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New brain therapy allows paralyzed patients to walk again: 'I feel my legs'

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New brain therapy allows paralyzed patients to walk again: 'I feel my legs'

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New research suggests that paralyzed patients could regain some degree of movement — perhaps even walk again.

In a study led by EPFL (Swiss Federal Technology Institute of Lausanne) and Lausanne University Hospital in Switzerland, two people with spinal cord injuries received deep brain stimulation (DBS) therapy.

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The therapy was applied to an “unexpected” part of the brain called the lateral hypothalamus, which has previously been associated with functions like eating and arousing from sleep.

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After the stimulation, the patients were able to walk without assistance and even climb stairs, according to a press release from Lausanne University Hospital.

The findings were published in the journal Nature Medicine.

One of the participants in the study was 54-year-old Wolfgang Jäger from Kappel, Austria, who experienced a spinal cord injury in 2006 that left him in a wheelchair. 

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The clinical trial participant, Wolfgang Jäger, gets out of his wheelchair and climbs up and down the steps using the deep brain stimulation of the lateral hypothalamus. (.NeuroRestore / EPFL)

After having electrodes implanted in the targeted area of his brain and receiving deep brain stimulation, he regained some lower-body mobility.

“Last year on vacation, it was no problem to walk a couple of steps down and back to the sea using the stimulation,” Jäger said in the release.

“I can also reach things in my cupboards in the kitchen.”

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Study author Jocelyne Bloch, neurosurgeon and professor at the Lausanne University Hospital, UNIL and EPFL, shared the immediate effects of the therapy.

“Once the electrode was in place and we performed the stimulation, the first patient immediately said, ‘I feel my legs,’” she said in the release. 

The therapy was applied to an “unexpected” part of the brain called the lateral hypothalamus, which has previously been associated with functions like eating and arousing from sleep. (.NeuroRestore / EPFL)

“When we increased the stimulation, she said, ‘I feel the urge to walk!’ This real-time feedback confirmed we had targeted the correct region, even if this region had never been associated with the control of the legs in humans.”

“At this moment, I knew we were witnessing an important discovery of the anatomical organization of brain functions,” added Bloch.

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“When we increased the stimulation, she said, ‘I feel the urge to walk!’”

The participants also reported “long-term improvement” in mobility even when the stimulation wasn’t actively being applied.

“This research highlights the unexpected role of the lateral hypothalamus, a brain region not previously associated with locomotion in humans,” lead researcher Dr. Grégoire Courtine, professor of neuroscience at EPFL and Lausanne University Hospital and co-director of the .NeuroRestore center, told Fox News Digital.

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“Our findings show that this approach not only enhances motor abilities during stimulation, but also induces a reorganization of nerve fibers, leading to lasting improvements even in the absence of stimulation.”

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DBS has traditionally been used to control tremors in people with movement disorders like Parkinson’s disease, the researchers noted.

A visual representation of deep brain stimulation of the lateral hypothalamus is shown. (.NeuroRestore / EPFL)

The concept of applying it to the lateral hypothalamus is unchartered territory.

Looking ahead, the researchers hope to combine DBS with spinal implants to enable further recovery from paralysis.

“Integrating our two approaches — brain and spinal stimulation — will offer a more comprehensive recovery strategy for patients with spinal cord injuries,” added Courtine.

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‘Pushing science forward’

Dr. Ann Murray, director of the Comprehensive Movement Disorder Clinic at WVU Rockefeller Neuroscience Institute in West Virginia, said the study’s results are “surprising and exciting.”

“The targeted location of the brain they were stimulating, the hypothalamus, has not historically been known to be involved in the mechanism of gait,” Murray, who was not involved in the study, told Fox News Digital.  

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“As we continue to better understand the brain networks, it will continue to enable us to modulate areas that aren’t working correctly,” she went on. 

“The brain communicates via electrical signaling, and technologies like deep brain stimulation therapy help us interface with the brain circuitry to improve and/or restore more normal connectivity.”

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“The brain communicates via electrical signaling, and technologies like deep brain stimulation therapy help us interface with the brain circuitry to improve and/or restore more normal connectivity,” a neurologist said. (.NeuroRestore / EPFL)

The potential for advancements in these types of technologies is “truly endless,” Murray said.

“I have the utmost hope that technologies like deep brain stimulation and other neuromodulation therapies will continue to advance the science in restoration of brain health for patients suffering neurologic injury.”

Potential limitations

The researchers acknowledged that there are some limitations of the research.

“This is precision medicine at its finest.”

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“This therapy is only beneficial for patients with incomplete injuries, where functional neural circuits remain but are not fully utilized,” Courtine told Fox News Digital.

“For complete spinal cord injuries, only localized epidural electrical stimulation or a brain-spine interface bridge may assist in restoring functional movements.”

After having electrodes implanted in the targeted area of his brain and receiving deep brain stimulation, a clinical trial participant was able to climb the stairs. (.NeuroRestore / EPFL)

He also pointed out that this study is an “early-stage safety and feasibility trial,” conducted without a control group. 

“For this therapy to become widely accessible, larger pivotal studies will need to be completed and thoroughly evaluated [before approval],” Courtine said.

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“This process may take several years before the therapy becomes available to patients.”

      

Murray also emphasized that caution must be taken with this type of stimulation.

“Anytime we are investigating brain therapies, a tremendous degree of safety and precision has to be applied,” she cautioned.  

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“The brain is the most precise, complicated organ in the body, which requires any treatment or innovation to appreciate not just the intended effects, but the potential unintended effects of interfering with certain networks.”

Every step of the process must be carefully executed by a comprehensive team, Murray said.

“Anytime we are investigating brain therapies, a tremendous degree of safety and precision has to be applied,” a neurologist cautioned.   (iStock)

“This is precision medicine at its finest — any misstep in any one of those stages can result in suboptimal outcomes.”

The goal, she said, is to standardize this process so that more patients have access to this “life-changing therapy.”

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Added Murray, “This should give hope to millions of patients across the world suffering from neurologic conditions, as this is pushing the technology, pushing the science forward, to expand treatment to people that have never had any other options.”

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Diabetes surge among Americans could be driven by ‘healthy’ breakfasts, doctor warns

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Diabetes surge among Americans could be driven by ‘healthy’ breakfasts, doctor warns

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Americans consume foods every day that are marketed as “healthy,” when they could be quietly destroying their health, one doctor warns.

Dr. Mark Hyman, physician and co-founder of Function Health in California, says that much of America’s daily diet is filled with unhealthy ingredients.

“The amount of refined starches and sugars that are everywhere is just staggering to me, given what we know about how harmful they are,” he shared in an interview with Fox News Digital. “I don’t think people really understand.”

Hyman, author of the new book “Food Fix Uncensored,” said he’s “astounded” by what people are eating, especially for breakfast.

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“People just eat sugar for breakfast,” he said. “They have muffins, they have bagels, they have croissants, they have sugar-sweetened coffees and teas.”

Dr. Mark Hyman is the author of the new book “Food Fix Uncensored.” (Function Health; Little, Brown Spark)

In addition to the traditionally sweet options for breakfast, some cereal brands and breakfast staples have adopted new “protein-packed” menu items and products, following health trends that encourage eating more protein.

“Highly processed food is not food.”

“Now, we’re seeing this halo of protein in certain things,” Hyman said, mentioning that many protein smoothies are “full of sugar.”

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The doctor also noted that some popular cereals are now marketed as having protein in them. “My joke is, if it has a health claim on the label, it’s definitely bad for you,” he said.

Instead of starting the day with a “quick fix” or processed food, Hyman suggests choosing whole sources of protein and fat for breakfast, adding that “if there’s a little carbohydrate in there, it’s fine.”

More products marketed as “high protein” have cropped up on supermarket shelves. (iStock)

For his own breakfast, Hyman said he has a protein shake with whey protein, avocado and frozen berries. Eggs and avocados are also a great protein-and-fat combo option, he added.

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“It’s not that complicated — people need to just think about their breakfast not being dessert,” he said. “No wonder we’re in this cycle of obesity and diabetes. One in three teenage kids now has type 2 diabetes or pre-diabetes. That’s just criminal.”

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Instead of counting calories and being in a caloric deficit as a way to lose weight and stay healthy, Hyman instead suggests focusing on how certain foods make you feel and how they impact your health.

“When you look at the way in which different types of calories affect your biology, you can just choose what you’re eating, and then you don’t have to worry about how much,” he told Fox News Digital.

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In addition to the traditionally sweet options for breakfast, some cereal brands and breakfast staples have adopted new “protein-packed” menu items and products. (iStock)

“For example, if you eat a diet that doesn’t cause your insulin to spike — which is low in starch and sugar, higher in protein and fat — you won’t develop those swings in blood sugar, you won’t develop the spikes in insulin, you won’t deposit hungry fat … You will break that cycle.”

People are more likely to “self-regulate when they eat real food” instead of processed foods, which “bypasses the normal mechanisms of satiety, fullness and brain chemistry,” according to Hyman.

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“Ultraprocessed food and junk food or highly processed food is not food,” he said. “It doesn’t support the health and well-being of an organism. It doesn’t do that. It does the opposite.”

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Scientists make startling discovery when examining prostate cancer tissue

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Scientists make startling discovery when examining prostate cancer tissue

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Small fragments of plastic were found in the tumors of most prostate cancer patients, according to a new study from NYU Langone Health. 

In past studies, microplastics have been found in almost every human organ and in bodily fluids, but their impact on human health still isn’t fully understood.

The researchers analyzed tissue samples from 10 patients with prostate cancer who underwent surgery to remove the entire organ. 

Using visuals of both benign samples and tumor samples, as well as specialized equipment, the scientists identified plastic particles in 90% of the tumor samples and 70% of benign tissue samples, according to the study press release.

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In past studies, microplastics were found in almost every single human organ along with bodily fluids, even the placenta. (iStock)

The cancerous tissue contained on average more than double the amount of plastic as healthy prostate tissue samples, the study found. This equates to about 40 micrograms of plastic per gram of tissue compared to 16 micrograms.

Researchers avoided contaminating the samples with other plastics by substituting standard tools with those made of aluminum, cotton and other non-plastic material, the release noted.

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The scientists say this is the first direct evidence linking microplastics to prostate cancer.

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“By uncovering yet another potential health concern posed by plastic, our findings highlight the need for stricter regulatory measures to limit the public’s exposure to these substances, which are everywhere in the environment,” said senior study author Vittorio Albergamo, assistant professor in the department of pediatrics at NYU Grossman School of Medicine, in the release.

Using visuals of both benign samples and tumor samples, as well as specialized equipment, the scientists identified plastic particles in 90% of the tumor samples and 70% of benign tissue samples. (iStock)

The study findings were presented during the American Society of Clinical Oncology’s Genitourinary Cancers Symposium in San Francisco on Feb. 26.

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“What is most striking is not that microplastics were detected, but that they were found embedded within tumor tissue itself,” Dr. David Sidransky, oncologist and medical advisor at SpotitEarly, a startup that offers an at-home breath-based test to detect early-stage cancer, told Fox News Digital.

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“While complete avoidance is unrealistic, people can take practical steps to reduce exposure.”

“We already know microplastics are present in water, air, blood and even placental tissue. Their detection in prostate tumors suggests systemic distribution and long-term bioaccumulation,” added Maryland-based Sidransky, who was not involved in the study.

Study limitations

Albergamo cautioned that a larger sample is needed to confirm the findings. Additionally, Sidransky noted that the presence of microplastics alone does not prove they cause cancer.

“Tumors can act as ‘biologic sinks,’ meaning they may accumulate circulating particles simply because of altered vasculature and permeability,” he said.

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A key unanswered question, according to the doctor, is whether microplastics are biologically active in ways that “promote DNA damage, immune modulation or chronic inflammation within the prostate.”

About one in eight men in the U.S. will be diagnosed with prostate cancer at some point in their lifetime, according to the Centers for Disease Control and Prevention.

The most actionable step men can take is appropriate screening and early detection, according to doctors. (iStock)

For those concerned about microplastics, Sidransky offered some insights.

“I believe the appropriate response is curiosity, not panic, and a commitment to understand more,” he said.

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“While complete avoidance is unrealistic, people can take practical steps to reduce exposure, such as minimizing heating food in plastic containers, reducing bottled water consumption when possible, and favoring glass or stainless steel alternatives.”

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The most actionable step men can take, however, is getting appropriate screenings to help ensure early detection, according to the doctor. Screening discussions should be individualized based on age, family history and other risk factors.

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How a Vegan Diet Can Help You Lose Weight 8X Faster

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How a Vegan Diet Can Help You Lose Weight 8X Faster


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