Science
Contributor: Slashing NIH research guarantees a less healthy, less wealthy America
In recent months, funding for biomedical research from the National Institutes of Health has been canceled, delayed and plunged into uncertainty. According to an April STAT News analysis, NIH funding has decreased by at least $2.3 billion since the beginning of the year. KFF Health News reports the full or partial termination of approximately 780 NIH grants between Feb. 28 and March 28 alone. Additional NIH funding cuts loom on the horizon, including proposed cuts to indirect costs.
Amid this volatility, one thing remains clear: NIH grant funding is a valuable, proven investment, economically and in terms of improving human health.
A recent United for Medical Research report shows that in fiscal year 2024, research funded by the NIH generated $94.58 billion in economic activity nationwide, a 156% return on investment. Further, the report shows that NIH funding supported 407,782 jobs nationwide. According to the NIH’s own figures, patents derived from work it has funded produce 20% more economic value than other U.S. patents.
These economic returns — including a return on investment that would thrill any startup or stock investor — cannot begin to capture the impact on individuals, families and communities in terms of increased longevity and higher quality of life.
While it is hard to precisely quantify human health improvements resulting from NIH-funded research, there are proxy measures. As one example, a study published in JAMA Health Forum found that NIH funding supported the development of 386 of 387 drugs approved by the Food and Drug Administration from 2010-19. Many of the approved drugs address the most pressing human health concerns of our time, including cancer, diabetes, cardiovascular disease, infectious diseases and neurological disorders such as Parkinson’s disease.
Many other NIH-funded advancements represent what is now considered common knowledge, such as the relationship between cholesterol and cardiovascular health, or standard practice, such as screening newborns for serious diseases that may be treatable with early medical intervention. But each of these fundamental aspects of contemporary medicine had to first be discovered, tested and proved. They represent what NIH funding can do — and the type of paradigm-shifting advancements in medicine that are now very much at risk.
Consider the biotechnology industry as one such paradigm shift. In the 1970s, Stanley Cohen and Herbert Boyer were the first scientists to clone DNA and to transplant genes from one living organism to another. This work launched the biotechnology industry.
Two decades later, the NIH and the Department of Energy began a 13-year effort to sequence the human genome, including through university-based research grants. In 2003, the consortium of researchers produced a sequence accounting for 92% of the human genome. In 2022, a group of researchers primarily funded by the NIH’s National Human Genome Research Institute produced a complete human genome sequence. This work paved the way for insights into inherited diseases, pharmacogenomics (how genetics affect the body’s response to medications) and precision medicine.
NIH funding has also led to major breakthroughs in cancer treatments. In 1948, Sidney Farber demonstrated the first use of a chemotherapy drug, aminopterin, to induce remission in children with acute leukemia. Before Farber’s research, which was funded in part by the NIH, children with acute leukemia were unlikely to survive even five years.
Over the years that followed, other modes of cancer treatment such as immunotherapy emerged, first as novel areas of inquiry, followed by drug development and clinical trials. NIH funding supported, among others, the development of CAR T cell therapy, which genetically modifies a patients’ own T-cells to fight cancer. CAR T cell therapy has improved outcomes for many patients with persistent blood cancers, and clinical trials are ongoing to discover other cancers that might be treatable with CAR T cell therapies.
For decades, scientists knew that breast cancer could run in families and hypothesized a genetic role. In the 1990s, teams of scientists — supported at least in part by NIH funding — tracked down the BRCA1 and BRCA2 genes responsible for inherited predispositions to breast and other cancers. Today, many people undergo testing for BRCA gene mutations to make informed decisions about prevention, screening and treatment.
These kinds of advancements, along with improvements in detection and screening, have meaningfully reduced cancer mortality rates. After hitting a smoking-related peak in 1991, U.S. mortality rates from all cancers dropped by 34% as of 2022, according to the American Cancer Society. For children with acute leukemias, who had effectively no long-term chance of survival just 75 years ago, the numbers are even more dramatic. The five-year survival rate is now approximately 90% for children with acute lymphocytic leukemia and between 65% and 70% for those with acute myelogenous leukemia.
These examples represent a fraction of the tremendous progress that has occurred through decades of compounding knowledge and research. Reductions in NIH funding now threaten similar breakthroughs that are the prerequisites to better care, better technology and better outcomes in the most common health concerns and diseases of our time.
It is not research alone that is threatened by NIH funding cuts. Researchers, too, face new uncertainties. We have heard firsthand the anxiety around building a research career in the current environment. Many young physician-scientists wonder whether it will be financially viable to build their own lab in the U.S., or to find jobs at research institutions that must tighten their belts. Many medical residents, fellows and junior faculty are considering leaving the U.S. to train and build careers elsewhere. Losing early-career researchers to other fields or countries would be a blow to talent for biomedical research institutions nationwide and weaken the country’s ability to compete globally in the biomedical sector.
The effects of decreased NIH funding might not be immediately visible to most Americans, but as grant cancellations and delays mount, there will be a price. NIH funding produces incredible results. Cuts will set scientific research back and result in losses in quality of life and longevity for generations of Americans in years to come.
Euan Ashley is the chair of the Stanford University department of medicine and a professor of medicine and of genetics. He is the author of “The Genome Odyssey: Medical Mysteries and the Incredible Quest to Solve Them.” Rachel Keranen is a writer in the Stanford department of medicine.
Science
Flu is hitting California early. Why doctors worry this year will be especially hard on kids
Fueled by a new viral strain, flu is hitting California early — and doctors are warning they expect the season may be particularly tough on young children.
Concentrations of flu detected in wastewater have surged in the San Francisco Bay Area, and the test positivity rate is rising in Los Angeles County and Orange County, according to state and county data. Hospitalizations and emergency room visits for flu are also rising in L.A. and Orange counties.
“We are at the point now where we’re starting to see a sharp rise in flu cases. This is a few weeks earlier than we usually experience, but very much akin to what was seen in the Southern Hemisphere’s experience with flu during their winter,” said Dr. Elizabeth Hudson, regional physician director of infectious diseases at Kaiser Permanente Southern California.
At Kaiser, flu cases are primarily being seen in clinics so far, but hospitalizations typically rise after Christmas. “We expect to see the same this year, too,” Hudson said.
“The number of cases appears to be higher at an earlier time in the usual flu season than we’ve seen in years past,” she added.
Flu levels are high in San Francisco’s sewage as well as in wastewater across San José, Sunnyvale and Palo Alto, according to WastewaterSCAN and the Santa Clara County Public Health Department.
One area of concern this winter has been the rise of a relatively new flu subvariant, known as H3N2 Flu A subclade K, which appeared toward the end of summer. That was months after officials decided which strains this fall’s flu vaccine would target.
Subclade K “is causing an active, early flu season, with more cases occurring in some countries within the Northern Hemisphere,” the California Department of Public Health said.
It remains unclear whether subclade K will reduce the efficacy of this year’s flu shot. Data recently released in Britain showed this season’s vaccines were 70% to 75% effective against hospitalization for children from the flu, and 30% to 40% effective in adults, which is within expectations, the U.S. Centers for Disease Control and Prevention noted.
This suggests “that influenza vaccination remains an effective tool in preventing influenza-related hospitalizations this season,” according to the agency.
However, the intended effectiveness of the flu vaccine against symptomatic disease caused by the new subvariant remains uncertain, the World Health Organization said.
Overall, flu rates in L.A. County remain relatively low, but are on the rise. Across California, flu hospitalizations are likewise low but increasing.
On a national level, severity indicators remain low, according to the CDC.
But the experience in other nations have led some experts to worry another severe flu season could be on deck for California.
Australia’s flu season, which is seasonally opposite from California’s, came far earlier than usual, hit with record strength and was particularly hard on the nation’s children.
Japan, Taiwan and Britain have also reported early spikes to their flu seasons.
“Whether or not this season will be more severe, only time will tell,” Hudson said of California. “We know that we have a mutation … which may make the flu vaccine work less well. But the vaccine still offers excellent protection against hospitalization and death, even with the mutated strain in circulation.”
Based on what happened in the Southern Hemisphere — particularly in Australia — “we are expecting this season to have a disproportionate impact on children under the age of 10,” Hudson said.
Already, three flu-associated pediatric deaths have been reported nationally this season, including two Friday.
During the flu season that ended in September, 280 children died from flu — the most since the swine flu pandemic season of 2009-10.
Overall, the 2024-25 season was considered the worst flu season since 2017-18, and hit adults hard as well. At least 38,000 people died from the flu last season, health authorities estimate.
Only a little more than half of the children who died from flu had an underlying medical condition, and 89% of those who died were not vaccinated, according to the CDC’s National Center for Immunization and Respiratory Diseases.
Among the children who died from flu last season, the most common complications experienced before death were shock or sepsis, pneumonia, acute respiratory distress syndrome, seizures and damage to the brain.
Early diagnosis of flu can help stave off the worst by giving those who are sick time to take antiviral medications like Tamiflu. Three out of five children who died from the flu during the 2024-25 season never received antiviral medication.
Emergency warning signs of flu complications in children include trouble breathing; bluish lips or face; ribs pulling in with each breath; chest pain; severe muscle pain, in which a child may refuse to walk; dehydration, signs of which include no urine for eight hours or no tears when crying; seizures; fevers above 104 degrees that are not controlled by medication; fever or cough that improve but return or worsen; and any fever in newborns younger than 12 weeks.
Since the official start of the respiratory virus season Oct. 1, the CDC estimates there have been at least 1,900 flu-related deaths, 49,000 hospitalizations and 4.6 million illnesses nationwide.
Doctors have been urging everybody to get the flu vaccine — the CDC recommends it for everyone age 6 months and up.
But vaccination rates have been lagging. Among children age 6 months to 17 years, an estimated 40.8% had been vaccinated as of the first week of December, according to the National Immunization Survey. In the last season before the COVID-19 pandemic, flu vaccination rates were notably higher by this time of year, at 51.2%.
At the end of last flu season, only 49.8% of children and teens had been vaccinated, the survey estimated, down from the 62.4% who had gotten their shots by the end of the 2019-20 flu season.
The decline in flu vaccinations has been seen locally, too. “Notably, fewer influenza vaccines have been administered this year compared to the same period last year,” the Orange County Health Care Agency said.
It takes about two weeks for protection to build, but getting vaccinated as soon as possible before travel or seeing friends and family “helps keep you and your loved ones safer,” the L.A. County Department of Public Health said in a statement to The Times.
Science
Why California’s milk cartons may lose their coveted recycling symbol
California milk cartons may lose their coveted recycling symbol, the one with the chasing arrows, potentially threatening the existence of the ubiquitous beverage containers.
In a letter Dec. 15, Waste Management, one of the nation’s largest waste companies, told the state the company would no longer sort cartons out of the waste stream for recycling at its Sacramento facility. Instead, it will send the milk- and food-encrusted packaging to the landfill.
Marcus Nettz, Waste Management’s director of recycling for Northern California and Nevada, cited concerns from buyers and overseas regulators that cartons — even in small amounts — could contaminate valuable material, such as paper, leading them to reject the imports.
The company decision means the number of Californians with access to beverage carton recycling falls below the threshold in the state’s “Truth in Recycling” law, or Senate Bill 343.
And according to the law, that means the label has to come off.
The recycling label is critical for product and packaging companies to keep selling cartons in California as the state’s single-use packaging law goes fully into effect. That law, Senate Bill 54, calls for all single-use packaging to be recyclable or compostable by 2032. If it isn’t, it can’t be sold or distributed in the state.
The labels also provide a feel-good marketing symbol suggesting to consumers the cartons won’t end up in a landfill when they’re discarded, or find their way into the ocean where plastic debris is a large and growing problem.
On Tuesday, the state agency in charge of waste, CalRecycle, acknowledged Waste Management’s change.
In updated guidelines for the Truth in Recycling law, recycling rates for carton material have fallen below the state threshold.
It’s a setback for carton manufacturers and their customers, including soup- and juice-makers. Their trade group, the National Carton Council, has been lobbying the state, providing evidence that Waste Management’s Sacramento Recycling and Transfer Station successfully combines cartons with mixed paper and ships it to Malaysia and other Asian countries including Vietnam, proving that there is a market. The Carton Council persuaded CalRecycle to reverse a decision it made earlier this year that beverage cartons did not meet the recycling requirements of the Truth in Recycling law.
Brendon Holland, a spokesman for the trade group, said in an email that his organization is aware of Waste Management’s decision, but its understanding is that the company will now sort the cartons into their own dedicated waste stream “once a local end market is available.”
He added that even with “this temporary local adjustment,” food and beverage cartons are collected and sorted in most of California, and said this is just a “temporary end market adjustment — not a long-term shift away from historical momentum.”
In 2022, Malaysia and Vietnam banned imports of mixed paper bales — which include colored paper, newspapers, magazines and other paper products — from the U.S. because they were so often contaminated with non-paper products and plastic, such as beverage cartons. Waste Management told The Times on Dec. 5 that it has a “Certificate of Approval” by Malaysia’s customs agency to export “sorted paper material.” CalRecycle said it has no regulatory authority on “what materials may or may not be exported.”
Adding the Sacramento facility to the list of waste companies that were recycling cartons meant that the threshold required by the state had been met: More than 60% of the state’s counties had access to carton recycling.
At the time, CalRecycle’s decision to give the recycling stamp to beverage cartons was controversial. Many in the environmental, anti-plastic and no-waste sectors saw it as a sign that CalRecycle was doing the bidding of the plastic and packaging industry, as opposed to trying to rid the state of non-recyclable, polluting waste — which is not only required by law, but is something state Atty. Gen. Rob Bonta is investigating.
Others said it was a sign that the Truth in Recycling law was working: Markets were being discovered and in some cases, created, to provide recycling.
“Recyclability isn’t static, it depends on a complicated system of sorting, transportation, processing, and, ultimately, manufacturers buying the recycled material to make a new product,” said Nick Lapis, director of advocacy for Californians Against Waste.
He said this new information, which will likely remove the recycling label from the cartons, also underscores the effectiveness of the law.
“By prohibiting recyclability claims on products that don’t get recycled, SB 343 doesn’t just protect consumers. It forces manufacturers to either use recyclable materials or come to the table to work with recyclers, local governments and policymakers to develop widespread sustainable and resilient markets,” he said.
Beverage and food cartons — despite their papery appearance — are composed of layers of paper, plastic and sometimes aluminum. The sandwiched blend extends product shelf life, making it attractive to food and beverage companies.
But the companies and municipalities that receive cartons as waste say the packaging is problematic. They say recycling markets for the material are few and far between.
California, with its roughly 40 million residents, has some of the strictest waste laws in the nation. In 1989, the state passed legislation requiring cities, towns and municipalities to divert at least 50% of their residential waste away from landfills. The idea was to incentivize recycling and reuse. However an increasing number of products have since entered the commercial market and waste stream — such as single use plastics, polystyrene and beverage cartons — that have limited (if any) recycling potential, can’t be reused, and are growing in number every year.
Fines for municipalities that fail to achieve the required diversion rates can run $10,000 a day.
As a result, garbage haulers often look for creative ways to deal with the waste, including shipping trash products overseas or across the border. For years, China was the primary destination for California’s plastic, contaminated paper and other waste. But in 2018, China closed its doors to foreign garbage, so U.S. exporters began dumping their waste in smaller southeast Asian countries, including Malaysia and Vietnam.
They too have now tried to close the doors to foreign trash as reports of polluted waterways, chokingly toxic air, and illness grows — and as they struggle with inadequate infrastructure to deal with their own domestic waste.
Jan Dell, the founder and CEO of Last Beach Cleanup, released a report with the Basel Action Network, an anti-plastic organization, earlier this month showing that the Sacramento facility and other California waste companies were sending bales of carton-contaminated paper to Malaysia, Vietnam and other Asian nations.
According to export data, public records searches and photographic evidence collected by Dell and her co-authors at the Basel Action Network, more than 117,000 tons or 4,126 shipping containers worth of mixed paper bales were sent by California waste companies to Malaysia between January and July of this year.
Dell said these exports violate international law. A spokesman for Waste Management said the material they were sending was not illegal — and that they had received approval from Malaysia.
However, the Dec. 15 letter suggests they were receiving more pushback from their export markets than they’d previously disclosed.
“While certain end users maintain … that paper mills are able to process and recycle cartons,” some of them “have also shared concerns … that the inclusion of cartons … may result in rejection,” wrote Nettz.
Dell said she was “pleased” that Waste Management “stopped the illegal sortation of cartons into mixed paper bales. Now we ask them and other waste companies to stop illegally exporting mixed paper waste to countries that have banned it.”
Science
Video: Why Scientists Are Performing Brain Surgery on Monarchs
new video loaded: Why Scientists Are Performing Brain Surgery on Monarchs
By Alexa Robles-Gil, Leila Medina, Joey Sendaydiego and Mark Felix
December 23, 2025
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