Health
Ozempic and Wegovy could double as kidney disease treatment, study suggests
Semaglutide medications — including Ozempic and Wegovy — have been shown to reduce the risk of kidney failure and the risk of death among people with kidney disease and type 2 diabetes.
In a trial led by UNSW Sydney between June 2019 and May 2021, researchers found that a small weekly dose of semaglutide lessened the likelihood of “major kidney events” by 24%, according to a press release.
The study, funded by Novo Nordisk and published in The New England Journal of Medicine, included more than 3,500 participants with type 2 diabetes and chronic kidney disease from 28 countries.
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The participants received 1.0 mg per week of semaglutide, which is less than what is typically prescribed for weight loss or diabetes, the release noted.
The median follow-up was 3.4 years.
“It’s the same chemical compound, but we used a lower dose … we did that deliberately because people with kidney disease tend to be more sensitive to the effects and side effects of drugs,” said the study’s lead author, professor Vlado Perkovic of UNSW Sydney, in the release.
“That’s helpful in terms of being able to perhaps have the drug more widely used than might have otherwise been the case given the current supply limitations.”
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The group of people taking semaglutide were also 18% less likely to experience a heart attack, stroke and other cardiovascular events, the study found.
Why does semaglutide have this effect?
Patients with type 2 diabetes and chronic kidney disease are at a significant risk for kidney failure, cardiovascular events and death, according to Dr. Brett Osborn, a neurologist and longevity expert in Florida.
“The recent study published in the New England Journal of Medicine highlights semaglutide’s potential to mitigate these risks,” Osborn, who was not involved in the study, told Fox News Digital.
Semaglutide works by improving glycemic control, Osborn noted — which is crucial in mitigating diabetic nephropathy (kidney disease).
“It also lowers inflammation — particularly within the blood vessel lining,” he said.
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This reduces blood vessel damage and improves blood flow through the kidneys.
“Overall, semaglutide offers substantial renal and cardiovascular protection for patients with type 2 diabetes and chronic kidney disease,” Osborn said.
“At a base level, semaglutide, through indirect mechanisms, improves vascular health. The better blood flow to your organs — be it your heart, brain or kidneys — the longer you are likely to live.”
Outside the spectrum of diabetes, Osborn said he believes these medications will have a major impact on human health, comparing them to the advent of antibiotics at the turn of the century.
Dr. Marc Siegel, clinical professor of medicine at NYU Langone Medical Center and a Fox News medical contributor, also said this was a “very important” study.
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“This lifesaving result is likely due to the metabolic effects of the drug, which helps with reducing inflammation, overcoming insulin resistance, and improving insulin function and glucose metabolism at the cellular level,” Siegel told Fox News Digital.
“This study has broader implications for all patients who have kidney failure.”
“Improved kidney function means improved heart function, and pressure on the heart from failed kidneys is a major cause of heart attack and death.”
Siegel added, “This study has broader implications for all patients who have kidney failure or are at risk for it.”
Novo Nordisk, the Denmark-based company that makes Ozempic and Wegovy, announced the positive primary results from the trial at the European Renal Association (ERA) Congress in Sweden last week.
“FLOW is the first ever renal outcomes trial with a GLP-1 receptor agonist, and demonstrated a statistically significant reduction in kidney disease progression, cardiovascular death, and all-cause mortality risk with semaglutide 1 mg,” Michael Radin, executive medical director for diabetes at Novo Nordisk, said in a statement sent to Fox News Digital.
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“This study highlights our drive to make a meaningful difference in the lives of people living with type 2 diabetes and CKD and to deliver innovations to address current unmet medical needs in CKD pending FDA approval.”
To leverage semaglutide as a treatment for kidney disease, there is a need to overcome supply shortages and conduct research about combining the medication with other therapies, the researchers stated in the release.
Novo Nordisk will also need to seek regulatory approval for the drug to be used for chronic kidney disease patients.
“The challenge is to get these results into clinical practice, to get the drug used by the people who will benefit from it, who will live longer without dialysis, without heart attacks, without strokes, if they take this drug,” Perkovic said.
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Health
How The Great British Bake Off Host Alison Hammond Lost 150 Lbs Naturally
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Health
One state leads country in human bird flu with nearly 40 confirmed cases
A child in California is presumed to have H5N1 bird flu, according to the San Francisco Department of Public Health (SFDPH).
As of Dec. 23, there had been 36 confirmed human cases of bird flu in the state, according to the California Department of Public Health (CDPH).
This represents more than half of the human cases in the country.
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The latest pediatric patient, who lives in San Francisco, experienced fever and conjunctivitis (pink eye) as a result of the infection.
The unnamed patient was not hospitalized and has fully recovered, according to the SFDPH.
The child tested positive for bird flu at the SFDPH Public Health Laboratory. The U.S. Centers for Disease Control and Prevention (CDC) will perform additional tests to confirm the result.
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It is not yet known how the child was exposed to the virus and an investigation is ongoing.
“I want to assure everyone in our city that the risk to the general public is low, and there is no current evidence that the virus can be transmitted between people,” said Dr. Grant Colfax, director of health, in the press release.
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“We will continue to investigate this presumptive case, and I am urging all San Franciscans to avoid direct contact with sick or dead birds, especially wild birds and poultry. Also, please avoid unpasteurized dairy products.”
Samuel Scarpino, director of AI and life sciences and professor of health sciences at Northeastern University in Boston, is calling for “decisive action” to protect individuals who may be in contact with infected livestock and also to alert the public about the risks associated with wild birds and infected backyard flocks.
“While I agree that the risk to the broader public remains low, we continue to see signs of escalating risk associated with this outbreak,” he told Fox News Digital.
Experts have warned that the possibility of mutations in the virus could enable person-to-person transmission.
“While the H5N1 virus is currently thought to only transmit from animals to humans, multiple mutations that can enhance human-to-human transmission have been observed in the severely sick American,” Dr. Jacob Glanville, CEO of Centivax, a San Francisco biotechnology company, told Fox News Digital.
“This highlights the requirement for vigilance and preparation in the event that additional mutations create a human-transmissible pandemic strain.”
As of Jan. 10, there have been a total of 707 infected cattle in California, per reports from the California Department of Food and Agriculture (CDFA).
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In the last 30 days alone, the virus has been confirmed in 84 dairy farms in the state.
Health
Chronic Pain Afflicts Billions of People. It’s Time for a Revolution.
“In the beginning, everyone thought they were going to find this one breakthrough pain drug that would replace opioids,” Gereau said. Increasingly, though, it’s looking like chronic pain, like cancer, could end up having a range of genetic and cellular drivers that vary both by condition and by the particular makeup of the person experiencing it. “What we’re learning is that pain is not just one thing,” Gereau added. “It’s a thousand different things, all called ‘pain.’”
For patients, too, the landscape of chronic pain is wildly varied. Some people endure a miserable year of low-back pain, only to have it vanish for no clear reason. Others aren’t so lucky. A friend of a friend spent five years with extreme pain in his arm and face after roughhousing with his son. He had to stop working, couldn’t drive, couldn’t even ride in a car without a neck brace. His doctors prescribed endless medications: the maximum dose of gabapentin, plus duloxetine and others. At one point, he admitted himself to a psychiatric ward, because his pain was so bad that he’d become suicidal. There, he met other people who also became suicidal after years of living with terrible pain day in and day out.
The thing that makes chronic pain so awful is that it’s chronic: a grinding distress that never ends. For those with extreme pain, that’s easy to understand. But even less severe cases can be miserable. A pain rating of 3 or 4 out of 10 sounds mild, but having it almost all the time is grueling — and limiting. Unlike a broken arm, which gets better, or tendinitis, which hurts mostly in response to overuse, chronic pain makes your whole world shrink. It’s harder to work, and to exercise, and even to do the many smaller things that make life rewarding and rich.
It’s also lonely. When my arms first went crazy, I could barely function. But even after the worst had passed, I saw friends rarely; I still couldn’t drive more than a few minutes, or sit comfortably in a chair, and I felt guilty inviting people over when there wasn’t anything to do. As Christin Veasley, director and co-founder of the Chronic Pain Research Alliance, puts it: “With acute pain, medications, if you take them, they get you over a hump, and you go on your way. What people don’t realize is that when you have chronic pain, even if you’re also taking meds, you rarely feel like you were before. At best, they can reduce your pain, but usually don’t eliminate it.”
A cruel Catch-22 around chronic pain is that it often leads to anxiety and depression, both of which can make pain worse. That’s partly because focusing on a thing can reinforce it, but also because emotional states have physical effects. Both anxiety and depression are known to increase inflammation, which can also worsen pain. As a result, pain management often includes cognitive behavioral therapy, meditation practice or other coping skills. But while those tools are vital, it’s notoriously hard to reprogram our reactions. Our minds and bodies have evolved both to anticipate pain and to remember it, making it hard not to worry. And because chronic pain is so uncomfortable and isolating, it’s also depressing.
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