Health
Weight loss, diabetes drugs can cause mood changes: What to know about behavioral side effects
GLP-1 receptor agonists (GLP-1 RAs), medications that help control type 2 diabetes and obesity, can have a profound impact on physical wellness – but what about mental health?
Some examples of these medications include semaglutides, such as Ozempic and Wegovy, and liraglutide, like Victoza and Saxenda.
Various studies have pointed toward GLP-1 RAs causing mental health complications, such as anxiety and depression.
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The National Institutes of Health (NIH) published research in June 2024 that considered the correlation between semaglutide therapy and “exacerbating mood disturbances.”
The study highlighted the association of negative mood changes in patients with type 2 diabetes with a history of depression, warning healthcare providers to be aware of this “potential risk.”
Studies have debated the correlation between GLP-1 RA drugs and mood changes. (iStock)
But a more recent study, published in the journal Diabetes, Obesity and Metabolism, suggested that these mood changes were linked to genetic variations across diverse populations and ancestries within the U.K. Biobank.
While GLP-1 RA variants had “consistent cardiometabolic effects” across all groups, the researchers said the negative impacts on mental health were “more varied,” concluding that any behavioral changes are “likely not acting directly through [the medications].”
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Doctors weigh in on medications and mood
Dr. Brett Osborn, a Florida neurosurgeon who often prescribes GLP-1 RAs to his patients, believes that there is “no consistent causal relationship” between these medications and mental illness.
“Researchers assayed genetic markers across almost half a million people from different backgrounds in search of a link between the gene behind GLP-1 receptors and mental health problems like depression, anxiety or suicidal ideation — and they didn’t find it,” he summarized.
GLP-1 receptor agonists have been linked to mood changes, patients and doctors have reported. (iStock)
People who are obese or battling type 2 diabetes are “often already depressed” without the medication, the doctor pointed out.
“These conditions take a toll – physically, emotionally and socially,” he said. “So, yes, a large portion of patients starting GLP-1 drugs are already dealing with mental health struggles. But that’s not because of the drug — that’s because of the disease.”
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Once these individuals begin dropping weight, blood sugar stabilizes and energy improves, which usually lifts their mood as well.
“GLP-1 drugs help people reclaim their health,” Osborn noted. “They reduce inflammation. They lower blood sugar. They shrink waistlines.”
“And when people look and feel better, when their bodies finally start working for them instead of against them, they often smile more, not less.”
“GLP-1 drugs help people reclaim their health,” one doctor said. “And when people look and feel better, when their bodies finally start working for them instead of against them, they often smile more, not less.” (iStock)
Dr. Muhammad Ghanem, a bariatric surgeon at Orlando Health Weight Loss and Bariatric Surgery Institute, shared in a separate interview with Fox News Digital that while some of his patients have reported mood changes, others “don’t have that at all.”
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“Depression or mood changes are very common regardless, especially nowadays, and so it’s hard to [determine] whether this is related to the GLP-1 agonist medications, or whether it just happens to be that they started suffering from these after they started that medication,” he said.
“It’s really hard to tell whether it’s a personality change that can happen because of weight loss or if it’s a side effect because of mood changes,” he added. “I don’t think we have enough data to reach that conclusion yet.”
For those who are interested in GLP-1 RA medications or are experiencing mood changes while taking them, an expert stressed the importance of keeping in close contact with medical providers. (iStock)
Patients who lose weight with GLP-1 RAs can experience a “big boost” in confidence, as well as a change in personality and even relationships, according to Ghanem.
“It really depends on the person and the support system they have,” he said. “You need proper, randomized controlled trials to reach a conclusion, and better studies to determine whether this is related to the medication itself or just weight loss.”
“It’s important for all doctors who prescribe these drugs to be aware and check the patient’s history.”
For those who are interested in these medications or are experiencing mood changes while taking them, the surgeon stressed the importance of keeping in close contact with medical providers.
“Just like any other medication, they can have potential side effects,” he said.
Ghanem recommended seeking out professionals and practices who take a “holistic approach” to weight loss, offering mental health support in addition to medication.
Dr. Brunilda Nazario, MD, chief physician editor of medical affairs at WebMD, told Fox News Digital that “obesity is complicated.”
“Obesity specialists … are cautiously excited about how well these drugs work,” she said.
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“With current studies showing conflicting results on mood disorders and the use of GLP-1 drugs, it’s important for all doctors who prescribe these drugs to be aware and check the patient’s history before prescribing [them].”
“Don’t be afraid to ask for help if you feel something is not right — your health depends on it,” one expert suggested. (iStock)
Nazario stressed that it’s “vital” for GLP-1 RA users to listen to their bodies, urging them to pay attention to their feelings and know the symptoms of mood disorders.
“Don’t be afraid to ask for help if you feel something is not right — your health depends on it,” he added.
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Nazario noted that GLP-1 RAs can affect mood in many different ways.
“They are not all negative — they have the potential to improve mood as well,” she said. “Just seeing great results can boost self-esteem, confidence and body image.”
Health
Diabetes surge among Americans could be driven by ‘healthy’ breakfasts, doctor warns
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Americans consume foods every day that are marketed as “healthy,” when they could be quietly destroying their health, one doctor warns.
Dr. Mark Hyman, physician and co-founder of Function Health in California, says that much of America’s daily diet is filled with unhealthy ingredients.
“The amount of refined starches and sugars that are everywhere is just staggering to me, given what we know about how harmful they are,” he shared in an interview with Fox News Digital. “I don’t think people really understand.”
Hyman, author of the new book “Food Fix Uncensored,” said he’s “astounded” by what people are eating, especially for breakfast.
“People just eat sugar for breakfast,” he said. “They have muffins, they have bagels, they have croissants, they have sugar-sweetened coffees and teas.”
Dr. Mark Hyman is the author of the new book “Food Fix Uncensored.” (Function Health; Little, Brown Spark)
In addition to the traditionally sweet options for breakfast, some cereal brands and breakfast staples have adopted new “protein-packed” menu items and products, following health trends that encourage eating more protein.
“Highly processed food is not food.”
“Now, we’re seeing this halo of protein in certain things,” Hyman said, mentioning that many protein smoothies are “full of sugar.”
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The doctor also noted that some popular cereals are now marketed as having protein in them. “My joke is, if it has a health claim on the label, it’s definitely bad for you,” he said.
Instead of starting the day with a “quick fix” or processed food, Hyman suggests choosing whole sources of protein and fat for breakfast, adding that “if there’s a little carbohydrate in there, it’s fine.”
More products marketed as “high protein” have cropped up on supermarket shelves. (iStock)
For his own breakfast, Hyman said he has a protein shake with whey protein, avocado and frozen berries. Eggs and avocados are also a great protein-and-fat combo option, he added.
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“It’s not that complicated — people need to just think about their breakfast not being dessert,” he said. “No wonder we’re in this cycle of obesity and diabetes. One in three teenage kids now has type 2 diabetes or pre-diabetes. That’s just criminal.”
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Instead of counting calories and being in a caloric deficit as a way to lose weight and stay healthy, Hyman instead suggests focusing on how certain foods make you feel and how they impact your health.
“When you look at the way in which different types of calories affect your biology, you can just choose what you’re eating, and then you don’t have to worry about how much,” he told Fox News Digital.
In addition to the traditionally sweet options for breakfast, some cereal brands and breakfast staples have adopted new “protein-packed” menu items and products. (iStock)
“For example, if you eat a diet that doesn’t cause your insulin to spike — which is low in starch and sugar, higher in protein and fat — you won’t develop those swings in blood sugar, you won’t develop the spikes in insulin, you won’t deposit hungry fat … You will break that cycle.”
People are more likely to “self-regulate when they eat real food” instead of processed foods, which “bypasses the normal mechanisms of satiety, fullness and brain chemistry,” according to Hyman.
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“Ultraprocessed food and junk food or highly processed food is not food,” he said. “It doesn’t support the health and well-being of an organism. It doesn’t do that. It does the opposite.”
Health
Scientists make startling discovery when examining prostate cancer tissue
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Small fragments of plastic were found in the tumors of most prostate cancer patients, according to a new study from NYU Langone Health.
In past studies, microplastics have been found in almost every human organ and in bodily fluids, but their impact on human health still isn’t fully understood.
The researchers analyzed tissue samples from 10 patients with prostate cancer who underwent surgery to remove the entire organ.
Using visuals of both benign samples and tumor samples, as well as specialized equipment, the scientists identified plastic particles in 90% of the tumor samples and 70% of benign tissue samples, according to the study press release.
In past studies, microplastics were found in almost every single human organ along with bodily fluids, even the placenta. (iStock)
The cancerous tissue contained on average more than double the amount of plastic as healthy prostate tissue samples, the study found. This equates to about 40 micrograms of plastic per gram of tissue compared to 16 micrograms.
Researchers avoided contaminating the samples with other plastics by substituting standard tools with those made of aluminum, cotton and other non-plastic material, the release noted.
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The scientists say this is the first direct evidence linking microplastics to prostate cancer.
“By uncovering yet another potential health concern posed by plastic, our findings highlight the need for stricter regulatory measures to limit the public’s exposure to these substances, which are everywhere in the environment,” said senior study author Vittorio Albergamo, assistant professor in the department of pediatrics at NYU Grossman School of Medicine, in the release.
Using visuals of both benign samples and tumor samples, as well as specialized equipment, the scientists identified plastic particles in 90% of the tumor samples and 70% of benign tissue samples. (iStock)
The study findings were presented during the American Society of Clinical Oncology’s Genitourinary Cancers Symposium in San Francisco on Feb. 26.
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“What is most striking is not that microplastics were detected, but that they were found embedded within tumor tissue itself,” Dr. David Sidransky, oncologist and medical advisor at SpotitEarly, a startup that offers an at-home breath-based test to detect early-stage cancer, told Fox News Digital.
“While complete avoidance is unrealistic, people can take practical steps to reduce exposure.”
“We already know microplastics are present in water, air, blood and even placental tissue. Their detection in prostate tumors suggests systemic distribution and long-term bioaccumulation,” added Maryland-based Sidransky, who was not involved in the study.
Study limitations
Albergamo cautioned that a larger sample is needed to confirm the findings. Additionally, Sidransky noted that the presence of microplastics alone does not prove they cause cancer.
“Tumors can act as ‘biologic sinks,’ meaning they may accumulate circulating particles simply because of altered vasculature and permeability,” he said.
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A key unanswered question, according to the doctor, is whether microplastics are biologically active in ways that “promote DNA damage, immune modulation or chronic inflammation within the prostate.”
About one in eight men in the U.S. will be diagnosed with prostate cancer at some point in their lifetime, according to the Centers for Disease Control and Prevention.
The most actionable step men can take is appropriate screening and early detection, according to doctors. (iStock)
For those concerned about microplastics, Sidransky offered some insights.
“I believe the appropriate response is curiosity, not panic, and a commitment to understand more,” he said.
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“While complete avoidance is unrealistic, people can take practical steps to reduce exposure, such as minimizing heating food in plastic containers, reducing bottled water consumption when possible, and favoring glass or stainless steel alternatives.”
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The most actionable step men can take, however, is getting appropriate screenings to help ensure early detection, according to the doctor. Screening discussions should be individualized based on age, family history and other risk factors.
Health
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