Health

Alzheimer’s risk declines sharply with one daily lifestyle change, researchers say

Published

4 months ago

November 28, 2025

Alzheimer’s risk declines sharply with one daily lifestyle change, researchers say

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Increasing physical activity in midlife or later may reduce the chances of developing dementia by up to 45%, according to a recent study published in JAMA Network Open.

Researchers at the Boston University School of Public Health analyzed data from more than 4,300 people in the Framingham Heart Study Offspring, all of whom were dementia-free at the start of the study.

The individuals completed a questionnaire reporting their amount of sleep and level of physical activity (sedentary, slight, moderate or heavy), according to the study report.

DEMENTIA RISK COULD BE LINKED TO WALKING SPEED, STUDY SUGGESTS

Study design and key findings

The researchers analyzed the individuals’ physical activity throughout three life stages — early adult (ages 26-44 years), midlife (45-64 years) and late life (65-88 years).

Increasing physical activity in midlife or later may reduce the chances of developing dementia by up to 45%, according to a recent study published in JAMA Network Open. (iStock)

They followed the participants for an average span of 37.2, 25.9 and 14.5 years, respectively, to monitor the onset of Alzheimer’s and other types of dementia.

Those in the top two quintiles of midlife physical activity were associated with a 40% lower all-cause dementia risk over a 26-year period, compared to those with the lowest activity level.

RATES OF DEMENTIA ARE LOWER IN PEOPLE WHO EAT THIS SPECIFIC DIET, RESEARCH SHOWS

People in the top two quintiles of late-life physical activity were associated with a 36% to 45% lower dementia risk over 15 years.

Thise with the highest midlife physical activity were associated with a 40% lower all-cause dementia risk over a 26-year period, compared to those with the lowest activity level. (iStock)

“These results may help to inform more precise and effective strategies to prevent or delay the onset of dementia in later life, and support evidence that the benefits of physical activity on the brain may extend to earlier in life than previously thought,” study author Phillip Hwang, Ph.D., from the Department of Epidemiology at the Boston University School of Public Health, told Fox News Digital.

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Higher activity in midlife was associated with lower dementia risk only in people without APOE4, a genetic variant linked to higher Alzheimer’s risk.

However, this was not the case with the late-life higher activity group, which showed reduced dementia risk among both APOE4 carriers and those without the gene, according to the study.

The exercise-brain link

“There are several possible mechanisms through which physical activity is thought to lower the risk of dementia, such as improving brain structure and function, reducing inflammation and exerting benefits on vascular function,” Hwang told Fox News Digital.

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Physical activity may also directly impact Alzheimer’s disease pathology, such as the buildup of toxic beta-amyloid in the brain, according to the researcher.

Physical activity may also directly impact Alzheimer’s disease pathology, such as the buildup of toxic beta-amyloid in the brain. (iStock)

“These potential mechanisms may contribute to facilitating cognitive reserve, which can delay late-life cognitive impairment.”

More research is needed to understand whether these possible causes all happen at the same time throughout a person’s life, or if different causes emerge at different stages, the researchers said.

Expert reactions

Dr. Cathryn Devons, M.D., who specializes in geriatric medicine at Phelps Hospital Northwell Health in Sleepy Hollow, New York, was not part of the study but commented on the findings.

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Exercise can lower the risk of hypertension, stroke, vascular disease, cholesterol levels and diabetes — “all the things that put you at risk for circulatory problems to the brain,” she told Fox News Digital.

The doctor also noted that exercise is known to help to reduce inflammation, which can protect brain health.

Study limitations

One limitation of the study is that physical activity was based on self-reporting, Hwang told Fox News Digital.

Physical activity may also directly impact Alzheimer’s disease pathology, such as the buildup of toxic beta-amyloid in the brain. (AP Photo/Evan Vucci, File)

“While we can say from these results that higher levels of overall physical activity are associated with reduced dementia risk, these results cannot translate well to recommendations about specific exercise types,” he said.

Also, the level of physical activity in early adulthood was not linked with all-cause dementia or Alzheimer’s dementia.

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“We may have been underpowered to detect associations with early adult life physical activity due to the small number of dementia cases in this age group,” the authors noted.

Devons agreed that while the study may have limitations, it supports the idea of exercise lowering the risk of dementia.

Amy McGorry is a contributing health writer for Fox News Digital. Follow her on Twitter @amymcgorry.

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Health

Another state bans ‘gas station heroin’ as officials warn of deadly risks

Published

4 hours ago

March 27, 2026

Press Room

Another state bans ‘gas station heroin’ as officials warn of deadly risks

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Conversation-starters

→ March Madness sparks surprising surge in men’s sexual procedure

→ Cannabis benefits called into question in major study

→ ‘Call a Boomer’ payphones help cure loneliness across generations

Along a bustling sidewalk in Boston, a bright yellow payphone invites folks to “Call a Boomer.” (Matter Neuroscience)

Food for thought

→ Eating meat tied to lower dementia risk, study suggests

→ Stomach issues might have nothing to do with eating habits

→ Why your sugar cravings won’t go away, even after cutting sweets

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This article was written by Fox News staff.

Health

Dementia risk signals could lie in simple blood pressure readings, researchers say

Published

16 hours ago

March 27, 2026

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Dementia risk signals could lie in simple blood pressure readings, researchers say

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Simple measurements taken during routine blood pressure checks could predict dementia risk years before symptoms appear.

That’s according to new research presented this week at the American College of Cardiology’s Annual Scientific Session in Louisiana.

The findings draw on two studies led by researchers at Georgetown University, which suggest that monitoring how blood vessels age and stiffen over time can provide a window into future cognitive health.

LURKING DEMENTIA RISK EXPOSED BY BREAKTHROUGH TEST 25 YEARS BEFORE SYMPTOMS

Data shows rates of dementia and aging-related cognitive decline are expected to increase as populations age, and half of U.S. adults have high blood pressure (hypertension).

Scientists believe that efforts to better address hypertension, a key contributor to heart disease and a risk factor for dementia, could affect both cardiac and brain health.

Data shows rates of dementia and aging-related cognitive decline are expected to increase as populations age. Meanwhile, half of U.S. adults have high blood pressure. (iStock)

“Blood pressure management isn’t just about preventing heart attacks and strokes; it may also be one of the most actionable strategies for preserving cognitive health,” Dr. Newton Nyirenda, the study’s lead author and an epidemiologist at Georgetown University in Washington, said in a press release.

The research focused on two metrics, the pulse pressure-heart rate index and estimated pulse wave velocity. Both were calculated using data collected during standard doctor visits, such as heart rate, age and blood pressure.

“Blood pressure management isn’t just about preventing heart attacks and strokes; it may also be one of the most actionable strategies for preserving cognitive health.”

Researchers examined five years of data patterns for more than 8,500 people in the SPRINT trial, a large study of adults 50 years and older with hypertension. In the follow-up, 323 of the participants developed probable dementia.

HIDDEN BRAIN CONDITION MAY QUADRUPLE DEMENTIA RISK IN OLDER ADULTS, STUDY SUGGESTS

In one study, the team found the pulse pressure-heart rate index was a strong independent predictor of dementia risk in adults over 50. For participants under 65, every one-unit increase was associated with a 76% higher risk of developing dementia.

For participants under 65, an increase in the pulse pressure-heart rate index was associated with a 76% higher risk of developing dementia. (iStock)

The second study found that adults with consistently elevated or rapidly increasing pulse wave velocity were more likely to develop dementia than those with stable velocity, even after accounting for factors like smoking, gender and cardiovascular history.

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“Our findings suggest that vascular aging patterns may provide meaningful insight into future dementia risk,” said Nyirenda. “This reinforces the idea that managing vascular health earlier in life may influence long-term brain health.”

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The team emphasized that clinicians should tailor risk assessments and treatment strategies to the individual.

Further studies are needed to confirm these parameters and determine whether changing vascular aging trajectories reduces dementia risk. (iStock)

“You don’t want to wait until a patient starts manifesting cognitive decline before you act,” said senior study author Sula Mazimba, an associate professor at the University of Virginia.

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Researchers noted the study could not establish causation. Other limitations included the fact that participants already had hypertension and elevated cardiovascular risk, meaning the findings may not apply to people without those conditions.

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Further studies are needed to confirm these findings and to determine whether improving blood vessel health over time could reduce dementia risk.

Khloe Quill is a lifestyle production assistant with Fox News Digital. She and the lifestyle team cover a range of story topics including food and drink, travel, and health.

Health

Everything You Need To Know About Zepbound for Weight Loss, Including Costs

Published

1 day ago

March 26, 2026

Press Room

Everything You Need To Know About Zepbound for Weight Loss, Including Costs

What Is Zepbound? Weight-Loss Benefits, Costs and Dosage

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