Published March 25, 2026 12:36PM
Fitness
What Happens to Your Body When You Take Ozempic Without Exercising
Losing weight doesn’t necessarily make you fitter, a new study finds.
(Photo: Oleg Breslavtsev / Getty)
Is exercise obsolete in the age of Ozempic? Now that the initial hype has settled down, nobody makes that claim with a straight face. In fact, one of the big fears among people taking GLP-1 agonists (the class of drug to which Ozempic belongs) is that they’ll lose too much muscle along with all the fat, leaving them weaker and less healthy. But at this point, there’s very little data on what happens when you combine these drugs with an exercise routine (or lack thereof).
A newly published study in the journal Sports Medicine steps into this gap. It’s a secondary analysis of data from a previously published study by researchers at the University of Copenhagen in Denmark, funded in part by the Novo Nordisk Foundation (Novo Nordisk is the company that makes Ozempic). The study follows volunteers taking another Novo Nordisk GLP-1 agonist called liraglutide (sold under the brand names Victoza and Saxenda) for an entire year, with or without the addition of a regular exercise program. The results show that without exercise, both health and physical function suffer—and it’s not just about muscle.
What the GLP-1 Study Found
The study involved 193 adults between the ages of 18 and 65. It’s a little unusual in that they started by following an eight-week very-low-calorie diet before starting either exercise or the GLP-1 drug. That’s because the original study was designed to look at ways of maintaining weight loss. Everyone included in the study lost at least 5 percent of their starting weight, which resulted in an average weight loss of 29 pounds. Then, for the following year, they either exercised, took the GLP-1 drug, did both, or did neither. (Those who didn’t get the drug got a placebo.)
The exercise program involved two group exercise classes per week, including 30 minutes of intervals on an exercise bike, then 15 minutes of circuit training (step-ups, boxing, squats, kettlebells, and so on). The subjects were also asked to do two additional workouts on their own; the details were up to them, but most chose running, cycling, brisk walking, or circuits. Adherence was decent: they averaged 2.65 workouts a week and met standard public health guidelines for physical activity.
The first outcome of interest (as reported in the original analysis) is weight. Here’s the trajectory of the four groups:
Doing nothing was the worst option. Exercising and taking a GLP-1 drug was the best option. If you had to choose one or the other, the drug looks marginally better, though the difference wasn’t statistically significant.
Does Fitness or Fatness Matter More?
There’s a longstanding debate about the relative health effects of being overweight versus being aerobically unfit. The two often go together, so they get conflated—but they’re not the same thing. The general trend of evidence, according to the Danish research team, is that it’s better for health and longevity to be fit and overweight than unfit and normal weight. This distinction is important in the context of GLP-1 drugs, because if they help you lose weight without gaining fitness, then the health benefits may be less than you’d expect.
Figuring out how to measure fitness in this context isn’t straightforward. When you lose weight, you’ll generally lose some muscle mass in addition to fat loss. Both strength and aerobic fitness (as measured by VO2 max) are roughly proportional to muscle mass, so your absolute fitness might appear to decline when you lose a lot of weight. But if you lose less strength or fitness in proportion to your overall weight loss, you’ll still end up with greater functional fitness: you’ll have an easier time getting up from a chair, be able to walk for longer, and so on.
One of the simple functional tests the Danish study included was a stair-climb test: climb up and down an 11-step stairway twice, as fast as possible. Here’s what those results looked like:
It’s clear here that the exercise program helped people speed up and down the stairs more quickly, whether or not they were taking the GLP-1 drug. Just taking the drug without exercising didn’t have any benefit.
There are a whole bunch of other fitness measures in the paper: VO2 max tests, leg strength tests, body composition tests to measure muscle mass in the arms and legs. The fitness outcomes can be expressed in absolute terms, or relative to total body weight, or relative to muscle mass. No matter how you express it, the overall pattern, with a few minor exceptions, is the same as the graph above: exercise makes you fitter, simply taking the drug doesn’t.
(An example of a minor exception: the drug alone was enough to improve relative leg strength, i.e. leg strength divided by total body weight, because weight decreased more than strength. But adding exercise worked even better.)
This conclusion—that the best way to get fitter is to exercise—is not exactly surprising. But I think it has been overlooked in discussions about GLP-1 drugs. I’ve certainly seen lots of chatter about the dangers of muscle loss with Ozempic, and the need to pound protein and lift weights. That’s a legitimate concern, but aerobic fitness is an even better predictor of longevity and marker of general health. GLP-1 drugs have remarkable properties, but they haven’t made exercise obsolete.
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Fitness
I’m a fitness writer and these are the 44 best deals I’ve found in the Amazon Big Spring Sale
Lou Mudge is a Health Writer at Future Plc, working across Fit&Well and Coach. She previously worked for Live Science, and regularly writes for Space.com and Pet’s Radar. Based in Bath, UK, she has a passion for food, nutrition and health and is eager to demystify diet culture in order to make health and fitness accessible to everybody.
Multiple diagnoses in her early twenties sparked an interest in the gut-brain axis and the impact that diet and exercise can have on both physical and mental health. She was put on the FODMAP elimination diet during this time and learned to adapt recipes to fit these parameters, while retaining core flavors and textures, and now enjoys cooking for gut health.
Fitness
Exercise scientist reveals the strength training mistake many women make, even after lifting for years
Wondering how much weight you should be lifting in the gym to build strength? Dr Stacy Sims says that not going heavy enough could be the biggest mistake women are making in their workouts.
What strength training looks like might differ (for example, some prefer callisthenics over classic weight training) for some, but one thing is clear – it needs to be a challenge.
This is something exercise scientist Dr Stacy Sims was keen to emphasise to journalist Clare Johnston on a recent episode of her podcast, The Honest Channel. The pair discussed why intensity really matters for women when they’re strength training, rather than just doing the same exercise for as many sets or reps as possible.
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Dr Sims says she believes many women don’t push themselves enough when working out, which is why we might not see results as quickly as we want. “There’s an inherent difference between building muscle and building strength. So we know that again, one of the first things that will come is strength, but how are we actually maximising that for women?” she says.
How much weight should I lift?
Dr Sims recommends lifting a weight you can complete for a maximum of six to eight repetitions, leaving just one or two in reserve. As she says in her video on perimenopause and resistance training: if it doesn’t challenge you, it doesn’t change you.
Doing lots of repetitions with lighter dumbbells or other weights won’t have the same effect, she warns. Doing many reps over time improves your muscles’ endurance, but not how fibres within the muscle are working and how tightly they’re contracting, which is what you need to build strength – especially in perimenopause.
“When we start having changes in oestrogen, one of the first things that goes is pure power and strength because oestrogen affects our contractile proteins actin and myosin,” she says. She explains that adding load (lifting heavier) means actin and myosin “hold onto each other a lot harder and to have a very strong and tight contraction – that’s what strength and power are”. This means that if you’re not challenging your muscles to work harder through progressive overload, you won’t see the results you may be aiming for, because the proteins in your muscles are only ever contracting lightly.
“It’s not just about building lean mass, it’s about how strong that muscle is as we go about building it. How do we go about preserving strength and fast-twitch fibres and all the things women need to conserve as we get older to have a really good health span,” Dr Sims explains.
Fast-twitch muscle fibres are needed for heavy weight lifting, sprinting and reaction ability, but they can fatigue quickly and reduce in size and number as we age. This is because of the fall in oestrogen we experience as we enter perimenopause. Men don’t have this problem because their testosterone levels stay more stable throughout their lives.
Taking supplements like creatine, alongside regular exercise, has been shown to improve this as well.
Dr Sims says lifting heavy weights and doing plyometric exercises – explosive, high-intensity exercises such as jumping or hopping – helps women increase and maintain their fast-twitch muscle fibres. She says if we focus on lifting heavy weights for fewer reps, there’s no need to be in the gym for hours every week – welcome news for all of us.
As for how often you should lift weights, she suggests at least three sessions every week with active recovery days between them. This should include mobility exercises and zone 2 exercise, such as a walking workout.
If you’re new to strength training, remember to speak to a trained professional first to ensure you avoid injury.
Fitness
Jogging 101: Benefits for Your Body and Mind
Walking and running share a number of benefits — but what about that sweet middle ground between the two?
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“Jogging is about creating a steady pace,” says sports and exercise medicine specialist Leonardo Oliveira, MD. “Instead of focusing on speed, you’re focused more on endurance with good, quality steps.”
Before your next jaunt, Dr. Oliveira shares the many benefits of jogging and how it can help improve your overall health and wellness.
9 benefits of jogging
Unlike running, where you’re focused on targeting different heart rate zones, jogging involves keeping a more stable and persistent pace. If you’re jogging at a moderate intensity, for example, your target heart rate will usually fall into zone 2, at 60% to 70% of your max heart rate.
“When you’re jogging, you should be able to carry on a conversation as you breathe through your nose,” says Dr. Oliveira. “If you’re doing just 15 minutes of jogging three times a week, you’re already going to notice the benefits.”
Here’s how you can benefit from jogging.
1. Reduces stress
Jogging, like other exercises, can help decrease your stress levels. As an aerobic exercise, it helps release endorphins, which can boost your mood and create feelings of euphoria or satisfaction. Not only does it provide an outlet for pent-up energy, but jogging outside also allows you to spend more time in nature, which provides even more mental health benefits.
“Research shows exercise can be as effective as medication when treating depression because of its wide-ranging benefits,” says Dr. Oliveira.
2. Burns calories
Jogging is a full-body exercise that offers a higher calorie burn than some other aerobic exercises. According to the widely used Compendium of Physical Activities, jogging burns about 7.5 calories per kilogram of body weight each hour. That means you can burn about:
- 8 times as many calories as sitting quietly
- 4 times as many calories as walking
- 2.6 times as many calories as stationary cycling
“Jogging will burn more calories in a shorter period of time than cycling, especially if you’re not used to exercising,” reports Dr. Oliveira.
3. Improves insulin resistance and boosts metabolism
Insulin resistance is one of the biggest barriers to having a healthy metabolism. Insulin helps your body break down glucose for energy. But if your body can’t do that, your metabolism slows down, leading to:
- Lower energy levels
- Weight gain
- An inability to burn fat
“Exercising at higher intensities helps increase metabolism and insulin resistance,” says Dr. Oliveira. “But researchers have also found that even lower-intensity exercises, like jogging, for longer periods of time can have the same effect.”
4. Strengthens your heart
Jogging also has positive impacts on your heart and its ability to pump blood to the rest of your body. That’s because it contributes to hypertrophy, or the strengthening of your heart’s muscle tissues.
“As you develop endurance, the amount of blood in one pump increases,” explains Dr. Oliveira. “When your heart gets stronger, it contracts more efficiently, which decreases your resting heart rate.”
5. Improves lung expansion and gas exchange
The more you work on building endurance and stamina, the more likely it is that you’ll improve your overall ability to breathe — both at rest and while jogging.
“Consistent aerobic exercise helps your lungs get stronger and more efficient,” says Dr. Oliveira. “Over time, you won’t need to breathe as often because each breath brings in more oxygen than before.”
6. Activates muscles
Jogging activates major muscle groups, including your:
- Quads
- Hamstrings
- Glutes
- Core
- Back
“Strength training is a good complement to jogging because it can help strengthen all the areas of your body,” says Dr. Oliveira. “This can help you handle longer distances.”
7. Reduces stiffness
“Jogging is one of those activities where once you get going, you start to feel better,” notes Dr. Oliveira. “It’s an exercise that helps warm up your muscles and lubricate your joints, which can help with the overall sense of stiffness that comes with age.”
That said, jogging is still a high-impact exercise because it forces you to bear down weight as your feet hit the pavement. Consider working with a physical therapist or athletic trainer to reduce the risk of further injury if you:
- Have arthritis
- Have an active injury
- Had previous sprains or fractures in your lower body
8. Improves endurance
“The more you jog, the more you’ll increase your functional aerobic capacity,” says Dr. Oliveira. “Someone who jogs regularly will have better physical fitness that will help them last longer on a bike or a walk than someone who’s just getting started.”
Your ability to breathe and move also extends to other daily activities that demand cardiovascular strength and endurance, like climbing stairs.
9. Provides better quality of life and other mental health benefits
Research shows that any amount of jogging — even just once a week — can improve your quality of life and lower your risk of dying from cancer and cardiovascular-related issues.
“Jogging is a great form of exercise, but it’s not the only one,” notes Dr. Oliveira. “The most important thing is to work on being healthy and strong. And for a lot of people, if you’re looking to advance your physical fitness, jogging is a good place to start.”
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