Health
COVID pandemic restrictions had 'alarming' impact on teenagers’ brains, new study finds
The pandemic’s negative effects on kids and teens — academically, socially and otherwise — have been shown in numerous studies, and now the latest long-term effect appears to be accelerated aging of young brains.
A team of researchers at the University of Washington studied 160 teens between the ages of 9 and 17. They had gathered data in 2018 for a different study on changes in brain structure during adolescence, but the COVID pandemic interrupted that research.
“Once the pandemic was underway, we started to think about which brain measures would allow us to estimate what the pandemic lockdown had done to the brain,” lead author Neva Corrigan, Ph.D., a research scientist at the University of Washington, said in a press release.
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“What did it mean for our teens to be at home rather than in their social groups — not at school, not playing sports, not hanging out?”
The researchers found that the pandemic caused teenage brains to age faster than normal.
The pandemic’s negative effects on kids’ and teens’ mental health have been shown in numerous studies. (iStock)
“The lifestyle changes due to the COVID-19 pandemic lockdowns appear to have affected brain development during adolescence, causing the brain to mature much faster than is typical,” Corrigan told Fox News Digital via email.
“This accelerated maturation was more widespread throughout the brain, and larger in magnitude, for females as compared to males.”
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On average, the young females’ brains aged 4.2 years faster than normal, and male brains were accelerated by 1.4 years.
Thirty regions in the female brain showed accelerated aging, compared to only two regions in the male brain, researchers found.
The findings were published in the Proceedings of the National Academy of Sciences on Sept. 9.
The researchers found that the pandemic caused teenage brains to age faster than normal. (iStock)
The researchers believe that the accelerated brain aging was due to the stress associated with the restrictive measures taken to curb COVID’s spread, Corrigan said.
“Accelerated development of the cerebral cortex during development has been well-established by previous research to be associated with chronic stress,” she noted.
Recommendations to parents
This study highlights the fact that teenagers’ brains are highly vulnerable to stressors in their environment, according to Corrigan.
“We recommend that parents of children who were teens during the pandemic stay connected to their teens, and also look out for signs of depression and anxiety, as accelerated cortical thinning increases the risk of developing these and other neuropsychiatric disorders,” she advised.
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“We also think parents should be aware that their teens’ social lives are very important to their brain development, and [they should] encourage healthy activities with peers.”
While these findings “seem alarming,” Corrigan said, it’s not known whether the accelerated aging will have long-term effects on continued brain development throughout the teens’ lives.
“It is not clear whether the cerebral cortex of these teens that showed accelerated maturation will return to a thickness that is more appropriate for their age with time, or whether these effects are permanent,” she told Fox News Digital.
It’s not known whether the accelerated aging will have long-term effects on continued brain development throughout the teens’ lives, a researcher noted. (iStock)
She also pointed out that “cortical thinning” is a natural process in aging and can actually allow the brain to function more efficiently.
“It is not clear that all the consequences of accelerated maturation are negative,” Corrigan added.
Potential limitations
The researchers acknowledged several limitations of the study, the first being its smaller sample size.
“Although we collected data from 160 teens prior to the lockdowns, and 130 teens after the lockdowns ended, larger samples are always better when conducting research,” Corrigan told Fox News Digital.
“What did it mean for our teens to be at home rather than in their social groups — not at school, not playing sports, not hanging out?”
“Also, since the study was not initially designed for the effects of the COVID pandemic, we did not collect the type of behavioral measures that would have allowed us to determine what exact lifestyle disruptions or stressors associated with the lockdowns might have been the greatest contributors to the stress experienced by the teens,” she said.
The researchers also only studied a limited age range, so they couldn’t determine whether the findings apply to other ages.
On average, the young females’ brains aged 4.2 years faster than normal, and male brains were accelerated by 1.4 years. (iStock)
“Finally, we do not know whether contraction of the COVID-19 virus itself may have contributed to these findings, although in the community from which our study sample was derived, we found no reports of a sex disparity in the contraction of the virus,” Corrigan said.
‘Downrange effects’
Dr. Brett Osborn, a Florida neurologist, was not involved in the study, but commented on the “detrimental consequences” of pandemic-related stress for teens.
“We recommend that parents of children who were teens during the pandemic stay connected to their teens, and also look out for signs of depression and anxiety,” a researcher said. (iStock)
“High levels of stress, often associated with elevated cortisol, can wreak havoc on the brain,” he told Fox News Digital.
Cortisol, the body’s primary stress hormone, is typically released by the adrenal glands during acute stress, Osborn explained, but it can become harmful when present at high levels for prolonged periods.
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“This chronic elevation is particularly damaging to brain structures like the hippocampus (the region associated with memory) and the prefrontal cortex, which is responsible for higher-level cognitive functions like decision-making and social behavior.”
“While the pandemic is over, this is not the end.”
Long-term exposure to high cortisol levels can negatively impact memory, emotional regulation, impulse control, focus and concentration, according to Osborn.
“Over time, these changes may predispose individuals to mental health disorders such as depression and anxiety, which are already known to be exacerbated by high cortisol levels,” he added.
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Overall, Osborn said, the study sheds light on “yet another downrange effect” of the COVID-19 pandemic.
The doctor added, “While the pandemic is over, this is not the end.”
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A deadly, drug-resistant fungus already spreading rapidly through U.S. hospitals is becoming even more threatening worldwide, though there may be hope for new treatments, according to a new scientific review.
Candida auris (C. auris), often described as a “superbug fungus,” is spreading globally and increasingly resisting human immune systems, Hackensack Meridian Center for Discovery and Innovation (CDI) researchers said in a review published in early December.
The findings reinforce prior CDC warnings that have labeled C. auris an “urgent antimicrobial threat” — the first fungal pathogen to receive that designation — as U.S. cases have surged, particularly in hospitals and long-term care centers.
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Approximately 7,000 cases were identified across dozens of U.S. states in 2025, according to the CDC, and it has reportedly been identified in at least 60 countries.
Candida auris is a drug-resistant fungus spreading in hospitals worldwide. (Nicolas Armer/Picture Alliance via Getty Images)
The review, published in Microbiology and Molecular Biology Reviews, helps explain why the pathogen is so difficult to contain and warns that outdated diagnostics and limited treatments lag behind. It was conducted by Dr. Neeraj Chauhan of the Hackensack Meridian CDI in New Jersey, Dr. Anuradha Chowdhary of the University of Delhi’s Medical Mycology Unit and Dr. Michail Lionakis, chief of the clinical mycology program at the National Institutes of Health.
Their findings stress the need to develop “novel antifungal agents with broad-spectrum activity against human fungal pathogens, to improve diagnostic tests and to develop immune- and vaccine-based adjunct modalities for the treatment of high-risk patients,” the researchers said in a statement.
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“In addition, future efforts should focus on raising awareness about fungal disease through developing better surveillance mechanisms, especially in resource-poor countries,” they added. “All these developments should help improve the outcomes and prognosis of patients afflicted by opportunistic fungal infections.”
Candida auris can survive on skin and hospital surfaces, allowing it to spread easily. (iStock)
First identified in 2009 from a patient’s ear sample in Japan, C. auris has since spread to dozens of countries, including the U.S., where outbreaks have forced some hospital intensive care units to shut down, according to the researchers.
The fungus poses the greatest risk to people who are already critically ill, particularly those on ventilators or with weakened immune systems. Once infected, about half of patients may die, according to some estimates.
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Unlike many other fungi, C. auris can survive on human skin and cling to hospital surfaces and medical equipment, allowing it to spread easily in healthcare settings.
“It is resistant to multiple antifungal drugs, and it tends to spread in hospital settings, including on equipment being used on immunocompromised and semi-immunocompromised patients, such as ventilators and catheters,” Dr. Marc Siegel, Fox News senior medical analyst and clinical professor of medicine at NYU Langone, previously told Fox News Digital.
Scientists say the unique cell wall structure of C. auris makes it harder to kill. (iStock)
It is also frequently misdiagnosed, delaying treatment and infection control measures.
“Unfortunately, symptoms such as fever, chills and aches may be ubiquitous, and it can be mistaken for other infections,” Siegel said.
In September, he said intense research was ongoing to develop new treatments.
Only four major classes of antifungal drugs are currently available, and C. auris has already shown resistance to many of them. While three new antifungal drugs have been approved or are in late-stage trials, researchers warn that drug development has struggled to keep pace with the fungus’s evolution.
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Despite the sobering findings, there is still room for cautious optimism.
The fungus can cling to skin and hospital surfaces, aiding its spread. (iStock)
In separate research published in December, scientists at the University of Exeter in England discovered a potential weakness in C. auris while studying the fungus in a living-host model.
The team found that, during infection, the fungus activates specific genes to scavenge iron, a nutrient it needs to survive, according to their paper, published in the Nature portfolio journal Communications Biology in December.
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Because iron is essential for the pathogen, researchers believe drugs that block this process could eventually stop infections or even allow existing medications to be repurposed.
“We think our research may have revealed an Achilles’ heel in this lethal pathogen during active infection,” Dr. Hugh Gifford, a clinical lecturer at the University of Exeter and co-author of the study, said in a statement.
New research is underway to develop better treatments and diagnostics for C. auris. (iStock)
As researchers race to better understand the fungus, officials warn that strict infection control, rapid detection and continued investment in new treatments remain critical.
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Health experts emphasize that C. auris is not a threat to healthy people.
Fox News Digital has reached out to the CDI researchers and additional experts for comment.
Fox News Digital’s Angelica Stabile contributed reporting.
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The New York State Department of Health reported a record surge in influenza activity, with 71,123 positive flu cases recorded statewide during the week ending December 20.
Health officials said the figure represents the highest number of flu cases ever reported in a single week since influenza became a reportable disease in New York in 2004.
State health data show the weekly total reflects a 38% increase from the previous reporting period, signaling a rapidly intensifying flu season.
There have been 189,312 reported positive flu cases so far this season, while influenza-related hospitalizations rose 63% in the most recent week.
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New York reported the highest weekly total of cases ever recorded since influenza became reportable in 2004. (iStock)
“We are seeing the highest number of flu cases ever recorded in a single week in New York state,” Health Commissioner Dr. James McDonald said in a press release.
There have been 189,312 reported flu cases so far this season, with influenza-related hospitalizations increasing 63% in the most recent week. (iStock)
Earlier this month, the department declared influenza prevalent statewide, a designation that requires unvaccinated health care workers to wear masks in patient care settings.
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Health officials continue to emphasize that vaccination remains the most effective way to prevent severe illness and hospitalization from influenza.
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New Yorkers who have not yet received a seasonal flu shot are still encouraged to do so, with experts saying vaccination can offer protection even later in the season.
Health officials continue to urge New Yorkers to take preventive steps, including vaccination and staying home when sick, to limit further spread. (iStock)
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To help limit further spread, the department advises individuals experiencing flu-like symptoms — including fever, cough, sore throat, or body aches — to stay home. State health officials also recommend frequent handwashing, using hand sanitizer, and avoiding close contact with sick individuals.
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For those who become ill, officials say antiviral medications are available and are most effective when started within 48 hours of symptom onset.
Health officials also added that people at higher risk for complications should contact a health care provider promptly for evaluation and possible treatment.
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The department noted that flu activity typically peaks in January, meaning case counts could continue to climb in the weeks ahead.
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