Health
What to know about Cushing’s syndrome, which led to Amy Schumer’s dramatic weight loss
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Comedian Amy Schumer, 44, has recently come clean about her struggle with Cushing’s syndrome, leading to a dramatic weight loss.
Schumer’s transformation has sparked conversation online, to which she responded in a now-deleted Instagram post that shut down speculation about cosmetic enhancements.
“I didn’t lose 30lbs — I lost 50,” she emphasized on social media, adding that she does not get Botox or filler.
AMY SCHUMER DROPPED 50 POUNDS TO BATTLE DISEASE THAT ‘CAN KILL YOU’ IF UNTREATED
Schumer doubled down that her weight loss was not about her appearance, but about staying alive.
“Not to look hot, which does feel fun and temporary,” she said. “I did it to survive. I had a disease that makes your face extremely puffy that can kill you, but the internet caught it and that disease has cleared.”
Amy Schumer attends Variety’s 2024 Power of Women: New York event on May 2, 2024, in New York City on the left. On the right, Schumer later poses for a photo posted to Instagram after her weight loss. (Marleen Moise/WireImage; Amy Schumer/Instagram)
“Sorry for whatever feeling it’s giving you that I lost that weight,” she added. “I’ve had plastic surgery over the years and I use [Mounjaro]. Sorry to anyone they let down. I’m pain free. I can [play] tag with my son.”
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The actress also addressed her shifting hormones, saying that she’s “happy to share more if anyone has any questions about how I’m looking or feeling or where I am in my perimenopause process.”
“I didn’t lose 30lbs — I lost 50,” Schumer emphasized on social media, adding that she does not get Botox or filler. (Amy Schumer/Instagram)
What is Cushing’s syndrome?
Schumer previously revealed that she had been diagnosed with Cushing’s syndrome, a hormonal disorder that can cause extreme swelling, fatigue and potentially fatal complications.
Dr. Peter Balazs, a hormone and weight loss specialist in New Jersey, provided more details on the condition in an interview with Fox News Digital.
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“Cushing’s syndrome is caused by prolonged, high exposure to cortisol, which is your body’s main stress hormone,” he said. “Usually, the excess cortisol is a result of prolonged steroid use. We see this many times with patients who have some autoimmune disorder.”
Balazs said the “key” to Cushing’s syndrome is not just weight gain, but a “specific redistribution” of fat caused by too much cortisol.
Amy Schumer is photographed during a guest interview on The Tonight Show Starring Jimmy Fallon on Feb. 13, 2024 (left), and later seen walking through midtown New York City on Oct. 28, 2025 (right). (Todd Owyoung/NBC via Getty Images; Raymond Hall/GC Images/Getty Images)
Fat may be driven to the abdomen, chest, upper back (referred to as a “buffalo hump”) or face, sometimes considered “moon face,” the doctor said.
Cortisol also breaks down protein, which leads to a thinning in the arms and legs. “Weight gain can be tough, involuntary and hard to manage,” Balazs added.
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Cortisol stimulates “hunger centers” in the brain, raises blood sugar and promotes fat storage, especially deep belly fat, according to the doctor.
Cushing’s syndrome can also cause high blood pressure, bone loss and sometimes type 2 diabetes, per Mayo Clinic.
In addition to weight gain in certain areas, other symptoms may include pink or purple stretch marks on the stomach, hips, thighs, breasts and underarms, as well as acne, slow wound healing, and thin, frail skin that bruises easily.
With Cushing’s syndrome, fat may accumulate in the abdomen, chest, face or upper back (referred to as a “buffalo hump”). (iStock)
Women with Cushing’s syndrome often experience thick, dark hair on the face and body, as well as irregular periods. Symptoms among men can include a lower sex drive, reduced fertility and erectile dysfunction.
Mayo Clinic listed other potential symptoms, including extreme fatigue, muscle weakness, depression, anxiety, irritability, mood swings, trouble with concentration and memory, headache, sleeplessness, skin darkening and stunted growth in children.
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Those with symptoms should contact their doctor immediately, especially if they are taking steroids to treat health issues like asthma, arthritis or inflammatory bowel disease, as these medications can exacerbate the condition.
The Mayo Clinic has reported that the “sooner treatment starts, the better the chances for recovery.”
“I’ve had plastic surgery over the years and I use [Mounjaro],” Schumer stated in a social media post. (George Frey/Bloomberg)
For patients like Schumer, weight loss is typically not the main goal, Balazs noted, but it is a “critical sign” of successful treatment.
“The primary goal is to normalize your high cortisol levels,” he said. “I believe Amy Schumer got treated first for her underlying problem. Once the cortisol is normalized, which is the most important step, there’s a role to use adjunct medications to decrease weight.”
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Among GLP-1s, Mounjaro is an “excellent choice to decrease deep belly fat and increase insulin sensitivity of cells,” Balazs added.
Fox News Digital’s Stephanie Giang-Paunon contributed to this report.
Fox News Digital reached out to Schumer’s rep requesting comment.
Health
Giant golden spiders could spread this summer; experts downplay health risk
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Large, palm-sized spiders are spinning massive golden webs across porches and power lines, and, according to experts, they’re here to stay.
The Joro spider, which has a leg span up to 4 inches and markings of neon yellow, blue-black and red, was first recorded in Georgia in 2013.
Since its arrival — likely as a hitchhiker on a shipping container or an airplane from Asia, experts say — the arachnid has been steadily marching north.
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The spiders have so far been spotted in Georgia, North Carolina, South Carolina and Tennessee.
They are expected to spread throughout eastern North America, at least as far north as Pennsylvania and possibly further in warmer, coastal areas, according to Penn State.
Joro spiders can “fly” by shooting out silk parachutes that carry them on the wind. (Stuart Cahill/Boston Herald)
To travel, the spider uses a technique called “ballooning,” in which hatchlings release fine silk threads that catch air currents and carry them over long distances.
Ian Williams, an entomologist with Orkin, said he counted 200 adult spiders by September of last year on his one-acre property near Atlanta.
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“They’re quite intimidating looking spiders, and they make very large webs,” he told Fox News Digital. “The webbing itself, if it catches the sunlight, has a golden hue to it. And it’s very strong.”
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Despite the arachnid’s striking appearance, experts agree that people shouldn’t panic. Research shows the Joro is among the “shyest” spiders ever documented. When disturbed, they often sits motionless for over an hour rather than attacking.
Joro spiders like to spin their webs up high near houses, trees and even power lines, an expert said. (Stuart Cahill/Boston Herald)
“While they’re large spiders, they don’t have large fangs. And, so, it’s difficult for them to bite humans,” Williams noted.
Even in the rare event of a nip, the expert said the venom is weak, comparable to a localized bee sting, and carries “no medical importance.”
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As an invasive species, the Joro’s impact is still being weighed by scientists.
“One of the big concerns is that they potentially out-compete native species of spiders,” Williams said.
Physical removal is more efficient than pesticides, according to an expert. (iStock)
A prolific hunter, the Joro spider catches everything from mosquitoes to large, meaty insects like cicadas. It is unclear whether it steals food from native garden spiders.
To prevent Joro spiders from nesting on your porch or property, experts recommend using a broom or long pole to knock the web down.
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“Spiders may get the message, ‘Hey, I’m not going to keep remaking my same web in the same area,’” Williams said.
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Physical removal is more effective than pesticides, which often miss the spiders in their high, open-air webs.
For those who spot a Joro spider in a new area, experts suggest logging the sighting on apps like iNaturalist to help researchers track their northern migration.
Health
Another state bans ‘gas station heroin’ as officials warn of deadly risks
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Health
Dementia risk signals could lie in simple blood pressure readings, researchers say
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Simple measurements taken during routine blood pressure checks could predict dementia risk years before symptoms appear.
That’s according to new research presented this week at the American College of Cardiology’s Annual Scientific Session in Louisiana.
The findings draw on two studies led by researchers at Georgetown University, which suggest that monitoring how blood vessels age and stiffen over time can provide a window into future cognitive health.
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Data shows rates of dementia and aging-related cognitive decline are expected to increase as populations age, and half of U.S. adults have high blood pressure (hypertension).
Scientists believe that efforts to better address hypertension, a key contributor to heart disease and a risk factor for dementia, could affect both cardiac and brain health.
Data shows rates of dementia and aging-related cognitive decline are expected to increase as populations age. Meanwhile, half of U.S. adults have high blood pressure. (iStock)
“Blood pressure management isn’t just about preventing heart attacks and strokes; it may also be one of the most actionable strategies for preserving cognitive health,” Dr. Newton Nyirenda, the study’s lead author and an epidemiologist at Georgetown University in Washington, said in a press release.
The research focused on two metrics, the pulse pressure-heart rate index and estimated pulse wave velocity. Both were calculated using data collected during standard doctor visits, such as heart rate, age and blood pressure.
“Blood pressure management isn’t just about preventing heart attacks and strokes; it may also be one of the most actionable strategies for preserving cognitive health.”
Researchers examined five years of data patterns for more than 8,500 people in the SPRINT trial, a large study of adults 50 years and older with hypertension. In the follow-up, 323 of the participants developed probable dementia.
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In one study, the team found the pulse pressure-heart rate index was a strong independent predictor of dementia risk in adults over 50. For participants under 65, every one-unit increase was associated with a 76% higher risk of developing dementia.
For participants under 65, an increase in the pulse pressure-heart rate index was associated with a 76% higher risk of developing dementia. (iStock)
The second study found that adults with consistently elevated or rapidly increasing pulse wave velocity were more likely to develop dementia than those with stable velocity, even after accounting for factors like smoking, gender and cardiovascular history.
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“Our findings suggest that vascular aging patterns may provide meaningful insight into future dementia risk,” said Nyirenda. “This reinforces the idea that managing vascular health earlier in life may influence long-term brain health.”
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The team emphasized that clinicians should tailor risk assessments and treatment strategies to the individual.
Further studies are needed to confirm these parameters and determine whether changing vascular aging trajectories reduces dementia risk. (iStock)
“You don’t want to wait until a patient starts manifesting cognitive decline before you act,” said senior study author Sula Mazimba, an associate professor at the University of Virginia.
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Researchers noted the study could not establish causation. Other limitations included the fact that participants already had hypertension and elevated cardiovascular risk, meaning the findings may not apply to people without those conditions.
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Further studies are needed to confirm these findings and to determine whether improving blood vessel health over time could reduce dementia risk.
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