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CDC warns of ‘dual mutant’ flu strain that could evade antiviral drugs: ‘Need to closely monitor’

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CDC warns of ‘dual mutant’ flu strain that could evade antiviral drugs: ‘Need to closely monitor’

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A new “dual mutant” strain of H1N1 influenza could pose a threat in the U.S., according to the Centers for Disease Control and Prevention (CDC).

Details about the two strains, I223V and S247N, were published in the journal Emerging Infectious Diseases, which is published by the CDC.  

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At least two cases of the flu mutations have been confirmed in humans in the U.S., the agency announced on Wednesday.

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The researchers identified a total of 101 samples of the “dual mutant” virus.

The concern is that these strains of flu have shown to be resistant to the antiviral medications that are typically used to treat the virus — notably Tamiflu (oseltamivir), the common flu medication from Switzerland-based Roche.

A new “dual mutant” strain of H1N1 influenza could pose a threat in the U.S., according to the Centers for Disease Control and Prevention. (iStock)

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“The dual mutants that we tested retained susceptibility to other approved influenza antiviral drugs, including baloxavir,” the researchers wrote in the study findings.

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“Our study highlights the need to closely monitor the evolution of dual mutants, because additional changes may further affect susceptibility to antiviral drugs or provide a competitive advantage over circulating wild-type viruses.”

The strains have been detected in 15 countries across five continents, but are mostly prevalent in Europe, the study found.

Flu virus

“The dual mutants that we tested retained susceptibility to other approved influenza antiviral drugs, including baloxavir,” the researchers wrote. (iStock)

The researchers determined that the mutations have been circulating globally since May 2023.

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I223V and S247N were first tested by Hong Kong scientists, who published their findings in The Lancet Microbe in March 2024. 

Those researchers also found that the mutant strains lessened the effectiveness of Tamiflu.

                                            

Dr. Marc Siegel, clinical professor of medicine at NYU Langone Medical Center and a Fox News medical contributor, said it is “highly unusual” to see an influenza A strain (H1N1, which is a distant cousin of the Spanish flu, he noted) spreading throughout southern U.S. states at this time of year. 

woman blowing nose

People who contract the flu can take antiviral medications to ease symptoms, the CDC stated, which is most important for high-risk patients. (iStock)

“Flu season is usually over by March,” Siegel told Fox News Digital. “Flu doesn’t spread as easily in hot, humid weather.”

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He added, “This mutation worries me because the use of Tamiflu — especially in high-risk groups and the elderly — is really helpful at decreasing severity, and it looks like the reaction to it is less.”

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The doctor said he would still recommend using the drug, however, because it has some impact — “or consider other anti-flu drugs.”

Siegel also advised a vaccine booster for the elderly or those in high-risk groups.

Woman getting vaccine

The CDC recommends that everyone 6 months and older receives an annual vaccine during heightened flu spread. (iStock)

So far this season, the CDC estimates that there have been at least 35 million illnesses, 390,000 hospitalizations and 24,000 deaths from the flu, as published on the agency’s website.

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The CDC recommends that everyone 6 months and older receives an annual vaccine during heightened flu spread.

For more Health articles, visit www.foxnews/health 

People who contract the flu can take antiviral medications to ease symptoms, the CDC stated, which is most important for high-risk patients.

Fox News Digital reached out to Roche and to the CDC for additional comment.

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Drinking alcohol is linked to six types of cancer, experts say: ‘It’s toxic’

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Drinking alcohol is linked to six types of cancer, experts say: ‘It’s toxic’

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It’s long been known that no amount of alcohol is good for the body — and now new research spotlights the potential harm it can cause.

More than 5% of all cancer cases are caused by drinking alcohol, according to the Cancer Progress Report 2024 from the American Association for Cancer Research (AACR).

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Among the modifiable risk factors for cancer, alcohol is the third biggest, behind obesity (7.6% of cases) and cigarette smoking (19.3%).

TO REDUCE CANCER RISK, SKIP THE ALCOHOL, REPORT SUGGESTS

“Excessive levels of alcohol consumption increase the risk for six different types of cancer, including certain types of head and neck cancer, esophageal squamous cell carcinoma, and breast, colorectal, liver and stomach cancers,” said Rajarshi Sengupta, PhD, lead author of the AACR Cancer Progress Report 2024, in a statement sent to Fox News Digital.

More than 5% of all cancer cases are caused by drinking alcohol, according to the Cancer Progress Report 2024 from the American Association for Cancer Research. (iStock)

“Further, research shows that alcohol intake at an early age can increase the risk of cancer later in life.”

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Based on these findings, limiting or eliminating alcohol can reduce the risk of developing alcohol-related cancers by 8% and the risk of all cancers by 4%, the report noted.

Addiction expert warns of risks

There has been a “roller coaster of information” about whether alcohol is harmful, according to addiction psychiatrist Dr. Adam Scioli of Caron Treatment Centers in Pennsylvania.

“There have even been reports for years that it could be beneficial for one’s health — but we know now that alcohol ingestion is one of the modifiable risk factors for cancer,” Scioli, who is not affiliated with AACR, told Fox News Digital.

‘DOES SMARTPHONE EXPOSURE CAUSE BRAIN CANCER?’: ASK A DOCTOR

Around 75,000 Americans each year are diagnosed with a cancer that is linked in some way to alcohol use, according to Scioli. 

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The more someone drinks — both in volume and frequency — the higher the risk, he warned.

Doctor holding lung x-ray and woman smoking

Among the modifiable risk factors for cancer, alcohol is the third biggest, behind obesity (7.6% of cases) and cigarette smoking (19.3%). (iStock)

“Alcohol is a toxin,” Scioli said. 

“We’ve long known that it impacts any number of organs, essentially starting with the brain and working its way down to the colorectal system.”

Is there a ‘safe’ amount?

Moderate alcohol use is defined as one drink or less in one day for women. 

For men, it is two drinks or fewer per day, according to the Centers for Disease Control and Prevention (CDC).

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“We’ve long known that alcohol impacts any number of organs, starting with the brain and working its way down to the colorectal system.”

“Drinking alcohol in moderation may increase your overall risks of death and chronic disease,” the agency stated on its website.

“Even low levels of alcohol use (less than one drink per day) can raise the risk of certain cancers.”

      

Scioli agreed, emphasizing that “we can definitely say there’s no added health benefit to ingestion of alcohol.”

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“The line between safety and danger is debatable, and is different for each person.”

While risk factors like tobacco use are widely known, public awareness about the link between alcohol and cancer is still low, according to Sengupta.

alcoholic beverages

Moderate alcohol use is defined as one drink or less in one day for women, and two drinks or fewer for men, per the CDC. (iStock)

Most Americans (51%) are not aware that alcohol increases cancer risk, per AACR data.

“It’s been flying under the radar for far too long — especially given the number of Americans who have met the criteria for alcohol use disorder, which is around 29 million Americans in 2023,” said Scioli.

What needs to change?

The good news, according to Scioli, is that with modifiable risk factors like alcohol, reducing the intake decreases the risk. 

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As the report stated, those who are successful in decreasing their drinking or abstaining below those moderate risk levels will see a risk reduction in overall cancers, he noted.

cancer patient looks out window

Around 75,000 Americans each year are diagnosed with a cancer that is linked in some way to alcohol use, an expert said. (iStock)

“We need to do a much better job of making the public aware of the risks inherent in drinking — particularly moderate to heavy drinking,” Scioli said. 

“And we need to make the public aware that there are mechanisms by which they can access help if they are unable to moderate their drinking or quit on their own.”

For more Health articles, visit www.foxnews.com/health

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To help raise awareness, Sengupta of the AACR called for public messaging campaigns, “such as cancer-specific warning labels displayed on alcoholic beverages.”

Along with that, she told Fox News Digital, “effective clinical strategies that reduce or eliminate alcohol consumption must be considered to reduce the burden of alcohol-related cancers.”

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Intermittent Fasting + Walking: The Science-Backed Combo That Helped This Grandma Lose 3X the Weight

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Intermittent Fasting + Walking: The Science-Backed Combo That Helped This Grandma Lose 3X the Weight


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New schizophrenia drug gets FDA approval, taking novel approach to treating brain disorder

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New schizophrenia drug gets FDA approval, taking novel approach to treating brain disorder

A new drug has been approved for the treatment of schizophrenia in adults.

On Thursday, the U.S. Food and Drug Administration (FDA) approved COBENFY (xanomeline and trospium chloride), an oral medication that is manufactured by Bristol Myers Squibb in New Jersey.

This marks the first new class of medications for the brain disorder in several decades, according to a press release.

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COBENFY is expected to be available in the U.S. in late October, the company noted.

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A new drug has been approved for the treatment of schizophrenia in adults. (iStock)

“Today’s landmark approval of our first-in-class treatment for schizophrenia marks an important milestone for the community, where after more than 30 years, there is now an entirely new pharmacological approach for schizophrenia — one that has the potential to change the treatment paradigm,” said Chris Boerner, PhD, board chair and chief executive officer at Bristol Myers Squibb, in the press release.

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Schizophrenia is a serious mental illness that affects a person’s thoughts, feelings and behaviors.

It often causes hallucinations, delusions, disordered speech and loss of touch with reality, Mayo Clinic states on its website.

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COBENFY

COBENFY (xanomeline and trospium chloride) is an oral medication that is manufactured by Bristol Myers Squibb in New Jersey. (Bristol Myers Squibb)

The disorder can also lead to lack of emotional expression, lack of motivation, cognitive dysfunction and social withdrawal.

Approximately 2.8 million people in the U.S. and 24 million people globally are living with schizophrenia.

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The disorder has traditionally been treated with antipsychotic medications, but around 40% of patients do not respond to treatments and 60% experience “inadequate improvement” in symptoms or “intolerable side effects,” studies have shown.

COBENFY

COBENFY is expected to be available in the U.S. in late October, the company noted. (Bristol Myers Squibb)

COBENFY works differently than the currently available schizophrenia medications.

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“Due to its heterogeneous nature, schizophrenia is not a one-size-fits-all condition, and people often find themselves in a cycle of discontinuing and switching therapies,” said Rishi Kakar, MD, chief scientific officer and medical director at Segal Trials and investigator in the drug’s clinical trials, in the release. 

“Schizophrenia is not a one-size-fits-all condition, and people often find themselves in a cycle of discontinuing and switching therapies.”

“The approval of COBENFY is a transformative moment in the treatment of schizophrenia because, historically, medicines approved to treat schizophrenia have relied on the same primary pathways in the brain.”

“By leveraging a novel pathway, COBENFY offers a new option to manage this challenging condition.”

Bristol Myers Squibb

“Today’s landmark approval of our first-in-class treatment for schizophrenia marks an important milestone for the community,” said Chris Boerner, PhD, board chair and chief executive officer at Bristol Myers Squibb. (iStock)

Sam Clark, founder and CEO at Terran Biosciences — a biotech company that develops treatments and technologies for neurological and psychiatric diseases in New York City — commented on the new approval in a statement sent to Fox News Digital.

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“I am excited that the FDA has just approved [COBENFY] as a treatment for patients with schizophrenia, marking a big leap forward in the psychiatry space,” he said. 

      

“These patients live with a difficult disease, and this drug with a novel mechanism of action will surely make a significant impact,” Clark continued. 

“We look forward to seeing the renaissance continue as this approval paves the way for future breakthroughs and novel patient-focused therapeutics.”

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The approval follows three phases of clinical trials in which COBENFY was shown to result in a “statistically significant improvement in illness.”

schizophrenia split

Schizophrenia is a serious mental illness that affects a person’s thoughts, feelings and behaviors and often causes hallucinations and delusions. (iStock)

In terms of safety, the medication’s most common side effects during clinical trials were nausea, indigestion, vomiting, diarrhea, constipation, hypertension, abdominal pain, accelerated heart rate, dizziness and gastroesophageal reflux disease, the release stated.

Patients with certain existing medical conditions may experience other, more serious risks.

For more Health articles, visit www.foxnews.com/health

People should discuss potential complications with a doctor before starting the medication.

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Fox News Digital reached out to Bristol Myers Squibb and the Schizophrenia & Psychosis Action Alliance requesting comment.

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