Health
Ozempic, the happy drug? Study suggests weight-loss medications could reduce depression, anxiety
For the millions of people who take Ozempic and Wegovy, weight loss is the best-known outcome — but a new study suggests the medications could also help squash depression.
Investigators from Epic Research, a health analytics firm based in Verona, Wisconsin, found that patients with diabetes who were prescribed glucagon-like peptide-1 receptor agonist (GLP-1) medications were less likely to develop depression compared to people who are not taking the drugs.
GLP-1 medications include semaglutide (Ozempic or Wegovy), tirzepatide (Mounjaro), dulaglutide (Trulicity) and exenatide (Byetta and Bydureon).
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“The likelihood of anxiety in diabetic patients is lower for those on all five GLP-1 medications studied,” the researchers wrote in a release on Epic’s website.
For those without diabetes, semaglutide was linked to a lower likelihood of depression and anxiety, while liraglutide did not show any statistically significant benefit.
Weight loss is the best-known perk of Ozempic and Wegovy, but a new study suggests the medications could also help to reduce depression. (iStock)
The study analyzed the GLP-1 medications and mental health diagnoses of 3,081,254 diabetic patients and 929,174 non-diabetic patients.
Dr. Brett Osborn, a Florida neurologist and founder of the longevity company Senolytix, was not surprised to hear of the Epic Research study findings.
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“Ozempic’s potential antidepressive effects are garnering interest, both from the scientific community and those seeking holistic ways to manage their mental health alongside physical conditions,” he told Fox News Digital.
Weight loss often leads to a boost in mood and overall outlook in Osborn’s patients, he noted.
GLP-1 medications include semaglutide (Ozempic or Wegovy), tirzepatide (Mounjaro), dulaglutide (Trulicity) and exenatide (Byetta and Bydureon). (Getty Images)
“Losing weight can significantly impact an individual’s self-esteem and overall mood, leading to a more positive outlook on life,” the doctor said.
“The confidence boost that comes with achieving weight loss goals can be transformative, reducing feelings of depression and enhancing mental well-being.”
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Dr. Jennifer Bourgeois, PharmD, a Dallas-based pharmacy and health expert with SingleCare, a prescription discount service, said none of the companies that produce GLP-1 medications studied the effect on depression in the original clinical trials.
“At this time, none of the GLP-1 medications used to improve glycemic control in adults with type 2 diabetes or in chronic weight management claim to curb depression and anxiety,” she told Fox News Digital.
That doesn’t mean it’s not possible, however, the expert said.
Physical and mental mood-lifters
In previous research, Ozempic and other GLP-1 drugs were shown to have antidepressant-like effects in diabetic mice with type 2 diabetes, suggesting that the drugs have direct effects on brain chemistry and connectivity, Osborn said.
“It is thought that this results from GLP-1’s influence on the release of neurotransmitters, such as norepinephrine and serotonin, in a deep brain region known as the hypothalamus,” Osborn said.
Weight loss often leads people to adopt healthier lifestyle habits, such as regular exercise and improved dietary choices, an expert pointed out. (iStock)
GLP-1 drugs also modify the release of dopamine in the amygdala, the “emotional center” of the brain, Osborn said, which is involved in mood regulation.
While Bourgeois agrees that these medications may impact mood via brain changes, she said the likelier reason for the reduced depression and anxiety is the positive mental and physical health effects of weight loss.
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Weight loss induced by GLP-1 medications triggers biological changes that positively impact mood regulation, Bourgeois said.
“As excess adipose tissue (body fat) decreases, the production of inflammatory cytokines reduces, leading to a decrease in systemic inflammation,” she said.
“Research suggests that chronic inflammation may disrupt neurotransmitters like serotonin and dopamine as well as the balance of gut bacteria, potentially leading to mood imbalances.”
A pharmacist holds boxes of Eli Lilly & Co. Mounjaro brand tirzepatide medication at a pharmacy in Provo, Utah, on Monday, Nov. 27, 2023. (Getty Images)
The boost to self-esteem and body image can also curb depression and anxiety, Bourgeois noted, leading to an overall more positive outlook.
“Individuals who achieve weight loss through GLP-1 receptor agonists may experience a sense of accomplishment and empowerment, which can positively influence their mental health,” she said.
There may also be a “trickle-down” effect, with weight loss often leading people to adopt healthier lifestyle habits — such as regular exercise and improved dietary choices, the expert pointed out.
“These lifestyle changes can have profound effects on mental health,” she said.
The boost to self-esteem and body image that comes with weight loss can also curb depression and anxiety, experts say. (iStock)
“Physical activity is known to stimulate the release of endorphins, which promote feelings of happiness and euphoria, and a nutrient-rich diet can provide essential vitamins and minerals that support brain function and mood regulation.”
More research needed
While the Epic data is “promising,” said Bourgeois, “more research is needed to determine if the medication itself is responsible for the reduction in depression and anxiety diagnoses.”
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“Other factors like physical activity, diet and sleep were not controlled and could be contributing to the mood-altering effects.”
Osborn added, “I’m not saying that Ozempic will become a first-line treatment for depression, but it certainly highlights the interconnectedness of physical and mental health.”
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Health
Loneliness may be silently eroding your memory, new research reveals
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Feeling lonely may take a toll on older adults’ memory — but it may not speed up cognitive decline, according to a new study.
Researchers from Colombia, Spain and Sweden analyzed data from more than 10,000 adults ages 65 to 94 across 12 European countries and found those who reported higher levels of loneliness did worse on memory tests at the start of the study, according to research published this month in the journal Aging & Mental Health.
Over a seven-year period, however, memory decline occurred at a similar rate regardless of how lonely participants felt.
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“The finding that loneliness significantly impacted memory, but not the speed of decline in memory over time was a surprising outcome,” lead author Dr. Luis Carlos Venegas-Sanabria of the School of Medicine and Health Sciences at the Universidad del Rosario said in a statement.
Loneliness may be linked to memory performance in older adults, a new study suggests. (iStock)
“It suggests that loneliness may play a more prominent role in the initial state of memory than in its progressive decline,” Venegas-Sanabria said, adding that the findings highlight the importance of addressing loneliness as a factor in cognitive performance.
The findings add to debate about whether loneliness contributes to dementia risk. While loneliness and social isolation are often considered risk factors for cognitive decline, research results have been mixed.
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The study looked at data from the long-running Survey of Health, Ageing and Retirement in Europe (SHARE), which tracked 10,217 older adults between 2012 and 2019. Participants were asked to recall words immediately and after a delay to measure memory performance.
Social isolation and loneliness could play a surprising role in cognitive health among seniors. (iStock)
Loneliness was assessed using three questions about how often participants felt isolated, left out or lacking companionship.
About 8% of participants reported high levels of loneliness at the outset. That group tended to be older, more likely to be female and more likely to have conditions such as depression.
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Researchers found that those with higher loneliness had lower scores on both immediate and delayed memory tests at baseline. Still, all groups — regardless of loneliness level — experienced similar declines in memory over time.
The results suggest loneliness may not directly accelerate the progression of memory loss, though it remains linked to poorer cognitive performance overall.
Researchers look at a brain scan at the National Institutes of Health in Bethesda, Maryland. (Saul Loeb/AFP/Getty Images)
Experts warn, however, that the findings should not be interpreted to mean loneliness is harmless.
“The finding that lonely older adults start with worse memory but don’t decline faster is actually the most interesting part of the paper, and I think it’s easy to misread,” said Jordan Weiss, Ph.D., a scientific advisor and aging expert at Assisted Living Magazine and a professor at NYU Grossman School of Medicine.
“It likely means loneliness does its damage earlier in life, well before people show up in a study like this at 65-plus,” Weiss told Fox News Digital.
By older age, long-term social patterns may already be established, making it harder to detect when the effects of loneliness first took hold, an aging expert says. (iStock)
He suggested that by older age, long-term social patterns may already be established, making it harder to detect when the effects of loneliness first took hold.
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“By the time you’re measuring someone in their late 60s, decades of social connection patterns are already baked in,” he said.
Weiss, who was not involved in the research, added that loneliness may coincide with other health conditions, and noted that participants who felt more isolated also had higher rates of depression, high-blood pressure and diabetes. The link, he said, may reflect a cluster of health risks rather than a direct cause.
“While they can go hand-in-hand, it’s not clear that loneliness contributes to dementia,” a psychotherapist says. (iStock)
Amy Morin, a Florida-based psychotherapist and author, said the findings reflect a broader pattern in research on loneliness and brain health, and that the relationship may be more complex than it appears.
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“The evidence shows there’s a link between loneliness and cognitive decline but there’s no direct evidence of a cause and effect relationship,” she said. “So while they can go hand-in-hand, it’s not clear that loneliness contributes to dementia.”
Morin added that loneliness, which can fluctuate, may not be the root of the problem, but rather a symptom of other underlying mental or physical health issues.
Researchers suggested screening for loneliness be incorporated into routine cognitive assessments as one way to support healthy aging. (iStock)
She said staying socially and mentally engaged is crucial for overall brain health.
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“It’s important to be proactive about social activities,” Morin said. “Joining a book club, having coffee with a friend, or attending faith-based services can be a powerful way to maintain connections in older age.”
The researchers also suggested screening for loneliness be incorporated into routine cognitive assessments as one way to support healthy aging.
Fox News Digital reached out to the researchers for comment.
Health
Eat More To Lose Weight? She Dropped 55 Pounds by Having 5 Meals a Day
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Health
Intermittent fasting’s real benefit may come after you start eating again
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Research continues to uncover new details on how fasting may help extend life.
A new study published in the journal Nature Communications investigated how intermittent fasting can boost longevity in small worms often used in aging research.
Researchers from the University of Texas Southwestern Medical Center in Dallas compared worms that were fed normally to those that underwent a 24-hour fast in early adulthood and were then fed again, according to a press release.
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The scientists measured a variety of factors, including stored fat, gene activity related to fat metabolism and lifespan.
The results showed that the life-boosting benefit did not depend on the fasting itself but on the body’s behavior after eating again.
Experts say sustainability is key when choosing a long-term weight-loss strategy. (iStock)
Study lead Peter Douglas, associate professor of molecular biology and a member of the Hamon Center for Regenerative Science and Medicine at UT Southwestern, suggested that these discoveries “shift the focus toward a neglected side of the metabolic coin – the re-feeding phase.”
“Our data suggest that the health-promoting effects of intermittent fasting are not merely a product of the fast itself, but are dependent on how the metabolic machinery recalibrates during the subsequent transition back to a fed state,” he said.
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“Our findings bridge a gap between lipid metabolism and aging research,” he added. “By targeting aging, the single greatest risk factor for human disease, we move beyond treating isolated conditions toward a preventive model of medicine that enhances quality of life for all individuals.”
Lauri Wright, director of nutrition programs at the University of South Florida’s College of Public Health, called this a “high-quality” study that adds an “important nuance to how we think about fasting and longevity.”
Intermittent fasting typically involves limiting meals to an eight-hour daily window or fasting every other day. (iStock)
The benefits of the refeeding phase after fasting were “especially interesting,” Wright, who was not involved in the study, told Fox News Digital.
“The researchers showed that longevity was linked to the body’s ability to turn off fat breakdown after fasting, allowing cells to restore energy balance,” she reiterated.
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“From a scientific standpoint, that’s a meaningful shift because it suggests fasting is not just about burning fat, but about metabolic flexibility.”
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Fasting may support longevity through triggering metabolic switching, enhancing cellular repair and stress resistance and improving markers like insulin sensitivity, research shows.
Limitations and cautions
Although this study provides “important insight” on the power of refeeding, Wright noted that the findings should be approached with caution, as the study was done on worms and cannot always be translated to humans.
“Additionally, it explains how a process might work in a controlled lab condition rather than real-world eating behaviors,” she added as a limitation. “Finally, the study is short-term and doesn’t give us the long-term translation on lifespan outcomes.”
The review found intermittent fasting was barely more effective than doing nothing, according to the study authors. (iStock)
Wright cautioned that fasting is “not a magic solution for longevity, and how you eat overall matters more than when you eat.”
“I advise, first and foremost, to focus on diet quality, including a variety of fruits and vegetables, healthy fats and minimally processed foods,” she said.
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For those who are considering fasting, it’s better to stick with a moderate plan — like a 12- to 14-hour overnight fast — rather than going to extremes, Wright said. After fasting, she recommends focusing on well-balanced meals.
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Several groups of people should be cautioned against fasting, according to Wright, including those with diabetes who are on insulin or hypoglycemic medications, those who are pregnant or breastfeeding, anyone with a history of eating disorders and older adults at risk of malnutrition.
Anyone considering intermittent fasting should consult with a doctor before starting.
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