Illinois
Higher acetaminophen intake in pregnancy linked to attention deficits in young children
CHAMPAIGN, Ill. — A new study links increased use of acetaminophen during pregnancy – particularly in the second trimester – to modest but noticeable increases in problems with attention and behavior in 2-, 3- and 4-year-olds. The study adds to a growing body of evidence linking the frequent use of acetaminophen in pregnancy to developmental problems in offspring.
The findings are detailed in the journal Neurotoxicology and Teratology.
The research is part of the Illinois Kids Development Study at the University of Illinois Urbana-Champaign, which explores how environmental exposures influence child development. The study tracked hundreds of children, collecting data on their prenatal chemical exposures and asking caregivers to assess their behaviors and traits at ages 2, 3 and 4.
While acetaminophen is considered the safest painkiller and fever reducer available during pregnancy, previous studies have found evidence of a range of possible negative outcomes for children exposed to the drug in gestation, said Megan Woodbury, who led the research as a graduate student at the U. of I. with comparative biosciences professor emerita Susan Schantz, the principal investigator of the IKIDS program at Illinois. Woodbury is now a postdoctoral researcher at Northeastern University in Boston. Schantz is a faculty member of the Beckman Institute for Advanced Science and Technology at the U. of I.
A recent study led by Woodbury and Schantz linked higher acetaminophen exposure in pregnancy to language delays in children.
Some previous studies have found no relationship between acetaminophen use in pregnancy and attention and behavior in childhood, while other, usually larger studies found relationships between more frequent use of the medication during pregnancy and attention-related and behavioral problems in offspring. Most of the latter studies were conducted in older children and questioned pregnant participants about their use of acetaminophen at most once per trimester. The new study asked pregnant parents about their acetaminophen use six times over the course of the pregnancy – roughly once every four-to-six weeks – offering a more precise picture of the magnitude and timing of the drug exposures.
The researchers also asked caregivers to answer dozens of standardized questions about their child’s behavior and ability to pay attention at ages 2, 3 and 4. More than 300 children were assessed at age 2, with 262 assessed again at 3, and 196 at age 4.
“Our most important finding was that with increasing acetaminophen use by pregnant participants, especially during the second trimester, their children showed more attention-related problems and ADHD-type behaviors, which we call ‘externalizing behaviors,’ at every age we measured,” Woodbury said.
“The kinds of behaviors the caregivers reported included things like the child talking out of turn, not paying attention, not being quiet when they were supposed to be quiet, not sitting down when they were supposed to be sitting down, and being a little aggressive with other children,” Schantz said.
The findings are not an indication that the children have attention-deficit/hyperactivity disorder or that they will be diagnosed with ADHD at a later date, Schantz said. But the children seem to be having more trouble with attention than peers of the same age who were less exposed or not exposed to acetaminophen in the womb.
Woodbury, who herself is pregnant, says she does not want to scare others away from using acetaminophen in pregnancy when needed. Extreme headaches or other painful episodes and fevers can be debilitating and even dangerous, calling for use of the drug. She said she has turned to acetaminophen once per trimester so far. But she also chooses not to use it for minor aches, pains or slight fevers.
More research is needed to test whether more frequent use of acetaminophen during the second trimester of pregnancy may be particularly problematic for the developing brain, the researchers said. The study also is limited as participants were mostly white, non-Hispanic and of higher economic status. Schantz and her team are working to broaden the cohort of participants in IKIDS to include pregnant people from a greater diversity of social, economic and racial backgrounds.
This research was supported by the Children’s Environmental Health and Disease Prevention Research Center funded by the National Institute of Environmental Health Sciences and the U.S. Environmental Protection Agency and the National Institutes of Health Environmental Influences on Child Health Outcomes program.
ILLINOIS — On the weekend, we present a week in review of the top stories and headlines from all across Illinois. Here’s a roundup of some of the most-read stories across the state. You can also find your local Patch and catch up on those stories by clicking here.
Murder Charge Filed In I-80 Road Rage Shooting Death
State police responded to a 911 call of a shooting on I-80 and found a 30-year-old man who had been shot to death after a road rage-related crash, officials said.
Detective Killed In Shooting
Police said the officer, 40, was fatally shot after responding to a report of an armed person leaving a bank. The person accused in the shooting was also shot and is hospitalized, police said.
Happy Friday, Illinois Land!
Instead of doing the usual column with post-Thanksgiving word puns involving side dishes and jokes about turkeys, I will use my time to point out a few things that I now know about college basketball in 2025, and the place that Illinois occupies inside of that stratosphere.
I will also discuss where Illinois fits into the landscape of the Big Ten. I think you’ll like how I see that unfolding. My pending Big Ten Analysis will highlight the lack of good depth in the conference.
It is not exactly a banner year for the Big Ten in men’s college basketball. To say the least.
Despite the fact that the Big Ten has dropped in the national landscape, and despite the fact that Illinois lost to a True Elite in 2025 against Alabama in Birmingham by double digits, it’s great beyond words to have a head basketball coach leading your program playing basketball the way it needs to be played at this present date.
Brad Underwood has turned Illinois into a National Program. Do not confuse this with being a national powerhouse.
As I see it, here are the five levels of Illinois basketball. National Championship Contender can replace Blue Blood for Illinois. There was no way for me to get in a shot at Indiana and its fans unless I constituted it this way.
For reference: Indiana is now No. 61 in KenPom (76 in OER, and 51 in DER). I was told that they are the conference favorite. I was also told Illinois cannot play defense. More on this in a bit.
- Conference Bottomfeeder (Year 1-2): 26-39 in his first two seasons, 11-27 in the Big Ten. I would call this 1990s Era coaching. Up the line, full court pressure, etc.
- Respected NCAA Tournament Team (Year 3+): This will be five-straight non-bubble NCAATs for Underwood, six if you count the COVID-19 cancellation of 2020.
- Big Ten Power (Year 3+): In turn, this makes you a Final Four contender on semi-annual basis, at a minimum. I don’t mean make a Final Four, but be a Top Four seed. No one believes that NC State had a better season than Illinois last year.
- National (and International) Program (Year 4+): Playing games on CBS on Thanksgiving by request, re-hiring arguably the country’s top assistant coach (Orlando Antigua), signing two potential lottery picks from two countries outside the United States. I could go on, but I won’t. You get it.
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- Blue Blood (Never): This outdated term continues to keep Indiana fans from jumping off the nearest bridge for the last three-plus decades. Illinois will never be here. UCONN can’t get into the club with six National Championships since 1999.
Having said that, I’m going to say this.
John Calipari is in the Naismith Memorial Basketball Hall of Fame. He has taken three different programs to the Final Four: Massachusetts, Memphis and Kentucky. He is an all-time great coach with a dazzling record (814-260, for a .758 winning percentage).
Calipari won an NCAA Tournament and cut down the nets in 2012, his third year in Lexington leading the Cats. He was outstanding at Kentucky (410-123), winning games at a .769 clip during his 15-year tenure.
He inexplicably missed the NCAA Tournament twice, going just 9-16 in 2021. His last three years, Kentucky lost 30 games and twice in the NCAAT to vastly inferior teams against No. 15 St. Peter’s and last year against No. 14 Oakland.
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Please read the words I type. Do not create a false narrative around comparing Calipari and Underwood, in totality.
Underwood certainly has not had the career of Calipari — it’s not close — nor will he likely end up in the Hall of Fame anywhere outside of Champaign. Not impossible, but not likely.
Looking to the future, it’s clear which coach of the pair from the Thanksgiving matchup in Kansas City has the brighter future. This isn’t close, either.
While Underwood’s Illini blitzed Arkansas with a barrage of threes, high ball screens and floor spacing for play makers, Calipari and Kentu…Arkansas…had a plan “to attack the rim all game,” according to Calipari post-game.
Arkansas ATTEMPTED 17 threes. Illinois MADE 15. Illinois was +30 in in this category.
Frees (points at the free throw line) and threes (points behind the arc) is something I look at during every halftime, and after every game.
Illinois was +29 in this category. BU’s squad scored 90 points on the elite Arkansas defense, which was ranked No. 8 in KenPom DER prior to the contest.
The Illini had 60 of their 90 points (67.7%) of their points on Frees and Threes. Check on this stat every game that Underwood and Illinois play the entirety of the season. It will likely tell the story.
Factor in 2P% defense and you can get the winner of every game Illinois plays this year. The defensive strategy of Illinois is to defend the bucket and the arc. Despite giving a bucket full to Alabama in the lone loss (100-87), Illinois is currently No. 21 in DER.
Let’s take a look at pace of play, and how it affects efficiency, from a large scale perspective. What Illinois is doing is hard to copy.
For that matter, the Illinois offense is now No. 18 in OER (Offensive Efficiency Rating). Of the top 21 in DER on KenPom, Illinois has the FASTEST tempo, at No. 36.
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In summary, Illinois plays in the Top 10% in pace of play and ranks even better in efficiency at both ends. It’s not only extremely difficult to do, but largely unnecessary.
When you play fast and efficient on offense, defense lessens in importance in direct correlation with how more efficient your offense can be. In short, play fast and good on offense and you outscore your opponent and win based on simple math.
Here are the avearages for defensive and offensive efficiency. The lower the number, the faster the pace.
Top 5 DERs in terms of pace average: 260.6
Top 5 OERs in terms of pace average: 66.8
Illinois pace of play: 36 (Top 21 in both DER and OER)
I know it’s a lot of numbers. I get it. Underwood has embraced the numbers game and turned Illinois from a Big Ten Bottomfeeder to a National Program.
You may not like it, but you’re gonna learn to love it.
Please take The Scientific Poll.
Poll
What is the win ceiling for Illinois men’s basketball in 2024-25?
This is threes and frees. This is creating space. This is the winning formula.
This is Illinois Basketball.
KANSAS CITY (AP) — Freshman Kasparas Jakucionis scored a season-high 23 points, Tomislav Ivisic had 21 points and 10 rebounds and Illinois beat No. 19 Arkansas 90-77 on Thursday in the Thanksgiving Hoops Showcase.
Jakucionis hit two free throws to give Illinois a double-digit lead with 3:49 remaining in the game. Arkansas had a turnover and a missed jumper on its next two possessions and Jakucionis hit an open 3-pointer to make it 85-71 at 2:42.
Kylan Boswell added 18 points for Illinois (6-1). Head coach Brad Underwood broke a tie with J. Craig Ruby (1922-36) for fifth place in program history with 149 wins.
Adou Thiero went 12 of 21 from the line and scored 26 points for Arkansas (5-2). Zvonimir Ivisic had 13 points, six rebounds and two blocks.
Takeaways
Tomislav Ivisic won the battle against his twin brother, Zvonimir. Along with his double-double, Tomislav Ivisic made 6 of 9 3-pointers and blocked three shots. The 7-foot-1 center, playing his first college season, had 13 points and seven rebounds in the first half.
Key moment
Illinois stated the game on a 21-6 run and maintained at least a nine-point lead the rest of the way. Ben Humrichous made the Illini’s fifth 3-pointer with 12:36 left in the first half while Arkansas was 3 of 9 from the field.
Key stat
Illinois made 55% of its shots in the first half, including 9 of 16 from 3-point range, while Arkansas was 0 for 7 from long distance and shot 44% overall. The Illini finished 15 of 31 from distance. Arkansas shot 5 of 17 beyond the arc.
Up next
Arkansas plays at Miami in the second SEC/ACC Challenge on Tuesday. Illinois plays at Northwestern on Dec. 6 to begin Big Ten play.
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