Health
Testosterone therapy could help boost women's sex drive as they age, but risks exist, experts say
Celebrities’ use of testosterone to boost their sex drive could lead more women to try hormone replacement therapy (HRT), experts say.
Actress Kate Winslet recently revealed in an appearance on the “How to Fail” podcast with Elizabeth Day that a dip in libido could mean an imbalance in testosterone levels.
“A lot of people don’t know this, but women have testosterone in their body; when it runs out, like eggs, it’s gone,” the “Titanic” actress, 48, told a listener.
KATE WINSLET ADMITS TO USING TESTOSTERONE THERAPY TO ‘FEEL SEXY AGAIN’
“So, once it’s gone, you have to replace it, and that is something that can be done, and you’ll feel sexy again,” Winslet said.
“I know,” she added, without offering additional details.
What to know about HRT
Hormone expert Dan Holtz, co-founder of the Beverly Hills Rejuvenation Center, echoed that HRT is used to “optimize hormone levels in men and women as they go through life.”
“Benefits may include better sleep, improved energy, less anxiety [and] improved metabolic rate,” he said in a response sent to Fox News Digital.
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Holtz has worked with numerous celebrities to optimize their hormone levels. He confirmed that many women and men have reported a “noticeable improvement in libido after optimizing testosterone.”
Some women have also reported an improvement in libido when correcting a deficiency in DHEA (dehydroepiandrosterone), a hormone the body produces in the adrenal gland, according to the expert.
HRT is often referred to as menopause hormone therapy (MHT), a medical treatment to relieve menopause symptoms, according to women’s health and menopause expert Dr. Mary Claire Haver of Friendswood, Texas.
“As we approach menopause, the natural decline in estrogen, progesterone and testosterone can lead to symptoms such as hot flashes, night sweats, mood changes, muscle and joint pain, brain fog, vaginal dryness and low libido,” she told Fox News Digital.
“Every woman’s situation is unique, and we need to balance the potential benefits against the risks.”
“For many women, these symptoms can severely affect their quality of life.”
Hormone therapy works by replenishing the estrogen, progesterone and testosterone levels that the body is no longer producing in sufficient amounts, Haver noted.
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“The goal is to alleviate symptoms by restoring health-promoting hormone levels, but MHT also has additional benefits, like maintaining bone density, which reduces the risk of osteoporosis – a concern for postmenopausal women,” she added.
Targeting testosterone
While women have much lower levels of testosterone compared to men, the hormone is “crucial” to maintaining libido and sexual function in females, according to Haver — in addition to boosting energy and mood.
When testosterone levels decline — which occurs as women grow older and approach menopause — a decrease in sexual desire, arousal and satisfaction can result, the expert said.
That’s because the hormone acts on a key region of the brain involved in regulating sexual behavior, she added.
Studies have shown that for some women, boosting testosterone levels can lead to “noticeable improvements” in sexual health, Haver said.
“Women need to know that low libido is a legitimate medical concern, not just something they have to ‘push through.’”
“By increasing testosterone levels, these brain centers become more responsive to sexual stimuli, which can lead to an increase in libido,” she said.
Haver encouraged women who are experiencing low libido to consider testosterone therapy as part of a “broader treatment plan.”
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“The goal is to restore levels to the normal physiological range for women, improving sexual desire without pushing the body into a ‘male’ hormone profile,” she told Fox News Digital.
Potential risks
Mayo Clinic confirmed that testosterone therapy may boost sex drive for some women after menopause, but noted that there is limited research on its safety and long-term effectiveness.
It has also been shown to cause some side effects.
“Most often, other treatments are tried before testosterone,” the clinic stated on its website.
“These include low doses of the hormone estrogen, and a type of counseling called sex therapy. Some depression medicines also may boost sex drive.”
HRT is “not a one-size-fits-all solution,” and there are potential risks if it’s done inappropriately, Haver warned.
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“Studies have shown that estrogen-containing hormone therapy can increase the risk of certain conditions, such as blood clots and stroke,” the doctor said.
“Testosterone therapy can also increase the risk of unwanted hair growth, deepening of the voice and acne.”
Those risks can vary based on factors like the type of hormones used, the dosage, the delivery method and how long it’s administered, according to Haver.
“Every woman’s situation is unique, and we need to balance the potential benefits against the risks, with the proper dosage, formulations and delivery system.”
Haver recommends MHT for women who are within 10 years of menopause onset and are under 60 years old — “particularly for those suffering from moderate to severe symptoms.”
Interdisciplinary care
Some women can feel “dismissed or not fully supported” when discussing sexual health concerns with medical providers, Haver noted.
“Sexual function in women can be influenced by hormones, neurotransmitters, mental health, relationship dynamics and even chronic medical conditions,” she said.
Effective treatment addresses these root causes rather than just offering “superficial fixes,” she said.
“Women need to know that low libido is a legitimate medical concern, not just something they have to ‘push through.’”
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For those interested in HRT, Holtz suggested finding a well-established and reputable company or provider with a track record of success.
Haver added that it’s essential for women to have a thorough discussion with their medical provider to assess their specific health needs and determine the best treatment plan.
Fox News Digital’s Caroline Thayer contributed to this report.
Health
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Health
California fires and mental health toll: Celebrities and therapists offer tips
As Los Angeles battles the worst wildfires in the city’s history, thousands of people have been displaced or have seen their homes burn to the ground.
Around 130,000 people were ordered to evacuate and some 10,000 structures were destroyed, according to the Associated Press. At least 10 people have died as a result of the blazes.
The devastation of the fires has undoubtedly taken a grave toll on the psyches of those affected, experts agree.
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Fox News Digital spoke with celebrities and mental health experts, who offered the following guidance for the people impacted.
Recognize your feelings
For those who have experienced a loss from the fires, common reactions include shock, disbelief and confusion, according to David Kessler, a grief counselor in Los Angeles and founder of Grief.com.
“I call it grief brain,” he told Fox News Digital.
“Your mind is trying to comprehend what happened, and it’s a hard thing for it to do, because this is unimaginable that your house, your safety, is suddenly gone.”
Not all grief is related to death, Kessler noted, as there are many different types of losses.
“I always say grief is a change you didn’t want — and certainly a fire is a change we didn’t want,” he added.
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It’s important to “self-validate” the reality of the loss, he said.
“People might give you toxic positivity of, ‘well, at least no one died,’” he said. “And while that’s true, the reality is you still have lost your home. Don’t let anyone minimize that.”
“The loss of a home is devastating and it can take years to recover.”
“I think we’re going to deal with a lot of depression after this, a lot of sadness.”
Actor Steve Guttenberg, who lives in Pacific Palisades, California, where fires erupted on Tuesday, shared how the disaster has impacted his own mental health.
“I’ve seen so much tragedy the last three or four days that I’ve got to be careful to … keep a hold of my mind,” he said in an interview with Fox News Digital.
“And I think that we’re going to deal with a lot of depression after this, a lot of sadness. And it’s going to be really tough because this is like nothing you’ve ever seen.”
Gutenberg noted that while it’s “very normal” to be down, he is trying not to let himself “go down that hole.”
“But I’m pretty sad about this,” he added.
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Jonathan Alpert, a psychotherapist in Manhattan and Washington, D.C., noted that the grief following the Los Angeles fires is “profound.”
“It’s not just about the physical loss of homes or belongings — it’s also about the sense of safety and normalcy that has been lost,” he told Fox News Digital.
“It’s important for people to feel emotions and not ignore them. This is a normal reaction to such overwhelming loss and tragedy.”
Reach out for support
Guttenberg emphasized the importance of maintaining connections with others and drawing support from the community during a disaster of this magnitude.
“We’re social animals — we need people,” he said. “So I’m reaching out to my friends. There’s no way to meet right now because it’s so dangerous — so the best thing you cn do … is call and reach out and maybe you can drive somewhere.”
Most of the people in town have evacuated, he pointed out. “There’s probably 10% of the population left here. Or less.”
Kessler reiterated that connection is critical after this type of trauma. “We need to be taken care of. We need other people around us. People equal safety,” he said.
“We need other people around us. People equal safety.”
Pastor Jesse Bradley of Grace Community Church outside Seattle, Washington, agreed that it’s essential to avoid isolating yourself after a loss.
“We need God and we need each other. Community is vital,” he told Fox News Digital.
“Family, friends and neighbors care about you. God sends His love through these people. Reject isolation. Don’t shut down and don’t shut people out.”
Take action
“In times of crisis such as this, regaining even small amounts of control can be grounding,” Alpert said.
He recommends creating a plan for what’s next, whether it’s finding temporary housing, accessing local resources or starting the process of rebuilding.
“Taking action — no matter how small — can help you move forward.”
Kessler agreed, noting that people who are in the area but did not experience loss may feel a sense of relief mixed with guilt.
“If you do have survivor’s guilt, I always say the best thing is to take action,” he advised.
In the longer term, advocacy efforts can be a powerful tool in dealing with trauma, Alpert noted.
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“Working to improve fire prevention policies, supporting relief efforts or helping neighbors rebuild can provide a sense of purpose and empowerment during this difficult time,” he said.
Some people may be angry about the systems that failed to prevent the fires in the first place, Alpert acknowledged, and this anger can be a “powerful motivator.”
“Taking action — no matter how small — can help you move forward.”
“Use that energy to demand better, but don’t get stuck on the anger,” he advised.
“By holding leaders accountable for the policies — or lack thereof — that contributed to this devastation, and by asking the right questions and demanding answers, you might start to feel better.”
Seek professional help as needed
“The L.A. fires no doubt will not just leave physical scars, but deep emotional ones, too,” Alpert said.
“For many people, the fear, panic and helplessness experienced during the fires don’t just disappear — they linger, creating flashbacks, anxiety and difficulty functioning.”
In many cases, this can lead to post-traumatic stress disorder (PTSD). Symptoms of this condition can include vivid memories of the fires, nightmares, hypervigilance or avoidance of anything that reminds someone of the event, Alpert said.
“It’s important to see this not as weakness, but rather, the mind’s and body’s way of trying to cope with extreme stress.”
“While the fires were devastating, they don’t diminish your strength or character.”
As you seek help, it’s also important to understand that PTSD doesn’t define you, he added.
“It’s a part of your experience, not your identity. While the fires were devastating, they didn’t diminish your strength or character.”
Lean on your faith
For those who have experienced traumatic grief, Kessler emphasized the importance of faith and spirituality.
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“They help ground us in a world full of fear,” he said. “And when we’ve lost everything, it can feel like our faith is the one thing we have to hold onto.”
During a time of crisis, Guttenberg said it’s important to “rely on anything that you believe in.”
“If you believe in your mom and dad, you rely on them, your brothers and sisters, your friends, your family. God, the universe.”
Above all, he added, “Just remember, you’re not alone. God is always with you. Jesus is always with you. You’ve got to hang on to that.”
Find ways to exercise gratitude
During times of hardship, it’s important to recognize the good things that are still in your life, Pastor Bradley said.
“It’s easy to be consumed with what you no longer have,” he told Fox News Digital.
For more Health articles, visit www.foxnews.com/health
“You need to be intentional to take inventory of the blessings in your life. For example, you might lose a home or business, but you still have family.”
This mindset will help you keep a healthy perspective and protect gratitude, Bradley added.
Health
Scientists May Be Able to Make Grapefruits Compatible With Medications They Currently Interfere With
You may be among the millions of people who have seen a surprisingly specific warning like this on the labels of drugs you take:
Avoid eating grapefruit or drinking grapefruit juice while using this medication.
Such warnings are issued for dozens of substances, including docetaxel, a cancer drug; erythromycin, an antibiotic; and some statins, the cholesterol-lowering drugs prescribed to more than a third of American adults over 40.
The problem is a set of molecules, furanocoumarins. High levels of furanocoumarins interfere with human liver enzymes, among other processes. In their presence, medications can build up to unhealthy levels in the body. And grapefruits and some related citrus fruits are full of them.
But there is no such warning for other kinds of citrus, such as mandarins and other oranges. Citrus researchers at the Volcani Center in Israel reported Wednesday in the journal The New Phytologist that, by crossing mandarins and grapefruit, they’ve uncovered genes that produce furanocoumarins in some citrus fruits. It’s a finding that opens the possibility of creating grapefruit that doesn’t require a warning label.
Scientists had worked out the compounds’ structures and pieced together a basic flowchart of how they are made years ago, said Yoram Eyal, a professor at the Volcani Center. But the precise identities of enzymes catalyzing the process — the proteins that snip off a branch here, or add a piece there — remained mysterious. He and his colleagues knew that one way to identify them was to breed citrus high in furanocoumarins with those without. If the offspring of such a cross had varying levels of the substances, it should be possible, by digging into their genetics, to pinpoint the genes for the proteins.
“We were afraid to approach it, because it’s very time-consuming and it takes many years,” he said, noting how involved it can be to grow new trees from seeds and assess their genetics. “But finally, we decided we have to dive in.”
When they examined the offspring of a mandarin and a grapefruit, the researchers saw something remarkable. Fifty percent of the young plants had high levels of furanocourmains, and 50 percent had none. That particular signature meant something very specific, in terms of how the ability to make these substances is inherited.
“We saw there was only one gene that could have controlled it,” said Livnat Goldenberg, a Volcani Center researcher who is the lead author of the new study.
The researchers soon identified the gene controlling the production of furanocoumarins in leaves and fruit, which produces an enzyme called 2-oxoglutarate-dependent dioxygenase, or 2OGD for short. Mandarins, it turns out, have a mutated form of this gene that keeps the enzyme from functioning properly. This version cropped up in all the mandarin and orange varieties the researchers checked, explaining why they do not cause the same problems as grapefruit in people taking prescription medications. In these plants, furanocoumarin production is paused.
With gene editing technology, it should be possible to alter the gene in grapefruit as well, Dr. Eyal suggests. The team at the Volcani Center is now exploring that project.
Looking at how widespread this mutated version is in mandarins and some other citrus, the scientists speculate that some gene nearby on the genome must play an important role in a highly prized trait. A long-ago citrus breeder, selecting for some unknown quality, must have unwittingly spread this furanocoumarin-busting version of the gene to an ancestor of modern varieties of mandarins and oranges.
All these years later, that person’s work is coming to light, under the gaze of geneticists, who may, someday, put grapefruit back on the menu.
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