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New baldness treatment shows dramatic hair-regrowth gains in major trial

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New baldness treatment shows dramatic hair-regrowth gains in major trial

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A new experimental scalp treatment called clascoterone has shown strong results in helping reduce male-pattern hair loss (also known as androgenetic alopecia, or AGA).

Experts call the results promising, claiming that this could be the first new approach to reversing hair loss in decades.

Conducted by Cosmo Pharmaceuticals in Ireland, the two large, late-stage trials — named Scalp 1 and Scalp 2 — enrolled a combined total of 1,465 men across the U.S. and Europe, according to a press release.

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Participants either used the topical solution or a placebo under randomized conditions. The main measure of success was “target-area hair count” (TAHC), an objective count of hairs in a defined scalp area.

The topical solution works by blocking the action of dihydrotestosterone (DHT) — a hormone that causes genetically sensitive hair follicles to shrink — directly at the follicle receptor rather than affecting hormones system-wide, according to Cosmo Pharmaceuticals.

Cosmo Pharmaceuticals reported strong phase 3 results for clascoterone in treating male-pattern hair loss. (iStock)

This localized approach attempts to address the biological root cause of AGA without exposing the body to additional hormones.

In the Scalp 1 group, clascoterone showed a 539% relative improvement in hair count compared with the placebo group. The participants in Scalp 2 showed a 168% relative improvement, the release stated.

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“We really don’t have a very effective cream or lotion for hair loss, so this may be valuable for widespread clinical use.”

One study showed “statistical significance” in patient-reported outcomes, while the other showed a “favorable trend,” the release noted. When data from both trials were combined, the improvement was described as “statistically significant” and aligned with the counted-hair results.

“For decades, patients have had to choose between available treatment options with limited efficacy or safety issues due to systemic hormonal exposure, often resulting in patients not treating their hair loss at all,” Maria Hordinsky, M.D., from the University of Minnesota’s Department of Dermatology, said in a statement sent to Fox News Digital.

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“These findings show the potential for clascoterone 5% topical solution to change that equation by delivering real, measurable regrowth with negligible systemic exposure,” added Hordinsky.

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Patient-reported outcomes — how study participants perceived their hair growth — were also positive.

If approved, the treatment would be the first new approach in nearly three decades. (iStock)

“I think this is promising,” Marc Siegel, M.D., senior medical analyst for Fox News, told Fox News Digital. “We really don’t have a very effective cream or lotion for hair loss,” added the doctor, who was not involved in the study.

Minoxidil lotion, one of the most widely used, FDA-approved topical treatments, generally has limited effectiveness, Siegel noted. “So, this may well be valuable for widespread clinical use.”

Potential limitations and risks

Siegel, who was not involved in the trials, referenced the study’s claim that the only side effect was “local irritation,” and said the medication appeared to be generally safe.

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Safety and tolerance of the drug appeared to be comparable to the placebo group. Side effects were minimal and occurred at similar rates in both the active and placebo groups, with most found to be unrelated to the drug, according to the researchers.

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The researchers noted that the improvement in the study participants was in comparison to the placebo group in the study — it doesn’t guarantee that men will grow five times more hair than with other treatments.

Safety outcomes for the medication were similar to placebo, with no unexpected adverse effects, the researchers said. (iStock)

Each individual’s results depend on how much hair they had at the start, and without the full data, it’s unclear how much visible growth most men will achieve.

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“You do need to watch out for allergic reactions, and in rare cases, adrenal insufficiency, since the cream is an anti-androgen,” Siegel cautioned. This means because this treatment blocks androgens (male hormones), it could slightly affect the adrenal glands, which help the body manage stress hormones.

Full data, including long-term results and detailed absolute hair-count changes, are still pending regulatory review. (iStock)

Also, these are top-line results, as more detailed data — including long-term durability, variation between different degrees of hair loss and extended safety over 12 months — have yet to be released.

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If approved, this would be the first scalp treatment that works by blocking DHT right at the hair follicle — the first of its kind made specifically for male hair loss, the company says.

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Cosmo plans to complete a full 12-month safety follow-up by spring 2026 before submitting the medication for regulatory approval in the U.S. and Europe.

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Loneliness may be silently eroding your memory, new research reveals

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Loneliness may be silently eroding your memory, new research reveals

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Feeling lonely may take a toll on older adults’ memory — but it may not speed up cognitive decline, according to a new study.

Researchers from Colombia, Spain and Sweden analyzed data from more than 10,000 adults ages 65 to 94 across 12 European countries and found those who reported higher levels of loneliness did worse on memory tests at the start of the study, according to research published this month in the journal Aging & Mental Health.

Over a seven-year period, however, memory decline occurred at a similar rate regardless of how lonely participants felt.

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“The finding that loneliness significantly impacted memory, but not the speed of decline in memory over time was a surprising outcome,” lead author Dr. Luis Carlos Venegas-Sanabria of the School of Medicine and Health Sciences at the Universidad del Rosario said in a statement.

Loneliness may be linked to memory performance in older adults, a new study suggests. (iStock)

“It suggests that loneliness may play a more prominent role in the initial state of memory than in its progressive decline,” Venegas-Sanabria said, adding that the findings highlight the importance of addressing loneliness as a factor in cognitive performance.

The findings add to debate about whether loneliness contributes to dementia risk. While loneliness and social isolation are often considered risk factors for cognitive decline, research results have been mixed.

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The study looked at data from the long-running Survey of Health, Ageing and Retirement in Europe (SHARE), which tracked 10,217 older adults between 2012 and 2019. Participants were asked to recall words immediately and after a delay to measure memory performance.

Social isolation and loneliness could play a surprising role in cognitive health among seniors. (iStock)

Loneliness was assessed using three questions about how often participants felt isolated, left out or lacking companionship.

About 8% of participants reported high levels of loneliness at the outset. That group tended to be older, more likely to be female and more likely to have conditions such as depression.

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Researchers found that those with higher loneliness had lower scores on both immediate and delayed memory tests at baseline. Still, all groups — regardless of loneliness level — experienced similar declines in memory over time.

The results suggest loneliness may not directly accelerate the progression of memory loss, though it remains linked to poorer cognitive performance overall.

Researchers look at a brain scan at the National Institutes of Health in Bethesda, Maryland. (Saul Loeb/AFP/Getty Images)

Experts warn, however, that the findings should not be interpreted to mean loneliness is harmless.

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“The finding that lonely older adults start with worse memory but don’t decline faster is actually the most interesting part of the paper, and I think it’s easy to misread,” said Jordan Weiss, Ph.D., a scientific advisor and aging expert at Assisted Living Magazine and a professor at NYU Grossman School of Medicine.

“It likely means loneliness does its damage earlier in life, well before people show up in a study like this at 65-plus,” Weiss told Fox News Digital.

By older age, long-term social patterns may already be established, making it harder to detect when the effects of loneliness first took hold, an aging expert says. (iStock)

He suggested that by older age, long-term social patterns may already be established, making it harder to detect when the effects of loneliness first took hold.

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“By the time you’re measuring someone in their late 60s, decades of social connection patterns are already baked in,” he said.

Weiss, who was not involved in the research, added that loneliness may coincide with other health conditions, and noted that participants who felt more isolated also had higher rates of depression, high-blood pressure and diabetes. The link, he said, may reflect a cluster of health risks rather than a direct cause.

“While they can go hand-in-hand, it’s not clear that loneliness contributes to dementia,” a psychotherapist says. (iStock)

Amy Morin, a Florida-based psychotherapist and author, said the findings reflect a broader pattern in research on loneliness and brain health, and that the relationship may be more complex than it appears.

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“The evidence shows there’s a link between loneliness and cognitive decline but there’s no direct evidence of a cause and effect relationship,” she said. “So while they can go hand-in-hand, it’s not clear that loneliness contributes to dementia.”

Morin added that loneliness, which can fluctuate, may not be the root of the problem, but rather a symptom of other underlying mental or physical health issues.

Researchers suggested screening for loneliness be incorporated into routine cognitive assessments as one way to support healthy aging. (iStock)

She said staying socially and mentally engaged is crucial for overall brain health.

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“It’s important to be proactive about social activities,” Morin said. “Joining a book club, having coffee with a friend, or attending faith-based services can be a powerful way to maintain connections in older age.”

The researchers also suggested screening for loneliness be incorporated into routine cognitive assessments as one way to support healthy aging.

Fox News Digital reached out to the researchers for comment.

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Eat More To Lose Weight? She Dropped 55 Pounds by Having 5 Meals a Day

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Eat More To Lose Weight? She Dropped 55 Pounds by Having 5 Meals a Day


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Eat More To Lose Weight? How Small Meals Boost Fat Burn




















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Intermittent fasting’s real benefit may come after you start eating again

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Intermittent fasting’s real benefit may come after you start eating again

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Research continues to uncover new details on how fasting may help extend life.

A new study published in the journal Nature Communications investigated how intermittent fasting can boost longevity in small worms often used in aging research.

Researchers from the University of Texas Southwestern Medical Center in Dallas compared worms that were fed normally to those that underwent a 24-hour fast in early adulthood and were then fed again, according to a press release.

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The scientists measured a variety of factors, including stored fat, gene activity related to fat metabolism and lifespan.

The results showed that the life-boosting benefit did not depend on the fasting itself but on the body’s behavior after eating again.

Experts say sustainability is key when choosing a long-term weight-loss strategy. (iStock)

Study lead Peter Douglas, associate professor of molecular biology and a member of the Hamon Center for Regenerative Science and Medicine at UT Southwestern, suggested that these discoveries “shift the focus toward a neglected side of the metabolic coin – the re-feeding phase.”

“Our data suggest that the health-promoting effects of intermittent fasting are not merely a product of the fast itself, but are dependent on how the metabolic machinery recalibrates during the subsequent transition back to a fed state,” he said.

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“Our findings bridge a gap between lipid metabolism and aging research,” he added. “By targeting aging, the single greatest risk factor for human disease, we move beyond treating isolated conditions toward a preventive model of medicine that enhances quality of life for all individuals.”

Lauri Wright, director of nutrition programs at the University of South Florida’s College of Public Health, called this a “high-quality” study that adds an “important nuance to how we think about fasting and longevity.”

Intermittent fasting typically involves limiting meals to an eight-hour daily window or fasting every other day. (iStock)

The benefits of the refeeding phase after fasting were “especially interesting,” Wright, who was not involved in the study, told Fox News Digital.

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“The researchers showed that longevity was linked to the body’s ability to turn off fat breakdown after fasting, allowing cells to restore energy balance,” she reiterated.

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“From a scientific standpoint, that’s a meaningful shift because it suggests fasting is not just about burning fat, but about metabolic flexibility.”

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Fasting may support longevity through triggering metabolic switching, enhancing cellular repair and stress resistance and improving markers like insulin sensitivity, research shows.

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Limitations and cautions

Although this study provides “important insight” on the power of refeeding, Wright noted that the findings should be approached with caution, as the study was done on worms and cannot always be translated to humans.

“Additionally, it explains how a process might work in a controlled lab condition rather than real-world eating behaviors,” she added as a limitation. “Finally, the study is short-term and doesn’t give us the long-term translation on lifespan outcomes.”

The review found intermittent fasting was barely more effective than doing nothing, according to the study authors. (iStock)

Wright cautioned that fasting is “not a magic solution for longevity, and how you eat overall matters more than when you eat.”

“I advise, first and foremost, to focus on diet quality, including a variety of fruits and vegetables, healthy fats and minimally processed foods,” she said.

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For those who are considering fasting, it’s better to stick with a moderate plan — like a 12- to 14-hour overnight fast — rather than going to extremes, Wright said. After fasting, she recommends focusing on well-balanced meals.

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Several groups of people should be cautioned against fasting, according to Wright, including those with diabetes who are on insulin or hypoglycemic medications, those who are pregnant or breastfeeding, anyone with a history of eating disorders and older adults at risk of malnutrition.

Anyone considering intermittent fasting should consult with a doctor before starting.

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