Health
Children with total deafness regain hearing after ‘groundbreaking’ gene therapy: ‘Like a miracle’
Five children who were born completely deaf have had some reversal of hearing loss after receiving a “groundbreaking” gene therapy.
The clinical trial, which was co-led by Mass Eye and Ear in Boston and the Eye & ENT Hospital of Fudan University in Shanghai, was the first in the world to apply gene therapy to children in both ears, according to the researchers.
The research has just been published in Nature Medicine on June 5.
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In addition to regaining their hearing, the children participating in the trial — who ranged in age from 1 to 11 years old — were also able to identify the origins and locations of sounds, even in noisy environments, researchers said.
This was a follow-up to an earlier trial that began in Dec. 2022, in which the research team successfully performed the gene therapy in just one ear. This new study showed that treating both ears led to even greater benefits.
Five children who were born completely deaf have had their hearing loss reversed after receiving a “groundbreaking” gene therapy. (Eye & ENT Hospital of Fudan University)
All the children in the study had a hereditary form of deafness called DFNB9, which is caused by mutations in the OTOF gene.
The condition occurs when the OTOF gene is unable to produce a protein called otoferlin, which is essential for transmitting sound signals from the ear to the brain.
As a result, the children could not hear or speak.
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“The children were chosen because they would benefit most from early intervention of gene therapy, especially in speech acquisition,” study author Zheng-Yi Chen, DPhil, an associate scientist in the Eaton-Peabody Laboratories at Mass Eye and Ear in Boston, told Fox News Digital in an interview.
“From a safety standpoint, however, it is more risky for children.”
How the procedure works
During the “minimally invasive” surgical procedure, the doctors administered an injection of the human OTOF gene into the children’s inner ears.
The children remained in the hospital for around seven to 10 days for observation.
“After four weeks, the kids showed hearing perception in tests, and then gradually they gained the ability to speak,” Chen said.
Dr. Yilai Shu is shown communicating with a young patient at the Eye & ENT Hospital of Fudan University. (Eye & ENT Hospital of Fudan University)
Within the families, response to sound was noticed within two to three weeks.
“All five patients have restoration of hearing, speech perception improvements, and sound source perception in noisy environments,” Chen said.
The participants experienced only low-grade adverse effects, such as fever and vomiting.
“This is the first time in history that hearing loss is being reversed by gene therapy.”
“There were no serious adverse effects,” he said. “They all recovered without any intervention.”
The gene therapy is intended to be a one-time treatment and will not need to be repeated, the researchers said, although the children will likely require speech therapy.
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Until now, there has not been any single treatment for hearing loss, other than cochlear implants, according to researcher Yilai Shu M.D., PhD, director of the Diagnosis and Treatment Center of Genetic Hearing Loss at Fudan Hospital in Shanghai.
“This is the first time in history that hearing loss is being reversed by gene therapy,” Shu told Fox News Digital. “And, of course, we believe this will have a profound impact on children’s lives.”
Dr. Yilai Shu’s team is pictured working in the lab of the Eye & ENT Hospital of Fudan University. (Eye & ENT Hospital of Fudan University)
Chang Yiyi, a mother in Shanghai whose 3-year-old son, Zhu Yangyang, participated in the trial, spoke to Fox News Digital about the experience.
“When Zhu couldn’t speak at 2 years old and didn’t have a response to sound, we realized there was a problem,” she said.
After hearing tests, it was determined that Yiyi’s son had total deafness.
“It was unbelievable — the best feeling. It was like a miracle.”
“He would get very frustrated because he couldn’t understand, couldn’t speak, couldn’t hear,” she said.
Twenty-three days after receiving the gene therapy, the boy first responded to someone calling out to him.
“It was unbelievable — the best feeling,” Yiyi told Fox News Digital. “It was like a miracle.”
“Now he can say ‘Mommy’ and ‘I want’ and some simple sentences.”
Dr. Yilai Shu (center) is pictured in the operating room at the Eye & ENT Hospital of Fudan University. (Eye & ENT Hospital of Fudan University)
Approximately 430 million people worldwide have disabling hearing loss, including 34 million children, according to the World Health Organization.
More than 50% of hearing loss cases are the result of genetics.
Gene therapy is promising but limitations exist, expert says
Dr. Amy Sarow, the Michigan-based lead audiologist at Soundly, a hearing health care marketplace, noted that gene therapy has had some success in the treatment of cancer and eye disease, along with other emerging areas.
“It is exciting to think about how gene therapy could impact millions of individuals with hearing loss worldwide,” Sarow, who was not involved in the experimental gene therapy, told Fox News Digital.
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“However, it is essential to emphasize that there are many causes of hearing loss, and one type of gene therapy will not be right for every type.”
Even among genetic causes of deafness, different genes may cause abnormalities or dysfunction that affect different auditory pathways, according to Sarow.
“Thus, development of specific treatment interventions is dependent on causality and will still take time to develop.”
Dr. Yilai Shu examines a young patient at the Eye & ENT Hospital of Fudan University. (Eye & ENT Hospital of Fudan University)
Additionally, Sarow noted, a “reversal” of hearing loss does not mean that an individual will have normal hearing ability fully restored.
“The first three years of life are very important to language acquisition, and although these children would be behind their normal-hearing peers (having spent the first few years of life profoundly deaf), they would still have the possibility to ‘catch up’ to some degree,” she said.
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“Research tells us that the younger the intervention, the better for potential language development.”
As with any intervention, there can be risks with gene therapy. “One potential risk is that treatment may not be successful in every case,” Sarow said.
“Another potential risk is that the targeted gene therapy may not work in the targeted region.”
What’s next?
The next step is to follow the trial patients for a longer time period to ensure that the positive results are stable, Shu said.
Until now, there has not been any single treatment for hearing loss, other than cochlear implants, according to one of the researchers. (iStock)
Based on the results of the first study, the researchers expect that the patients’ hearing abilities will continue to improve over time.
“Then we want to expand to older patients, and gauge how the treatment works for aging adults,” he said.
“Ultimately, we want the patient to have a choice about which treatment option they want to go with.”
The researchers also plan to start the process of seeking FDA approval to bring the gene therapy to the U.S.
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“We are working to bring this to people outside China, including the U.S., as quickly as possible,” Shu Fox News Digital.
The researchers also hope to extend this type of gene therapy to treat other types of deafness in the future.
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People who regularly visit museums or participate in creative activities may be aging more slowly on a biological level, according to a new study from the United Kingdom.
Researchers from University College London analyzed data from more than 3,500 adults and found that people who frequently engaged in arts and cultural activities showed signs of slower biological aging in several DNA-based measurements.
The findings were published in the journal Innovation in Aging.
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The study examined activities including painting, photography, dancing, singing, visiting museums and attending cultural events or historic sites.
People who frequently visit museums or engage in artistic activities may experience slower biological aging. (iStock)
Researchers compared participation in those activities with “epigenetic clocks,” scientific tools that examine chemical changes in DNA over time.
Adults who participated more often, and in a wider variety of activities, tended to show slower aging scores compared to people who rarely engaged in arts or cultural experiences.
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The association appeared even stronger among adults over age 40.
Researchers also noted that the effect sizes were comparable to those linked to physical activity, one of the most widely studied behaviors associated with healthy aging.
The study found that adults who engaged more often in arts and cultural activities showed slower biological aging. (iStock)
Jessica Mack, a health and wellness expert and founder of The Functional Consulting Group who was not involved in the study, said the findings reflect a growing understanding that health is influenced by more than exercise and nutrition alone.
“Arts and cultural engagement may be associated with slower epigenetic aging, with effects comparable in some measures to physical activity,” Mack told Fox News Digital.
She said activities such as visiting museums and engaging with music or art may help reduce stress, improve emotional regulation and increase social connection.
Experts say these activities may reduce stress, improve emotional regulation, and strengthen social connections. (iStock)
“These are not ‘extra’ lifestyle activities,” Mack said. “They may be deeply connected to how the body manages inflammation, stress hormones, mood and overall resilience.”
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Mack added that people experiencing stress, social isolation, retirement or caregiving responsibilities may especially benefit from meaningful cultural engagement.
Experts cautioned, however, that the study does not prove arts engagement directly slows aging.
“This is an observational study, not an experiment,” Professor Steve Horvath of UCLA, a longevity researcher and pioneer in epigenetic aging research who was not involved in the study, told Fox News Digital.
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“So when researchers find that the people who go to museums have younger epigenetic age, we cannot tell whether the museum visits slowed their aging, or whether their slower aging is what allowed them to keep visiting museums,” he said.
While the findings suggest a link, experts caution that the study cannot prove arts and cultural activities directly slow aging. (iStock)
Horvath said both explanations may be true to some degree, though he described the research as “methodologically careful” and worthy of further study.
The findings remained consistent even after accounting for factors such as smoking, income, body weight and other lifestyle habits.
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He added that regardless of whether arts engagement is directly slowing biological aging, staying socially and mentally active is still associated with healthier aging overall.
“The prescription is the same,” he said. “Keep going.”
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Fitness influencer and trainer Mark Langowski, known on social media as @bodybymark, hosted a pushup and plank competition in New York City this week, where he urged the public to get up and get moving.
On his platform of nearly two million Instagram followers, Langowski asks fit people to share their workout routines. He was able to meet more in-shape New Yorkers at his Washington Square Park meet-up, in partnership with Oikos yogurt on May 12.
A male and a female winner who achieved the most pushups or held a plank the longest were gifted $500 each.
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Besides the cash prize, the inspiration was to get more people moving, Langowski shared during an interview with Fox News Digital.
Fitness influencer and trainer Mark Langowski, known on social media as @bodybymark, hosted a pushup and plank competition in New York City this week, where he urged the public to get up and get moving. (Kelly McGreal/Fox News Digital)
“[It’s] a way to encourage strength and overall fitness in New York City and all around the country,” he said.
“We got together and we’re doing a plank competition, pushup competition. We had a guy just do 111 pushups. We’re just getting people moving.”
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Langowski said the attributes of a great competitor include strength, humility and confidence.
“The people who … did the most, they didn’t say they were going to do the most,” he said. “And there were other people who said they could do 150, and they did 70.”
Having a bit of humility helps make a good competitor, the trainer added.
@BodybyMark films the pushup competition’s male winner during a meet-up in Washington Square Park in New York City on May 12, 2026. (Kelly McGreal/Fox News Digital)
Pushups and planks mark a “good general baseline” for measuring fitness level, according to Langowski. Some other basics include pull-ups, squats and endurance challenges, like running a mile — the kind of basics included in an elementary school fitness assessment.
For those who haven’t yet mastered these basics but want to get in better shape, Langowski shared some advice on how to get started.
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“Get with a trainer or someone who knows how to progress you,” he advised. “A lot of people are like, ‘I can’t do a pushup, so I’m never going to do one.’ That’s not the way.”
Langowski recommends starting with pushups on your knees or against a wall, then gradually progressing to standard pushups by moving onto your toes and lowering yourself fully to the ground before pushing back up.
The trainer recommends starting with pushups on your knees or against a wall, then gradually progressing to standard pushups by moving onto your toes and lowering yourself fully to the ground before pushing back up. (Milan Markovic/iStock)
“You’ll be surprised after you do that for a couple weeks, a couple months, a couple years – you’re going to be able to do a lot,” he said. “Nobody was born being able to do 111 pushups. They put in the work and they started somewhere.”
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The trainer noted that in addition to practicing, it’s just as important to give the body rest and to support muscle growth with proper protein intake and an overall healthy diet.
But perhaps the most crucial step toward getting in shape, according to Langowski, is having the motivation to get started
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“I know that’s easy for me to say – I’ve been in fitness and been relatively fit most of my life,” he said. “And I know a lot of people are sitting on the couch and they either feel sorry for themselves or they’re going through a tough time … You’ve just got to get out there.”
The trainer noted that in addition to practicing, it’s just as important to give the body rest and to support muscle growth with proper protein intake and an overall healthy diet. (iStock)
The trainer suggested starting with a simple walk — even just around the block — with no gym equipment required.
“You don’t need an expensive gym membership to get in good shape,” he said. “Most of the people that I stop on the street, they don’t have a gym membership at all. They do it in their living room.”
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“And that’s where you can do the exercises I mentioned – the squats, the lunges, the pushups,” Langowski went on.
“So, I would encourage people just to start, but also to get some friends or get a trainer, someone to support you and do it safely.”
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Researchers have shed fresh light on how a simple, centuries-old Chinese practice could be almost as effective as some medications in lowering blood pressure.
Baduanjin is a form of exercise that’s been widely practiced in China for at least 800 years. It involves a series of eight slow movements, gentle breathing and meditation — and typically takes only about 10 minutes to complete.
In a clinical trial, researchers studied 216 adults age 40 and older with Stage 1 hypertension. Over the course of a year, participants performed either baduanjin, self-directed exercise or brisk walking.
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Researchers found that participants who practiced baduanjin five times per week experienced lower blood pressure within three months.
The results were “comparable to reductions seen with some first-line medications,” they wrote in their report published by the American College of Cardiology.
High blood pressure, if left untreated, can lead to heart attack and stroke. Now, researchers have shed new light on how a simple, centuries-old Chinese practice could be almost as effective as some medications in lowering blood pressure. (andreswd/Getty Images)
Baduanjin also showed “comparable results and safety profile to brisk walking at one year,” the researchers further reported.
“Given its simplicity, safety and ease at which one can maintain long-term adherence, baduanjin can be implemented as an effective, accessible and scalable lifestyle intervention for individuals trying to reduce their [blood pressure],” said the senior author of the study, Jing Li, M.D., Ph.D.
Dr. Matthew Saybolt, medical director of the Hackensack Meridian Jersey Shore University Medical Center’s Structural Heart Disease Program, said he was surprised by an aspect of the study’s results.
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“I was biased and expected that higher intensity exercise like brisk walking would have resulted in greater improvement in blood pressure than baduanjin, but the effects were the same,” Saybolt told Fox News Digital. (He was not affiliated with the study.)
Dr. Antony Chu, clinical assistant professor at Brown University’s Warren Alpert School of Medicine, was born and raised in the U.S. to immigrant parents — his mother is from Hong Kong and his father is from Taiwan.
Practitioners of baduanjin, such as those in this class, incorporate slow movements with mindful breathing. (Xinhua News Agency/Getty Images)
Having spent a lot of summers in Asia, Chu told Fox News he experienced “the best of both worlds” concerning Eastern and Western medicine, including exposure to the benefits of baduanjin.
“[These researchers] are taking a lot of things that have been commonplace for many, many centuries or millennia and then just applying mathematical modeling and statistical analysis to sort of give [them] some credibility,” Chu said.
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“Western medicine is reactionary,” Chu also said.
He compared the philosophies to a house on fire: Eastern medicine practitioners are more invested in preventing the fire, whereas Western medicine is more focused on “all those things that it would need to do to try to put that fire out,” he said, sharing his opinion.
A new study shows how people with high blood pressure can reduce it without medicine. (FG Trade/Getty Images)
Left untreated, high blood pressure has dangers that are “too numerous to count,” Saybolt said. The risks include increased risks of stroke, heart attack, atrial fibrillation and congestive heart failure.
Baduanjin, Chu said, is effective at reducing blood pressure, which he likened to “the water pressure and the pipes of your house,” by calming the nervous system and reducing stress.
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“People are totally stressed out,” Chu said. “And stress reduction is huge.”
Saybolt said the study offers hope for people with hypertension — “and that hope doesn’t immediately have to include pharmaceuticals.”
Baduanjin is easily incorporated into most lifestyles and can be done without equipment almost anywhere and at any time. (Getty Images)
Saybolt added that he’s always advocated for lifestyle modifications, including healthy diet and exercise, “as key therapies for treatment of diseases and to improve longevity.”
With the baduanjin data, Saybold said he is now “more optimistic than ever,” as “we have evidence that a very low impact exercise with mindfulness can yield a benefit.”
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Chu said that translating overwhelming medical guidelines is a big part of his job.
“It’s not to just tell somebody, ‘Hey, your blood pressure’s too high, pick a pill,” he said.
Baduanjin has been a preventative health practice the Chinese have been incorporating into their routines for centuries. (Xinhua News Agency/Getty Images)
“Lifestyle changes” can be daunting for many people, he added.
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“They always make it sound like you have to live for seven years in Tibet on a mountain somewhere, and it’s really not that.”
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His simple translation for the baduanjin study is this: “Close the door in your office and just say, ‘I can’t be bothered for 10 minutes,’ and just focus on breathing slowly and moving your arms or legs around.”
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