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Thinking about peptides? Doctors reveal key dos and don’ts as ‘Wild West’ market grows

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Thinking about peptides? Doctors reveal key dos and don’ts as ‘Wild West’ market grows

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The peptide boom is under scrutiny as the FDA weighs easing restrictions on several drugs in the category.

Peptides, which are short chains of amino acids that serve as the building blocks of proteins, have gained popularity among wellness influencers and fitness gurus as a means of building muscle, healing injuries or appearing younger.

Similar to how GLP-1s (glucagon-like peptide-1 agonists) suppress appetite and trigger weight loss, peptides can signal other functions, like the release of growth hormones.

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But unlike GLP-1 drugs — which were extensively studied and regulated — many peptides lack comparable evidence and oversight, said New York endocrinologist Dr. Philip Rabito, adding that some are “not reviewed by the FDA for safety, effectiveness or quality before marketing.”

Peptides under FDA review, including BPC-157, are often marketed for tendon and gut healing, injury recovery and inflammation reduction, despite warnings about the risks of unapproved treatments.

Similar to how GLP-1s, such as Ozempic, suppress appetite and trigger weight loss, peptides can signal other functions, like the release of growth hormones. (iStock)

Even as regulators consider loosening restrictions, the market has been widely described as a “Wild West,” with various versions sold online without a prescription.

In an interview with Fox News Digital, board-certified internist and longevity expert Dr. Amanda Kahn, who prescribes peptides in her own New York practice, confirmed that interest has grown “significantly” across the U.S.

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Peptides are popular because they “sit at the intersection of wellness optimization and medicine,” according to the doctor.

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“As a class, they are targeted biosimilar molecules that can influence specific pathways like inflammation, recovery and metabolism in a way that feels more biologically synergistic than traditional pharmaceuticals,” she said.

Most patients spend a few hundred to thousands of dollars on these drugs per month, according to Kahn. Costs can be high because peptides are often custom-made and must meet strict quality and sterility standards.

Peptides are popular because they “sit at the intersection of wellness optimization and medicine,” according to one doctor. (iStock)

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“At the same time, patients today are far more proactive and invested in their health,” Kahn added. “They’re not waiting to get sick; they want to feel better, recover faster and age more intentionally.”

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Peptides have evolved rapidly from just a few years ago, when they were largely focused on weight loss, the expert said, with growing interest in energy, post-illness or injury recovery, muscle preservation and sleep quality.

But these drugs are not one-size-fits-all, experts warn, especially when not prescribed by a professional or cleared by a reputable pharmacy.

There is growing interest in peptides for more muscle preservation and sleep quality, an expert said. (iStock)

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Peptides dos and don’ts

Experts shared the following guidance on using peptides.

Do use peptides within reason

Kahn recommends using peptides with “a clear, clinical rationale, not just because they’re trending.”

“Think of peptides as part of a broader health plan, not a standalone solution,” she advised.

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Kahn said patients often come into her practice focused on weight or appearance, but in-depth testing may uncover underlying issues such as inflammation, metabolic dysfunction, hormonal imbalance or recovery deficits.

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“It’s both aesthetic and medical, but the trend in my internal medicine practice has always been toward specific health concerns,” she added.

Do work with a clinician

Dr. Kent Bradley, chief medical officer at 10X Health in California, recommends approaching peptides with “curiosity and rigor” and discussing the science with a physician.

“Work with a clinician who provides a baseline of biomarkers before you introduce peptides,” he recommended during an interview with Fox News Digital. “You will need to know where you’re starting in order to measure the impact.”

Experts recommend working with a physician to determine which peptides are right for you. (Getty Images)

Do find a credible source

Peptides should always be purchased from “reputable compounding pharmacies by prescription,” Kahn emphasized.

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“While they are powerful signaling molecules, when used appropriately, they can be very safe and effective,” she said. “When used incorrectly, [with] the wrong dose, wrong indication or poor sourcing, they can be dangerous or ineffective.”

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She added, “The key is clinical oversight, proper selection and individualized use.”

The current peptide ecosystem — including unlicensed providers and “gray market” access — is “more dangerous than the molecules themselves,” Kahn warned.

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It’s important to use pharmacies that meet FDA 503A or 503B regulations to ensure consumer safety, the expert added.

Don’t stack peptides without a purpose

Multiple peptides should not be combined without understanding how they interact with each other, nor should they be injected as mixtures, Kahn warned.

Some products marketed as “natural” online may still have the capacity to cause complications, an expert warned. (iStock)

“Don’t treat them as risk-free supplements,” she said. “They are biologically active and should be used thoughtfully.”

“Peptides should be cycled, paused and re-assessed — don’t ‘set it and let it go.’”

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Don’t self-prescribe

Dose-response and drug interactions require medical oversight, and peptides should be prescribed by a doctor, according to Bradley. Some products that are marketed as “natural” may still have the capacity to do harm to the body, he warned.

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Don’t use them as a shortcut or substitute

Fundamental pillars of health, like sleep, nutrition and exercise, should be addressed before using a peptide as a “shortcut” to fix health complications, Kahn said.

Bradley agreed, adding that “the same instinct that drives patients toward unnecessary surgery drives them toward complex peptide stacks when the real leverage is upstream and boring.”

Younger individuals most likely don’t need to take peptides for muscle building, according to a fitness expert. (iStock)

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Kenny Santucci, a fitness expert and founder of Strong New York, shared with Fox News Digital that he takes peptides for muscle building himself – but noted that it’s not right for everyone.

Especially for younger individuals, whose bodies are “already working at optimal levels,” peptides may be unnecessary, he said.

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“If you take care of yourself — if you’re eating right, sleeping right, working out — you probably don’t need much,” he said. 

“I think as you get older, these things start to help out a little bit, or if you suffer from an injury and you want to take something that will help repair the tissue quicker, that’s great.”

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Zero sugar, more problems? Study reveals surprising gut health effects

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Zero sugar, more problems? Study reveals surprising gut health effects

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Eliminating sugar from your diet may seem like the key to healthy eating, but research suggests it could have unintended effects on digestive health.

A study presented at ENDO 2026, the Endocrine Society’s annual meeting, suggests that a total lack of sucrose, or table sugar, may harm gut health and disrupt the body’s natural metabolism.

To explore how the total absence of dietary sugar impacts the body, researchers at the Dasman Diabetes Institute in Kuwait City conducted a 16-week study on two groups of mice. Both groups were placed on a low-fat diet, but with one critical difference.

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One group consumed a low-fat diet that included a standard amount of sucrose, while the other group ate a low-fat diet that was completely sugar-free, according to the study’s press release.

Throughout the trial, the scientists monitored a wide variety of physiological factors, including the animals’ weight, glucose tolerance, insulin sensitivity, hormone levels, internal inflammation and the specific composition of their gut bacteria.

A total lack of dietary sugar can cause imbalances in the gut bacteria and lead to signs of fatty liver disease, even without any weight gain, researchers said. (iStock)

The study outcome suggested that completely removing sugar caused several unexpected health problems.

“Completely removing sucrose from a low-fat diet may unexpectedly disrupt gut health and promote inflammation and metabolic dysfunction,” Rasheed Ahmad, principal scientist and head of the Immunology & Microbiology Department at the Dasman Diabetes Institute, said in the release.

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Even though the mice on the sugar-free diet did not gain any extra weight compared to the control group, their internal health indicators deteriorated.

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The animals that lacked sucrose developed an imbalance in their gut microbes and increased inflammation within the intestines and liver.

They also showed signs of poor glucose regulation, insulin resistance and cellular changes associated with fatty liver disease, according to the research.

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Future dietary guidelines may shift away from strict, absolute sugar bans and instead focus on overall gut health through balanced nutrition. (iStock)

“The findings suggest that complete removal of sucrose from a low-fat diet may negatively affect gut microbiota and metabolic health,” Ahmad concluded.

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While the risks of high-sugar diets are well-established, the researchers noted that little attention has been given to the effects of completely eliminating sugar from low-fat meals.

Scientists say these new findings highlight that dietary carbohydrates play a valuable role in supporting balance between the immune system and the gut microbiome.

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Completely cutting sucrose from a low-fat diet can unexpectedly trigger gut inflammation and disrupt the metabolism, experts say. (iStock)

Because this research was conducted on mice over a relatively short 16-week period, further clinical trials are necessary to determine whether a completely sugar-free diet causes the same gut and liver inflammation in humans.

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Additionally, the study focused specifically on removing sucrose from low-fat meals, meaning the results might not apply to people eliminating sugar while following higher-fat or ketogenic eating plans, the researchers noted.

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The team believes that future dietary guidelines may shift away from strict, absolute sugar restrictions and instead place a greater emphasis on maintaining a diverse, healthy population of gut bacteria through balanced nutrition.

“In the long term, these findings could help improve strategies for preventing and managing metabolic disorders, fatty liver disease and chronic inflammatory conditions,” Ahmad said.

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Can You Lose Weight Without Exercise? 7 Surprisingly Easy Tricks

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Can You Lose Weight Without Exercise? 7 Surprisingly Easy Tricks


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Cure for certain cancers is ‘realistic’ goal in next decade, pharma lead says

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Cure for certain cancers is ‘realistic’ goal in next decade, pharma lead says

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A cure for cancer could be on the horizon in the next decade, according to experts.

During the WSJ Leadership Institute CEO Summit in London last week, Johnson & Johnson Chairman and CEO Joaquin Duato reflected on the pharmaceutical company’s projections on the future of cancer treatment.

In the next 10 years, the goal is to “try to eliminate cancer,” Duato shared.

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“That’s a high goal, and we are already making significant progress in certain cancers,” he said.

Duato used multiple myeloma as an example, noting that the life expectancy is currently 10 years, when it was previously “only single years.”

Joaquin Duato, chairman and CEO of Johnson and Johnson, speaks at the Punchbowl News Conference at Union Station on March 10, 2026, in Washington, DC. (Heather Diehl/Getty Images)

“We have treatments now that utilize your own immune system to attack the cancer,” he said at the summit. “For patients who were already going into hospice, so they didn’t have any other alternative, they are [at] more than five years, with a single administration, in remission. That [is] spectacular.”

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“When patients see that, they cannot believe that because they have been coming to the hospital every week [for] a decade, having multiple therapies.”

The goal is to “try to eliminate cancer” in the next 10 years, the pharmaceutical executive said. (iStock)

According to Duato, Johnson & Johnson is working to understand the biology of cancer growth and to formulate new technologies to address it.

“It’s realistic to believe that we are going to cure certain cancers, and some others we’re going to turn into chronic diseases,” he predicted.

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“Cancer is an important thing – I cannot think about anybody who has not been touched by cancer,” he went on. “But there are many other opportunities for us to actually advance science, to address very important social problems.”

Duato called out dementia as another “important problem” in need of a solution.

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He predicted that life expectancy, which has risen steadily over the past century, will continue to increase as longevity technologies and solutions advance, improving quality of life along the way.

Duato commented that J&J has been optimistic about the role artificial intelligence will play in the future of healthcare, calling it a “force multiplier.”

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Biomarkers and AI can help with the earlier diagnosis of cancer, as well as a more advanced and personalized approach to surgery, a doctor noted. (iStock)

Fox News senior medical analyst Dr. Marc Siegel agreed with Duato’s outlook on the future of cancer care, noting that certain cancers will turn into chronic diseases while others will find outright cures.

“Advances [will be] based on the use of AI to help guide targeted treatments with expanding knowledge of cancer mutations and how to target them,” he predicted, speaking to Fox News Digital.

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Siegel added that biomarkers and AI can help with earlier diagnoses, as well as a more advanced and personalized approach to surgery.

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J&J recently acquired Firefly Bio, a biotech firm that produces drugs that enter cancer cells to “target certain proteins that contain difficult to treat gene mutations,” the doctor added.

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