Health
Eleanor Maguire, Memory Expert Who Studied London Cabbies, Dies at 54
Eleanor Maguire, a cognitive neuroscientist whose research on the human hippocampus — especially those belonging to London taxi drivers — transformed the understanding of memory, revealing that a key structure in the brain can be strengthened like a muscle, died on Jan. 4 in London. She was 54.
Her death, at a hospice facility, was confirmed by Cathy Price, her colleague at the U.C.L. Queen Square Institute of Neurology. Dr. Maguire was diagnosed with spinal cancer in 2022 and had recently developed pneumonia.
Working for 30 years in a small, tight-knit lab, Dr. Maguire obsessed over the hippocampus — a seahorse-shaped engine of memory deep in the brain — like a meticulous, relentless detective trying to solve a cold case.
An early pioneer of using functional magnetic resonance imaging (f.M.R.I.) on living subjects, Dr. Maguire was able to look inside human brains as they processed information. Her studies revealed that the hippocampus can grow, and that memory is not a replay of the past but rather an active reconstructive process that shapes how people imagine the future.
“She was absolutely one of the leading researchers of her generation in the world on memory,” Chris Frith, an emeritus professor of neuropsychology at University College London, said in an interview. “She changed our understanding of memory, and I think she also gave us important new ways of studying it.”
In 1995, while she was a postdoctoral fellow in Dr. Frith’s lab, she was watching television one evening when she stumbled on “The Knowledge,” a quirky film about prospective London taxi drivers memorizing the city’s 25,000 streets to prepare for a three-year-long series of licensing tests.
Dr. Maguire, who said she rarely drove because she feared never arriving at her destination, was mesmerized. “I am absolutely appalling at finding my way around,” she once told The Daily Telegraph. “I wondered, ‘How are some people so bloody good and I am so terrible?’”
In the first of a series of studies, Dr. Maguire and her colleagues scanned the brains of taxi drivers while quizzing them about the shortest routes between various destinations in London.
The results, published in 1997, showed that blood flow in the right hippocampus increased sharply as the drivers described their routes — meaning that specific area of the brain played a key role in spatial navigation.
But that didn’t solve the mystery of why the taxi drivers were so good at their jobs.
Dr. Maguire kept digging. Using M.R.I. machines, she measured different regions in the brains of 16 drivers, comparing their dimensions with those in the brains of people who weren’t taxi drivers.
“The posterior hippocampi of taxi drivers were significantly larger relative to those of control subjects,” she wrote in Proceedings of the National Academy of Sciences. And the size, she found, correlated with the length of a cabby’s career: The longer the cabby had driven, the bigger the hippocampus.
Dr. Maguire’s study, published in March 2000, generated headlines around the world and turned London taxi drivers into unlikely scientific stars.
“I never noticed part of my brain growing,” David Cohen, a member of the London Cab Drivers Club, told the BBC. “It makes you wonder what happened to the rest of it.”
Dr. Maguire wondered, too: Why (and how) did their hippocampi grow?
She followed up with other studies. One showed that the hippocampi of bus drivers — whose routes were set rather than navigated from memory — didn’t grow. Another showed that prospective taxi drivers who failed their tests did not gain any hippocampus volume in the process.
The implications were striking: The key structure in the brain governing memory and spatial navigation was malleable.
In a roundabout way, Dr. Maguire’s findings revealed the scientific underpinnings of the ancient Roman “method of loci,” a memorization trick also known as the “memory palace.”
This technique involves visualizing a large house and assigning an individual memory to a particular room. Mentally walking through the house fires up the hippocampus, eliciting the memorized information. Dr. Maguire studied memory athletes — people who train their brains to memorize vast amounts of information quickly — who used this method, and observed that its effectiveness was “reflected in its continued use over two and a half millennia in virtually unchanged form.”
But recalling information was only half the story.
In studying patients with damage to the hippocampus, including those with amnesia, Dr. Maguire found that they couldn’t visualize or navigate future scenarios. One taxi driver, for instance, struggled to make his way through busy London streets in a virtual-reality simulation. Other amnesiacs couldn’t imagine an upcoming Christmas party or a trip to the beach.
“Instead of visualizing a single scene in their mind, such as a crowded beach filled with sunbathers, the patients reported seeing just a collection of disjointed images, such as sand, water, people and beach towels,” the journal Science News reported in 2009.
The hippocampus, it turns out, binds snippets of information to construct scenes from the past — and the future.
“The whole point of the brain is future planning,” Dr. Maguire was quoted as saying in Margaret Heffernan’s book “Uncharted: How to Navigate the Future” (2020). “You need to survive and think about what happened when I was last here, is there a scary monster that will come out and eat me? We create models of the future by recruiting our memories of the past.”
Eleanor Anne Maguire was born on March 27, 1970, in Dublin. Her father, Paddy Maguire, was a factory worker. Her mother, Anne Maguire, was a receptionist.
Growing up, Eleanor was obsessed with “Star Trek.”
“My first scientific hero was fictional — Spock, science officer on the Starship Enterprise,” she told the journal Current Biology in 2012. “He embodied so much of what attracted me to science. He was inquisitive, logical, honest, meticulous, calm, fearless in facing the unknown, innovative and unafraid of taking risks.”
She graduated from University College Dublin in 1990 with a degree in psychology, and returned to earn her doctorate there after receiving a master’s degree from the University College of Swansea (now Swansea University).
Dr. Maguire joined the faculty at University College London in 1995 and never left.
She is survived by her parents. Her brother, Declan, died in 2019, also of cancer.
At Dr. Maguire’s memorial service, Dr. Price spoke about the energy and excitement her friend and longtime colleague generated at the lab, recalling that Dr. Maguire’s mother had called nightly to remind her daughter to go home.
“It wasn’t just a job,” Dr. Price said. “It consumed us, day and night.”
There was a sense that they were onto something big.
“We were among the first to use cutting-edge technology to peer inside the healthy, living human brain and witness its functions in action,” Dr. Price said. “It was an exhilarating and transformative time in neuroscience, and Eleanor’s curiosity and creativity were instrumental to numerous discoveries.”
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Feeling lonely may take a toll on older adults’ memory — but it may not speed up cognitive decline, according to a new study.
Researchers from Colombia, Spain and Sweden analyzed data from more than 10,000 adults ages 65 to 94 across 12 European countries and found those who reported higher levels of loneliness did worse on memory tests at the start of the study, according to research published this month in the journal Aging & Mental Health.
Over a seven-year period, however, memory decline occurred at a similar rate regardless of how lonely participants felt.
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“The finding that loneliness significantly impacted memory, but not the speed of decline in memory over time was a surprising outcome,” lead author Dr. Luis Carlos Venegas-Sanabria of the School of Medicine and Health Sciences at the Universidad del Rosario said in a statement.
Loneliness may be linked to memory performance in older adults, a new study suggests. (iStock)
“It suggests that loneliness may play a more prominent role in the initial state of memory than in its progressive decline,” Venegas-Sanabria said, adding that the findings highlight the importance of addressing loneliness as a factor in cognitive performance.
The findings add to debate about whether loneliness contributes to dementia risk. While loneliness and social isolation are often considered risk factors for cognitive decline, research results have been mixed.
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The study looked at data from the long-running Survey of Health, Ageing and Retirement in Europe (SHARE), which tracked 10,217 older adults between 2012 and 2019. Participants were asked to recall words immediately and after a delay to measure memory performance.
Social isolation and loneliness could play a surprising role in cognitive health among seniors. (iStock)
Loneliness was assessed using three questions about how often participants felt isolated, left out or lacking companionship.
About 8% of participants reported high levels of loneliness at the outset. That group tended to be older, more likely to be female and more likely to have conditions such as depression.
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Researchers found that those with higher loneliness had lower scores on both immediate and delayed memory tests at baseline. Still, all groups — regardless of loneliness level — experienced similar declines in memory over time.
The results suggest loneliness may not directly accelerate the progression of memory loss, though it remains linked to poorer cognitive performance overall.
Researchers look at a brain scan at the National Institutes of Health in Bethesda, Maryland. (Saul Loeb/AFP/Getty Images)
Experts warn, however, that the findings should not be interpreted to mean loneliness is harmless.
“The finding that lonely older adults start with worse memory but don’t decline faster is actually the most interesting part of the paper, and I think it’s easy to misread,” said Jordan Weiss, Ph.D., a scientific advisor and aging expert at Assisted Living Magazine and a professor at NYU Grossman School of Medicine.
“It likely means loneliness does its damage earlier in life, well before people show up in a study like this at 65-plus,” Weiss told Fox News Digital.
By older age, long-term social patterns may already be established, making it harder to detect when the effects of loneliness first took hold, an aging expert says. (iStock)
He suggested that by older age, long-term social patterns may already be established, making it harder to detect when the effects of loneliness first took hold.
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“By the time you’re measuring someone in their late 60s, decades of social connection patterns are already baked in,” he said.
Weiss, who was not involved in the research, added that loneliness may coincide with other health conditions, and noted that participants who felt more isolated also had higher rates of depression, high-blood pressure and diabetes. The link, he said, may reflect a cluster of health risks rather than a direct cause.
“While they can go hand-in-hand, it’s not clear that loneliness contributes to dementia,” a psychotherapist says. (iStock)
Amy Morin, a Florida-based psychotherapist and author, said the findings reflect a broader pattern in research on loneliness and brain health, and that the relationship may be more complex than it appears.
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“The evidence shows there’s a link between loneliness and cognitive decline but there’s no direct evidence of a cause and effect relationship,” she said. “So while they can go hand-in-hand, it’s not clear that loneliness contributes to dementia.”
Morin added that loneliness, which can fluctuate, may not be the root of the problem, but rather a symptom of other underlying mental or physical health issues.
Researchers suggested screening for loneliness be incorporated into routine cognitive assessments as one way to support healthy aging. (iStock)
She said staying socially and mentally engaged is crucial for overall brain health.
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“It’s important to be proactive about social activities,” Morin said. “Joining a book club, having coffee with a friend, or attending faith-based services can be a powerful way to maintain connections in older age.”
The researchers also suggested screening for loneliness be incorporated into routine cognitive assessments as one way to support healthy aging.
Fox News Digital reached out to the researchers for comment.
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Research continues to uncover new details on how fasting may help extend life.
A new study published in the journal Nature Communications investigated how intermittent fasting can boost longevity in small worms often used in aging research.
Researchers from the University of Texas Southwestern Medical Center in Dallas compared worms that were fed normally to those that underwent a 24-hour fast in early adulthood and were then fed again, according to a press release.
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The scientists measured a variety of factors, including stored fat, gene activity related to fat metabolism and lifespan.
The results showed that the life-boosting benefit did not depend on the fasting itself but on the body’s behavior after eating again.
Experts say sustainability is key when choosing a long-term weight-loss strategy. (iStock)
Study lead Peter Douglas, associate professor of molecular biology and a member of the Hamon Center for Regenerative Science and Medicine at UT Southwestern, suggested that these discoveries “shift the focus toward a neglected side of the metabolic coin – the re-feeding phase.”
“Our data suggest that the health-promoting effects of intermittent fasting are not merely a product of the fast itself, but are dependent on how the metabolic machinery recalibrates during the subsequent transition back to a fed state,” he said.
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“Our findings bridge a gap between lipid metabolism and aging research,” he added. “By targeting aging, the single greatest risk factor for human disease, we move beyond treating isolated conditions toward a preventive model of medicine that enhances quality of life for all individuals.”
Lauri Wright, director of nutrition programs at the University of South Florida’s College of Public Health, called this a “high-quality” study that adds an “important nuance to how we think about fasting and longevity.”
Intermittent fasting typically involves limiting meals to an eight-hour daily window or fasting every other day. (iStock)
The benefits of the refeeding phase after fasting were “especially interesting,” Wright, who was not involved in the study, told Fox News Digital.
“The researchers showed that longevity was linked to the body’s ability to turn off fat breakdown after fasting, allowing cells to restore energy balance,” she reiterated.
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“From a scientific standpoint, that’s a meaningful shift because it suggests fasting is not just about burning fat, but about metabolic flexibility.”
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Fasting may support longevity through triggering metabolic switching, enhancing cellular repair and stress resistance and improving markers like insulin sensitivity, research shows.
Limitations and cautions
Although this study provides “important insight” on the power of refeeding, Wright noted that the findings should be approached with caution, as the study was done on worms and cannot always be translated to humans.
“Additionally, it explains how a process might work in a controlled lab condition rather than real-world eating behaviors,” she added as a limitation. “Finally, the study is short-term and doesn’t give us the long-term translation on lifespan outcomes.”
The review found intermittent fasting was barely more effective than doing nothing, according to the study authors. (iStock)
Wright cautioned that fasting is “not a magic solution for longevity, and how you eat overall matters more than when you eat.”
“I advise, first and foremost, to focus on diet quality, including a variety of fruits and vegetables, healthy fats and minimally processed foods,” she said.
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For those who are considering fasting, it’s better to stick with a moderate plan — like a 12- to 14-hour overnight fast — rather than going to extremes, Wright said. After fasting, she recommends focusing on well-balanced meals.
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Several groups of people should be cautioned against fasting, according to Wright, including those with diabetes who are on insulin or hypoglycemic medications, those who are pregnant or breastfeeding, anyone with a history of eating disorders and older adults at risk of malnutrition.
Anyone considering intermittent fasting should consult with a doctor before starting.
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