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Ozempic and Wegovy could double as kidney disease treatment, study suggests

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Ozempic and Wegovy could double as kidney disease treatment, study suggests

Semaglutide medications — including Ozempic and Wegovy — have been shown to reduce the risk of kidney failure and the risk of death among people with kidney disease and type 2 diabetes.

In a trial led by UNSW Sydney between June 2019 and May 2021, researchers found that a small weekly dose of semaglutide lessened the likelihood of “major kidney events” by 24%, according to a press release.

The study, funded by Novo Nordisk and published in The New England Journal of Medicine, included more than 3,500 participants with type 2 diabetes and chronic kidney disease from 28 countries.

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The participants received 1.0 mg per week of semaglutide, which is less than what is typically prescribed for weight loss or diabetes, the release noted. 

The median follow-up was 3.4 years.

Semaglutide medications — including Ozempic and Wegovy — have been shown to reduce the risk of kidney failure and the risk of death among people with kidney disease and type 2 diabetes. (iStock)

“It’s the same chemical compound, but we used a lower dose … we did that deliberately because people with kidney disease tend to be more sensitive to the effects and side effects of drugs,” said the study’s lead author, professor Vlado Perkovic of UNSW Sydney, in the release.

“That’s helpful in terms of being able to perhaps have the drug more widely used than might have otherwise been the case given the current supply limitations.”

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The group of people taking semaglutide were also 18% less likely to experience a heart attack, stroke and other cardiovascular events, the study found.

Why does semaglutide have this effect?

Patients with type 2 diabetes and chronic kidney disease are at a significant risk for kidney failure, cardiovascular events and death, according to Dr. Brett Osborn, a neurologist and longevity expert in Florida.

“The recent study published in the New England Journal of Medicine highlights semaglutide’s potential to mitigate these risks,” Osborn, who was not involved in the study, told Fox News Digital. 

Dr. Brett Osborn, a neurologist and longevity expert in Florida, noted that patients with type 2 diabetes and chronic kidney disease are at a significant risk for kidney failure, cardiovascular events and death.  (Dr. Brett Osborn)

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Semaglutide works by improving glycemic control, Osborn noted — which is crucial in mitigating diabetic nephropathy (kidney disease). 

“It also lowers inflammation — particularly within the blood vessel lining,” he said. 

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This reduces blood vessel damage and improves blood flow through the kidneys.

“Overall, semaglutide offers substantial renal and cardiovascular protection for patients with type 2 diabetes and chronic kidney disease,” Osborn said.

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“At a base level, semaglutide, through indirect mechanisms, improves vascular health. The better blood flow to your organs — be it your heart, brain or kidneys — the longer you are likely to live.”

Semaglutide works by improving glycemic control, one doctor noted, which is crucial in mitigating diabetic nephropathy (kidney disease).  (Getty Images)

Outside the spectrum of diabetes, Osborn said he believes these medications will have a major impact on human health, comparing them to the advent of antibiotics at the turn of the century.

Dr. Marc Siegel, clinical professor of medicine at NYU Langone Medical Center and a Fox News medical contributor, also said this was a “very important” study.

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“This lifesaving result is likely due to the metabolic effects of the drug, which helps with reducing inflammation, overcoming insulin resistance, and improving insulin function and glucose metabolism at the cellular level,” Siegel told Fox News Digital. 

“This study has broader implications for all patients who have kidney failure.”

“Improved kidney function means improved heart function, and pressure on the heart from failed kidneys is a major cause of heart attack and death.”

Siegel added, “This study has broader implications for all patients who have kidney failure or are at risk for it.”

Novo Nordisk, the Denmark-based company that makes Ozempic and Wegovy, announced the positive primary results from the trial at the European Renal Association (ERA) Congress in Sweden last week. (LISELOTTE SABROE/Scanpix Denmark/AFP via Getty Images)

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Novo Nordisk, the Denmark-based company that makes Ozempic and Wegovy, announced the positive primary results from the trial at the European Renal Association (ERA) Congress in Sweden last week.

“FLOW is the first ever renal outcomes trial with a GLP-1 receptor agonist, and demonstrated a statistically significant reduction in kidney disease progression, cardiovascular death, and all-cause mortality risk with semaglutide 1 mg,” Michael Radin, executive medical director for diabetes at Novo Nordisk, said in a statement sent to Fox News Digital. 

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“This study highlights our drive to make a meaningful difference in the lives of people living with type 2 diabetes and CKD and to deliver innovations to address current unmet medical needs in CKD pending FDA approval.”

Wegovy is an injectable prescription weight loss medicine that has helped people with obesity. (Michael Siluk/UCG/Universal Images Group via Getty Images)

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To leverage semaglutide as a treatment for kidney disease, there is a need to overcome supply shortages and conduct research about combining the medication with other therapies, the researchers stated in the release.

Novo Nordisk will also need to seek regulatory approval for the drug to be used for chronic kidney disease patients.

“The challenge is to get these results into clinical practice, to get the drug used by the people who will benefit from it, who will live longer without dialysis, without heart attacks, without strokes, if they take this drug,” Perkovic said.

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Common nighttime noise exposure may trigger heart problems, study suggests

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Common nighttime noise exposure may trigger heart problems, study suggests

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Living near heavy traffic could negatively impact your heart health.

A European study, published in the journal Environmental Research, found that exposure to nighttime road traffic noise is linked to changes in the blood, leading to worsened cholesterol and cardiovascular risks.

The researchers considered data from the U.K. Biobank, Rotterdam Study, and Northern Finland Birth Cohort 1966, including more than 272,000 adults over the age of 30, according to a press release.

Nighttime road noise exposure was estimated at all participants’ homes based on national noise maps. Researchers also took blood samples to measure the participants’ metabolic biomarkers for disease, then mapped the link between nightly noise levels and existence of biomarkers.

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Exposure to loud noise was associated with increased concentrations of cholesterol-related biomarkers. (iStock)

The study found that people exposed to louder noise at night — especially sounds above 55 decibels — showed changes in 48 different substances in their blood. Twenty of these associations “remained robust” throughout all cohorts.

Exposure to loud noise was associated with increased concentrations of cholesterol-related biomarkers, especially LDL “bad” cholesterol, IDL (intermediate-density lipoprotein) and unsaturated fatty acids.

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As noise levels increased, starting at around 50 decibels, cholesterol markers rose steadily, the release stated.

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The authors concluded that this study “provides evidence that nighttime road traffic noise exposure from 50 dB upward is associated with alterations in blood cholesterol and lipid profiles in adults.”

Researchers noted a link between traffic noise and cardiometabolic disease. (iStock)

Study co-author Yiyan He, doctoral researcher at the University of Oulu in Finland, noted that in this type of research, small effect sizes are expected, and environmental exposures such as traffic noise are “typically modest.”

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“Despite this, we observed statistically robust and consistent associations across many biomarkers, especially those related to LDL and IDL lipoproteins,” she told Fox News Digital.

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“We also identified a clear exposure-response pattern starting at around 50 dB, suggesting that metabolic changes become more evident as noise levels increase.”

This aligns with public health guidance, as the World Health Organization recommends lower nighttime noise limits at around 40 to 45 dB, Yiyan He added.

“This finding may clarify the association between traffic noise and cardiometabolic diseases,” the researchers wrote. (iStock)

“The 55 dB level is often used as an interim benchmark associated with substantial noise annoyance and sleep disturbance,” she said. “In our study, we observed associations not only at 55 dB, but also indications of effects emerging at around 50 dB.”

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The strength and consistency of the cholesterol-related associations were surprising, as these changes are usually “subtle.”

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“Instead, we found consistent associations across multiple large European cohorts, which strengthens confidence that the findings may reflect real biological patterns,” Yiyan He went on. “We were also interested to see that effects were minimal below ~50 dB, suggesting a possible threshold-like pattern.”

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The researcher noted that these findings were consistent across genders, education levels and obesity status.

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The study was restricted to White Europeans, which posed a limitation. There was also a lack of information on the fasting status in the UK Biobank.

Changes in cholesterol levels were more severe than researchers expected. (iStock)

“Fasting can influence levels of certain metabolites, particularly fatty acids,” Yiyan He said. “However, based on UK Biobank documentation, fewer than 10% of participants were fasting for at least eight hours, and our main findings focused on cholesterol-related biomarkers, which are generally less sensitive to short-term fasting.”

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The researchers also lacked information on bedroom location, indoor noise exposure and time spent at home.

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“These factors may introduce non-differential exposure misclassification,” Yiyan He said. “Additionally, noise exposure estimates were based on participants’ temporary residential addresses at the time of blood sampling, without considering the duration of residence.”

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“Many of these limitations would tend to bias results toward the null, so the consistent associations we observed remain noteworthy.”

Experts recommend taking measures to limit traffic noise at night. (iStock)

Based on this latest research, Yiyan He noted that nighttime noise is a “health-relevant exposure,” not just “an annoyance.”

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“Our findings suggest that nighttime traffic noise may subtly but consistently affect metabolic health,” she said. “While the changes in cholesterol and lipid levels for any one individual are small, traffic noise affects a very large number of people, which means the potential public health impact could be substantial.”

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The researcher recommends taking measures like improving sound insulation, using noise-reducing strategies and placing bedrooms on the quieter side of the home when possible.

“Because sleep is a key pathway linking noise to health, protecting the nighttime sleep environment is especially important,” she added.

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‘SuperAgers’ stay mentally sharp well past 80, as scientists reveal the reason

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