Health
Weight loss, diabetes drugs can cause mood changes: What to know about behavioral side effects

GLP-1 receptor agonists (GLP-1 RAs), medications that help control type 2 diabetes and obesity, can have a profound impact on physical wellness – but what about mental health?
Some examples of these medications include semaglutides, such as Ozempic and Wegovy, and liraglutide, like Victoza and Saxenda.
Various studies have pointed toward GLP-1 RAs causing mental health complications, such as anxiety and depression.
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The National Institutes of Health (NIH) published research in June 2024 that considered the correlation between semaglutide therapy and “exacerbating mood disturbances.”
The study highlighted the association of negative mood changes in patients with type 2 diabetes with a history of depression, warning healthcare providers to be aware of this “potential risk.”
Studies have debated the correlation between GLP-1 RA drugs and mood changes. (iStock)
But a more recent study, published in the journal Diabetes, Obesity and Metabolism, suggested that these mood changes were linked to genetic variations across diverse populations and ancestries within the U.K. Biobank.
While GLP-1 RA variants had “consistent cardiometabolic effects” across all groups, the researchers said the negative impacts on mental health were “more varied,” concluding that any behavioral changes are “likely not acting directly through [the medications].”
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Doctors weigh in on medications and mood
Dr. Brett Osborn, a Florida neurosurgeon who often prescribes GLP-1 RAs to his patients, believes that there is “no consistent causal relationship” between these medications and mental illness.
“Researchers assayed genetic markers across almost half a million people from different backgrounds in search of a link between the gene behind GLP-1 receptors and mental health problems like depression, anxiety or suicidal ideation — and they didn’t find it,” he summarized.

GLP-1 receptor agonists have been linked to mood changes, patients and doctors have reported. (iStock)
People who are obese or battling type 2 diabetes are “often already depressed” without the medication, the doctor pointed out.
“These conditions take a toll – physically, emotionally and socially,” he said. “So, yes, a large portion of patients starting GLP-1 drugs are already dealing with mental health struggles. But that’s not because of the drug — that’s because of the disease.”
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Once these individuals begin dropping weight, blood sugar stabilizes and energy improves, which usually lifts their mood as well.
“GLP-1 drugs help people reclaim their health,” Osborn noted. “They reduce inflammation. They lower blood sugar. They shrink waistlines.”
“And when people look and feel better, when their bodies finally start working for them instead of against them, they often smile more, not less.”

“GLP-1 drugs help people reclaim their health,” one doctor said. “And when people look and feel better, when their bodies finally start working for them instead of against them, they often smile more, not less.” (iStock)
Dr. Muhammad Ghanem, a bariatric surgeon at Orlando Health Weight Loss and Bariatric Surgery Institute, shared in a separate interview with Fox News Digital that while some of his patients have reported mood changes, others “don’t have that at all.”
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“Depression or mood changes are very common regardless, especially nowadays, and so it’s hard to [determine] whether this is related to the GLP-1 agonist medications, or whether it just happens to be that they started suffering from these after they started that medication,” he said.
“It’s really hard to tell whether it’s a personality change that can happen because of weight loss or if it’s a side effect because of mood changes,” he added. “I don’t think we have enough data to reach that conclusion yet.”

For those who are interested in GLP-1 RA medications or are experiencing mood changes while taking them, an expert stressed the importance of keeping in close contact with medical providers. (iStock)
Patients who lose weight with GLP-1 RAs can experience a “big boost” in confidence, as well as a change in personality and even relationships, according to Ghanem.
“It really depends on the person and the support system they have,” he said. “You need proper, randomized controlled trials to reach a conclusion, and better studies to determine whether this is related to the medication itself or just weight loss.”
“It’s important for all doctors who prescribe these drugs to be aware and check the patient’s history.”
For those who are interested in these medications or are experiencing mood changes while taking them, the surgeon stressed the importance of keeping in close contact with medical providers.
“Just like any other medication, they can have potential side effects,” he said.
Ghanem recommended seeking out professionals and practices who take a “holistic approach” to weight loss, offering mental health support in addition to medication.
Dr. Brunilda Nazario, MD, chief physician editor of medical affairs at WebMD, told Fox News Digital that “obesity is complicated.”
“Obesity specialists … are cautiously excited about how well these drugs work,” she said.
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“With current studies showing conflicting results on mood disorders and the use of GLP-1 drugs, it’s important for all doctors who prescribe these drugs to be aware and check the patient’s history before prescribing [them].”

“Don’t be afraid to ask for help if you feel something is not right — your health depends on it,” one expert suggested. (iStock)
Nazario stressed that it’s “vital” for GLP-1 RA users to listen to their bodies, urging them to pay attention to their feelings and know the symptoms of mood disorders.
“Don’t be afraid to ask for help if you feel something is not right — your health depends on it,” he added.
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Nazario noted that GLP-1 RAs can affect mood in many different ways.
“They are not all negative — they have the potential to improve mood as well,” she said. “Just seeing great results can boost self-esteem, confidence and body image.”

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Health
Low-calorie diets linked to surprising mental health effect, new research shows

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Embarking on a low-calorie diet could potentially lead to negative mental health, researchers in Toronto, Canada, have revealed.
A new study, published in BMJ Nutrition, Prevention and Health, investigated how the adoption of restrictive diets could instigate depressive symptoms.
Using the National Health and Nutrition Examination Survey, researchers analyzed nearly 29,000 adults who reported their dietary habits and also completed a mental health questionnaire.
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Nearly 8% of these adults reported depressive symptoms.
Compared to those who did not follow a specific diet, those who stuck to a calorie-restrictive diet — including overweight individuals — saw an increase in depressive symptom severity, the study found.
A new study found that calorie-restrictive eating can lead to depressive symptoms. (iStock)
People who followed a nutrient-restricted diet saw a larger increase in symptoms, while men who followed any diet reportedly showed “higher somatic symptom scores” compared to non-dieters.
The researchers concluded that there are “potential implications of widely followed diets on depressive symptoms, and a need for tailored dietary recommendations based on BMI and sex.”
Potential limitations
Judith S. Beck, PhD, president of the Beck Institute for Cognitive Behavior Therapy in Pennsylvania, reacted to these findings in an interview with Fox News Digital.
The expert, who was not involved in the research, noted that it only showed an association between low-calorie diets and depression.
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“This is an important distinction, [because] correlation does not equal causation, and having a few depressive symptoms does not mean you have the condition of depression,” she said.
Beck noted that depression and negative emotions can also be caused by multiple cognitive, emotional or behavioral factors that are “more directly associated with depressive symptoms.”

Men showed higher scores for depressive symptoms than women, the study found. (iStock)
Fostering healthy habits
Certified holistic nutritionist Robin DeCicco in New York City commented that most Americans would benefit from losing weight, as 70% of Americans are overweight or obese, according to the Centers for Disease Control and Prevention (CDC).
This can be done by reducing the intake of sugary drinks and processed foods, and learning how to incorporate more whole foods like lean protein, vegetables, fruits and nuts, recommended DeCicco, who also was not involved in the study.
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The nutritionist also warned against following fad diets.
“It’s not sustainable or healthy to follow these trends because, most often, they are not educating the public on the type of nutrients you need to function mentally and physically, which is why it doesn’t surprise me that people can experience depressive and cognitive-affective symptoms when losing weight.”

Cutting out some high-fat foods like avocado and olive oil is also eliminating nutrients like omega-3 fatty acids, a nutritionist cautioned. (iStock)
The quality of calories “matters dramatically,” DeCicco noted.
“While weight loss is about calories in and calories out, it’s also about the type of calories and what we need for fuel, protection against disease, and mental and physical satisfaction,” she said.
“Food has the power to help us or harm us, and if we’re not eating certain foods known to promote mental well-being, we will definitely suffer from cognitive impairment and unstable mood.”
As an example, cutting out fats because they’re high in calories — like salmon, avocado, olive oil and nuts — also cuts out nutrients like omega-3 fatty acids, which can reduce inflammation, prevent disease and improve cognition, mood and brain health, DeCicco noted.

“Food has the power to help us or harm us, and if we’re not eating certain foods known to promote mental well-being, we will definitely suffer from cognitive impairment and unstable mood.” (iStock)
“If someone wants to lose weight but also has a health history of cognitive decline or is diagnosed with depression, it is even more important to emphasize the food groups mentioned above,” DeCicco added.
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Beck echoed the importance of eating in a “very healthy way,” while also recommending that people consider cognitive behavioral therapy (CBT).
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“CBT helps people learn the cognitive (thinking) and behavioral skills they need to eat as healthily as possible given their circumstances, and to change their thinking so they can make long-term changes in their eating and improve their overall health,” she said.
Fox News Digital reached out to the study researchers for comment.
Health
How to Tackle Your To-Do List if You Struggle With Executive Functioning

The pomodoro technique. Power poses. Planners. Denise Daskal has tried them all, searching for the right strategy to improve her executive functioning, or the mental skills used to manage time and pursue goals.
Ms. Daskal has spent hours hunting through TikTok, reading books and taking classes to become better organized and more focused both at work and in her personal life. But the long list of strategies, while somewhat helpful, has felt exhausting, she said.
“My mind breaks a bit when I get overwhelmed and I have too much coming at me all at once,” said Ms. Daskal, 63, who lives in Dearborn, Mich., and was diagnosed with attention deficit hyperactivity disorder a few years ago.
Conditions like A.D.H.D., autism, obsessive compulsive disorder and depression can impede executive functioning; so can the period of life when women transition in and out of menopause. Life circumstances such as parenting young children, getting a bad night’s sleep or even missing a meal can scramble a person’s ability to focus and complete tasks, too.
Here’s how to understand executive functioning, and figure out which coping strategies might work for you.
What is executive functioning?
Executive functions are life management skills that help people “convert intentions into actions,” said Ari Tuckman, a psychologist in West Chester, Pa., and author of the “The ADHD Productivity Manual.”
In other words, if you plan to do something, executive functions help you do it at the right time and place because it will benefit you, either now or in the future, he added. These skills are essential for planning, solving problems, managing time, making decisions and initiating tasks, as well as controlling your emotions and attention.
Amy Dorn, 44, a mother of three in Evergreen, Colo., who has A.D.H.D., has trouble staying calm when her brain becomes overstimulated by too many things happening at once. It doesn’t take long before she becomes frazzled. Sometimes, she said, she’ll even “scream at the top of my lungs.”
There are no quick fixes, but the self-awareness that her brain is different helps her calm down faster, take a deep breath and say she’s sorry.
“The kids call me the apologizer,” she said.
Her tendency to go from 0 to 100 may never go away, she added, so her family has found ways to prevent overstimulation from happening in the first place. Her husband changed his working hours, arriving home earlier to ensure that she has an extra hand shuttling the kids to activities. And they have limited their children to one sport per season.
Moving beyond tips and tricks
There’s no shortage of techniques to help with executive functioning, like the pomodoro method that Ms. Daskal tried, the gist of which is a 25-minute burst of focused attention followed by a short break.
But before trying one of these strategies, experts say, it may help to start with a brief self-analysis.
Identify which aspects of executive functioning are most problematic for you.
Tamara Rosier, the founder of the ADHD Center of West Michigan and the author of “You, Me, and Our ADHD Family,” said that difficulty starting a task was the most common executive functioning issue for her clients. The to-do list can feel overwhelming, which may lead to frustration, anxiety and avoidance.
When Ms. Daskal planned to finally clean out her garage, for example, she was so paralyzed by the prospect that she went out and adopted a dog instead.
Potty training a puppy seemed simpler than confronting the thousands of little decisions required to organize her space, she explained.
Next, look for solutions that address your problem.
For task initiation, ask yourself, “What’s making this hard to start?”
It might be perfectionism, fear or unclear steps, Dr. Rosier said. Once you have a better idea of what’s slowing you down, try to address it. If you’re unsure of what steps to take because your are overwhelmed with emotion, make a list of what is overwhelming. Then ask yourself, “Am I overcomplicating this task?” Challenge yourself to think of the simplest way to do it, Dr. Rosier said.
Another strategy, she added, is to use “body doubling,” which is working alongside someone else — virtually or in person — to create momentum. For example, the Attention Deficit Disorder Association offers an online “productivity powerhour” where people can gather to work toward a goal. You can also pair your task with something pleasant like music or a podcast to make it feel more enjoyable.
Try solving the problem outside your mind.
“Externalizing” your thought process — by discussing your problem with a friend, writing it down or physically manipulating the things you’re working on — can be more helpful than trying to hold everything in your mind, Dr. Tuckman said.
Ms. Dorn, for example, often forgets things that seem boring or mundane. She now wears a recording device on her wrist and says her to-do list out loud, then plays it back later in the day.
Set expectations for yourself and others.
Personal strategies are less effective if your environment isn’t friendly to people with executive functioning deficits, such as a job that requires you to complete a complex task on the computer while continuing to receive instant messages that may or may not require a response, breaking focus on the main task.
Ms. Daskal decided to pivot from owning a salon and spa, which involved managing a facility and a staff, to focus on her dream of starting a new nail polish brand. This time around, she said, she’s mindful of how many responsibilities she’s taking on and which ones need to be outsourced. That helps her make time for sleep and exercise.
“I limit both what I attempt to do in a day as well as the time I attempt to do them,” she said. Her mantra: “One step at a time, one thing at a time.”
Setting expectations with the people you interact with is also important, Dr. Tuckman said. Say you’re always late to meet friends. You can work on arriving earlier while also being honest, saying, “Don’t leave until I text you,” Dr. Tuckman suggested.
Don’t judge yourself too harshly.
If you’ve had trouble with executive functioning, it can be easy to blame yourself — especially if other people are continually suggesting that you fall short.
Remind yourself that you aren’t flawed or irresponsible, Dr. Tuckman said. Rather, you have difficulty following through on what you intend to do and juggling all of the other demands of life in order to make it happen, he added.
This mind-set can be “tremendously validating,” he said, especially when someone has tried so hard — sometimes even harder than others — yet doesn’t have as much to show for it.
“If you are someone who struggles with executive functions, critical people with very specific expectations may not be the people who should have a starring role in your life,” Dr. Tuckman said. “It’s not just you are a bad fit for them — they are a bad fit for you.”
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