Health
New Alzheimer’s blood test predicts who is likely to develop dementia in 5 to 10 years
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A simple blood test detecting a specific protein linked to Alzheimer’s disease may help predict future cognitive decline in older adults up to a decade before any noticeable symptoms appear, according to a new study.
The Harvard-led research, presented at the Alzheimer’s Association International Conference in London and simultaneously published in The Journal of the American Medical Association, could transform how doctors assess dementia risk and help patients prepare for the disease.
By measuring a blood biomarker called p-tau217, which tracks the buildup of damaging proteins in the brain, clinicians may soon be able to assess Alzheimer’s risk much like they use cholesterol tests to estimate heart disease risk, researchers say.
ALZHEIMER’S BLOOD TESTS MAY PREDICT SYMPTOMS YEARS IN ADVANCE, BUT EXPERTS URGE CAUTION
In one of the largest analyses of its kind, researchers tracked nearly 2,700 cognitively healthy adults averaging 70 years of age for up to a decade.
A simple blood test measuring the p-tau217 protein could predict future cognitive decline in symptom-free older adults up to 10 years before any noticeable memory problems begin. (iStock)
They found that symptom-free individuals with high levels of p-tau217 had an estimated 78% chance of developing cognitive impairment within 10 years and a roughly one in three chance within five years. Even those with moderately elevated levels faced a 45% risk over a decade.
The p-tau217 protein is a modified form of tau, which forms tangles in the brain and is associated with memory loss. The blood test provided information beyond what standard brain scans and genetic testing can offer, according to the researchers.
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Rachel Buckley, the study’s lead author and an associate professor of neurology at Harvard Medical School, said the findings provide some of the clearest evidence yet that dementia risk can be detected years before memory problems begin.
Even individuals with only moderately elevated levels of the biomarker face a significant 45% risk of cognitive decline over 10 years. (iStock)
“Once verified, these blood tests could be used to recruit patients for clinical trials of treatments to prevent cognitive decline and dementia,” she said in a press release.
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“In the future, when treatments are approved for use early in the disease process, these tests could help guide monitoring, treatment decisions and counseling for patients and families.”
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The researchers cautioned that p-tau217 cannot fully predict an individual’s future on its own. Other factors like age, genetics, kidney function and racial background can also influence biomarker levels and dementia risk.
Researchers found identical, consistent risk patterns across nearly 2,700 participants from six international research groups. (iStock)
The team emphasized the need for longer studies in more diverse groups to perfect these risk estimates.
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Maria Carrillo, chief science officer at the Alzheimer’s Association in Chicago, said targeting the silent stage of the disease before memory issues arise is where future treatments could have the greatest impact.
“Identifying people at risk earlier could fundamentally change how we diagnose, treat and potentially prevent dementia,” she told Fox News Digital, noting that earlier detection could allow people to begin interventions before symptoms develop.
Health
The daytime habit that could transform your sleep, according to new study
‘Gutfeld!’: Make Daylight saving time permanent
Sean Davis, CEO and co-founder of The Federalist, alongside comedian Joe Machi, passionately advocate for making daylight saving time permanent. Davis humorously claims ‘mornings are stupid,’ emphasizing the desire for afternoon sunlight when more people are awake. Machi highlights the safety and enjoyment of children being able to see in the evening when picked up from after-school activities.
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Spending more time in bright daylight could help people fall asleep earlier and get deeper sleep at night, according to new research.
A study led by researchers at the University of Manchester found that adults with brighter and more consistent daytime light exposure tended to fall asleep earlier, wake up earlier and experience more deep sleep during the first part of the night.
The findings, published in the journal NPJ Biological Timing and Sleep, were based on more than 500 days of data collected from 89 adults who wore light sensors and sleep trackers while keeping daily sleep diaries.
DOCTORS SAY 8 FORGOTTEN HABITS COULD HELP FIGHT STRESS, OBESITY AND CHRONIC DISEASE
Getting more bright daylight during the day may help people fall asleep earlier and experience deeper sleep at night, new research suggests. (iStock)
Participants who spent more time in brighter daylight generally fell asleep and woke up earlier than those with less light exposure. Those with more consistent daytime light exposure also experienced healthier sleep timing and more deep sleep early in the night, according to the study.
Jennifer Martin, Ph.D., a clinical psychologist and professor at Florida International University’s Herbert Wertheim College of Medicine, said the findings align with what sleep experts already know about how light affects the body’s internal clock.
“Light impacts human sleep through a specific pathway, starting with the eye,” Martin, who was not involved in the study, told Fox News Digital.
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“When light hits specific cells in the retina, it communicates to the brain that it’s daytime, meaning we should be alert and active.”
Morning light is especially beneficial because it helps keep the body’s sleep-wake cycle consistent, Martin said. She recommends spending time outdoors early in the day when possible.
Light helps signal the body that it’s time to be awake, experts say. (iStock)
“Exposure to sunlight early in the day is really good for healthy sleep,” she said. “Regular morning light helps people feel sleepy around the same time each evening and build a strong sleep routine.”
Limiting bright light in the evening can also help improve sleep, Martin said.
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She recommends avoiding bright light during the last couple of hours before bedtime and maintaining a consistent wake-up time each morning.
“Varying your wake time by more than about one hour can lead to feelings of ‘jet lag’ and contribute to trouble with regularly sleeping well,” Martin said.
Avoiding bright light during the last couple of hours before bedtime and maintaining a consistent wake-up time each morning can also support healthy sleep. (iStock)
She added that adults should aim for at least seven hours of sleep each night and seek help from a sleep specialist if sleep problems become chronic.
While the findings suggest brighter daytime light may support healthier sleep, the researchers said the study has several limitations.
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They noted that the research found an association between daytime light exposure and sleep patterns but did not prove that one directly caused the other.
The researchers also measured light exposure using wrist-worn devices rather than at the eyes, where light directly influences the body’s internal clock, and did not account for factors such as physical activity or meal timing that could affect sleep.
Fox News Digital reached out to the study researchers for comment.
Health
Leading oncologist reveals 6 habits that could promote longevity and reduce your risk of chronic illness
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The health and wellness information put out on television, podcasts, social media, websites and elsewhere can be overwhelming, but a leading oncologist and University of Pennsylvania bioethicist argues healthy aging can be simplified into six evidence-based rules.
“Don’t be a schmuck” is the first principle offered by Dr. Ezekiel Emanuel in his book, “Eat Your Ice Cream: Six Simple Rules for a Long and Healthy Life.”
“Don’t be stupid,” Emanuel said recently on the ZOE Science & Nutrition podcast. “This is something my father used to say to his three sons very commonly when we were doing something dumb.”
Emanuel’s brothers are former Chicago Mayor Rahm Emanuel and powerful talent agent Ari Emanuel.
Emanuel argued that obviously dangerous activities, such as BASE jumping, climbing Mount Everest and smoking and vaping are examples of being a schmuck because they carry a high risk of death.
His other principles for living longer and reducing disease risk include prioritizing an active social life, staying mentally active with new hobbies and opportunities to learn, limiting processed and sugary foods and drinks without being overly restrictive, engaging in moderate exercise and getting proper sleep.
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“Our entire brain is constructed around social interactions, and it does way more for us,” Emanuel said. “We know that if you’re lonely, socially isolated, you dramatically increase your risks of mortality.
“More than 3 million people worldwide have been enrolled in studies about social interaction and longevity,” he added. “And the socially isolated, people who have zero or one friends, don’t see friends a lot. Those people are much more likely to die in the next few years.”
A leading health expert argues that loneliness poses health risks comparable to smoking cigarettes. (iStock)
According to Emanuel, being socially isolated or lonely “is the equivalent of smoking 15 cigarettes a day.”
Both close relationships and casual social interactions contribute to well-being, he said.
Emanuel explained why he thinks much of society’s obsession with wellness is toxic and what he labels as “the wellness industrial complex” gets wrong.
Dr. Ezekiel Emanuel said the wellness industrial complex’s obsession with wellness is toxic. (iStock)
“You should not be obsessed about wellness,” Emanuel said on the podcast. “You should be obsessed about living a meaningful life. That’s really what’s important, and wellness is only a means to an end.”
Much of the wellness industry focuses on self-denial, which is misguided, said Emanuel.
“Biology for humans is about homeostasis, the balance between one extreme and another,” he said.
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Society’s current obsession with wellness is nothing new, he added.
“Wellness is a response to a topsy-turvy world, a lot of uncertainty about what the future’s bringing, people feeling like their life’s out of control,” he said.
“And, so, wellness is a response. This is something I can control — what I eat, the vaccines I get, the exercise — and I think that’s what we have today. This is a lot about self-control transmuted into wellness as the outlet.”
Dr. Ezekiel Emanuel said he is a teetotaler himself but says he serves alcohol at his dinner parties because he believes it acts as a social lubricant. (iStock)
The body thrives when it doesn’t take dieting or exercising to extremes, Emanuel said. He is a teetotaler himself, but his wife enjoys cocktails, and when they have a dinner party, they serve alcohol.
Don’t drink alone or use alcohol to drown your sorrows or avoid dealing with them, Emanuel advised.
The ZOE podcast asked Emanuel to advise listeners who aren’t following any of his six rules what to try first.
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“Dinner parties,” he said. “You cook, and you both have good, healthy food because you’ve cooked it. Ynd you’ve challenged your mind ‘cause you’re adding a new recipe, and you’re figuring out how to do it right.
Hosting a dinner party is a healthy activity people should engage in, a health expert says. (iStock)
“You have people over, so you’ve got social connections,” he continued. “You’re challenging your mind with a good conversation. And when it’s all over, you go out for a walk so you get some physical activity.
“This is like you’ve done almost everything in wellness. All of those elements are key to wellness, and it’s the kind of thing you can do, you know, once a weekend or … And you’ll be happier.”
Health
9 Ways To Reverse Stress-Related Weight Gain Fast—One Woman Shed 100 Lbs!
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