Rhode Island
Experiencing low back pain? Clinical trial at Brown Health could help.
The injection could be “revolutionary” for treating degenerative disc disease, said the trial’s principal investigator
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A clinical trial at Brown University Health to treat chronic low back pain with a one-time, non-surgical injection treatment is seeking to enroll patients in Rhode Island.
The trial is testing whether a single injection of rexlemestrocel-L, an experimental stem cell therapy derived from healthy adult donors, combined with hyaluronic acid, a gel-like substance found in the body’s joints, and delivered directly into the damaged disc, can provide prolonged relief for low back pain.
Low back pain, or degenerative disc disease, can affect quality of life, disrupt daily activities, commission people out of work and have an impact on a person’s mood, said Alexios Carayannopoulos, chief of physical medicine and rehabilitation at Rhode Island Hospital, Newport Hospital and Brown Health Medical Group and the principal investigator in the trial.
The treatment Carayannopoulos is investigating involves an injection without the need for an incision or hardware. While other treatments, such as anti-inflammatory pills, physical therapy or steroid injections, assuage the pain, they don’t treat the underlying issues with the damaged disc. The trial’s injection aims to do more than numb pain: it seeks to change the environment inside the disc, reducing inflammation and potentially slowing or stabilizing disc degeneration, according to Carayannopoulos.
Earlier clinical trials of the injection with over 400 patients “found substantial pain improvements” lasting up to two to three years, according to Carayannopoulos. They also showed signs that the injection slowed disc height loss.
Carayannopoulos reckons the treatment could be “revolutionary” for managing chronic low back pain.
“We have struggled through many years trying to figure out the holy grail for treating back pain,” Carayannopoulos said.
There are surgical options and non-surgical options for treating low back pain. In most cases, the non-surgical options are sought first, but some patients still get unnecessary surgeries, according to Carayannopoulos.
The new treatment could also cut back on the use of opioids, which for some patients can be addictive to the point of overdose. More than half of opioid prescriptions are for low back pain, according to Carayannopoulos.
“If we can identify a treatment that has long-term promise, then we can sort of have a paradigm shift in the way we organize and treat a cohort of patients with degenerative disc pain, which is one of the common contributors to low back pain,” Carayannopoulos said.
Carayannopoulos did not have data on how many people suffer from low back pain in Rhode Island, but based on the number of spine centers in the state and anecdotal evidence, he reckons there is a significant number of people with the condition.
“Part of that comes from some of the legacy of blue-collar work that’s being done, industry stuff, line work that’s still being done, some jewelry business. But the type of stuff that we see is often degenerate, meaning it’s happened over time,” he said.
The trial is funded by Mesoblast, an Australia-based medicine company specializing in inflammatory diseases. It is designed for adults 18 years and older who have experienced chronic low back pain for at least six months, have been diagnosed with degenerative disc disease and have not found relief from other treatment options.
The trial is recruiting participants at Rhode Island Hospital and Newport Hospital. They will not be charged for participating and will be reimbursed for time and travel, according to Brown Health. To inquire about the trial, call 401-793-9177 or fill out a pre-screening information form online.
The trial is in its third phase, where researchers and clinicians are comparing results with a larger group of patients. It will be followed by a fourth phase, which will seek FDA approval to monitor long-term effectiveness and safety.
Rhode Island
Rhode Island to phase out sale of rat poisons under new law
(WJAR) — Rhode Island will begin phasing out the sale of certain rat poisons after Gov. Dan McKee signed new legislation into law Thursday, making the Ocean State the second in the nation to adopt restrictions on the products.
The law targets first- and second-generation anticoagulant rodenticides, commonly used to control rats and mice.
Supporters say the poisons are harming wildlife, while critics argue they are among the most effective tools available to manage rodent populations.
Under the law, the sale of first-generation anticoagulant rodenticides will be prohibited beginning March 1, 2027.
Restrictions on second-generation anticoagulant rodenticides will take effect Jan. 1, 2028. A statewide prohibition on both types is scheduled to take effect Jan. 1, 2029.
Licensed commercial applicators and certain public health, agricultural and municipal uses are exempt from the restrictions.
Supporters said birds of prey such as hawks, owls and eagles are particularly vulnerable because they consume poisoned rodents. (WJAR file photo)
The legislation was backed by the Audubon Society of Rhode Island, which says the poisons can move through the food chain and kill predators that feed on rodents.
“Across the country, and again, with Rhode Island making this move, the second only to California, we’ve seen just too many cases of off-species targets either being sickened or worse with these rodenticides,” said Maxwell McFarland, director of advocacy for the Audubon Society of Rhode Island.
McFarland said birds of prey such as hawks, owls and eagles are particularly vulnerable because they consume poisoned rodents.
“What we’re seeing is these are accumulating in the natural predators meant to manage these rodent populations,” McFarland said. “So primarily our hawks, owls and eagles.”
According to McFarland, wildlife rehabilitators in Rhode Island have documented widespread exposure to the poisons among injured birds brought into their care.
“They’ve had hundreds of raptors admitted into their care over the past couple of years, and every single one has shown signs of anticoagulant rodenticide poisoning,” he said.
Supporters of the law say reducing the use of rodenticides will encourage communities to adopt alternative pest-control methods, including improved sanitation, securing trash and sealing buildings to prevent rodent access.
The law also creates a voluntary municipal Integrated Pest Management pilot program aimed at helping communities transition away from anticoagulant rodenticides.
Not everyone supports the change.
Tony DeJesus, former vice president of Big Blue Bug Solutions, said the restrictions will make it more difficult for homeowners and businesses to control rats and mice. (WJAR)
Tony DeJesus, former vice president of Big Blue Bug Solutions, said the restrictions will make it more difficult for homeowners and businesses to control rats and mice.
“It’s gonna have a major impact on our business. And not only that, but on the homeowners,” DeJesus said.
DeJesus said over-the-counter rodent control products commonly used by homeowners will no longer be available once the law takes effect.
“Homeowners will not be able to go out anymore and buy things like Decon and some of the other over-the-counter baits once this goes into effect,” he said.
He also expressed concern about the impact on restaurants and public health.
“The main thing is that when we start talking about how this is gonna affect it, rats carry disease,” DeJesus said. “Food poisoning is associated with both rats and mice in restaurants and things.”
DeJesus pointed to California, which enacted similar restrictions, as a cautionary example.
“The proof in the pudding is the state of California that did the same thing three years ago,” he said. “And now Los Angeles has been voted the rattiest city in the United States.”
McFarland said the legislation provides communities and pest-control companies with time to adapt before the restrictions fully take effect.
“We believe that it’s a fair timeline where communities, municipalities and pest management companies can learn, unlearn rather, the status quo of how they’re applying these rodenticides,” he said.
The Audubon Society said Rhode Island’s law follows similar action taken in California and comes as other New England states consider comparable legislation.
State officials say the first restrictions under the new law will take effect in March 2027.
Rhode Island
Send-off ceremony held for Special Olympics Rhode Island athletes heading to USA Games
WARWICK, R.I. (WJAR) — The local community hosted a send-off celebration for Special Olympics Rhode Island athletes on Friday.
Twenty-four athletes, along with partners, coaches, and medical personnel, are traveling to Minneapolis for the 2026 Special Olympics USA Games.
The local community hosted a send-off celebration for Special Olympics Rhode Island athletes on Friday. (WJAR)
Textron hosted the team in a private jet for travel to the games, officials said.
“The USA Games represent months of dedication, hard work, and perseverance for our athletes,” President and CEO of Special Olympics Rhode Island Ed Pacheco said. “Our athletes, Unified partners, and coaches carry with them the hopes and aspirations of achieving gold while representing the very fabric of our great state. This journey would not be possible without Textron, and we are incredibly grateful for their support in creating a once-in-a-lifetime experience for Team Rhode Island as they travel to compete on the national stage.”
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Officials said the 2026 Special Olympics USA Games will be held from Saturday through next Friday.
Rhode Island
Rhode Island Pride turns 50 this weekend: ‘Queer joy is resistance’ – The Boston Globe
“They were truly the unrelenting voices of their time, and made sure that this was something that happened because they knew it was important,” Jess Motyl-Szary, director of Rhode Island Pride, said in an interview on Thursday.
The 1976 pride march came after local Bicentennial Committee organizers “refused meeting space for the group of community members hosting the Congress of People with Gay Concerns,” according to research by Matthew Lawrence and published on the Providence Public Library’s website.
“Calling themselves Toward a Gayer Bicentennial Committee, the group sued the official Bicentennial Committee and won the right to assemble at the Old State House, where about 30 people met in June 1976 to discuss civil rights concerns,” according to Lawrence.
But the contingent also had to fight to join the Bicentennial Parade after they were initially denied the right to do so by officials who pointed to the state’s anti-sodomy law at the time, according to Motyl-Szary.
The 76ers “knew that being a part of an existing parade meant there was a little bit of safety there, because it was an existing infrastructure,” Motyl-Szary said.
“But it also meant that there was a much higher visibility for them to be able to be out there, be proud, and show other people who might not have been out that there is a safe space for them,” Motyl-Szary said.
With the assistance of the American Civil Liberties Union, they won the right to march, she said.
“It wasn’t safe to be out in the ’70s,” Motyl-Szary said. “Incredibly great people marched. Some had to march with paper bags on their heads because there were no legal protections to protect their jobs, their home, their families, but [it was] still incredibly brave to go out there, create visibility, and create this organization.
“Being here 50 years later, and being a part of their legacy has been so incredible,” she said.
A lot has changed for LGBTQIA+ Rhode Islanders in the decades since, Motyl-Szary said.
“But the closeness of it still feels relevant because we’re seeing these continued attacks in our community, and a very real resurgence of attacks on the LGBTQIA+ community, especially our trans brothers, sisters, and siblings,” Motyl-Szary said.

Since returning to office last year, the Trump Administration has taken aim at transgender rights across the country, especially after President Donald Trump signed an executive order recognizing two sexes, male and female. Among other actions, Trump has often sought to tie adherence to the order with federal funding requirements, and the administration has also attempted to gather private medical records from hospitals that provided gender-affirming care to transgender children and teens.
Reflecting on what pride means to her right now, Motyl-Szary said pride festivities are new to at least somebody every year.
“Someone is coming and getting to feel this embrace, this huge hug of their community for the first time every year,” she said. “And in a time like this, when our community is being told that we are hated by the rest of our community, by the rest of our country, when we are told we should hate ourselves, coming out and celebrating ourselves, loving ourselves, loving each other is so incredibly important. Our community creates the space that we need.”
Motyl-Szary said she also believes that “queer joy is resistance.”
“There is a real need for us to have a space and a celebration of who we are and to remind ourselves that we are worthy of love and that we are worthy of being a part of a community that gathers, celebrates, and fights for ourselves and our rights,” she said.
Rhode Island Pride kicks off on Friday night with the “Golden Anniversary Eve” party from 6 to 8 p.m. at the 195 District Park in Providence, Motyl-Szary said.
Festivities continue at the park on Saturday with yoga at 10 a.m. and PrideFest entertainment beginning at 11 a.m., alongside approximately 260 vendors, she said. A rally at 2 p.m. will focus on “what’s happening, get people motivated to be involved in [the] community to speak up and be an activist in whatever way is right for their path of activism,” Motyl-Szary said.
The Illuminated Night Parade steps off at 7:30 p.m. at Washington and Empire streets before moving through downtown Providence, according to organizers.
Christopher Gavin can be reached at christopher.gavin@globe.com.
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