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New Parkinson's drug could slow or reverse progression of disease, researchers say: 'Big step forward'

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New Parkinson's drug could slow or reverse progression of disease, researchers say: 'Big step forward'

A new drug is being tested to relieve Parkinson’s disease (PD) symptoms – and it’s reportedly showing promise.

The drug is designed to slow or halt the progression of the disease in patients by targeting toxic proteins that build up in the brain, according to the study published in the journal Nature Medicine on June 20.

Researchers conducted a phase 1 placebo-controlled trial of an investigational immunotherapy drug called UB-312, testing for safety, tolerability and immunogenicity (strength of immune response).

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The trial results showed that the drug was generally safe and well-tolerated by patients as a disease-modifying treatment for Parkinson’s.

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The researchers stated that to their knowledge, this is the first report showing a positive effect of an investigational therapy of this kind.

In a new study, Parkinson’s patients reported improved daily movement after being administered UB-312. (iStock)

There is currently no cure for Parkinson’s, only drugs that treat the symptoms.

“UB-312 is designed to modify the course of Parkinson’s disease by targeting the underlying cause,” Lou Reese, co-founder of Vaxxinity, the Texas-based pharmaceutical company that worked on the study, told Fox News Digital.

Leiden University Medical Centre in the Netherlands, University of Texas McGovern Medical School, and Mayo Clinic in Rochester, Minnesota, also helped conduct the study.

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“In our phase 1 trial, we showed that UB-312 may be able to stop or even reverse the course of disease by successfully targeting aggregated alpha-synuclein.” 

(Alpha-synuclein is an acidic protein that builds up in the brains of Parkinson’s patients.)

UB-312 is given as an injection, typically via multiple doses over several months, Reese noted.

“Time and science will help us to determine if this newer approach will fare better.”

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During the trial, PD patients reported improved daily movement after receiving the new drug.

The medication was found to be safe and well-tolerated in healthy people and Parkinson’s patients alike, with only minimal side effects that included headaches and fatigue, according to Reese.

doctor applying adhesive to patient's arm after injecting man

The drug UB-312 is administered via injection, typically via multiple doses over several months. (iStock)

UB-312 works by targeting the “harmful Parkinson’s protein” alpha-synuclein and producing antibodies against it, the researcher said.

In the trial, 12 out of 13 patients developed antibodies, which Reese described as a “big step forward in PD treatment.”

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“These antibodies reached the brain and interacted with the target protein,” he said.

Based on the “promising” results of Phase 1, UB-312 will now progress into phase 2 trials, focusing on a larger patient population while optimizing the dose, according to Reese.

illustration of a human brain and reaction points

Alpha-synuclein antibodies “reached the brain and interacted with the target protein,” the researcher said. (iStock)

“The ultimate goal is to develop effective, disease-modifying treatments that can improve outcomes and provide hope for individuals living with Parkinson’s disease,” he added.

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“This is exciting because we are targeting the root cause of Parkinson’s and not the symptoms. It’s the first drug ever to take a patient from positive to negative.”

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Some doctors, however, cautioned that Parkinson’s patients shouldn’t get their hopes up just yet.

“People with Parkinson’s should be aware that although the findings were interesting, this was only a safety, tolerability and immunogenicity study, and thus there is a long way to go for development of this treatment,” Michael S. Okun, M.D., Parkinson’s Foundation medical adviser and director at the Norman Fixel Institute for Neurological Diseases at the University of Florida Health, told Fox News Digital.

An elderly man's hand is trembling because of Parkinson's disease

Scientists “worry” that this approach may not improve outcomes or slow disease progression, one doctor told Fox News Digital. (iStock)

Okun was not involved in the study.

The injections did seem to “rev up the immune system,” Okun acknowledged, as the researchers observed the appearance of antibodies in the blood samples of most study participants.      

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“The worry that many scientists have about this approach is that it may neither improve clinical outcomes nor slow disease progression,” he added.

“Two similar antibody trials of prasinezumab and cinpanemab were published in 2022 in The New England Journal of Medicine, but both of those trials failed to meet their primary outcomes.”

Okun concluded that “time and science will help us to determine if this newer approach will fare better.”

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Doctors express concern about Biden’s apparent cognitive issues during debate: 'Troubling indicators'

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Doctors express concern about Biden’s apparent cognitive issues during debate: 'Troubling indicators'

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The first presidential debate of 2024 left many Americans and even some traditional Democratic allies wondering about President Biden’s mental fitness for office based on what appeared to be his unclear train of thought at times and his raspy voice on Thursday night.

The White House responded to these concerns, claiming that the president, who is 81, was fighting a cold, but some doctors said they perceive the health issues go beyond the sniffles — with one noting that “it is an issue of fitness, not of age.”

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Dr. Brett Osborn, a Florida neurosurgeon who specializes in cognitive function, told Fox News Digital on Friday about his concerns. 

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“President Biden’s performance in [Thursday] night’s debate reignited longstanding discussions about his cognitive abilities and his overall leadership capacity,” Osborn told Fox News Digital. 

“Throughout the evening, Biden struggled to maintain a coherent narrative, often losing his train of thought mid-sentence, and providing vague, rambling and undecipherable answers to highly critical questions,” said Osborn, expressing his professional opinion.

Joe Biden is shown on Friday, June 28, the day after the debate, at a rally in Raleigh, North Carolina. Dr. Marc Siegel, inset left, and Dr. Brett Osborn, inset right, weighed in on President Biden’s performance during the Thursday night presidential debate, sharing concerns about his health from their point of view. (Fox News; Getty Images; Dr. Brett Osborn)

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“His frequent pauses, stumbling over words and reliance on notes underscored concerns about his mental acuity,” Osborn added. 

“Biden struggled to maintain a coherent narrative, often losing his train of thought mid-sentence.”

These seeming signs of cognitive decline highlight a “growing inability” to manage the complexities required by the job of the presidency, according to the neurosurgeon.

“His difficulty in articulating clear, concise responses and his apparent disorientation during the debate were seen by many – including his own constituents – as very troubling indicators of his overall health and an obvious decline in his cognitive function,” Osborn said.

presidents trump and biden during the debate

Former President Donald Trump and President Joe Biden are shown during the first presidential debate of the 2024 election at CNN’s studios in Atlanta, Georgia, on Thursday, June 27, 2024. (Jabin Botsford/The Washington Post)

“President Biden lacks the mental sharpness required for the highest office in the land … especially amid [today’s] current national and international crises.”

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The neurosurgeon, who has not treated Biden personally, also mentioned the 46th president has undergone multiple surgeries for brain aneurysms.

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There is a famous saying in neurosurgery, Osborn noted: “When the air hits your brain, you’re never the same.” 

The surgeon surmised, “The odds have been stacked against him for years, long before his presidency.”

joe biden ahead of debate in georgia

Joe Biden reacts as supporters greet him at his debate watch party at Hyatt Regency Atlanta on June 27, 2024, in Atlanta, Georgia. (Derek White/Getty Images for DNC)

Dr. Marc Siegel, physician, clinical professor of medicine at NYU Langone Medical Center and a Fox News medical contributor, also spoke with Fox News Digital about concerns from his end.

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“The debate is, in a way, a psychiatric or cognitive stress test,” he told Fox News Digital. 

         

Although Biden was able to respond to questions and seemed to be spatially aware, according to Siegel, the president did display “frequent disorientation” and had “problems with spontaneity or redirecting,” the doctor said. 

He has not personally examined Biden.

split image of joe biden and dr. marc siegel

Dr. Marc Siegel, at right, joined “Fox & Friends” on Friday, June 28, to discuss the presidential debate on Thursday evening.  (Kevin D. Liles for The Washington Post via Getty Images; Fox News)

Siegel described Biden’s speech as “meandering,” noting that he ended sentences in different places than intended, and “often mixed up ‘trillions’ and ‘billions’ and ‘millions.’”

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Siegel confirmed that a physical illness, even with a cold, can bring out cognitive issues “even more.”

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“Even so, it’s hard to believe this is all from a cold,” Siegel told Fox News Digital. “Either way, we need someone who is sharp despite a cold.” 

The NYU Langone physician noted that cognitive issues “wax and wane,” so they won’t always present the same way.

Biden looking dazed

President Joe Biden looks over at former President Donald Trump during the first presidential debate of the 2024 election season on June 27, 2024.  (Andrew Caballero-Reynolds/AFP via Getty Images)

While the age of both candidates has been raised as a concern, Siegel countered that what’s important is a president’s physical and mental fitness.

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“It is an issue of fitness, not of age,” he said. “It is an issue of mental acuity, which is especially important if there is a crisis.” 

While Biden is 81 (he turns 82 in November), Trump is 78 years old. 

During an appearance on “Fox & Friends” on Friday morning, Siegel also spoke about the possibility of cold medications impacting Biden’s performance.

“It is an issue of fitness, not of age. It is an issue of mental acuity.”

“None of the medications that he would be taking for a cold, except something that might make him drowsy, would be relevant here,” he said. 

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“And I don’t think they would give him something that would make him drowsy before a debate,” he said.

He added, “We’ve been watching this a long time. This is something progressive.”

Fox News Digital reached out to the Biden campaign and to the White House press office for comment.

President Biden speaks

Earlier this year, concerns emerged about Biden’s age and memory after the release of a special counsel’s report.  (AP Photo/Damian Dovarganes)

Earlier this year, concerns emerged about Biden’s age and memory after the release of a special counsel’s report. The report described the Democrat’s memory as “hazy,” “fuzzy,” “faulty,” “poor” and having “significant limitations,” the Associated Press noted at the time.

The report indicated that Biden could not recall certain milestones in his own life, such as the date his own son Beau died of brain cancer, as Fox News Digital reported at the time. (Beau Biden passed away on May 30, 2015.)

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“My memory is fine,” Biden responded afterward from the White House. 

“A person with growing problems of memory and judgment is frequently the last to acknowledge it.”

The New York Times editorial board and others have called on Biden to step out of the race after his debate performance. 

Vice President Kamala Harris acknowledged that Biden had a “slow start” to the debate, but she defended his performance overall and his record during his time in the White House.

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Said Dr. Siegel in a New York Post opinion piece that ran in the publication on Saturday morning, “This isn’t a question of age. Cognition varies widely with age, and it isn’t fair to say that executive function is automatically impaired at a certain point in life. But it’s a sad medical fact that a person with growing problems of memory and judgment is frequently the last to acknowledge it.”

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Learn About the Real Life Spouses of the 'Yellowstone' Cast

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Your July 2024 Horoscope: Zodiac Sign Monthly Forecast | Woman's World

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