Health
People With A.D.H.D. Are Likely to Die Significantly Earlier Than Their Peers, Study Finds
A study of more than 30,000 British adults diagnosed with attention deficit hyperactivity disorder, or A.D.H.D., found that, on average, they were dying earlier than their counterparts in the general population — around seven years earlier for men, and around nine for women.
The study, which was published Thursday in The British Journal of Psychiatry, is believed to be the first to use all-cause mortality data to estimate life expectancy in people with A.D.H.D. Previous studies have pointed to an array of risks associated with the condition, among them poverty, mental health disorders, smoking and substance abuse.
The authors cautioned that A.D.H.D. is substantially underdiagnosed and that the people in their study — most of them diagnosed as young adults — might be among the more severely affected. Still, they described their findings as “extremely concerning,” highlighting unmet needs that “require urgent attention.”
“It’s a big number, and it is worrying,” said Joshua Stott, a professor of aging and clinical psychology at University College London and an author of the study. “I see it as likely to be more about health inequality than anything else. But it’s quite a big health inequality.”
The study did not identify causes of early death among people with A.D.H.D. but found that they were twice as likely as the general population to smoke or abuse alcohol and that they had far higher rates of autism, self-harming behaviors and personality disorders than the general population. In adulthood, Dr. Stott said, “they find it harder to manage impulses, and have more risky behaviors.”
He said health care systems might need to adjust in order to better serve people with A.D.H.D., who may have sensory sensitivity or difficulty managing time or communicating with clinicians during brief appointments. He said he hoped treatments for substance abuse or depression could be adapted for patients with A.D.H.D.
“If it’s about systems, it’s malleable,” he said. “This doesn’t have to be.”
Previous studies have pointed to an unusual number of early deaths for people with A.D.H.D. A 2022 meta-analysis in the journal JAMA Pediatrics found that deaths from unnatural causes, such as accidents or suicide, were 2.81 times higher among those diagnosed with A.D.H.D. than in the general population.
A 2019 study that used actuarial tables to predict life expectancy concluded that adults diagnosed with A.D.H.D. in childhood had an 8.4-year reduction in life expectancy compared with the general population, something the authors attributed to reduced education and income, higher rates of smoking and alcohol consumption and reduced sleep.
Russell Barkley, the lead author of that study, said the data made it clear that A.D.H.D. should not be seen as a childhood disorder, like bed-wetting, but as a lifelong problem.
“To me, the best analog is diabetes,” said Dr. Barkley, a retired professor of clinical psychology at Virginia Commonwealth University. “This is a disorder that you’ve got to manage, like high blood pressure, like cholesterol and diabetes. You’ve got to treat this for life.”
The new study examined 9,561,450 patients in Britain’s National Health Service primary care practices, among whom 30,039 had been diagnosed with A.D.H.D. Each person in the A.D.H.D. group was matched with 10 peers without the disorder for the purposes of comparison. Among those with A.D.H.D., 193 male patients and 148 female patients died during the follow-up period, which lasted from 2000 to 2019.
Stephen Hinshaw, a professor of psychology at the University of California, Berkeley, who studies A.D.H.D. but was not involved in the new British research, described the study as “a major finding,” the first analysis of deaths of subjects diagnosed with the disorder. He said it was unfortunate that the subjects’ causes of death were not included.
“There are risk factors to work on,” he said. “That is the key limitation of the study, because it would be really important to know, in terms of prevention, should we be focused on suicidality? Better diet and exercise? Depression?”
Diagnosis of A.D.H.D. has shifted in recent years, as clinicians concluded that many older people, especially women and people of color, had gone undiagnosed early in life and could benefit from treatment. As first-time diagnoses surged among older people, prevalence has remained consistent among children, at around 11 percent in the United States and 5 percent in Britain.
Dr. Stott said he hoped that, as these demographic changes took hold, health care systems would make more effort to identify the needs of neurodivergent patients. In past decades, he said, they may have been viewed dismissively by caregivers, as “the naughty kid at school.”
“If you’re constantly told, as a kid, sit down, stop being so naughty — if you talk to people with A.D.H.D., that is their experience — stop talking, go and sit outside,” he said. “It’s all of these things that wear down at your life chances, in many ways.”
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Brain aging may accelerate after cancer treatment, study suggests
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Surviving cancer as a child or young adult may have a lasting impact on aging, new research suggests.
Researchers at the University of Rochester Medical Center looked at whether life-saving treatments, like chemotherapy and radiation, could speed up biological aging.
They also aimed to determine whether this age acceleration was linked to cognitive issues related to memory, focus and learning.
The team analyzed blood samples from a group of 1,400 long-term survivors treated at St. Jude Children’s Research Hospital, using epigenetic clocks — tools that estimate biological age by examining chemical tags on DNA.
Biological age is determined based on damage the cells accumulate over time, versus chronological age, which is measured by how long someone has been alive, according to scientists.
Biological age is determined based on the damage cells accumulate over time, according to scientists. (iStock)
“These well-established aging-related biomarkers have previously been associated with neurocognitive impairment and decline in older non-cancer populations, particularly in cognitive domains related to aging and dementia, such as memory, attention and executive function,” the study stated.
Most of the group consisted of acute lymphoblastic leukemia survivors, or Hodgkin lymphoma survivors. Participants were at least five years past their treatment, though some had survived for several decades.
They underwent neurocognitive testing to measure their attention span, memory and information processing speed.
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Chemotherapy was found to have the greatest impact on aging acceleration. The study suggests the treatment can alter DNA structure and cause cellular damage.
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“It’s no surprise to find out that young people with cancer who have chemo early in life are affected in terms of long-term aging,” Dr. Marc Siegel, senior medical analyst for Fox News, told Fox News Digital.
Participants underwent neurocognitive testing to measure their attention span, memory and speed of information processing. (iStock)
Researchers also found that cellular aging was closely linked to cognitive performance, as survivors of a higher biological age had more difficulty with memory and attention.
“Chemo poisons and damages cellular function — hopefully the cancer cells more than normal cells, but there is a significant impact on normal cells as well,” said Siegel, who was not involved in the study.
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“There is also something called ‘chemo brain,’ which causes at least temporary difficulty with memory, concentration, word finding and brain fog,” the doctor added.
The research team hopes to use these findings to focus on intervention efforts, specifically by determining when accelerated aging begins.
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“Young cancer survivors have many more decades of life to live,” lead study author AnnaLynn Williams, PhD, said in a press release. “If these accelerated aging changes are occurring early on and setting them on a different trajectory, the goal is to intervene to not only increase their lifespan, but improve their quality of life.”
The team hopes this research will help in the development of early intervention tools that aim to prevent cognitive decline. (iStock)
There were some limitations to the study. The researchers could not adjust for chronic health conditions or education because they are directly impacted by treatment.
Additionally, the study only looked at the survivors at a single point of time, so it could not directly prove causation.
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The study was published in the journal Nature Communications.
Fox News Digital reached out to the researchers for comment.
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