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New baldness treatment shows dramatic hair-regrowth gains in major trial

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New baldness treatment shows dramatic hair-regrowth gains in major trial

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A new experimental scalp treatment called clascoterone has shown strong results in helping reduce male-pattern hair loss (also known as androgenetic alopecia, or AGA).

Experts call the results promising, claiming that this could be the first new approach to reversing hair loss in decades.

Conducted by Cosmo Pharmaceuticals in Ireland, the two large, late-stage trials — named Scalp 1 and Scalp 2 — enrolled a combined total of 1,465 men across the U.S. and Europe, according to a press release.

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Participants either used the topical solution or a placebo under randomized conditions. The main measure of success was “target-area hair count” (TAHC), an objective count of hairs in a defined scalp area.

The topical solution works by blocking the action of dihydrotestosterone (DHT) — a hormone that causes genetically sensitive hair follicles to shrink — directly at the follicle receptor rather than affecting hormones system-wide, according to Cosmo Pharmaceuticals.

Cosmo Pharmaceuticals reported strong phase 3 results for clascoterone in treating male-pattern hair loss. (iStock)

This localized approach attempts to address the biological root cause of AGA without exposing the body to additional hormones.

In the Scalp 1 group, clascoterone showed a 539% relative improvement in hair count compared with the placebo group. The participants in Scalp 2 showed a 168% relative improvement, the release stated.

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“We really don’t have a very effective cream or lotion for hair loss, so this may be valuable for widespread clinical use.”

One study showed “statistical significance” in patient-reported outcomes, while the other showed a “favorable trend,” the release noted. When data from both trials were combined, the improvement was described as “statistically significant” and aligned with the counted-hair results.

“For decades, patients have had to choose between available treatment options with limited efficacy or safety issues due to systemic hormonal exposure, often resulting in patients not treating their hair loss at all,” Maria Hordinsky, M.D., from the University of Minnesota’s Department of Dermatology, said in a statement sent to Fox News Digital.

HAIR-LOSS DRUG TIED TO SUICIDES, DEPRESSION AND ANXIETY IN GLOBAL STUDY

“These findings show the potential for clascoterone 5% topical solution to change that equation by delivering real, measurable regrowth with negligible systemic exposure,” added Hordinsky.

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Patient-reported outcomes — how study participants perceived their hair growth — were also positive.

If approved, the treatment would be the first new approach in nearly three decades. (iStock)

“I think this is promising,” Marc Siegel, M.D., senior medical analyst for Fox News, told Fox News Digital. “We really don’t have a very effective cream or lotion for hair loss,” added the doctor, who was not involved in the study.

Minoxidil lotion, one of the most widely used, FDA-approved topical treatments, generally has limited effectiveness, Siegel noted. “So, this may well be valuable for widespread clinical use.”

Potential limitations and risks

Siegel, who was not involved in the trials, referenced the study’s claim that the only side effect was “local irritation,” and said the medication appeared to be generally safe.

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Safety and tolerance of the drug appeared to be comparable to the placebo group. Side effects were minimal and occurred at similar rates in both the active and placebo groups, with most found to be unrelated to the drug, according to the researchers.

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The researchers noted that the improvement in the study participants was in comparison to the placebo group in the study — it doesn’t guarantee that men will grow five times more hair than with other treatments.

Safety outcomes for the medication were similar to placebo, with no unexpected adverse effects, the researchers said. (iStock)

Each individual’s results depend on how much hair they had at the start, and without the full data, it’s unclear how much visible growth most men will achieve.

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“You do need to watch out for allergic reactions, and in rare cases, adrenal insufficiency, since the cream is an anti-androgen,” Siegel cautioned. This means because this treatment blocks androgens (male hormones), it could slightly affect the adrenal glands, which help the body manage stress hormones.

Full data, including long-term results and detailed absolute hair-count changes, are still pending regulatory review. (iStock)

Also, these are top-line results, as more detailed data — including long-term durability, variation between different degrees of hair loss and extended safety over 12 months — have yet to be released.

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If approved, this would be the first scalp treatment that works by blocking DHT right at the hair follicle — the first of its kind made specifically for male hair loss, the company says.

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Cosmo plans to complete a full 12-month safety follow-up by spring 2026 before submitting the medication for regulatory approval in the U.S. and Europe.

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Denise Austin Is a Fan of Walking To Lose Belly Fat—It Can Trim Your Waist 4”

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Denise Austin Is a Fan of Walking To Lose Belly Fat—It Can Trim Your Waist 4”


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Doctors reveal what ‘reasonable’ drinking looks like — and who should avoid alcohol

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Doctors reveal what ‘reasonable’ drinking looks like — and who should avoid alcohol

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With 40% of adults resolving to drink less alcohol in 2026, according to a recent survey, some may be struggling to find a healthy balance.

Health experts agree that each person’s relationship with alcohol is unique, based on history, tolerance and lifestyle.

Dr. Ezekiel Emanuel, a Pennsylvania-based oncologist and author of the new book “Eat Your Ice Cream: Six Simple Rules for a Long and Healthy Life,” has noted that indulging in certain activities – like eating ice cream or drinking alcohol – may not be healthy to do every day, but can provide some benefits in moderation.

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“There has been a lot of research on alcohol,” he said in a recent interview with “CBS Sunday Morning.” “The safest level is probably zero. There are some studies … where it’s half a cup a day, three cups a week.”

“On the other hand, 60% [to] 65% of the public drinks,” he went on. “You’re not going from 65% to zero, so you have to give people reasonable advice.”

A doctor shared “reasonable” drinking advice for striking a balanced relationship with alcohol. (iStock)

Emanuel advised against binge-drinking or drinking alone, both of which are “really bad for you.”

“[But] if you’re using alcohol as a lubricant for social interaction, which many people do, that’s probably good,” he said. “You’re getting some benefit from the social interaction.”

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HIGHER STROKE RISK LINKED TO CONSUMING CERTAIN AMOUNT OF ALCOHOL, STUDY FINDS

When social drinking becomes risky

While drinking’s stress-relieving factors may be helpful for some, indulging in alcoholic drinks can be risky for those with a pre-disposition to addiction, experts caution.

In a recent episode of “The Huberman Lab” podcast, Dr. Andrew Huberman and guest Dr. Keith Humphreys, professor of psychiatry and behavioral sciences at Stanford School of Medicine, discussed the fine line between indulging for pleasure and potentially fostering an issue.

Experiences with alcohol can be different for every individual, experts say. (iStock)

According to Huberman, who is also a Stanford University neuroscientist, up to 10% of people experience alcohol as a “dopaminergic,” making them feel “spectacularly good.”

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Others may drink and experience a cue to stop, like dizziness, nausea, “blacking out,” severe hangovers or other negative effects.

“The safest level is probably zero.”

“Some people really can drink five or six drinks, and then the next day they’re at work hammering away,” he said. “The conversation becomes very difficult to have, because it sounds like it’s highly individual how people will react.”

DOCTOR REVEALS WHAT 30 DAYS WITHOUT ALCOHOL DOES TO THE BRAIN AND BODY AMID DRY JANUARY

High-risk groups

One of the greatest risk factors for becoming an alcoholic is having your first drink before the age of 14, according to Huberman.

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“I find that some people will have their first drink, and it’s like a magic elixir for their physiology,” he said. “And there are very few things that can get somebody like that to stop drinking, except the risk of losing everything.”

While drinking’s stress-relieving factors may be helpful for some, indulging in alcoholic drinks can be risky for those with a pre-disposition to addiction, experts caution. (iStock)

Humphreys said the biggest indicator of personal risk is whether alcoholism runs in someone’s family — particularly if their parents were alcoholics.

“The father-to-son link is the strongest one you see in genetics,” he said. “Men drink more than women do … whether they’ve got an alcohol problem or not.”

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Drinking alcohol has been shown to be particularly harmful for women, as the risk of developing hormone-related cancers substantially increases.

Risk vs. benefit

For those who are not predisposed to addiction, Huberman noted that some studies suggest that certain types of consumption are OK in moderation, such as drinking red wine or having a maximum of two drinks per week.

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“I would love to believe [red wine] is healthy,” Humphreys responded. “It’s not … Why would there be a benefit to red wine that wasn’t in other alcoholic beverages?”

“There might be some cardiac benefits, but we don’t get to live our lives as single organs. We have a whole body,” he went on. “If that’s true, it’s smaller than the cancer risk. So, your net is you’re not going to get any mortality reduction from drinking alcohol.”

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“I would love to believe [red wine] is healthy,” one expert said. “It’s not … Why would there be a benefit to red wine that wasn’t in other alcoholic beverages?” (iStock)

Drinking two drinks per week — such as a 12-ounce beer, 4-ounce glass of wine or a 1-ounce shot of liquor — poses only a “very small risk” of health complications, but it’s not something Humphreys would recommend, as it’s “just not good for you,” he said.

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Despite the risks, however, the experts acknowledged the stress-relieving and social benefits of having a drink.

“Getting together with friends is enjoyable, enriching,” Humphreys said. “Good food and good wine taste good, and I value those things. And there are many other decisions we make like that where we endure some risk because we care about something else.”

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“It’s dangerous for someone my age to hike up a mountainside probably, but if the view is spectacular, I can say, ‘Oh, I’m going to accept that risk.’”

“Good food and good wine taste good, and I value those things.”

What’s become most dangerous about social drinking, according to Humphreys, is that some people feel they need to explain themselves when they stop.

Huberman echoed, “If you don’t drink at parties, or you refuse an offer of alcohol, people think there’s something wrong with you.”

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Given recent data on the risks of alcohol consumption, Humphreys said it should be simple to say no, much like opting not to smoke a cigarette.

“Health is a reason people still accept, I think, as a legitimate [reason] for changing behavior,” he added.

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Early peanut exposure in babies tied to sharp drop in food allergy diagnoses

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Early peanut exposure in babies tied to sharp drop in food allergy diagnoses

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Historically, parents were advised to avoid feeding peanuts to babies for the first few years of life, but emerging research has confirmed that introducing them sooner — as early as infancy — could help stave off food allergies.

A 2025 study led by the Children’s Hospital of Philadelphia analyzed medical records from dozens of pediatric practices across the U.S., finding that early introduction of peanuts resulted in a 27% decrease in peanut allergy diagnoses among children and a 38% decrease in overall food allergies.

The latest research also found that eggs had surpassed peanuts as the most common food allergen in the children studied. Beyond peanuts, other common food allergens include milk, egg and wheat.

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The new research — published in Pediatrics, the journal of the American Academy of Pediatrics, in October 2025 — focused on a two-year period after new guidance was issued by the National Institute of Allergy and Infectious Diseases, which first advised parents to introduce peanuts earlier. 

Emerging research has confirmed that introducing peanuts as early as infancy could help stave off food allergies. (iStock)

That updated guidance was based on a landmark 2015 study — the Learning Early About Peanut Allergy (LEAP) trial — which found that for infants who had severe eczema or an egg allergy, exposing them to peanuts when they were between 4 and 11 months old could reduce peanut allergy risk by 81%.

EATING BLUEBERRIES EARLIER IN LIFE COULD EASE ALLERGIES, STRENGTHEN IMMUNITY, NEW STUDY FINDS

The guidelines were updated again in 2021, encouraging the introduction of peanut, egg and other major food allergens as early as 4 to 6 months for all children — including those without a history of prior reaction, according to health experts.

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“Everyone has been wondering whether these landmark public health interventions have had an impact on reducing rates of IgE-mediated food allergies in the United States,” said first author Stanislaw Gabryszewski, M.D., Ph.D., an attending physician in the Division of Allergy and Immunology at the Children’s Hospital of Philadelphia, in a statement.

A 2025 study led by the Children’s Hospital of Philadelphia found that early introduction of peanuts resulted in a 27% decrease in peanut allergy diagnoses among children and a 38% decrease in overall food allergies. (iStock)

“We now have data that suggest the effect of this landmark public health intervention is occurring.”

The latest findings “are supportive of efforts to increase education and advocacy related to early food introduction practices,” the study authors wrote.

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“If confirmed, these findings would represent a meaningful public health advance — affirming that clinical research, when coupled with clear guidelines and committed dissemination, can indeed shift the trajectory of childhood food allergy.”

Study limitations

The study only included data through early 2019 and did not consider the guidance released in 2021, which recommended early introduction of multiple allergens regardless of risk, the researchers acknowledged.

It also relied on allergy diagnoses from electronic health records, which may miss some cases. Also, the researchers did not capture individual feeding patterns.

Parents are encouraged to discuss any concerns with their pediatrician before introducing potential food allergens. (iStock)

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Because the study was observational, it cannot prove cause and effect, but only association, the researchers noted. Other factors may influence the outcome.

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In some children, peanut allergy can trigger severe, life-threatening reactions, including difficulty breathing, swelling of the throat and a dangerous drop in blood pressure, according to Mayo Clinic. These reactions require immediate treatment with epinephrine, a life-saving allergy medication.

Not all parents may be comfortable with these revised guidelines, health experts say.

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“Not everyone has followed those guidelines, but this is further evidence that this early introduction is effective at preventing food allergies,” Dr. Susan Schuval, chief of the Division of Pediatric Allergy and Immunology at Stony Brook Children’s Hospital in New York, previously told Fox News Digital.

Parents are encouraged to discuss any concerns with their pediatrician before introducing potential food allergens.

Amy McGorry contributed reporting.

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