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Shingles infection linked to risk of cognitive decline, says study: ‘Long-term implications’

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Shingles infection linked to risk of cognitive decline, says study: ‘Long-term implications’

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Getting shingles just once could increase the risk of long-term confusion and memory loss, a new study has found.

The study, led by Brigham and Women’s Hospital and Harvard Medical School, linked the virus to greater chances of “subjective cognitive decline,” according to a Harvard press release.

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The findings were published in the journal Alzheimer’s Research & Therapy on Aug. 14.

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“Subjective cognitive decline” captures early changes in cognition that are noticed before evidence of cognitive impairment shows up on standard neuropsychological tests, explained study author Sharon Curhan, M.D., a physician and epidemiologist at Brigham and Women’s Hospital in Boston.

It was also associated with a higher risk of mild cognitive impairment (MCI) and dementia. 

Getting shingles just once could increase the risk of long-term confusion and memory loss, a new study has found. (iStock)

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“Shingles may contribute to dementia risk through neuroinflammation, damage to cerebral blood vessels (cerebral vasculopathy), or direct neuronal damage,” Curhan told Fox News Digital.

In this particular study, the researchers analyzed data from three large cohorts of more than 150,000 women and men over a 13-year period. 

The data came from the Nurses’ Health Study, the Nurses’ Health Study II and the Health Professionals Follow-Up Study, according to Curhan.

“We were surprised by the large magnitude and long duration of the increased risk.”

“There was a suggestion that the magnitude of the elevated risk may be greater among those who were not vaccinated with the shingles vaccine,” she said.

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The researchers determined that shingles was associated with a greater than 20% higher long-term risk of subjective cognitive decline.

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“We were surprised by the large magnitude and long duration of the increased risk, and [the fact] that it may be different in women and men,” Curhan told Fox News Digital. 

The elevated risk was even higher among those who were genetic carriers of APOE e4 — the gene that increases the risk for Alzheimer’s disease — than men who were not APOE e4 carriers, she noted, but this was not the case in women. 

Shingles virus

Known medically as herpes zoster, shingles is a painful, blistering rash caused by the varicella-zoster virus (VZV), which is the same virus that causes chickenpox. (iStock)

Although he noted that this is an observational study and does not prove cause and effect, Dr. Marc Siegel, senior medical analyst for Fox News, said he believes “the observation is real.”

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“Shingles is a reactivation of a virus that has been hiding inside nerves,” he told Fox News Digital. “It causes inflammation — and when inflammation involves the brain, it is associated with cognitive decline, which can lead to Alzheimer’s.”

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Previous studies have also looked at the association of herpes zoster and other viruses with Alzheimer’s and the other diseases that cause dementia, according to Heather M. Snyder, PhD, senior vice president of medical and scientific operations at the Alzheimer’s Association in Chicago.

“It is unclear if the virus is present in individuals because of changes associated with the diseases that cause cognitive decline, changes of the immune system, or some sort of cause and effect,” Snyder, who was not involved in the study, told Fox News Digital.

“When inflammation involves the brain, it is associated with cognitive decline.”

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Previous research has also shown that a history of shingles is also associated with higher long-term risk of a major cardiovascular event, such as a stroke or heart attack, which could last for many years after infection, Curhan warned. 

What to know about shingles

Shingles — medically known as herpes zoster — is a painful, blistering rash caused by the varicella-zoster virus (VZV), which is the same virus that causes chickenpox, according to the U.S. Centers for Disease Control and Prevention (CDC).

The rash and blisters usually scab over within seven to 10 days.

The infection is common, affecting about one in every three people in the U.S. in their lifetime.

Man with shingles

In addition to the rash, which typically appears as a stripe around one side of the body or face, symptoms can include fever, chills, headache and upset stomach. (iStock)

“A majority of adults have herpes zoster hidden in their brain cells, from prior infection at some previous point in their life,” said Snyder.

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In addition to the rash — which typically appears as a stripe around one side of the body or face — symptoms can include fever, chills, headache and upset stomach, according to the CDC.

In some cases (10% to 18%), the virus can lead to complications like long-term nerve pain.

One in every three people in the U.S. will have shingles in their lifetime.

Other rare but serious adverse effects can include vision loss, bacterial infections, pneumonia, brain inflammation (encephalitis), impaired hearing and death, per the CDC.

These complications are most likely to affect those with compromised immune systems.

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Antiviral treatments and pain relief medications are available for those with the condition.

Means of prevention

These findings show the “long-term implications” of shingles and highlight the importance of public health efforts to prevent the infection, Curhan noted. 

The vaccination has been shown to be 90% effective at preventing the infection and long-term nerve pain in adults age 50 and over who have healthy immune systems, according to the CDC.

Shingles vaccine

Shingles vaccination has been shown to be 90% effective at preventing the infection and long-term nerve pain in adults age 50 and over who have healthy immune systems, according to the CDC. (iStock)

“Given the growing number of Americans at risk for this painful and often disabling disease and the availability of an effective vaccine, shingles vaccination could provide a valuable opportunity to reduce the burden of subsequent health issues due to shingles, such as chronic pain (postherpetic neuralgia), cardiovascular complications, or cognitive decline and dementia,” said Curhan.

The CDC recommends routine shingles vaccination for people age 50 and older, regardless of whether they have had a prior episode of shingles or have had a previous vaccine. 

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CDC RECOMMENDS ADDITIONAL COVID VACCINE FOR ADULTS 65 AND OVER

“Anyone who may be eligible for the vaccine or who may have questions or concerns about vaccination should consult with a health care provider,” said Curhan.

Siegel echoed the merits of vaccination. 

  

“This study adds to the growing group of evidence that the shingles vaccine (Shingrix) is important for all those over 50 (who have had chicken pox or the varicella vaccine) to decrease the risk of reactivation of the shingles virus and/or complications of active infection,” he said.

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Potential limitations 

This was an observational study that primarily focused on a White, highly educated population, Curhan noted — which means future studies in other populations could strengthen the research.

“Also, we did not have information on vaccination status in the full study population, so we could only examine this relation among a subset,” she added. 

Woman itchy rash

“A majority of adults have herpes zoster hidden in their brain cells, from prior infection at some previous point in their life,” a doctor said. (iStock)

Much of the study period took place before the shingles vaccine became widely available, Curhan said — and even once it was introduced, the uptake was generally low. 

The more recent vaccine was not available until after the study. 

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“As uptake of the newer shingles vaccine increases, additional studies that evaluate whether vaccination status influences the relation of shingles and risk of cognitive decline would be informative,” Curhan said. 

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“Therefore, we are currently collecting this information among our participants and hope to conduct these studies in the future.”

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People with brain aneurysms at higher risk of some mental health disorders, study finds

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People with brain aneurysms at higher risk of some mental health disorders, study finds

People who have been diagnosed with a brain aneurysm may be more susceptible to certain mental health conditions, according to a study published by the American Heart Association (AHA).

The knowledge of an unruptured aneurysm increased the risk of anxiety, stress, depression, insomnia, bipolar disorder, eating disorders, and alcohol or drug misuse by 10% over a 10-year period, the researchers found.

An unruptured aneurysm occurs when a blood vessel in the brain becomes weak and bulges out — creating the risk of a potentially deadly rupture, per the AHA.

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The effect was most seen in adults under 40 years of age, and the risk was three times greater among those who received an official mental health diagnosis.

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The researchers analyzed data for 85,438 adults with untreated aneurysms between 2011 and 2019, comparing them to 331,000 adults without aneurysms.

An unruptured aneurysm occurs when a blood vessel in the brain becomes weak and bulges out, creating the risk of a potentially deadly rupture. (American Heart Association)

The data came from the National Health Information Database in South Korea.

The findings were published in Stroke, the peer-reviewed scientific journal of the American Stroke Association, a division of the AHA.

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“As a neurosurgeon who treats cerebral aneurysms, I often see people who do not undergo surgery, yet feel fear and/or anxiety about their condition before each imaging or screening test to monitor their condition,” said study co-author Na-Rae Yang, M.D., PhD, an assistant professor of neurosurgery in the department of neurosurgery at Ewha Womans University College of Medicine in Seoul, South Korea, in a press release.

“Even when it is medically judged and explained that follow-up observation is the best course for their aneurysm rather than surgery, they still worry about the very slim chance of developing a fatal brain bleed.”

Woman anxious headache

The fact that younger adults were more likely to have a “significant psychological burden” could be linked to other life stressors, an expert noted. (iStock)

The fact that younger adults were more likely to have a “significant psychological burden” could be linked to other life stressors, Yang noted, such as building their career and/or raising a family.

“This elevated rate of mental health conditions suggests that younger people might be particularly vulnerable, highlighting the need for targeted mental health support and interventions for this age group,” she added.

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Dr. Daniel T. Lackland, an American Heart Association EPI and Stroke Council member and professor of epidemiology at the Medical University of South Carolina, was not involved in the study but said he was not surprised by the findings.

“While there is no evidence that aneurysms directly cause anxiety and mental disorders, this study suggests there may be a connection between stress and aneurysms, and that unruptured aneurysms can increase emotional distress,” he told Fox News Digital. 

Man anxious headache

The knowledge of an unruptured aneurysm increased the risk of anxiety, stress, depression, insomnia, bipolar disorder, eating disorders, and alcohol or drug misuse by 10% over a 10-year period, the researchers found. (iStock)

“For example, an enlarging aneurysm may physically affect nearby sympathetic ganglia, which could produce panic or anxiety symptoms.”

Extreme emotional stress could also increase the risk of an enlarged aneurysm rupturing, which could increase anxiety, Lackland added.

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Based on the findings, Lackland recommends maintaining active and regular communication with health providers, particularly for individuals with a family history of brain aneurysms

“If diagnosed with a brain aneurysm, [the patient should] follow through with the appropriate and proper treatment,” he advised.

“Brain aneurysms, like aortic aneurysms, are life-threatening if they rupture, but can be treated with appropriate therapy and/or procedures.”

Woman with headache

Although the findings suggest an association between aneurysms and mental health conditions, they can’t prove cause and effect, the researchers noted. (iStock)

Dr. Bradley Serwer, a cardiologist and chief medical officer at VitalSolution, a Cincinnati-based company that offers cardiovascular and anesthesiology services to hospitals nationwide, has also noticed this phenomenon in his own practice.

“Whether the patient is told they have a brain aneurysm or they have an abnormal heart valve, irregular heart rhythm or aortic aneurysm, the psychological ramifications are significant,” Serwer, who was not involved in the research, told Fox News Digital.

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Younger patients may have fewer coping mechanisms, he noted.  

“They tend to perseverate more on the medical conditions, and this can lead to anxiety.”

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This study highlights the importance of taking a multidisciplinary approach to patient care, Serwer said, as well as the “dramatic need” for more behavioral and mental health services to support these individuals.

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Potential limitations

The study did have some limitations, the researchers acknowledged.

The analysis relied on a national database of medical codes rather than input from individual patients.

“Brain aneurysms, like aortic aneurysms, are life-threatening if they rupture, but can be treated with appropriate therapy and/or procedures.”

Additionally, the research did not take into account the size or location of the aneurysms.

Although the findings suggest an association between aneurysms and mental health conditions, they can’t prove cause and effect, the researchers noted.

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“As the authors indicate, there is inadequate evidence to indicate that brain aneurysms cause increased mental health risks,” said Lackland. 

“Also, the study was done in Korea — and it is unclear if the results can be generalized to other populations.”

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Most baby foods may not meet nutritional guidelines and use 'misleading claims,' study finds

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Most baby foods may not meet nutritional guidelines and use 'misleading claims,' study finds

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As much as 60% of baby foods on the market may not meet the nutritional standards set by the World Health Organization (WHO), a new study found.

The findings were published in the journal Nutrients last week.

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Researchers at The George Institute for Global Health — an independent medical research institute headquartered in Australia — reviewed 651 infant and toddler food products sold in the top 10 U.S. grocery chains, according to a press release.

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Seventy percent of the products did not include adequate amounts of protein, 25% did not meet calorie requirements, and 20% had sodium levels that exceeded WHO’s recommendations.

The researchers compared the foods’ data to WHO’s nutrient and promotion profile model (NPPM), which supports “appropriate promotion of food products” for infants and young children in Europe.

As much as 60% of baby foods on the market may not meet the nutritional standards set by the World Health Organization, a new study has found. (iStock)

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Baby food “pouches” were ranked as some of the least healthy choices, with fewer than 7% meeting total sugar recommendations, the institute noted.

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Infant formulas were not included in the study, as those are regulated separately by the U.S. Food and Drug Administration (FDA), the researchers noted.

“Only products available in the baby food section of the grocery store were included. This meant [that] yogurts located in the fridge section, drinks section, or under the ‘dairy, eggs and fridge’ tab online were not included,” they wrote.

Convenience foods labeled as culprits

Dr. Elizabeth Dunford, research fellow at The George Institute and adjunct assistant professor of nutrition at the University of North Carolina, expressed concern about the prevalence of “processed convenience foods” for babies and toddlers.

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Baby pouches

Baby food pouches were ranked the unhealthiest of the reviewed options. (iStock)

“Early childhood is a crucial period of rapid growth, and when taste preferences and dietary habits form, potentially paving the way for the development of chronic diseases such as obesity, diabetes and some cancers later in life,” Dunford said in the release. 

“Time-poor parents are increasingly choosing convenience foods, unaware that many of these products lack key nutrients needed for their child’s development and tricked into believing they are healthier than they really are.”

A ‘health halo’

The study also highlighted “misleading marketing practices,” claiming that more than 99% of baby food products contained at least one “prohibited claim” on the packaging. 

“We found that all but four products featured at least one prohibited claim on the pack, with an average of four prohibited claims per pack,” Dr. Daisy Coyle, research fellow and dietitian at The George Institute, told Fox News Digital.

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“These claims often give products a ‘health halo,’ deceiving busy parents into thinking they are a lot healthier than they are.”

Some of the most-cited misleading verbiage included “non-genetically modified (GM),” “organic,” “no BPA” and “no artificial colors/flavors.”

Feeding baby

“These numbers are truly alarming when you consider we’re talking about food for infants and toddlers,” a nutritionist told Fox News Digital.  (iStock)

“We saw this not only in the use of misleading claims, but also in the use of misleading names, where the product name did not reflect the main ingredients found on the ingredient list.”

Some products claimed to be “fruits” or “vegetables” even though those were not the primary ingredients, for example.

Among U.S. children 2 to 5 years old, the prevalence of obesity was 12.7% from 2017 to March 2020.

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“Our findings highlight the urgent need for better regulation and guidance in the infant and toddler foods market in the United States — the health of future generations depends on it,” added Dunford.

Among U.S. children 2 to 5 years old, the prevalence of obesity was 12.7% from 2017 to March 2020, according to data from the Centers for Disease Control and Prevention (CDC).

The young mother holds her daughter on her hip as she grocery shops

Based on the study findings, the researchers advised parents and caregivers to pay close attention to the claims made on baby food packaging. (iStock)

Based on the study findings, the researchers advised parents and caregivers to pay close attention to the claims made on baby food packaging.

“The ingredients list and nutrition label provide a far more accurate representation of what is in the product,” Coyle said. “One important thing to look out for is the amount of added sugar.”

Fox News Digital reached out to the American Academy of Pediatrics, major baby food manufacturers and WHO requesting comment.

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‘Critical issue’

Katie Thomson, an Oregon-based registered dietitian and founder of the Square Baby nutrition system, was not involved in the study but said it sheds light on a “critical issue.”

“These numbers are truly alarming when you consider we’re talking about food for infants and toddlers,” she told Fox News Digital. 

Baby pouches

“Time-poor parents are increasingly choosing convenience foods, unaware that many of these products lack key nutrients needed for their child’s development,” a nutritionist warned. (iStock)

“The core issue is that many of these products, especially pouches, are far too sweet to offer proper, balanced nutrition. This not only fails to meet nutritional needs, but also hinders the development of a child’s palate.”

“We’re essentially setting them up for a lifetime of poor eating habits.”

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As a mother, Thomson said, she understands the appeal of convenient, self-feeding options like pouches — but warned that this approach is “ultimately detrimental to children’s long-term health and eating habits.”

Lack of protein is the most glaring issue, according to Thomson — “it’s fundamental for everything from muscle development to immune function in growing bodies.”

      

“Many of these foods are also lacking in healthy fats, which are essential for brain development, and important micronutrients like calcium, iron and vitamin D,” she said. 

“There’s also a noticeable absence of those nutrient-dense green and earthy vegetables.”

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Grocery baby food

The researchers reviewed 651 infant and toddler food products sold in the top 10 U.S. grocery chains. (iStock)

Another often overlooked aspect, Thomson noted, is failure to include common allergens. 

“Early introduction of allergens, like peanuts, eggs and dairy, can actually help prevent food allergies from developing,” she said. 

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“However, many baby food products fail to include these important components, which can create a whole host of health issues later in life.”

When choosing nutrition for babies, Thomson recommends offering a diverse range of foods, flavors, textures and colors, with a balance of fat, fiber and protein, while keeping sugar content low. 

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Powdered formula

Infant formulas were not included in the study, as those are regulated separately by the U.S. Food and Drug Administration, the researchers noted. (iStock)

She recommends the following breakdown for a 4-ounce balanced meal.

  • Less than 6 grams of sugar
  • 2-4 grams of fat
  • 2-4 grams of fiber
  • 2-5 grams of protein

Potential limitations

The George Institute for Global Health, which has received previous funding from the Bill & Melinda Gates Foundation, the National Health and Medical Research Council, and other investors, stated that it received no external funding for this specific study.

The study did have some limitations, the researchers acknowledged.

“Although we analyzed data from a large representative dataset, we were unable to link to sales data for each product,” Coyle told Fox News Digital. 

Feeding baby

“More research is needed to know whether American families are more likely to purchase products that fail to meet WHO requirements,” the researchers said. (iStock)

“More research is needed to know whether American families are more likely to purchase products that fail to meet WHO requirements.”

Another limitation was that the WHO NPPM was developed for the European region.

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So it is “not necessarily 100% applicable to the U.S. infant and toddler foods market,” the researchers stated in the findings. 

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Parents and carers are not to blame, the researchers emphasized.

Coyle of The George Institute told Fox News Digital that “government regulation” is needed “to transform this sector to ensure infant and toddler foods are healthy and marketed appropriately.”

She added, “The health of our youngest generation and future generations depends on it.”

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