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Want to stay healthy after 40? Doctors say men should consider 14 medical tests

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Want to stay healthy after 40? Doctors say men should consider 14 medical tests

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Men account for higher rates of nearly all major chronic diseases — yet nearly two-thirds admit that they avoid going to the doctor for as long as possible, according to a Cleveland Clinic survey.

Physicians warn that once men enter their 40s, routine screenings become essential for spotting problems early, before preventable conditions turn life-threatening.

“When it comes to preventing heart attacks, strokes, fatigue, erectile dysfunction, metabolic disease and early aging, testing is essential,” Dr. Jack Wolfson, a cardiologist in Arizona, told Fox News Digital. “Most men have no idea what’s happening inside their bodies until it’s too late.”

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“If I could give one message to every man over 40: Test, don’t guess,” he went on. “Catch the problem early, fix it naturally, and live to 100 and beyond with vitality.”

Below, experts share some of the most important medical tests that men over 40 should discuss with their doctors — some of which are universally recommended, and others that apply to certain groups.

Men account for higher rates of nearly all major chronic diseases — yet nearly two-thirds admit that they avoid going to the doctor for as long as possible. (iStock)

1. Complete blood count (CBC)

Dr. Andrea Caamano, M.D., a New Jersey physician specializing in endocrinology, diabetes and metabolism, recommends that this blood test is performed yearly for men in their 40s and older.

“It tells us the state of a patient’s red blood cells, white blood cells and platelets, and tells of infection, allergic reactions, inflammation, anemia and clotting disorders,” she told Fox News Digital.

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The CBC is especially important in men undergoing testosterone replacement therapy (TRT), as testosterone stimulates the production of red blood cells — and an overproduction will raise the risk of clots and high blood pressure, according to the doctor.

“The test’s only limitation is that it does not tell us why something is happening,” Caamano said. “It will give us values, but not a reason when they are outside normal limits.”

“If I could give one message to every man over 40: Test, don’t guess.”

Health agencies such as the CDC, U.S. Preventive Services Task Force (USPSTF) and World Health Organization do not recommend a CBC test for every person without symptoms, but they do recommend it for people experiencing symptoms like anemia, infection, inflammation, fatigue, bleeding or bruising, or for those with a known medical condition.

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2. Comprehensive metabolic panel (CMP)

This blood test is commonly performed yearly, according to Caamano, especially for men using TRT.

“This blood test measures metabolic and organ function, giving information about the kidneys and liver, and electrolyte and glucose state,” she said. “It is important to catch any organ issue that can pop up on its own, or that can be age- or medication-induced.”

The CDC and USPSTF recommend that all adults 18 and over should undergo routine blood pressure screening. High blood pressure is defined as 130/80 mmHg or higher. (iStock)

The test can also catch things like liver and kidney disease, pre-diabetes, full-blown diabetes and electrolyte imbalances that can lead to blood pressure fluctuations and heart rhythm issues, according to the doctor.

Caamano recommends that men using TRT get a baseline CMP, then get monitored every three to six months in the first year of treatment and then yearly. Organizations like the USPSTF, CDC and WHO, however, only recommend CMPs when evaluating symptoms, monitoring chronic conditions or checking medication safety.

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3. Blood pressure

The CDC and USPSTF recommend that all adults 18 and over should undergo routine blood pressure screening. High blood pressure is defined as 130/80 mmHg or higher.

Individuals aged 40 and older — or those with elevated risk — are advised to be tested every year, while younger adults with consistently normal results may be screened every three to five years.

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“The use of TRT can increase blood pressure, so it is very important to monitor regularly,” Caamano said. “Increased blood pressure can be indicative of cardiovascular disease.”

4. Coronary artery calcium (CAC) score

Dr. Auda Auda, a board-certified physician at Baker Health in New York, names this as his top recommendation to protect against heart disease, which remains the No. 1 cause of death in men over 40.

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“A CAC scan directly measures calcified plaque in the coronary arteries, years before symptoms develop,” Auda told Fox News Digital. “For many men, it’s the difference between ‘normal annual labs’ and a silent, high-risk cardiovascular picture that would otherwise go unnoticed.”

A high CAC score identifies early coronary atherosclerosis, leading to targeted lifestyle changes, statins and risk modification to help prevent heart attack and stroke. (iStock)

A high CAC score identifies early coronary atherosclerosis, leading to targeted lifestyle changes, statins and risk modification to help prevent heart attack and stroke, the doctor noted.

The test should be done every five years if the score is 0, or every one to two years if the score is >0, Auda advised.

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“I’ve had multiple men in their 40s with ‘perfect’ cholesterol come back with CAC scores in the 200-400 range, completely changing their trajectory,” he shared.

Major health agencies, such as the American College of Cardiology (ACC), American Heart Association (AHA) and USPSTF, recommend CAC scoring for adults who are at intermediate risk of heart disease or when it’s unclear whether they should start statin therapy.

5. Advanced lipid profile

Dr. Jeremy M. Liff, a board-certified neurologist in New York, puts this test at the top of his list.

“Unlike a standard cholesterol panel, which only gives you HDL (‘good’ cholesterol) and LDL (‘bad’ cholesterol), the advanced version breaks down the specific types of LDL particles,” Liff told Fox News Digital. “Some LDL particles are far more dangerous than others.”

“Insulin resistance influences nearly every major organ, including the liver and the brain.”

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The advanced lipid profile helps to prevent “catastrophic” cardiovascular and cerebrovascular events, such as heart attacks and strokes, according to the doctor.

“This test gives men over 40 a much clearer picture of their cardiovascular risk and whether they need major dietary or lifestyle changes,” he said. “By identifying dangerous LDL particle types early, men can intervene before plaque buildup becomes life-threatening.”

The advanced lipid profile helps to prevent “catastrophic” cardiovascular and cerebrovascular events, such as heart attacks and strokes, according to a doctor. (iStock)

The advanced lipid profile may only need to be done once if the baseline looks excellent, according to the doctor. If results are poor, men should repeat the test every six months under their doctor’s guidance, he advised.

Major health organizations — including the ACC, AHA, Endocrine Society and USPSTF — regard advanced lipid profiles as optional decision-support tools rather than standard screening tests. 

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6. Thyroid function

This blood test can be done yearly to evaluate how well your thyroid gland is functioning, according to Caamano.

“Issues with thyroid function can lead to mood changes, fatigue, weight changes, palpitations and hair loss,” she told Fox News Digital.

The thyroid is often checked when men have symptoms such as fatigue, weight changes, palpitations or hair loss, while some physicians also order it periodically in midlife.

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The test measures levels of thyroid-stimulating hormone (TSH), which is made by the pituitary gland and tells the thyroid how much hormone to produce. It also measures levels of free T4 (the main hormone the thyroid releases) and free T3 (the active form that the body converts T4 into).

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Based on these three levels, a doctor can determine whether the thyroid is underactive or overactive.

“Issues with thyroid function can lead to mood changes, fatigue, weight changes, palpitations and hair loss,” one doctor cautioned. (iStock)

Major health agencies, such as the USPSTF, American Thyroid Association (ATA) and American College of Physicians, recommend this test for people who are at higher risk of thyroid disease, are experiencing symptoms or have autoimmune conditions.

7. Prostate-specific antigen (PSA)

A PSA blood test measures the level of prostate-specific antigen, a protein produced by both normal and cancerous cells of the prostate gland.

This test, sometimes along with a digital rectal exam, is used to screen for cancer or enlargement of the prostate, according to Caamano. 

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The USPSTF, American Urological Association (AUA) and American Cancer Society (ACS) recommend “shared decision-making” for men aged 55 to 69, warning of the risks of false positives, overdiagnosis and overtreatment with the PSA test.

8. Insulin sensitivity test

Some clinicians use additional markers of insulin sensitivity when taking a more proactive approach to metabolic health. These measures can provide insights that go beyond standard tests such as fasting glucose and HbA1c, which reflects average blood glucose over the past two to three months.

“Insulin resistance influences nearly every major organ, including the liver and the brain,” Liff told Fox News Digital. “It plays a major role in metabolic health, long-term inflammation and future disease risk.”

Poor insulin sensitivity is closely tied to fatty liver disease, cognitive decline and vascular problems. (iStock)

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Poor insulin sensitivity is closely tied to fatty liver disease, cognitive decline and vascular problems, according to the doctor. 

“Detecting it early allows men to make changes that protect long-term organ health, including the brain,” Liff said. “Depending on the initial findings, a repeat every six months may be appropriate.”

Major health agencies, such as the ADA (American Diabetes Association), USPSTF, CDC and WHO, generally recommend screening for diabetes and prediabetes using fasting glucose, HbA1c or a standard oral glucose tolerance test.

9. Hormone levels 

Caamano recommends that certain men over 40 get tested for hormones, including total testosterone, free testosterone, sex hormone binding globulin (SHBG), luteinizing hormone (LH), follicle-stimulating hormone (FSH) and estradiol, which can be measured in a blood draw. 

“These are done when men are having symptoms such as low libido, fatigue, breast enlargement or when they are using TRT,” she told Fox News Digital. 

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Consistency is key in hormonal testing, according to the doctor. “Testosterone should be measured in the morning, as it follows a pattern, peaking in the morning hours,” Caamano said. “Hormonal blood levels, along with symptoms, help determine the need for TRT.”

The Endocrine Society, the American College of Obstetricians and Gynecologists (ACOG), USPSTF and the American Urological Association only recommend hormone tests when there are clear symptoms or medical indications.

10. Omega-3 index

Cardiologist Wolfson, who is also founder of Natural Heart Doctor, a holistic cardiology practice, calls this test “the most powerful predictor of heart attack and sudden death risk” — though it’s not yet part of standard screening guidelines for everyone.

Low omega-3 levels, specifically eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are associated with a range of medical conditions, including heart attacks, strokes, high blood pressure, insulin resistance, poor cognition, mood disorders and more, studies have shown.

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Omega-3 fatty acids, or fish oil, “were associated with significant reductions in heart attacks,” the researchers found. (iStock)

“The omega-3 index is a direct measurement of omega-3 levels inside red blood cells, making it far more meaningful than a standard blood omega-3 test,” Wolfson told Fox News Digital.

He recommends that men 40 and older get the test once per year — “or every six months if supplementing and optimizing.”

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However, major health agencies like the AHA and the National Institutes of Health do not recommend routine omega-3 index testing for the general population, as the test is mainly used for patients with cardiovascular disease who are already considering omega-3 supplementation. 

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11. Carotid artery ultrasound

Narrowing of the carotid arteries reduces blood flow to the brain and increases the risk of stroke, according to Liff. The carotid artery ultrasound can reveal problems long before symptoms appear, potentially protecting brain health.

It may be considered in some high-risk men or when a doctor suspects carotid disease.

“Reduced blood flow from plaque buildup can trigger strokes or transient ischemic attacks,” Liff told Fox News Digital. “Catching the narrowing early allows for treatment, lifestyle changes or close monitoring before a serious event occurs.”

Narrowing of the carotid arteries reduces blood flow to the brain and increases the risk of stroke, an expert noted. (iStock)

If there is no evidence of disease, Liff recommends repeating the test every few years. “If narrowing is detected, a specialist should follow the patient more closely,” he advised.

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The USPSTF, AHA, American Stroke Association (ASA) and ACC only recommend the carotid artery ultrasound when there are neurological symptoms or high clinical suspicion of carotid disease based on medical history.

12. Colon cancer screening

The USPSTF, ACS and CDC now recommend screening average-risk adults for colon cancer from the ages of 45 to 75. 

Men with a family history of colorectal cancer should begin screenings at 40, Caamano noted. Those with a low risk level should begin screenings at 45, via colonoscopy or an at-home stool test. 

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“A colonoscopy should be done every 10 years unless polyps are found, which then drops the time to every three to five years — or for those with a family history of colorectal cancer, every five years,” she told Fox News Digital. “This screening is super important, as early detection can be lifesaving.”

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13. High-sensitivity C-reactive protein (hs-CRP)

High-sensitivity C-reactive protein (hs-CRP) is a blood test that detects low levels of C-reactive protein, a marker of inflammation in the body.

Wolfson refers to this test as the “inflammation alarm bell. “Chronic inflammation is a major driver of heart disease, strokes, cancer, dementia, diabetes and accelerated aging,” he told Fox News Digital, calling “hs-CRP ‘the single best early warning sign.’”

Dubbed the “sunshine hormone,” vitamin D is known to predict health span, according to an expert. (iStock)

The test helps to detect silent cardiovascular inflammation, early artery damage, hidden infections and inflammatory lifestyle triggers, such as poor sleep, stress, alcohol and toxins, Wolfson noted.

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He recommends that men in their 40s and older get the test every six months, or more frequently if levels are elevated or if symptoms are present. Per major health agencies, however, there is insufficient evidence that hs-CRP should be routinely performed unless someone experiences symptoms or is at intermediate cardiovascular risk.

14. Vitamin D

Dubbed the “sunshine hormone,” vitamin D is known to predict health span, according to Wolfson.

Low levels are linked to heart disease, cancer, autoimmune conditions, high blood pressure, depression, low testosterone, poor immune resilience and early aging, according to the doctor.

“It is one of the strongest indicators of lifestyle quality, including sun exposure, sleep habits, metabolic health and inflammation,” he told Fox News Digital. “Levels may be low in men who avoid the sun or overuse sunscreen.”

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Wolfson recommends vitamin D testing twice per year, ideally in the winter and summer, to capture seasonal changes. 

While many doctors will check vitamin D in midlife, especially if someone has risk factors or related conditions, major health agencies only recommend screenings for people who have symptoms of deficiency or are at higher risk due to medical conditions or certain medications.

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Anyone seeking more information about these or other health screenings should contact a doctor for individual recommendations.

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ChatGPT could miss your serious medical emergency, new study suggests

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ChatGPT could miss your serious medical emergency, new study suggests

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This story discusses suicide. If you or someone you know is having thoughts of suicide, please contact the Suicide & Crisis Lifeline at 988 or 1-800-273-TALK (8255).

Artificial intelligence has been touted as a boon to healthcare, but a new study has revealed its potential shortcomings when it comes to giving medical advice.

In January, OpenAI launched ChatGPT Health, the medical-focused version of the popular chatbot tool. 

The company introduced the tool as “a dedicated experience that securely brings your health information and ChatGPT’s intelligence together, to help you feel more informed, prepared and confident navigating your health.”

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But researchers at the Icahn School of Medicine at Mount Sinai have found that the tool failed to recommend emergency care for a “significant number” of serious medical cases.

The study, published in the journal Nature Medicine on Feb. 23, aimed to explore how ChatGPT Health — which is reported to have about 40 million users daily — handles situations where people are asking whether to seek emergency care.

Artificial intelligence has been touted as a boon to healthcare, but a new study has revealed its potential shortcomings when it comes to giving medical advice. (iStock)

“Right now, no independent body evaluates these products before they reach the public,” lead author Ashwin Ramaswamy, M.D., instructor of urology at the Icahn School of Medicine at Mount Sinai in New York City, told Fox News Digital.

“We wouldn’t accept that for a medication or a medical device, and we shouldn’t accept it for a product that tens of millions of people are using to make health decisions.”

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Emergency scenarios

The team created 60 clinical scenarios across 21 medical specialties, ranging from minor conditions to true medical emergencies.

Three independent physicians then assigned an appropriate level of urgency for each case, based on published clinical practice guidelines in 56 medical societies.

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The researchers conducted 960 interactions with ChatGPT Health to see how the tool responded, taking into account gender, race, barriers to care and “social dynamics.”

While “clear-cut emergencies” — such as stroke or severe allergy — were generally handled well, the researchers found that the tool “under-triaged” many urgent medical issues.  

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The team created 60 clinical scenarios across 21 medical specialties, ranging from minor conditions to true medical emergencies. (iStock)

For example, in one asthma scenario, the system acknowledged that the patient was showing early signs of respiratory failure — but still recommended waiting instead of seeking emergency care.

“ChatGPT Health performs well in medium-severity cases, but fails at both ends of the spectrum — the cases where getting it right matters most,” Ramaswamy told Fox News Digital. “It under-triaged over half of genuine emergencies and over-triaged roughly two-thirds of mild cases that clinical guidelines say should be managed at home.”

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Under-triage can be life-threatening, the doctor noted, while over-triage can overwhelm emergency departments and delay care for those in real need.

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Researchers also identified inconsistencies in suicide risk alerts. In some cases, it directed users to the 988 Suicide and Crisis Lifeline in lower-risk scenarios, and in others, it failed to offer that recommendation even when a person discussed suicidal ideations.

“ChatGPT Health performs well in medium-severity cases, but fails at both ends of the spectrum.”

“The suicide guardrail failure was the most alarming,” study co-author Girish N. Nadkarni, M.D., chief AI officer of the Mount Sinai Health System, told Fox News Digital.

ChatGPT Health is designed to show a crisis intervention banner when someone describes thoughts of self-harm, the researcher noted.

OpenAI launched ChatGPT Health, the medical-focused version of the popular chatbot tool, in January 2026. (Gabby Jones/Bloomberg via Getty Images)

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“We tested it with a 27-year-old patient who said he’d been thinking about taking a lot of pills,” Nadkarni said. “When he described his symptoms alone, the banner appeared 100% of the time. Then we added normal lab results — same patient, same words, same severity — and the banner vanished.” 

“A safety feature that works perfectly in one context and completely fails in a nearly identical context … is a fundamental safety problem.”

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The researchers were also surprised by the social influence aspect.

“When a family member in the scenario said ‘it’s nothing serious’ — which happens all the time in real life — the system became nearly 12 times more likely to downplay the patient’s symptoms,” Nadkarni said. “Everyone has a spouse or parent who tells them they’re overreacting. The AI shouldn’t be agreeing with them during a potential emergency.”

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Fox News Digital reached out to Open AI, creator of ChatGPT, requesting comment.

Physicians react

Dr. Marc Siegel, Fox News senior medical analyst, called the new study “important.” 

“It underlines the principle that while large language models can triage clear-cut emergencies, they have much more trouble with nuanced situations,” Siegel, who was not involved in the study, told Fox News Digital. 

ChatGPT and other LLMs can be helpful tools, a doctor said, but they “should not be used to give medical direction.” (iStock)

“This is where doctors and clinical judgment come in — knowing the nuances of a patient’s history and how they report symptoms and their approach to health.”

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ChatGPT and other LLMs can be helpful tools, Siegel said, but they “should not be used to give medical direction.”

“Machine learning and continued input of data can help, but will never compensate for the essential problem – human judgment is needed to decide whether something is a true emergency or not.”

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Dr. Harvey Castro, an emergency physician and AI expert in Texas, echoed the importance of the study, calling it “exactly the kind of independent safety evaluation we need.”

“Innovation moves fast. Oversight has to move just as fast,” Castro, who also did not work on the study, told Fox News Digital. “In healthcare, the most dangerous mistakes happen at the extremes, when something looks mild but is actually catastrophic. That’s where clinical judgment matters most, and where AI must be stress-tested.”

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Study limitations

The researchers acknowledged some potential limitations in the study design.

“We used physician-written clinical scenarios rather than real patient conversations, and we tested at a single point in time — these systems update frequently, so performance may change,” Ramaswamy told Fox News Digital.

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Additionally, most of the missed emergencies happened in situations where the danger depended on how the condition was changing over time. It’s not clear whether the same problem would happen with acute medical emergencies.

Because the system had to choose just one fixed urgency category, the test may not reflect the more nuanced advice it might give in a back-and-forth conversation, the researchers noted. 

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ChatGPT Health is designed to show a crisis intervention banner when someone describes thoughts of self-harm. (iStock)

Also, the study wasn’t large enough to confidently detect small differences in how recommendations might vary by race or gender.

“We need continuous auditing, not one-time studies,” Castro noted. “These systems update frequently, so evaluation must be ongoing.”

‘Don’t wait’

The researchers emphasized the importance of seeking immediate care for serious issues.

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“If something feels seriously wrong — chest pain, difficulty breathing, a severe allergic reaction, thoughts of self-harm — go to the emergency department or call 988,” Ramaswamy advised. “Don’t wait for an AI to tell you it’s OK.”

The researchers noted that they support the use of AI to improve healthcare access, and that they didn’t conduct the study to “tear down the technology.”

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“These tools can be genuinely useful for the right things — understanding a diagnosis you’ve already received, looking up what your medications do and their side effects, or getting answers to questions that didn’t get fully addressed in a short doctor’s visit,” Ramaswamy said. 

“That’s a very different use case from deciding whether you need emergency care. Treat them as a complement to your doctor, not a replacement.”

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“This study doesn’t mean we abandon AI in healthcare.”

Castro agreed that the benefits of AI health tools should be weighed against the risks.

“AI health tools can increase access, reduce unnecessary visits and empower patients with information,” he said. “They are not inherently unsafe, but they are not yet substitutes for clinical judgment.”

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“This study doesn’t mean we abandon AI in healthcare,” he went on. “It means we mature it. Independent testing and stronger guardrails will determine whether AI becomes a safety net or a liability.”

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Diabetes surge among Americans could be driven by ‘healthy’ breakfasts, doctor warns

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Diabetes surge among Americans could be driven by ‘healthy’ breakfasts, doctor warns

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Americans consume foods every day that are marketed as “healthy,” when they could be quietly destroying their health, one doctor warns.

Dr. Mark Hyman, physician and co-founder of Function Health in California, says that much of America’s daily diet is filled with unhealthy ingredients.

“The amount of refined starches and sugars that are everywhere is just staggering to me, given what we know about how harmful they are,” he shared in an interview with Fox News Digital. “I don’t think people really understand.”

Hyman, author of the new book “Food Fix Uncensored,” said he’s “astounded” by what people are eating, especially for breakfast.

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“People just eat sugar for breakfast,” he said. “They have muffins, they have bagels, they have croissants, they have sugar-sweetened coffees and teas.”

Dr. Mark Hyman is the author of the new book “Food Fix Uncensored.” (Function Health; Little, Brown Spark)

In addition to the traditionally sweet options for breakfast, some cereal brands and breakfast staples have adopted new “protein-packed” menu items and products, following health trends that encourage eating more protein.

“Highly processed food is not food.”

“Now, we’re seeing this halo of protein in certain things,” Hyman said, mentioning that many protein smoothies are “full of sugar.”

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The doctor also noted that some popular cereals are now marketed as having protein in them. “My joke is, if it has a health claim on the label, it’s definitely bad for you,” he said.

Instead of starting the day with a “quick fix” or processed food, Hyman suggests choosing whole sources of protein and fat for breakfast, adding that “if there’s a little carbohydrate in there, it’s fine.”

More products marketed as “high protein” have cropped up on supermarket shelves. (iStock)

For his own breakfast, Hyman said he has a protein shake with whey protein, avocado and frozen berries. Eggs and avocados are also a great protein-and-fat combo option, he added.

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“It’s not that complicated — people need to just think about their breakfast not being dessert,” he said. “No wonder we’re in this cycle of obesity and diabetes. One in three teenage kids now has type 2 diabetes or pre-diabetes. That’s just criminal.”

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Instead of counting calories and being in a caloric deficit as a way to lose weight and stay healthy, Hyman instead suggests focusing on how certain foods make you feel and how they impact your health.

“When you look at the way in which different types of calories affect your biology, you can just choose what you’re eating, and then you don’t have to worry about how much,” he told Fox News Digital.

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In addition to the traditionally sweet options for breakfast, some cereal brands and breakfast staples have adopted new “protein-packed” menu items and products. (iStock)

“For example, if you eat a diet that doesn’t cause your insulin to spike — which is low in starch and sugar, higher in protein and fat — you won’t develop those swings in blood sugar, you won’t develop the spikes in insulin, you won’t deposit hungry fat … You will break that cycle.”

People are more likely to “self-regulate when they eat real food” instead of processed foods, which “bypasses the normal mechanisms of satiety, fullness and brain chemistry,” according to Hyman.

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“Ultraprocessed food and junk food or highly processed food is not food,” he said. “It doesn’t support the health and well-being of an organism. It doesn’t do that. It does the opposite.”

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Scientists make startling discovery when examining prostate cancer tissue

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Scientists make startling discovery when examining prostate cancer tissue

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Small fragments of plastic were found in the tumors of most prostate cancer patients, according to a new study from NYU Langone Health. 

In past studies, microplastics have been found in almost every human organ and in bodily fluids, but their impact on human health still isn’t fully understood.

The researchers analyzed tissue samples from 10 patients with prostate cancer who underwent surgery to remove the entire organ. 

Using visuals of both benign samples and tumor samples, as well as specialized equipment, the scientists identified plastic particles in 90% of the tumor samples and 70% of benign tissue samples, according to the study press release.

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In past studies, microplastics were found in almost every single human organ along with bodily fluids, even the placenta. (iStock)

The cancerous tissue contained on average more than double the amount of plastic as healthy prostate tissue samples, the study found. This equates to about 40 micrograms of plastic per gram of tissue compared to 16 micrograms.

Researchers avoided contaminating the samples with other plastics by substituting standard tools with those made of aluminum, cotton and other non-plastic material, the release noted.

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The scientists say this is the first direct evidence linking microplastics to prostate cancer.

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“By uncovering yet another potential health concern posed by plastic, our findings highlight the need for stricter regulatory measures to limit the public’s exposure to these substances, which are everywhere in the environment,” said senior study author Vittorio Albergamo, assistant professor in the department of pediatrics at NYU Grossman School of Medicine, in the release.

Using visuals of both benign samples and tumor samples, as well as specialized equipment, the scientists identified plastic particles in 90% of the tumor samples and 70% of benign tissue samples. (iStock)

The study findings were presented during the American Society of Clinical Oncology’s Genitourinary Cancers Symposium in San Francisco on Feb. 26.

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“What is most striking is not that microplastics were detected, but that they were found embedded within tumor tissue itself,” Dr. David Sidransky, oncologist and medical advisor at SpotitEarly, a startup that offers an at-home breath-based test to detect early-stage cancer, told Fox News Digital.

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“While complete avoidance is unrealistic, people can take practical steps to reduce exposure.”

“We already know microplastics are present in water, air, blood and even placental tissue. Their detection in prostate tumors suggests systemic distribution and long-term bioaccumulation,” added Maryland-based Sidransky, who was not involved in the study.

Study limitations

Albergamo cautioned that a larger sample is needed to confirm the findings. Additionally, Sidransky noted that the presence of microplastics alone does not prove they cause cancer.

“Tumors can act as ‘biologic sinks,’ meaning they may accumulate circulating particles simply because of altered vasculature and permeability,” he said.

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A key unanswered question, according to the doctor, is whether microplastics are biologically active in ways that “promote DNA damage, immune modulation or chronic inflammation within the prostate.”

About one in eight men in the U.S. will be diagnosed with prostate cancer at some point in their lifetime, according to the Centers for Disease Control and Prevention.

The most actionable step men can take is appropriate screening and early detection, according to doctors. (iStock)

For those concerned about microplastics, Sidransky offered some insights.

“I believe the appropriate response is curiosity, not panic, and a commitment to understand more,” he said.

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“While complete avoidance is unrealistic, people can take practical steps to reduce exposure, such as minimizing heating food in plastic containers, reducing bottled water consumption when possible, and favoring glass or stainless steel alternatives.”

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The most actionable step men can take, however, is getting appropriate screenings to help ensure early detection, according to the doctor. Screening discussions should be individualized based on age, family history and other risk factors.

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