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Brain health warning sign could be hiding in plain sight, say researchers

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Brain health warning sign could be hiding in plain sight, say researchers

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A new study from the University of Southern California suggests that the way blood pressure fluctuates from one heartbeat to the next may be just as important as the overall blood pressure reading — especially when it comes to brain health in aging adults.

Researchers found that older adults who experienced greater beat-to-beat changes in blood pressure had smaller brain volumes in areas tied to memory, and higher levels of a protein linked to nerve-cell injury.

“Even when blood pressure is well-controlled with medication, the rapid fluctuation in blood pressure from heartbeat to heartbeat is associated with worse memory and signs of brain shrinkage and brain cell injury,” USC Professor Daniel Nation, senior author of the study, told Fox News Digital.

The study linked rapid blood pressure shifts to smaller memory-related brain regions in older adults. (iStock)

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“Blood pressure isn’t static; it’s always adapting to the body’s needs,” he added in a press release. “But as we age, that regulation can become less precise.”

The study included 105 adults between the ages of 55 and 89. The researchers measured the participants’ blood pressure continuously for several minutes while they underwent brain scans. 

SCIENTISTS UNCOVER HOW SOME 80-YEAR-OLDS HAVE THE MEMORY OF 50-YEAR-OLDS

In particular, they measured the stiffness of the adults’ arteries and how much their blood pressure changed between heartbeats.

Even when participants’ average blood pressure seemed healthy, those with the most erratic readings — combined with stiffer arteries — showed telltale signs of brain aging, the study found.

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People with erratic readings had smaller hippocampal and entorhinal cortex regions, which are among the first areas of the brain affected in Alzheimer’s disease.  (iStock)

Specifically, they had smaller hippocampal and entorhinal cortex regions, which are among the first areas of the brain affected in Alzheimer’s disease. They also had higher blood levels of neurofilament light, a biomarker of nerve-cell damage.

These findings were described as significant even after taking into account factors like age, sex and average blood pressure — suggesting that the fluctuations themselves, and not just overall pressure, may be a key risk factor.

The findings were first published online in the Journal of Alzheimer’s Disease on Oct. 17.

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For years, doctors have warned that high blood pressure raises dementia risk, but the USC study explores specifically how moment-to-moment instability can be a cause for concern.

Nation said the researchers were surprised to find that these rapid fluctuations in blood pressure were linked to brain injury, “regardless of whether they have hypertension or are treated with blood pressure-lowering medications.”

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In other words, someone could have “good” readings at the doctor’s office and still have dangerous spikes and dips that quietly stress the brain’s delicate blood vessels, the research suggests. Over time, that instability could contribute to memory decline and neurodegeneration.

Even well-controlled blood pressure may not protect against brain changes if readings fluctuate too much, the study suggests. (iStock)

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The researchers emphasized, however, that this study only shows correlation and does not prove causation, and that more research is needed.

“The findings are correlations in a cross-sectional study, which is like a snapshot in time,” Nation said. “Future studies should examine how these rapid blood pressure fluctuations change over time and whether they predict future brain shrinkage, brain cell injury and memory decline.”

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The team says there are currently no treatments specifically for these fluctuations.

“But it remains very important that people monitor their blood pressure and take blood pressure-lowering medications as prescribed in order to reduce their risk for brain injury and memory decline,” Nation said.

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“Development of therapies to address rapid blood pressure fluctuations should be a priority, since these rapid fluctuations are not fully addressed by existing treatments that focus on lowering average blood pressure,” he added.

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The Best Time To Drink Coffee for Weight Loss and a Faster Metabolism

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The Best Time To Drink Coffee for Weight Loss and a Faster Metabolism


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‘SuperAgers’ stay mentally sharp well past 80, as scientists reveal the reason

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‘SuperAgers’ stay mentally sharp well past 80, as scientists reveal the reason

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→ Some 80-year-olds still have razor-sharp brains — and now scientists know why

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→ 5 ways to preserve vision as you age, according to an ophthalmologist

SuperAger Ralph Rehbock sits with his wife in his home.  (Shane Collins, Northwestern University)

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A doctor says the second wave of flu season may be worse than previous years. (iStock)

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Stat of the week

More than 59% of women may have high blood pressure by 2050, according to a new report from the American Heart Association.

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Heart disease threat projected to climb sharply for key demographic

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Heart disease threat projected to climb sharply for key demographic

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A new report by the American Heart Association (AHA) included some troubling predictions for the future of women’s health.

The forecast, published in the journal Circulation on Wednesday, projected increases in various comorbidities in American females by 2050.

More than 59% of women were predicted to have high blood pressure, up from less than 49% currently.

The review also projected that more than 25% of women will have diabetes, compared to about 15% today, and more than 61% will have obesity, compared to 44% currently.

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As a result of these risk factors, the prevalence of cardiovascular disease and stroke is expected to rise to 14.4% from 10.7%.

The prevalence of cardiovascular disease and stroke in women is expected to rise to 14.4% from 10.7% by 2050. (iStock)

Not all trends were negative, as unhealthy cholesterol prevalence is expected to drop to about 22% from more than 42% today, the report stated.

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Dr. Elizabeth Klodas, a cardiologist and founder of Step One Foods in Minnesota, commented on these “jarring findings.”

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“The fact that on our current trajectory, cardiometabolic disease is projected to explode in women within one generation should be a huge wake-up call,” she told Fox News Digital.

NEARLY 90% OF AMERICANS AT RISK OF SILENT DISEASE — HERE’S WHAT TO KNOW

“Hypertension, diabetes, obesity — these are all major risk factors for heart disease, and we are already seeing what those risks are driving. Heart disease is the No. 1 killer of women, eclipsing all other causes of death, including breast cancer.”

Cardiovascular disease is the leading cause of death for women in the U.S. and around the world. (iStock)

Klodas warned that heart disease starts early, progresses “stealthily,” and can present “out of the blue in devastating ways.”

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The AHA published another study on Thursday revealing one million hospitalizations, showing that heart attack deaths are climbing among adults below the age of 55.

The more alarming finding, according to Klodas, is that young women were found more likely to die after their first heart attack than men of the same age.

DOCTOR SHARES 3 SIMPLE CHANGES TO STAY HEALTHY AND INDEPENDENT AS YOU AGE

“This is all especially tragic since heart disease is almost entirely preventable,” she said. “The earlier you start, the better.”

Children can show early evidence of plaque deposition in their arteries, which can be reversed through lifestyle changes if “undertaken early enough and aggressively enough,” according to the expert.

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Moving more is one part of protecting a healthy heart, according to experts. (iStock)

Klodas suggested that rising heart conditions are associated with traditional risk factors, like smoking, high blood pressure, high cholesterol, diabetes, obesity and a sedentary lifestyle.

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Doctors are also seeing higher rates of preeclampsia, or high blood pressure during pregnancy, as well as gestational diabetes. Klodas noted that these are sex-specific risk factors that don’t typically contribute to complications until after menopause.

The best way to protect a healthy heart is to “do the basics,” Klodas recommended, including the following lifestyle habits.

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Klodas especially emphasized making improvements to diet, as the food people eat affects “every single risk factor that the AHA’s report highlights.”

“High blood pressure, high blood sugar, high cholesterol, excess weight – these are all conditions that are driven in part or in whole by food,” she said. “We eat multiple times every single day, which means what we eat has profound cumulative effects over time.”

“Even a small improvement in dietary intake, when maintained, can have a massive positive impact on health,” a doctor said. (iStock)

“Even a small improvement in dietary intake, when maintained, can have a massive positive impact on health.”

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The doctor also recommends changing out a few snacks per day for healthier choices, which has been proven to “yield medication-level cholesterol reductions” in a month.

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“Keep up that small change and, over the course of a year, you could also lose 20 pounds and reduce your sodium intake enough to avoid blood pressure-lowering medications,” Klodas added.

“Women should not view the AHA report as inevitable. We have power over our health destinies. We just need to use it.”

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