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Diabetes 'rewires' the brain in surprising way, study finds

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Diabetes 'rewires' the brain in surprising way, study finds

Diabetes is known to cause many medical issues, from heart disease to vision problems — and now a new study suggests it could also impact memory and other cognitive functions.

After observing brain activity and behavior in rodent models, researchers at the University of Nevada, Las Vegas (UNLV) determined that type 2 diabetes can “rewire” the brain in ways similar to early-onset Alzheimer’s disease.

“Diabetes may be altering the brain similarly to early stages of Alzheimer’s disease,” said lead researcher and UNLV psychology professor James Hyman in the release. 

DIABETES RISK LOWERED BY EATING ONE SURPRISINGLY SWEET FOOD, STUDY SUGGESTS

“Further research is needed, but these findings have the potential to help researchers unlock clues to improved diagnostic or treatment strategies for the disease.”

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Diabetes has been shown to impact memory and other cognitive functions. (iStock)

The study was funded by the National Institutes of Health and published in The Journal of Neuroscience.

Previous studies have shown that people with type 2 diabetes have a higher risk of developing neurodegenerative disorders.

“Diabetes may be altering the brain similarly to early stages of Alzheimer’s disease.”

The reason, the researchers hypothesized, is that high blood sugar levels may impact the anterior cingulate cortex (ACC), a part of the brain that is involved in cognitive and emotional functions, according to a UNLV press release.

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The ACC is linked to key cognitive processes like motivation, decision-making, goal-tracking, pleasure-seeking, reward processing and regulation of emotions, according to the researchers.

In people with diabetes, high blood sugar impairs reward signals from the hippocampus (the part of the brain that controls memory and learning) to the ACC.

WEIGHT-LOSS, DIABETES DRUGS LINKED TO VISION PROBLEMS IN SMALL STUDY

“Rewards, or achieving goals, are important to helping us make future decisions, so if our brains are responding differently, it’s likely our future decisions will be different,” Hyman told Fox News Digital.

“This has big implications for those managing their type 2 diabetes, since compliance with testing and lifestyle changes are key aspects.”

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Researchers determined that type 2 diabetes can “rewire” the brain in ways similar to early-onset Alzheimer’s disease. (iStock)

This could also explain why it is so hard for many people to stick with new diets and exercise regimens, Hyman noted, because their brains don’t respond to normally rewarding events due to the disease. 

“This knowledge can help people persevere and remain diligent, since their failures are not due to personal weakness, but altered brain physiology,” he said.

“This kind of research opens new avenues not just for Alzheimer’s patients, but also for other diseases that impact the brain.”

Dr. Adam Scioli, chief medical officer at Caron Treatment Centers in Pennsylvania, said it is known that the reward system of the brain helps to imprint memory. 

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“It makes sense that any substance – like sugar – that impacts and overwhelms that reward system can have lasting impacts on cognitive and working memory,” Scioli, who was not involved in the study, told Fox News Digital.

The concept of reward and memory in type 2 diabetes has some similarities to addiction, according to the expert.

“Both conditions also involve altered hippocampus-ACC connectivity, which affects goal-oriented behavior and memory processing,” he said.

High blood sugar levels may impact the anterior cingulate cortex, a part of the brain that is involved in cognitive and emotional functions, the study found. (iStock)

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“This kind of research opens new avenues not just for Alzheimer’s patients, but also for other diseases that impact the brain,” Scioli added. 

“It also provides an avenue where we might be able to intervene earlier in these diseases and prevent or mitigate cognitive decline.”

More research needed

There were some limitations to the study, the researchers acknowledged.

“This was a study in rodents, so the translation to human conditions is challenging,” Hyman told Fox News Digital.

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“Additionally, we only modeled one aspect of type 2 diabetes — chronic hyperglycemia — and in humans there are more symptoms than that. It’s possible those other aspects may have different, either compounding or allaying, impacts.” 

Hyman’s team plans to conduct further research into the connection between diabetes and brain function.

“Be patient and understand that the disease has rewired your brain.”

“Alzheimer’s disease goes undetected for decades because our brains are good at finding ways to compensate,” he said. 

“Before diagnosis, people behave normally despite having changes in information processing. We even observed that in this study.”

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Based on these findings, the researchers recommend that people monitor their own blood glucose levels.  (iStock)

Based on these findings, Hyman hopes that people will be more likely to monitor their own blood glucose levels. 

“If diagnosed with type 2 diabetes, be sure to follow doctors’ orders closely and keep blood glucose levels stable,” he advised. “We think it’s the spikes of extremely low and high blood glucose that make people more vulnerable to Alzheimer’s.”

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For those having trouble with lifestyle changes, Hyman urged them to “not be so hard on yourself.”

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“Be patient and understand that the disease has rewired your brain.”

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Flu hospitalizations hit all-time weekly high in densely populated state, officials warn

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Flu hospitalizations hit all-time weekly high in densely populated state, officials warn

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The New York State Department of Health has announced the highest number of flu hospitalizations recorded in a single week.

The state confirmed the uptick in hospital visits in a press release on Jan. 2, as flu cases continue to rise in the region and nationwide.

New York State, including New York City, has consistently tracked the highest numbers of recorded respiratory illness cases in the country for the last few weeks, according to CDC data. Several other states have climbed to the “very high” category for respiratory activity as well, as of the week ending Dec. 27.

RECORD-BREAKING FLU NUMBERS REPORTED IN NEW YORK STATE, SPARKING WARNINGS FROM OFFICIALS

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The most recent data from the New York health department showed a total of 4,546 hospitalizations from Dec. 26, 2025, to Jan. 2, 2026 – a week-over-week increase of nearly 1,000. The prior week, the department announced the highest number of flu cases ever recorded in a single seven-day period.

The New York State Department of Health reported a total of 4,546 hospitalizations from Dec. 26, 2025, to Jan. 2, 2026. (iStock)

In a statement, New York’s Acting Commissioner of Health Dr. James McDonald noted the severity of this flu season compared to previous years.

“Almost 1,000 more people were admitted to a hospital during this most recent seven-day period compared to the prior week,” he confirmed. “There is still time to get a flu shot, and remember, flu can be treated with antiviral medication if started within 48 hours of symptom onset [as] your doctor deems appropriate.”

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Health officials are pushing for Americans to consider getting the flu vaccine, as experts consider it to be a top line of defense for preventing viral exposure and spread.

Flu symptoms can include fever, chills, headache, fatigue, cough, sore throat and runny nose. (iStock)

In a previous interview with Fox News Digital, Dr. Neil Maniar, professor of public health practice at Boston’s Northeastern University, emphasized that it’s not too late to get the flu vaccine, as peak season typically occurs in January.

“The vaccine still provides protection against serious illness resulting from the subclade K variant that seems to be going around,” he said.

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Even healthy individuals can become seriously ill from the flu, Maniar noted, “so a vaccine is beneficial for almost everyone.”

“Individuals typically start to develop some degree of protection within a few days and gain the full benefit within about two weeks, so now is the time for anyone who hasn’t gotten the vaccine yet.”

“The vaccine still provides protection against serious illness resulting from the subclade K variant that seems to be going around,” one doctor said. (iStock)

Flu symptoms can include fever, chills, headache, fatigue, cough, sore throat and runny nose.

A mutation of influenza A H3N2, called subclade K, has been detected as the culprit in rising global cases, causing more intense symptoms and higher risk of spread.

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“It’s becoming evident that this is a pretty severe variant of the flu,” Maniar said. “Certainly, in other parts of the world where this variant has been prevalent, it’s caused some severe illness, and we’re seeing an aggressive flu season already.”

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New York State recommends taking preventive actions to avoid flu infection. These include washing hands often; avoiding touching the eyes, nose and mouth; avoiding close contact with sick people; cleaning and disinfecting objects and surfaces; and staying home when feeling sick.

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Not all cancers should be treated right away, medical experts say — here’s why

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Not all cancers should be treated right away, medical experts say — here’s why

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When someone gets a cancer diagnosis, the initial reaction is usually to undergo treatment as quickly as possible — but for some types of disease, doctors may recommend a more conservative approach.

For certain cancers, immediate or aggressive treatment can cause more harm than good, according to multiple medical experts.

For example, treating slow-growing tumors with surgery, radiation or chemotherapy could create significant side effects without a survival benefit.

PROSTATE CANCER PATIENTS SEE LONGER SURVIVAL WITH NEW COMBINATION DRUG 

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“The fact that so many cancers will never kill you is not a justification for not knowing, because there is still plenty of room for ‘watchful waiting,’ as well as interventions that may improve quality of life even if they don’t extend life,” Dr. Marc Siegel, Fox News senior medical analyst, told Fox News Digital.

This is especially true as targeted cancer treatments emerge, which are more personalized and less likely to cause severe side effects, according to the doctor.

For precancerous, very early-stage breast conditions, careful monitoring may be more prudent than immediate surgery, research shows. (iStock)

“The fact that cancers are occurring earlier is a justification for heightened screenings, not the opposite,” Siegel added. “Information is power — what you do with that information is based on clinical judgment and the art of medicine.”

Below are some types of cancer that may not warrant treatment, according to research and doctors’ guidance.

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No. 1: Prostate cancer (low-risk)

While some types of prostate cancer should be treated right away, others are better addressed by “watchful waiting,” according to Sanoj Punnen, M.D., a urologic oncologist with Sylvester Comprehensive Cancer Center, part of the University of Miami Health System. 

“With respect to prostate cancer, for most low-risk cancers (Gleason 6 or grade group 1), we recommend initial observation and surveillance rather than immediate treatment,” he told Fox News Digital.

NEW PROSTATE CANCER TEST PINPOINTS DISEASE BETTER THAN PSA OPTION, STUDY FINDS

The Gleason score is a grading system that ranks prostate cancer cells in terms of how abnormal they are, with 6 being the lowest grade and 10 being the highest grade (barely resembling normal cells).

“For high-grade tumors like Gleason 8, 9 or 10, we believe they progress quickly, so we recommend treatment to prevent the risk of metastasis,” said Punnen, who is also vice chair of research and a professor with the Desai Sethi Urology Institute at UHealth. “For low-risk tumors, we think they pose little risk, so we recommend just observation.”

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“The fact that cancers are occurring earlier is a justification for heightened screenings, not the opposite.”

“But in the end, we can’t be sure, so our approach to observation includes serial monitoring of cancer status with PSA, MRI and occasional biopsy to ensure the tumor isn’t progressing.”

No. 2: Ductal carcinoma in situ (DCIS) 

Also known as stage 0 breast cancer, DCIS is a non-invasive disease marked by abnormal cells in the lining of the breast milk ducts. The “in situ” is Latin for “in the original place,” which indicates that the cancer has not spread outside the milk ducts.

For this precancerous, very early-stage breast condition, careful monitoring may be more prudent than immediate surgery, research shows.

While some types of prostate cancer should be treated right away, others are better addressed by “watchful waiting,” according to a urologic oncologist. (iStock)

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A 2024 study by the Dana-Farber Cancer Institute found that active monitoring for DCIS resulted in similar quality of life, mental health and symptom progression over a two-year period compared to a standard surgical approach.

NEW STUDY QUESTIONS WHETHER ANNUAL MAMMOGRAMS ARE NECESSARY FOR MOST WOMEN

“These results suggest that in the short term, active monitoring is a reasonable approach to management of low-risk DCIS,” the lead researcher said in a press release. “If longer-term follow-up supports the safety of active management from a cancer outcome standpoint, this approach could be considered as an option for women with this condition.”

“But it is also critical that we understand how women feel when they are living with this ‘watch and wait’ approach and how it impacts their overall quality of life.”

Other research has suggested that women with low-risk DCIS did not have a higher rate of invasive cancer after two years of active monitoring, although each patient should discuss their individual risk level with an oncologist.

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No. 3: Indolent (slow-growing) lymphomas

Non-Hodgkin lymphoma (NHL) is a type of cancer that starts in the lymphatic system, which includes the lymph nodes, spleen, thymus, bone marrow and other tissues. 

Indolent lymphomas are those that “grow and spread slowly,” according to the American Cancer Society.

THE DEADLY CANCER HIDING IN PLAIN SIGHT — AND WHY MOST PATIENTS NEVER GET SCREENED

The National Comprehensive Cancer Network (NCCN) recommends watchful waiting for asymptomatic, slow-growing follicular lymphoma, as a means of avoiding the toxicity of chemotherapy and immunotherapy until it’s absolutely necessary.

The Lymphoma Research Foundation confirms that doctors recommend “active surveillance” for some patients with slow-growing lymphoma.

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Indolent lymphomas are those that “grow and spread slowly,” according to the American Cancer Society. (iStock)

“This approach may be started after the initial diagnosis or after relapse, depending on the situation,” the foundation states on its website. “Active treatment is started if the patient begins to develop lymphoma-related symptoms or if there are signs that the disease is progressing.”

Treatment should be started right away for aggressive (fast-growing) lymphomas.

No. 4: Chronic lymphocytic leukemia

One of the most common adult leukemias, chronic lymphocytic leukemia (CLL) originates in white blood cells (lymphocytes) in the bone marrow and then spreads to the bloodstream, according to the American Cancer Society.

CLL tends to grow slowly, with many patients experiencing no symptoms for years. Eventually, the cancer calls can spread to the lymph nodes, liver and spleen.

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BREAKTHROUGH BLOOD TEST COULD SPOT DOZENS OF CANCERS BEFORE SYMPTOMS APPEAR

Some studies have shown that early treatment for CLL does not improve survival rates compared to observation, and that the benefits may not outweigh the risks.

In a 2023 study presented at the European Hematology Association 2023 Congress in Frankfurt, Germany, researchers found that early treatment did not prolong overall survival compared to a placebo in patients with early, asymptomatic CLL.

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“I believe it’s fair to conclude that ‘watch-and-wait’ should remain the standard of care in the era of targeted drugs,” said researcher Petra Langerbeins, M.D., when presenting the findings.

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No. 5: Low-grade endometrial cancer

For most patients with endometrial cancer, surgery is the first treatment, which entails removing the uterus, fallopian tubes and ovaries, according to the American Cancer Society.

However, in certain patients with low-grade cancer, such as older people, those with “frailty” and people with major health issues, doctors may recommend deferring surgery, which can pose a high risk.

The American Thyroid Association’s guidelines officially recommend active surveillance for very low-risk microcarcinomas. (iStock)

In cases where the patient has medical comorbidities or wants to preserve fertility, hormone treatment may be used instead of surgery, per the ACS.

“It’s usually also considered for cancer that is lower-grade, low-volume and slow-growing,” the above source stated.

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No. 6: Some early kidney cancers

In cases of kidney cancer with small tumors (≤3 cm) or benign lesions, doctors may recommend monitoring them instead of undergoing surgery for removal.

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The American Urological Association confirms that active surveillance is an option for some small renal masses (localized tumors).

“I believe it’s fair to conclude that ‘watch-and-wait’ should remain the standard of care in the era of targeted drugs.”

Deferred treatment is particularly recommended for older patients or those with “significant comorbidities,” research shows.

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“Shared decision-making about active surveillance should consider risks of intervention/competing mortality versus potential oncologic benefits of intervention,” the UAU states in its guidance.

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Data from the Delayed Intervention and Surveillance for Small Renal Masses (DISSRM) Registry showed that patients with active surveillance had a 99% or greater cancer-specific survival rate — virtually the same as patients who received immediate treatment.

No. 7: Small papillary thyroid cancers

Papillary thyroid cancer (PTC), the most common type of thyroid cancer, may not warrant treatment for small tumors measuring 1 centimeter (10 mm) or less, which are called microcarcinomas.

A young multiracial female is undergoing a diagnostic medical imaging procedure in a state-of-the-art hospital setting with CT simulator. The image illustrates the use of cutting-edge technology for healthcare and treatment in a modern medical environment. The portrayal highlights precision, care, and the sophistication of contemporary medical practices. (iStock)

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Research found that when using active surveillance for 10 to 20 years, less than 10% experienced significant growth, only 5% developed lymph node spread and there were no thyroid-cancer deaths.

The American Thyroid Association’s guidelines officially recommend active surveillance for very low-risk microcarcinomas.

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While many patients with low-risk tumors can safely delay treatment, this does not apply to all cancers or all patients. 

As cancer behavior and personal health factors vary widely, patients should consult their doctor to determine the most appropriate course of care based on their individual risk level.

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Brain Health Challenge: Test Your Knowledge of Healthy Habits

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Brain Health Challenge: Test Your Knowledge of Healthy Habits

Welcome to the Brain Health Challenge! I’m Dana Smith, a reporter at The New York Times, and I’ll be your guide.

To live a healthy life, it’s crucial to have a healthy brain. In the short term, it keeps you sharp and firing on all cylinders. In the long term, it can reduce your risk of cognitive decline, dementia and stroke.

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Practicing basic healthy behaviors, like eating nutritious food and getting regular exercise, is the best way to enhance your brain power and protect the longevity of your neurons. These types of lifestyle habits can benefit the brain at any age. And while they won’t guarantee that you’ll never develop dementia or another brain disease, several clinical trials have shown that they can improve cognition or slow decline.

Every day this week, you’ll do an activity that’s good for your brain, and we’ll dig into the science behind why it works. Some of these activities can provide a small immediate cognitive benefit, but the bigger reward comes from engaging in them consistently over time. So along with the neuroscience lessons, we’ll include a few tips to help you turn these actions into lasting habits.

To keep you accountable, we’re encouraging you to complete this challenge with a friend. If you don’t have a challenge buddy, no problem: We’re also turning the comments section into one big support group.

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There are so many fascinating ways your daily behaviors affect your brain. Take sleep, for example.

Lots of studies have shown that getting a good night’s rest (seven to eight hours) is associated with better memory and other cognitive abilities. That’s because sleep, especially REM sleep, is when your brain transfers short-term memories — things you learned or experienced during the day — into long-term storage.

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Sleep is also when your brain does its daily housekeeping. While you rest, the brain’s glymphatic system kicks into high gear, clearing out abnormal proteins and other molecular garbage, including the protein amyloid, which is a major contributor to Alzheimer’s disease. A buildup of amyloid is one reason experts think that people who routinely get less sleep have a higher risk of dementia.

What other behaviors play a big role in brain health? For today’s activity, we’re going to test your knowledge with a quiz. Share your score with your accountability partner and in the comments below — I’ll be in there too, cheering you on.

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