Connect with us

Science

Commentary: She was wrongly snagged by Trump's word police. Now her medical research is down the drain

Published

on

Commentary: She was wrongly snagged by Trump's word police. Now her medical research is down the drain

Nisha Acharya, an eye doctor and UC San Francisco professor, was at her campus clinic tending patients when a surprising email arrived.

Her federal research grant had just been terminated, according to a reporter for the Washington Post, who wondered if Acharya had any comment.

She was stunned. Her research, into the workings of the shingles vaccine, didn’t seem remotely controversial. The $3-million grant was the second she’d received, after years of similar work. The National Institutes of Health, which awarded the grant and regularly reviewed Acharya’s performance, had been pleased with all she’d accomplished.

Nevertheless, the NIH tersely informed the university its latest grant was among dozens terminated because the federal government, under President Trump, would no longer support research focused on “why individuals are hesitant to be vaccinated and/or explore ways to improve vaccine interest and commitment.”

Acharya’s research had nothing to do with any of that.

Advertisement

But the mention of “hesitancy” and “uptake” in her grant application — referring to the concern some cornea specialists had about the vaccine for those with shingles in the eye — was apparently all it took to snare Acharya in a dragnet mounted by the Trump administration word police.

Acharya fears the Trump administration’s heedless termination of grants will set back scientific and medical research for years to come.

(Paul Kuroda / For The Times)

Perhaps “hesitancy” and “uptake” generated an AI response, or triggered some on-the-hunt algorithm. Acharya can’t be entirely sure, but there’s no evidence an actual human being, much less any sort of expert on vaccines or shingles, reviewed her grant proposal or assessed her work.

Advertisement

She’s gotten no explanation beyond that one, formulaic March 10 email dispatched to the university. “I lost funding immediately,” Acharya said.

logo reading "Trump's America" with red hat in center

Views of the 47th president, from the ground up

The randomness of the administration’s action, and its apparent error, is maddening enough. But it’s also frightening, Acharya said, to think that political considerations are now guiding science and scientific research, erasing years of effort and thwarting potential cures and the chance at future breakthrough treatments.

“I don’t think government is in a position, or should be, to dictate what’s important in science,” Acharya said over lunch on UCSF’s sparkling Mission Bay campus.

Advertisement

Trump’s heedless, meddlesome policy, she suggested, is going to scare off a whole generation of would-be scientists and medical researchers, undermining the quest for knowledge, hurting the public and negatively affecting people’s health “for years to come.”

::

Acharya was in a high school when she reached a fork in the road. Now 50, she pressed her hands into a “V” shape to illustrate the two paths.

A computer screen filled with budgetary data

Acharya’s grant was worth $3 million spread over five years of research. She was in the second year of the grant when it was abruptly canceled.

(Paul Kuroda / For The Times)

Advertisement

At the time she was a violinist in the Chicago Youth Symphony, touring the world with the orchestra. She also loved science. Her father was a pharmaceutical chemist. Her mother taught high school math and chemistry.

She realized, Acharya said, she wasn’t ready to make the commitment or accept the all-encompassing sacrifice needed to forge a professional career in music. So science became her chosen route.

At Stanford, she majored in biology and received a master’s degree in health services research. From there, it was on to UCSF medical school. “I love scientific knowledge. But I really wanted to be able to directly interact with patients,” said Acharya, a self-described people person.

A favorite professor, who specialized in eye infection and inflammation, steered her into ophthalmology and helped Acharya find her life’s passion. She smiled broadly as she rhapsodized with mile-a-minute enthusiasm about her work, eyes wide and fingers fluttering over the table, as though she was once again summoning Bach or Paganini.

“The body affects everything in the eye,” she explained. “Like, if you have an infection, you can get it in the eye. If you have an autoimmune disease, you can have manifestations in the eye. You have blood pressure problems, you can see it in the eye. The eye is like, really, a window into the body.”

Advertisement

Acharya latest research was focused on how the shingles vaccine works.

Shingles is a rash brought on by the varicella zoster virus, which also causes chickenpox. Once chickenpox subsides, the virus can remain dormant in a person’s body for decades before erupting again.

“In the first grant, we showed that the vaccine is very effective at preventing shingles and shingles in the eye if you’ve never had it,” Acharya said. “But we hadn’t gotten to the question of what if you already have shingles in the eye?”

It was work, Acharya said, that no one else was doing, aimed at preventing a loss of vision or blindness. It was not, she repeatedly emphasized, an attempt to promote vaccination, a once-common practice now tangled in layers of political, social and cultural debate — or, for that matter, to dissuade anyone from getting vaccinated.

“This is the kind of research that you would think the government would want. Safety and effectiveness … the pros and the cons,” Acharya said, giving a small, puzzled shake of her head. “I wanted to just get the information out there so people can use it.”

Advertisement

Now that guidance won’t be available anytime soon.

If ever.
::

Acharya has never been politically active. Her whole life and career, she said, have been devoted to the furtherance of science.

While she leans left, she’s never been wedded to any party or ideology; Acharya has found reasons to agree — and disagree — with Democrats and Republicans alike.

She didn’t vote for Trump, but didn’t see her support for Kamala Harris as making any sort of stand for scientific inquiry, or as a means of protecting her grant. “It never crossed my mind,” she said.

Advertisement
A woman in a cream-colored jacket looks down on an open book on a table, with a glass medical display case behind her

Acharya flips through a 1954 book signed by renowned ophthalmologists and researchers in a conference room at UCSF.

(Paul Kuroda / For The Times)

The five-year grant paid 35% of Acharya’s salary — she was nearing the end of Year Two — and, while the loss of income isn’t great, she’ll manage. “I’m a professor and I’m a doctor as well,” she said. “I’m not going to lose my job.”

Acharya has been forced, however, to lay off two data analysts, and a third research position is in jeopardy. Her voice thickened as she discussed those let go. At one point, she seemed to be fighting back tears.

“I’ve cried with my team a lot,” she said over the soft thrum of conversation in the airy cafeteria-style bistro. “I’m just keeping it together because I have to … I still take care of patients. I still teach. I can’t lose it like that. I feel like … I have to find some way to keep on going.”

Advertisement

In its zeal to dismantle the federal government — driven more, it seems, by political calculation and a taste for vengeance than any well-thought-out design — the Trump administration has terminated hundreds of grants, ending research focused on Alzheimer’s disease, cancer, HIV/AIDS, heart disease, COVID-19, mental health services and addiction, among other areas of scientific pursuit.

Hundreds of millions of dollars that already have been spent are now wasted. The fruits of all that research have been blithely and abruptly lopped off the vine.

It’s impossible, Acharya said, to calculate the loss. It’s painful to even try. “All the things that might not be learned,” she mused wistfully. “All the potential gains out there” that may go unrealized.

The termination notice UCSF received from the National Institutes of Health gave Acharya 30 days to appeal if she believed the decision to end her research was made in error. She did so.

A few days later, the university received a pro forma email acknowledging receipt of Acharya’s appeal.

Advertisement

Since then, nothing.

Science

Can fire-resistant homes be sexy? ‘You be the judge,’ says this Palisades architect

Published

on

Can fire-resistant homes be sexy? ‘You be the judge,’ says this Palisades architect

At first glance, it looks like nothing more than a charming Spanish-revival, quintessentially Californian home — but this Pacific Palisades rebuild is constructed like a tank.

Every exterior wall of the steel-framed home is a foot-thick, fire-resistant barricade. The home is connected to a satellite fire monitoring service. Should a fire start in town, sturdy metal shutters descend to cover every window. An exterior sprinkler system can pump 40,000 gallons of water from giant tanks hidden behind the shrubs in the property’s yard. If the cameras and heat sensors around the house detect danger, the system can envelop the home in over 1,000 gallons of fire retardant and hundreds of gallons of fire-suppressing foam.

Palisades resident and architect Ardie Tavangarian is so confident in his design that he even asked the fire department if they could start a controlled fire on the property to test it all out. (They said no.)

Tavangarian built a career designing multimillion-dollar luxury homes in Los Angeles, but after the Palisades fire destroyed 13 of his works — including his family’s home — he found another calling: how to design a house that can handle what the Santa Monica Mountains throw at it. And how to do it quickly and affordably.

Water tanks form part of a backup water supply in a newly built fire-resistant home in Pacific Palisades.

Advertisement

“Nature is so powerful,” he said, sitting on a couch in the new house, which he built for his adult twin daughters. “We are guests living in that environment and expecting, ‘Oh, nature is going to be really kind to me.’ No, it’s not. It does what it’s supposed to do.”

Tavangarian watched the Jan. 1 Lachman fire from his property not far from here; a week later that fire rekindled, grew into the Palisades fire, and burned through his house. But the painful details of the fire — the missteps of the fire department, the empty reservoir — didn’t matter when it came to deciding how to rebuild, he said. The reality is, many fires have burned in these mountains. Many more will.

A sprinkler on a roof.

A sprinkler on the roof is part of a house-wide sprinkler system.

For the architect, who has spent much of his 45-year career designing for luxury, hardening a home against wildfire has brought a new kind of luxury to his homes: peace of mind.

Advertisement

It’s a sentiment that resonates with fire survivors: Tavangarian says he’s received considerable interest from other property owners in the Palisades looking to rebuild their houses.

The metal shutters and advanced outdoor sprinkler system are the flashiest parts of Tavangarian’s home hardening project, and the efficacy of these adaptations is still up for debate. Because the measures have not yet been widely adopted, there are few studies exploring how much or little they protect homes in real-world fires.

Ardie Tavangarian stands inside a house.

Architect Ardie Tavangarian inside the house he designed.

Anecdotal evidence has indicated the effectiveness of sprinklers can vary significantly based on the setup and the conditions during the fire. Extreme wind, for example, can make them less effective. Lab studies have generally found shutters can reduce the risk of windows shattering.

These measures aren’t cheap, either. Sprinkler systems can cost north of $100,000, for example. However, Tavangarian said when all was said and done, the home he built for his daughters cost around $700 per square foot — less than what Palisades residents said they expected to pay, but more than what Altadena residents expected for their rebuilds.

Advertisement

Tavangarian also hopes to see insurers increasingly consider the home-hardening measures property owners take when writing policies, which he said could potentially offset the extra cost in a decade or less. As he explored getting insurance for the new home, one insurer quoted him $80,000 a year. After he convinced the company to visit the property, it lowered the quote to just $13,000, he said.

A living room inside a fire-resistant house, with metal heat shields drawn over the windows.

The house includes metal heat shields that can drop down if a fire approaches.

The home also has essentially all of the other less flashy — but much cheaper and well-proven — home hardening measures recommended by fire professionals: The underside of the roof’s overhang is closed off — a common place embers enter a home. The roof, where burning embers can accumulate, is made of fire-resistant material. The windows, vulnerable to shattering in extreme heat, are made of a toughened glass. There is virtually no vegetation within the first five feet of the home.

When asked if he felt he had compromised on design, comfort or aesthetics for the extra protection — one of the many concerns Californians have with the state’s draft “Zone Zero” requirements that may significantly limit vegetation within five feet of a home — Tavangarian simply said, “You be the judge.”

Advertisement
Continue Reading

Science

Commentary: My toothache led to a painful discovery: The dental care system is full of cavities as you age

Published

on

Commentary: My toothache led to a painful discovery: The dental care system is full of cavities as you age

I had a nagging toothache recently, and it led to an even more painful revelation.

If you X-rayed the state of oral health care in the United States, particularly for people 65 and older, the picture would be full of cavities.

“It’s probably worse than you can even imagine,” said Elizabeth Mertz, a UC San Francisco professor and Healthforce Center researcher who studies barriers to dental care for seniors.

Mertz once referred to the snaggletoothed, gap-filled oral health care system — which isn’t really a system at all — as “a mess.”

But let me get back to my toothache, while I reach for some painkiller. It had been bothering me for a couple of weeks, so I went to see my dentist, hoping for the best and preparing for the worst, having had two extractions in less than two years.

Advertisement

Let’s make it a trifecta.

My dentist said a molar needed to be yanked because of a cellular breakdown called resorption, and a periodontist in his office recommended a bone graft and probably an implant. The whole process would take several months and cost roughly the price of a swell vacation.

I’m lucky to have a great dentist and dental coverage through my employer, but as anyone with a private plan knows, dental insurance can barely be called insurance. It’s fine for cleanings and basic preventive routines. But for more complicated and expensive procedures — which multiply as you age — you can be on the hook for half the cost, if you’re covered at all, with annual payout caps in the $1,500 range.

“The No. 1 reason for delayed dental care,” said Mertz, “is out-of-pocket costs.”

So I wondered if cost-wise, it would be better to dump my medical and dental coverage and switch to a Medicare plan that costs extra — Medicare Advantage — but includes dental care options. Almost in unison, my two dentists advised against that because Medicare supplemental plans can be so limited.

Advertisement

Sorting it all out can be confusing and time-consuming, and nobody warns you in advance that aging itself is a job, the benefits are lousy, and the specialty care you’ll need most — dental, vision, hearing and long-term care — are not covered in the basic package. It’s as if Medicare was designed by pranksters, and we’re paying the price now as the percentage of the 65-and-up population explodes.

So what are people supposed to do as they get older and their teeth get looser?

A retired friend told me that she and her husband don’t have dental insurance because it costs too much and covers too little, and it turns out they’re not alone. By some estimates, half of U.S. residents 65 and older have no dental insurance.

That’s actually not a bad option, said Mertz, given the cost of insurance premiums and co-pays, along with the caps. And even if you’ve got insurance, a lot of dentists don’t accept it because the reimbursements have stagnated as their costs have spiked.

But without insurance, a lot of people simply don’t go to the dentist until they have to, and that can be dangerous.

Advertisement

“Dental problems are very clearly associated with diabetes,” as well as heart problems and other health issues, said Paul Glassman, associate dean of the California Northstate University dentistry school.

There is one other option, and Mertz referred to it as dental tourism, saying that Mexico and Costa Rica are popular destinations for U.S. residents.

“You can get a week’s vacation and dental work and still come out ahead of what you’d be paying in the U.S.,” she said.

Tijuana dentist Dr. Oscar Ceballos told me that roughly 80% of his patients are from north of the border, and come from as far away as Florida, Wisconsin and Alaska. He has patients in their 80s and 90s who have been returning for years because in the U.S. their insurance was expensive, the coverage was limited and out-of-pocket expenses were unaffordable.

“For example, a dental implant in California is around $3,000-$5,000,” Ceballos said. At his office, depending on the specifics, the same service “is like $1,500 to $2,500.” The cost is lower because personnel, office rent and other overhead costs are cheaper than in the U.S., Ceballos said.

Advertisement

As we spoke by phone, Ceballos peeked into his waiting room and said three patients were from the U.S. He handed his cellphone to one of them, San Diegan John Lane, who said he’s been going south of the border for nine years.

“The primary reason is the quality of the care,” said Lane, who told me he refers to himself as 39, “with almost 40 years of additional” time on the clock.

Ceballos is “conscientious and he has facilities that are as clean and sterile and as medically up to date as anything you’d find in the U.S.,” said Lane, who had driven his wife down from San Diego for a new crown.

“The cost is 50% less than what it would be in the U.S.,” said Lane, and sometimes the savings is even greater than that.

Come this summer, Lane may be seeing even more Californians in Ceballos’ waiting room.

Advertisement

“Proposed funding cuts to the Medi-Cal Dental program would have devastating impacts on our state’s most vulnerable residents,” said dentist Robert Hanlon, president of the California Dental Assn.

Dental student Somkene Okwuego smiles after completing her work on patient Jimmy Stewart, 83, who receives affordable dental work at the Ostrow School of Dentistry of USC on the USC campus in Los Angeles on February 26, 2026.

(Genaro Molina / Los Angeles Times)

Under Proposition 56’s tobacco tax in 2016, supplemental reimbursements to dentists have been in place, but those increases could be wiped out under a budget-cutting proposal. Only about 40% of the state’s dentists accept Medi-Cal payments as it is, and Hanlon told me a CDA survey indicates that half would stop accepting Medi-Cal patients and many others will accept fewer patients.

Advertisement

“It’s appalling that when the cost of providing healthcare is at an all-time high, the state is considering cutting program funding back to 1990s levels,” Hanlon said. “These cuts … will force patients to forgo or delay basic dental care, driving completely preventable emergencies into already overcrowded emergency departments.”

Somkene Okwuego, who as a child in South L.A. was occasionally a patient at USC’s Herman Ostrow School of Dentistry clinic, will graduate from the school in just a few months.

I first wrote about Okwuego three years ago, after she got an undergrad degree in gerontology, and she told me a few days ago that many of her dental patients are elderly and have Medi-Cal or no insurance at all. She has also worked at a Skid Row dental clinic, and plans after graduation to work at a clinic where dental care is free or discounted.

Okwuego said “fixing the smiles” of her patients is a privilege and boosts their self-image, which can help “when they’re trying to get jobs.” When I dropped by to see her Thursday, she was with 83-year-old patient Jimmy Stewart.

Stewart, an Army veteran, told me he had trouble getting dental care at the VA and had gone years without seeing a dentist before a friend recommended the Ostrow clinic. He said he’s had extractions and top-quality restorative care at USC, with the work covered by his Medi-Cal insurance.

Advertisement

I told Stewart there could be some Medi-Cal cuts in the works this summer.

“I’d be screwed,” he said.

Him and a lot of other people.

steve.lopez@latimes.com

Advertisement
Continue Reading

Science

Diablo Canyon clears last California permit hurdle to keep running

Published

on

Diablo Canyon clears last California permit hurdle to keep running

Central Coast Water authorities approved waste discharge permits for Diablo Canyon nuclear plant Thursday, making it nearly certain it will remain running through 2030, and potentially through 2045.

The Pacific Gas & Electric-owned plant was originally supposed to shut down in 2025, but lawmakers extended that deadline by five years in 2022, fearing power shortages if a plant that provides about 9 percent the state’s electricity were to shut off.

In December, Diablo Canyon received a key permit from the California Coastal Commission through an agreement that involved PG&E giving up about 12,000 acres of nearby land for conservation in exchange for the loss of marine life caused by the plant’s operations.

Today’s 6-0 vote by the Central Coast Regional Water Board approved PG&E’s plans to limit discharges of pollutants into the water and continue to run its “once-through cooling system.” The cooling technology flushes ocean water through the plant to absorb heat and discharges it, killing what the Coastal Commission estimated to be two billion fish each year.

Advertisement

The board also granted the plant a certification under the Clean Water Act, the last state regulatory hurdle the facility needed to clear before the federal Nuclear Regulatory Commission (NRC) is allowed to renew its permit through 2045.

The new regional water board permit made several changes since the last one was issued in 1990. One was a first-time limit on the chemical tributyltin-10, a toxic, internationally-banned compound added to paint to prevent organisms from growing on ship hulls.

Additional changes stemmed from a 2025 Supreme Court ruling that said if pollutant permits like this one impose specific water quality requirements, they must also specify how to meet them.

The plant’s biggest water quality impact is the heated water it discharges into the ocean, and that part of the permit remains unchanged. Radioactive waste from the plant is regulated not by the state but by the NRC.

California state law only allows the plant to remain open to 2030, but some lawmakers and regulators have already expressed interest in another extension given growing electricity demand and the plant’s role in providing carbon-free power to the grid.

Advertisement

Some board members raised concerns about granting a certification that would allow the NRC to reauthorize the plant’s permits through 2045.

“There’s every reason to think the California entities responsible for making the decision about continuing operation, namely the California [Independent System Operator] and the Energy Commission, all of them are sort of leaning toward continuing to operate this facility,” said boardmember Dominic Roques. “I’d like us to be consistent with state law at least, and imply that we are consistent with ending operation at five years.”

Other board members noted that regulators could revisit the permits in five years or sooner if state and federal laws changes, and the board ultimately approved the permit.

Advertisement
Continue Reading

Trending