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Memory loss isn’t always Alzheimer’s: Experts warn of common but little-known dementia

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Memory loss isn’t always Alzheimer’s: Experts warn of common but little-known dementia

As Alzheimer’s disease is the most common form of dementia — affecting an estimated 6.7 million Americans — it’s not surprising that people who experience memory loss may suspect AD.

In fact, there is another common cognitive disorder with very similar symptoms, called limbic-predominant age-related TDP-43 encephalopathy — or LATE for short — that is often misdiagnosed as Alzheimer’s.

A recent report published in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association highlights the need to develop “objective criteria” for diagnosing and staging all types of dementia, including LATE.

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How is LATE different from Alzheimer’s?

LATE is a prevalent condition in late life and can contribute to memory loss and cognitive decline, according to report co-author Rebecca M. Edelmayer, Ph.D., Alzheimer’s Association vice president of scientific engagement in Chicago.

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“LATE is defined by changes in the TDP-43 protein in brain tissue and frequently co-exists with Alzheimer’s disease changes, such as buildup of beta amyloid plaques and tau tangles.” (iStock)

“LATE is defined by changes in the TDP-43 protein in brain tissue and frequently co-exists with Alzheimer’s disease changes, such as buildup of beta amyloid plaques and tau tangles,” she told Fox News Digital.

The newly proposed criteria aim to help clinicians better differentiate LATE from Alzheimer’s, ultimately leading to more precise diagnoses and improved treatment strategies, Edelmayer noted.

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LATE tends to have a slower rate of decline than Alzheimer’s, according to lead author David Wolk, professor of neurology at the University of Pennsylvania.

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The condition occurs in tandem with Alzheimer’s disease in about one-third of patients, the doctor estimated, and it seems to accelerate the course of disease.  

More than 25% of people over 80 have this form of dementia.

More than 25% of people over 80 have this common but little-known form of dementia. (iStock)

“Despite the commonality of the condition, most clinicians and patients have never heard of LATE and don’t consider this when memory loss is present,” Wolk noted.

“Knowing whether it is present with Alzheimer’s disease also impacts prognosis and may impact the efficacy of treatments.”

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“Most clinicians and patients have never heard of LATE and don’t consider this when memory loss is present.”

Before the criteria presented in the new report, there was not consensus on how to diagnose this condition.

“It was only defined at autopsy after death,” Wolk said. 

      

“These criteria provide a way for doctors to diagnose the disease, which is an important step both in clinical practice and ultimately research to better treat the condition.”

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While there is a diagnostic test to definitively measure Alzheimer’s disease, no such test exists for LATE, Wolk pointed out.

While there is a diagnostic test to definitively measure Alzheimer’s disease, no such test exists for LATE. (iStock)

“The criteria provide levels of likelihood of diagnosis, but cannot be definitive,” he told Fox News Digital. “Also, the criteria need to be validated in practice.”

In the near future, Edelmayer noted, advances in biological markers will help clinicians differentiate all the various types of dementia. 

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“Until those tools are available, clinical criteria for diagnosis — like the one we just published — can be used to support a more personalized medicine approach to treatment, care and enrollment into clinical studies,” she told Fox News Digital.

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“In addition, these new recommendations create a roadmap that identifies opportunities for further research, and the challenges that still remain for accurately diagnosing individuals with LATE.”

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Brain Health Challenge: Doctor Appointments for Your Mind and Body

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Brain Health Challenge: Doctor Appointments for Your Mind and Body

Congratulations, you’ve reached the final day of the Brain Health Challenge! Today, we’re asking you to do a few things that might feel a bit out of left field — like getting your blood pressure checked.

No, it isn’t as fun as playing Pips, but experts say it’s one of the most important things you can do for your brain. That’s because heart health and brain health are intrinsically linked.

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High blood pressure, in particular, can damage brain cells, and it’s a significant risk factor for stroke and dementia. When blood pressure is too high, it places stress on the walls of arteries in the brain. Over time, that added stress can cause the blood vessel walls to thicken, obstructing blood flow. In other cases, the increased pressure causes the artery walls to thin and leak blood into the brain.

These changes to the blood vessels can sometimes cause a large stroke to occur. More commonly, the damage leads to micro-strokes and micro-hemorrhages, which cause fewer immediate problems and often go unnoticed. But if someone has hypertension for years or decades, these injuries can build up, and the person may start to experience cognitive impairment.

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High blood pressure “is known as a silent killer for lots of reasons,” said Dr. Shyam Prabhakaran, the chair of neurology at the University of Chicago. “It doesn’t cause you any symptoms until it does.”

Because the damage accumulates over many years, experts say that managing blood pressure in midlife matters most for brain health. Hypertension can be addressed with medication or lifestyle changes, as directed by your doctor. But the first thing you need to do is know your numbers. If your blood pressure comes back higher than 120/80, it’s important to take it seriously, Dr. Prabhakaran said.

While you’re at it, there are a few other aspects of your physical health that you should check on.

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Your eyes and ears are two of them. Hearing and vision loss have both been shown to increase the risk of dementia. Experts think that with less sensory information coming in to stimulate the brain, the regions that process hearing and vision can start to atrophy. What’s more, people with sensory loss often withdraw or are left out of social interactions, further depriving them of cognitive stimulation.

Oral health can also affect your brain health. Research has found a connection between regular flossing and reduced odds of having a stroke. That may be because good oral health can help to reduce inflammation in the body. The bacteria that cause gum disease have also been tied to an increased risk of Alzheimer’s.

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And have you gotten your shingles vaccine? There is mounting evidence that it’s a powerful weapon for protecting against dementia. One study found that it lowered people’s odds of developing the condition by as much as 20 percent.

To wrap up this challenge, we want you to schedule a few medical appointments that benefit your brain, as well as your body.

After five days of feeding, exercising and challenging your brain, you are well on your way to better cognitive health. Thanks for joining me this week, and keep up the good habits!

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Health experts react as Andrew Huberman backs Trump admin’s new food pyramid

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Health experts react as Andrew Huberman backs Trump admin’s new food pyramid

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The Trump administration has taken a new approach to the food pyramid.

The Department of Health and Human Services (HHS) announced new guidelines on Wednesday with an updated, inverted pyramid. The top of the pyramid, which is now the wider part of the structure, is built on meat, fats, fruits and vegetables, while whole grains are at the narrow bottom.

This follows HHS Secretary Robert F. Kennedy Jr.’s mission to “Make America Healthy Again” (MAHA), aimed at addressing chronic disease, childhood illnesses and ultraprocessed foods.

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“The new guidelines recognize that whole, nutrient-dense food is the most effective path to better health and lower health care costs,” Kennedy said during a press briefing in Washington, D.C. 

“Protein and healthy fats are essential, and were wrongly discouraged in prior dietary guidelines. We are ending the war on saturated fats.”

The Trump administration announces the 2025-2030 Dietary Guidelines for Americans, putting “real food” back at the center of health. (realfood.gov)

The HHS secretary rallied against refined carbohydrates, food additives and added sugar, highlighting the health risks associated with sugar-sweetened beverages. 

Kennedy’s main message to Americans was to “eat real food.”

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TRUMP ADMIN’S NEW NUTRITION GUIDELINES TARGET ULTRA-PROCESSED FOODS, EASE UP ON RED MEAT AND SATURATED FATS

The announcement triggered reactions from top health and wellness voices, including Stanford neuroscientist Dr. Andrew Huberman, host of the “Huberman Lab” podcast.

In a post on X, Huberman shared the White House’s graphic of the new pyramid, praising the decisions that were made.

“Oatmeal (and I think that’s rice and sourdough) made the cut!” he commented. “In all seriousness, assuming overall calories are kept in check and people exercise & get sun(day)light, this looks spot on.”

He added, “Maybe up the veggies a bit, add low-sugar fermented foods like sauerkraut & this is great.”

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Huberman said in a thread on the same post that Americans “don’t have to eat all the foods” shown in the diagram.

“You won’t see me drinking milk or eating shrimp,” he said. “Nothing against shrimp, I just don’t like the taste. Aversion to crustaceans.”

“Maybe up the veggies a bit, add low-sugar fermented foods like sauerkraut & this is great,” Huberman commented on X. (Chance Yeh/Getty Images for HubSpot; iStock)

The new guidelines received praise from other major health figures, including former FDA commissioner Dr. David Kessler.

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“There should be broad agreement that eating more whole foods and reducing highly processed carbohydrates is a major advance in how we approach diet and health,” Kessler told The Associated Press.

“Protein and healthy fats are essential, and were wrongly discouraged in prior dietary guidelines.”

Dr. Bobby Mukkamala, president of the American Medical Association, shared in a statement that these guidelines “affirm that food is medicine and offer clear direction patients and physicians can use to improve health.”

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“The American Medical Association applauds the Administration’s new Dietary Guidelines for spotlighting the highly processed foods, sugar-sweetened beverages and excess sodium that fuel heart disease, diabetes, obesity and other chronic illnesses,” Mukkamala wrote.

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The American Medical Association applauded the HHS for its updated nutrition guidelines. (iStock)

But not all feedback was positive.

Some people expressed concern about prioritizing red meat and dairy, while calling for the limitation of saturated fat.

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Neal Barnard, president of the Physicians Committee for Responsible Medicine, shared in a reaction to STAT that while the guidelines “do have one or two good points, emphasizing fruits and vegetables and limiting alcohol,” the guidelines are “for the most part a strong reflection of industry influence.”

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Christopher Gardner, a nutrition expert at Stanford University, also spoke out against the new guidelines, as reported by NPR.

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“I’m very disappointed in the new pyramid that features red meat and saturated fat sources at the very top, as if that’s something to prioritize. It does go against decades and decades of evidence and research,” said Gardner, who was a member of the Dietary Guidelines Advisory Committee.

Fox News Digital’s Rachel Wolf, as well as Alexandria Hoff of Fox News, contributed reporting.

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Matt Damon’s Gluten-Free Diet Helped Him Lose 18 Pounds

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Matt Damon’s Gluten-Free Diet Helped Him Lose 18 Pounds


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Matt Damon’s Weight Loss: Actor Drops 18 Lbs with This Diet | Woman’s World




















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