risk for drug-resistant infections, which are often acquired in hospitals and care facilities.

Between 1990 and 2021, the report noted, deaths due to AMR increased by more than 80% for people ages 70 and older.

Across all ages, the mortality rate from resistant pathogens is projected to be highest in South Asia, Latin America and the Caribbean.

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New antibiotic development has been painfully slow, especially when compared with drugs with better financial incentives for producers. Vital as they are, antibiotics aren’t meant to be taken over the long term like medications for chronic conditions. The most powerful have to be used as rarely as possible, to give bacteria fewer opportunities to develop resistance.

In June, the World Health Organization warned that far too few new antibiotics are currently in the global development pipeline, and the ones that are there fall far short of the innovation required to vanquish the most dangerous microbes.

Of the 32 antibiotics under development against bugs on the WHO’s 2024 bacterial priority pathogen list, the organization noted, only 12 took nontraditional approaches, which is vital for staving off the rise of drug resistance. And of those 12, only four were active against pathogens that WHO identified as the most critical threat to public health.

The scenario laid out in the GRAM report is grim, its authors noted, but not inevitable. Improvements in vaccine distribution and access to clean drinking water and sanitation have helped halve AMR-related deaths among children younger than 5 between 1990 and 2021, even as superbugs proliferated.

With better infection control measures and accelerated drug development, the report found, up to 92 million lives could be saved between 2025 and 2050.

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“The data shows that if we take action toward better stewardship practices, improved access in low- and middle-income countries, and new investments to bolster the antibiotic pipeline, then we can save tens of millions of lives,” said James Anderson, chair of the AMR Industry Alliance.

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Virus that can cause paralysis in children is on the rise in California: A few safeguards

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Virus that can cause paralysis in children is on the rise in California: A few safeguards

A respiratory virus that in rare cases can cause polio-like paralysis in children is on the rise in California and across the nation, according to wastewater analyses.

Enterovirus D68 was detected in 207 out of 268 samples taken from wastewater sites across the nation in the last 10 days, says the nonprofit WastewaterSCAN.

In the same time period, EV-D68 was detected at a medium level at 17 wastewater sites in California, including facilities in Los Angeles, San Diego, San Francisco, Sacramento and San Jose. Because humans shed viruses in waste, wastewater sampling is used to measure the prevalence of infection in a community.

Most people who contract EV-D68 will experience slight respiratory symptoms or none at all, according to the Centers for Disease Control and Prevention. Nevertheless, its spread is troubling because the virus can lead to a rare and debilitating neurological condition called acute flaccid myelitis, or AFM.

AFM attacks motor neurons in the spinal cord’s gray matter, which controls movement. This causes muscles and reflexes to weaken and, in severe cases, can lead to paralysis and death, according to the CDC.

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Around 90% of cases occur in children, and there is no known treatment.

Dr. Robert Kim-Farley, an epidemiologist and infectious diseases expert with the UCLA Fielding School of Public Health, told The Times that the best way to avoid contracting EV-D68 is to practice common respiratory hygiene.

“This is covering your coughs and sneezes, it’s washing hands,” he said, “If you’ve been around someone who’s coughing and sneezing … make sure that you haven’t touched contaminated surfaces that they’ve been touching or shared cups or utensils.”

This year, the CDC has confirmed 13 cases of AFM, including one in California, as of Sept. 3.

The largest known outbreak of the illness took place in 2018, when 238 cases were confirmed across the country. Cases also spiked in 2014 and 2016.

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Most cases of EV-D68 will be mild and feel like a common cold. However, children with asthma are at higher risk of experiencing more severe symptoms, according to the CDC.

Here are some common symptoms of EV-D68:

  • Runny nose
  • Sneezing
  • Cough
  • Body aches
  • Wheezing and difficulty breathing

If the virus progresses to cause AFM, symptoms include:

  • Arm or leg weakness
  • Difficulty swallowing or slurred speech
  • Difficulty moving the eyes and drooping in the eyelids and face

Kim-Farley recommends people seek medical care if they develop any evidence of paralysis or weakness in the limbs or muscles after having had a respiratory or fever-inducing illness one to two weeks prior.

The paralysis caused by AFM is very similar to that caused by polio — which, like EV-D68, is also an enterovirus.

Polio was eradicated in the Unites States in 1979, thanks to a widespread vaccination campaign, according to the CDC. Unfortunately, there is no vaccine for EV-D68.

“Even though [EV-D68] is not vaccine-preventable, it’s always a good opportunity to realize there are other diseases that cause paralysis, like polio, that are vaccine-preventable” and against which children can be inoculated, Kim-Farley said.

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He also recommended getting the latest COVID-19 vaccine.

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Brett Favre, testifying at welfare fraud hearing, reveals he has Parkinson's

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Brett Favre, testifying at welfare fraud hearing, reveals he has Parkinson's

Testifying Tuesday before the House Ways and Means Committee, Hall of Fame quarterback Brett Favre said in a prepared statement that he was recently diagnosed with Parkinson’s disease.

Favre, 54, was testifying about welfare abuses in Mississippi and allegations that he and others used Temporary Assistance for Needy Families state funds for personal and corporate gains. Favre, who earned about $140 million during a 20-year NFL career that ended in 2010, said in his statement that he was unaware he was receiving welfare funds and was misled by public officials.

A Mississippi state audit found that $5 million in TANF funds paid for the construction of a volleyball arena at the University of Southern Mississippi — Favre’s alma mater — and that $1.7 million was paid to Prevacus, a company developing concussion medication. Favre’s daughter was a volleyball player at Southern Mississippi at the time and Favre is an investor in Prevacus, whose founder, Jacob VanLandingham, pleaded guilty to wire fraud in July.

Favre, who has not been charged criminally, repaid $1.1 million in TANF money for speeches he never gave. The Mississippi Department of Human Services filed a civil lawsuit against him and other defendants, citing text messages between Favre and officials as evidence of his involvement in embezzling funds.

Favre, a Green Bay Packers legend, played in more than 300 NFL games and has long advocated research into concussions and resulting brain trauma. Asked on the “Today” show in 2018 how many concussions he suffered, Favre replied that he was diagnosed with “three or four” but believed the true number was far higher.

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“When you have ringing of the ears, seeing stars, that’s a concussion,” Favre said on the show. “And if that is a concussion, I’ve had hundreds, maybe thousands, throughout my career, which is frightening.”

A 2020 study published in the journal Family Medicine and Community Health determined that “regardless of age, sex, socioeconomic status and residence, having suffered a single concussion in one’s lifetime increased the likelihood of later being diagnosed with Parkinson’s disease by 57%.”

“Sadly, I also lost an investment in a company that I believed was developing a breakthrough concussion drug I thought would help others, and I’m sure you’ll understand why it’s too late for me because I’ve recently been diagnosed with Parkinson’s,” Favre told the House committee Tuesday.

Favre was portrayed in court filings in the embezzlement case as a willing participant in the scheme that allegedly diverted millions of dollars meant for the poorest people in the nation’s poorest state.

Court documents and text messages outlined his alleged involvement in diverting TANF money. Favre and then-Mississippi Gov. Phil Bryant discussed via text using $5 million to help build the volleyball arena at Southern Mississippi.

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Favre also exchanged text messages with Nancy New, executive director of the education center responsible for allocating millions in government funds.

“If you were to pay me, is there any way the media can find out where it came from and how much?” Favre reportedly asked her in 2017.

New, who later pleaded guilty to 13 felony counts of fraud, bribery and racketeering for her role in the theft of TANF funds, replied: “We never have that information publicized.”

Journalist Anna Wolfe of Mississippi Today revealed the payouts in a Pulitzer Prize-winning series of articles starting in April 2022.

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Concern grows as bird flu outbreaks continue to rise among California dairy herds

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Concern grows as bird flu outbreaks continue to rise among California dairy herds

Reports of H5N1 bird flu outbreaks at California dairy herds are continuing to rise as the nation’s largest milk producer scrambles to contain the spread.

On Monday, officials reported that the number of infected dairy herds in the Central Valley had doubled over the weekend, rising from 17 to 34.

A spokesman for the California Department of Food and Agriculture said they expect more cases to be announced in the coming days and weeks, as testing continues.

With roughly 1,100 dairy herds in California — and 90% located in the San Joaquin Valley — concern is palpable, say industry insiders. Outbreaks interrupt milk production at affected dairies. Not only are the infected herds quarantined, but special testing must be conducted at nearby dairy farms as well.

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“Farmers are genuinely worried about the virus and do not feel it’s under control,” said Anja Raudabaugh, CEO of Western United Dairies, the trade association of California dairy farmers. She added the industry is hoping a vaccine for cows will be developed “that would protect our animals” and be compliant under trade agreements.

The threat to humans is considered low. However, infectious disease experts worry that the longer the the virus remains present in dairy farms, the greater the likelihood it could mix with a human virus and pose a greater risk to people.

Both state and federal health officials say milk is safe to drink, as long as it has been pasteurized.

Steve Lyle, an agriculture department spokesman, said the agency’s call to to test dairies within six miles of infected herds, as well dairies that share share personnel or equipment with infected herds, has allowed officials to detect infected dairies “at about the time or just before they are showing clinical signs –- during their incubation period.”

The U.S. Department of Agriculture is working on a bovine vaccination for bird flu, but noted in a statement that this does not mean efforts to control the virus have failed.

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“The pursuit of bovine vaccine development does not mean that biosecurity measures have failed,” the agency said in a prepared statement. “Nor does it mean that USDA believes the virus is here to stay. Vaccine development is one part of an overall strategy that includes enhanced and strengthened biosecurity efforts to contain the virus and help mitigate spread.”

The statement went on to say that a vaccine could prove helpful in eliminating the virus from the nation’s dairy cattle, but it’s just one tool.

“We continue to deploy all available efforts, including biosecurity and mandating the testing of lactating dairy cattle moving across state lines,” the statement said.

It is still unclear how the virus got into the state, but genetic sequencing suggests the virus is similar to that found in infected cattle in other states — and that it did not come from wild birds.

It is also unclear what impact the disease will have on milk production in the state, although Raudabaugh said it will not affect milk prices.

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“Dairy is a ‘loss leader’ at the grocery store,” she said, and is often the major incentive for other items in the store.

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