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Common pain relievers may raise heart disease and stroke risk, doctors warn

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Common pain relievers may raise heart disease and stroke risk, doctors warn

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Many might assume that over-the-counter (OTC) medications are generally safer than stronger prescription drugs, but research shows they can still present risks for some.

Certain common OTC painkillers have been linked to an increased risk of high blood pressure, stroke and heart attacks.

Potential risk of NSAIDs

Non-steroidal anti-inflammatory drugs (NSAIDs) — which are used to reduce pain, fever and inflammation — have been pinpointed as the class of medicines most linked to elevated cardiovascular risk.

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“This is because they reduce the production of certain chemicals called prostaglandins,” Maryam Jowza, M.D., an anesthesiologist at UNC Health in North Carolina, told Fox News Digital. “These chemicals are involved in inflammation, but they are also involved in other body functions, such as influencing the tone of blood vessels.”

Certain common OTC painkillers have been linked to an increased risk of high blood pressure, stroke and heart attacks. (iStock)

Dr. Marc Siegel, Fox News senior medical analyst, echoed the potential risk of NSAIDs. 

“They can lead to high blood pressure, heart attack and stroke via fluid retention and salt retention,” he told Fox News Digital. “This increases volume, puts a strain on the heart and raises blood pressure.”

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Common examples of NSAIDs include ibuprofen, naproxen, aspirin, diclofenac, indomethacin and celecoxib.

Randomized trials found that ibuprofen caused the biggest spikes in blood pressure, followed by naproxen and then celecoxib. 

“In general, the increase in blood pressure is more likely with higher doses and longer duration of treatment,” said Jowza, who is also an associate professor in the Department of Anesthesiology at the UNC School of Medicine.

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NSAIDs can also increase stroke risk, especially at high doses and with long-term use, the doctor added. 

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Diclofenac was linked to the highest cardiovascular risk, the doctor cautioned. Ibuprofen can also raise blood pressure and has been associated with a higher heart attack and stroke risk, but not as high as diclofenac. Naproxen carries a lower cardiovascular risk than ibuprofen or diclofenac, but is not entirely risk-free.

NSAIDs have been pinpointed as the class of medicines most linked to elevated cardiovascular risk. (iStock)

“The practical takeaway is that diclofenac is generally the least favorable choice in patients with elevated cardiovascular risk, and all NSAIDs should be used at the lowest effective dose for the shortest duration,” Dr. Nayan Patel, pharmacist and founder of Auro Wellness in Southern California, told Fox News Digital.

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Aspirin is an exception — although it is an NSAID, it actually reduces the risk of clots when taken at a low dose for prevention, under a doctor’s guidance. However, it can increase bleeding risk and blood pressure at high doses.

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Non-NSAIDs safer, but not risk-free

Non-NSAID pain relievers are commonly used for everyday aches, headaches and fever, but not swelling. They act mainly on the brain’s pain signals, not inflammation, according to medical experts.

Acetaminophen, the most common non-NSAID pain reliever, is also linked to an increase in blood pressure, although to a lesser extent, according to Jowza. 

“All NSAIDs should be used at the lowest effective dose for the shortest duration.”

“Acetaminophen was once thought to have little to no cardiovascular effects, but more recent evidence suggests it can increase blood pressure, especially with higher doses used in the long term,” she said, emphasizing the importance of blood pressure monitoring. “Its effect on stroke risk is less clear.”

Which groups are most vulnerable?

The groups at greatest risk, according to doctors, are those with existing health conditions, such as high blood pressure, prior stroke or heart disease, diabetes or kidney problems.

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“These groups are also more likely to experience NSAID-related fluid retention and destabilization of blood pressure control,” Patel said.

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Cardiovascular risk is generally higher for people 75 and older, the doctors agreed.

“Age amplifies risk largely because baseline cardiovascular risk increases with age, and kidney function reserve tends to decline,” Patel said. “Older adults are also more likely to be on antihypertensives, diuretics, antiplatelets or anticoagulants, so NSAIDs can destabilize blood pressure control and add safety complexity.”

Warning signs

Anyone experiencing chest pain, shortness of breath, sudden weakness or numbness, severe headache, confusion, slurred speech or vision changes should see a doctor immediately, Jowza advised.

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“These symptoms can point to a heart attack or stroke,” she warned. “Other symptoms of concern that may not develop as rapidly, like new swelling in the legs, should also prompt medical attention.”

Anyone experiencing chest pain, shortness of breath, sudden weakness or numbness, severe headache, confusion, slurred speech or vision changes should see a doctor immediately, a doctor advised. (iStock)

“Patients should also seek medical advice if they notice signs of fluid retention or kidney stress, such as rapidly rising blood pressure, swelling in the legs, sudden weight gain over a few days, reduced urine output or worsening shortness of breath,” Patel added.

Safer alternatives

For those at higher risk, Patel recommends non-NSAID approaches whenever possible. 

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“For many patients, this means starting with non-drug strategies such as heat or ice, physical therapy and activity modification,” he told Fox News Digital. “If medication is needed, acetaminophen is generally preferred over oral NSAIDs from a cardiovascular standpoint, although regular use should still be monitored in people with hypertension.”

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For localized joint or muscle pain, the doctor said topical NSAIDs can offer “meaningful relief” with “far lower” risk.

“Overall, pain management in high-risk patients should emphasize targeted therapy, conservative dosing and close blood pressure monitoring.”

Bottom line

The doctors emphasized that the overall risk is “very low” for people taking OTC pain relievers on a short-term basis, but it rises with long-term, high-dose use.

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“I would not hesitate to use an occasional dose if it were a low-risk individual with no prior history of heart attack or stroke,” Jowza said. “I also think short-term use in diabetics and hypertensives who are well-controlled is acceptable.”

Although aspirin is an NSAID, it actually reduces the risk of clots when taken at a low dose for prevention, under a doctor’s guidance. (iStock)

For those taking NSAIDs, the doctor suggested using “guard rails” — such as regularly testing blood pressure and kidney function, and setting limits on dosing — to make treatment as safe as possible.

Patel agreed that for most healthy individuals, occasional NSAID use “does not carry a meaningful cardiovascular risk.”

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“The concern is primarily with repeated or chronic use, higher doses, and use in people with underlying cardiovascular, kidney or blood pressure conditions,” he confirmed to Fox News Digital.

“That said, large population studies show that cardiovascular events can occur early after starting NSAIDs, particularly at higher doses, which is why even short-term use should be approached cautiously in higher-risk patients.”  

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Denise Austin Is a Fan of Walking To Lose Belly Fat—It Can Trim Your Waist 4”

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Denise Austin Is a Fan of Walking To Lose Belly Fat—It Can Trim Your Waist 4”


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Doctors reveal what ‘reasonable’ drinking looks like — and who should avoid alcohol

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Doctors reveal what ‘reasonable’ drinking looks like — and who should avoid alcohol

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With 40% of adults resolving to drink less alcohol in 2026, according to a recent survey, some may be struggling to find a healthy balance.

Health experts agree that each person’s relationship with alcohol is unique, based on history, tolerance and lifestyle.

Dr. Ezekiel Emanuel, a Pennsylvania-based oncologist and author of the new book “Eat Your Ice Cream: Six Simple Rules for a Long and Healthy Life,” has noted that indulging in certain activities – like eating ice cream or drinking alcohol – may not be healthy to do every day, but can provide some benefits in moderation.

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“There has been a lot of research on alcohol,” he said in a recent interview with “CBS Sunday Morning.” “The safest level is probably zero. There are some studies … where it’s half a cup a day, three cups a week.”

“On the other hand, 60% [to] 65% of the public drinks,” he went on. “You’re not going from 65% to zero, so you have to give people reasonable advice.”

A doctor shared “reasonable” drinking advice for striking a balanced relationship with alcohol. (iStock)

Emanuel advised against binge-drinking or drinking alone, both of which are “really bad for you.”

“[But] if you’re using alcohol as a lubricant for social interaction, which many people do, that’s probably good,” he said. “You’re getting some benefit from the social interaction.”

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When social drinking becomes risky

While drinking’s stress-relieving factors may be helpful for some, indulging in alcoholic drinks can be risky for those with a pre-disposition to addiction, experts caution.

In a recent episode of “The Huberman Lab” podcast, Dr. Andrew Huberman and guest Dr. Keith Humphreys, professor of psychiatry and behavioral sciences at Stanford School of Medicine, discussed the fine line between indulging for pleasure and potentially fostering an issue.

Experiences with alcohol can be different for every individual, experts say. (iStock)

According to Huberman, who is also a Stanford University neuroscientist, up to 10% of people experience alcohol as a “dopaminergic,” making them feel “spectacularly good.”

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Others may drink and experience a cue to stop, like dizziness, nausea, “blacking out,” severe hangovers or other negative effects.

“The safest level is probably zero.”

“Some people really can drink five or six drinks, and then the next day they’re at work hammering away,” he said. “The conversation becomes very difficult to have, because it sounds like it’s highly individual how people will react.”

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High-risk groups

One of the greatest risk factors for becoming an alcoholic is having your first drink before the age of 14, according to Huberman.

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“I find that some people will have their first drink, and it’s like a magic elixir for their physiology,” he said. “And there are very few things that can get somebody like that to stop drinking, except the risk of losing everything.”

While drinking’s stress-relieving factors may be helpful for some, indulging in alcoholic drinks can be risky for those with a pre-disposition to addiction, experts caution. (iStock)

Humphreys said the biggest indicator of personal risk is whether alcoholism runs in someone’s family — particularly if their parents were alcoholics.

“The father-to-son link is the strongest one you see in genetics,” he said. “Men drink more than women do … whether they’ve got an alcohol problem or not.”

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Drinking alcohol has been shown to be particularly harmful for women, as the risk of developing hormone-related cancers substantially increases.

Risk vs. benefit

For those who are not predisposed to addiction, Huberman noted that some studies suggest that certain types of consumption are OK in moderation, such as drinking red wine or having a maximum of two drinks per week.

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“I would love to believe [red wine] is healthy,” Humphreys responded. “It’s not … Why would there be a benefit to red wine that wasn’t in other alcoholic beverages?”

“There might be some cardiac benefits, but we don’t get to live our lives as single organs. We have a whole body,” he went on. “If that’s true, it’s smaller than the cancer risk. So, your net is you’re not going to get any mortality reduction from drinking alcohol.”

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“I would love to believe [red wine] is healthy,” one expert said. “It’s not … Why would there be a benefit to red wine that wasn’t in other alcoholic beverages?” (iStock)

Drinking two drinks per week — such as a 12-ounce beer, 4-ounce glass of wine or a 1-ounce shot of liquor — poses only a “very small risk” of health complications, but it’s not something Humphreys would recommend, as it’s “just not good for you,” he said.

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Despite the risks, however, the experts acknowledged the stress-relieving and social benefits of having a drink.

“Getting together with friends is enjoyable, enriching,” Humphreys said. “Good food and good wine taste good, and I value those things. And there are many other decisions we make like that where we endure some risk because we care about something else.”

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“It’s dangerous for someone my age to hike up a mountainside probably, but if the view is spectacular, I can say, ‘Oh, I’m going to accept that risk.’”

“Good food and good wine taste good, and I value those things.”

What’s become most dangerous about social drinking, according to Humphreys, is that some people feel they need to explain themselves when they stop.

Huberman echoed, “If you don’t drink at parties, or you refuse an offer of alcohol, people think there’s something wrong with you.”

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Given recent data on the risks of alcohol consumption, Humphreys said it should be simple to say no, much like opting not to smoke a cigarette.

“Health is a reason people still accept, I think, as a legitimate [reason] for changing behavior,” he added.

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Early peanut exposure in babies tied to sharp drop in food allergy diagnoses

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Early peanut exposure in babies tied to sharp drop in food allergy diagnoses

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Historically, parents were advised to avoid feeding peanuts to babies for the first few years of life, but emerging research has confirmed that introducing them sooner — as early as infancy — could help stave off food allergies.

A 2025 study led by the Children’s Hospital of Philadelphia analyzed medical records from dozens of pediatric practices across the U.S., finding that early introduction of peanuts resulted in a 27% decrease in peanut allergy diagnoses among children and a 38% decrease in overall food allergies.

The latest research also found that eggs had surpassed peanuts as the most common food allergen in the children studied. Beyond peanuts, other common food allergens include milk, egg and wheat.

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The new research — published in Pediatrics, the journal of the American Academy of Pediatrics, in October 2025 — focused on a two-year period after new guidance was issued by the National Institute of Allergy and Infectious Diseases, which first advised parents to introduce peanuts earlier. 

Emerging research has confirmed that introducing peanuts as early as infancy could help stave off food allergies. (iStock)

That updated guidance was based on a landmark 2015 study — the Learning Early About Peanut Allergy (LEAP) trial — which found that for infants who had severe eczema or an egg allergy, exposing them to peanuts when they were between 4 and 11 months old could reduce peanut allergy risk by 81%.

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The guidelines were updated again in 2021, encouraging the introduction of peanut, egg and other major food allergens as early as 4 to 6 months for all children — including those without a history of prior reaction, according to health experts.

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“Everyone has been wondering whether these landmark public health interventions have had an impact on reducing rates of IgE-mediated food allergies in the United States,” said first author Stanislaw Gabryszewski, M.D., Ph.D., an attending physician in the Division of Allergy and Immunology at the Children’s Hospital of Philadelphia, in a statement.

A 2025 study led by the Children’s Hospital of Philadelphia found that early introduction of peanuts resulted in a 27% decrease in peanut allergy diagnoses among children and a 38% decrease in overall food allergies. (iStock)

“We now have data that suggest the effect of this landmark public health intervention is occurring.”

The latest findings “are supportive of efforts to increase education and advocacy related to early food introduction practices,” the study authors wrote.

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“If confirmed, these findings would represent a meaningful public health advance — affirming that clinical research, when coupled with clear guidelines and committed dissemination, can indeed shift the trajectory of childhood food allergy.”

Study limitations

The study only included data through early 2019 and did not consider the guidance released in 2021, which recommended early introduction of multiple allergens regardless of risk, the researchers acknowledged.

It also relied on allergy diagnoses from electronic health records, which may miss some cases. Also, the researchers did not capture individual feeding patterns.

Parents are encouraged to discuss any concerns with their pediatrician before introducing potential food allergens. (iStock)

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Because the study was observational, it cannot prove cause and effect, but only association, the researchers noted. Other factors may influence the outcome.

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In some children, peanut allergy can trigger severe, life-threatening reactions, including difficulty breathing, swelling of the throat and a dangerous drop in blood pressure, according to Mayo Clinic. These reactions require immediate treatment with epinephrine, a life-saving allergy medication.

Not all parents may be comfortable with these revised guidelines, health experts say.

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“Not everyone has followed those guidelines, but this is further evidence that this early introduction is effective at preventing food allergies,” Dr. Susan Schuval, chief of the Division of Pediatric Allergy and Immunology at Stony Brook Children’s Hospital in New York, previously told Fox News Digital.

Parents are encouraged to discuss any concerns with their pediatrician before introducing potential food allergens.

Amy McGorry contributed reporting.

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